Tag: 100-200

On February 19, 2020, Wang, Ze-Shu; Chen, Yang-Bo; Zhang, Hao-Wen; Sun, Zhou; Zhu, Chunyin; Ye, Long-Wu published an article.Reference of 2-Amino-4-chlorobenzoic acid The title of the article was Ynamide Smiles Rearrangement Triggered by Visible-Light-Mediated Regioselective Ketyl-Ynamide Coupling: Rapid Access to Functionalized Indoles and Isoquinolines. And the article contained the following:

Here, a novel and practical radical Smiles rearrangement triggered by photoredox-catalyzed regioselective ketyl-ynamide coupling is reported, which represents the first radical Smiles rearrangement of ynamides. This method enables facile access to a variety of valuable 2-benzhydrylindoles with broad substrate scope in generally good yields under mild reaction conditions. In addition, this chem. can also be extended to the divergent synthesis of versatile 3-benzhydrylisoquinolines through a similar ketyl-ynamide coupling and radical Smiles rearrangement, followed by dehydrogenative oxidation Moreover, such an ynamide Smiles rearrangement initiated by intermol. photoredox catalysis via addition of external radical sources is also achieved. By control experiments, the reaction was shown to proceed via key ketyl radical and α-imino carbon radical intermediates. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Reference of 2-Amino-4-chlorobenzoic acid

The Article related to cascade regioselective coupling smiles rearrangement iridium photocatalyst, benzoylbenzyl ethynylsulfonamide preparation coupling regioselective smiles rearrangement iridium photocatalyst, indole benzhydryl preparation, isoquinoline benzhydryl preparation and other aspects.Reference of 2-Amino-4-chlorobenzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On October 18, 1985, Nagao, Yoshimitsu; Ikeda, Takao; Inoue, Takehisa; Yagi, Masahiro; Shiro, Motoo; Fujita, Eiichi published an article.Reference of trimethyloxosulphonium chloride The title of the article was Utilization of sulfur-containing leaving group. 7. Highly selective nonenzymic chiral induction into 3-methylglutaric acid and cis-4-cyclohexen-1,2-ylenebis(acetic acid) utilizing a functional five-membered heterocycle 4(R)-MCTT. And the article contained the following:

Diamide I, prepared by treatment of 3-methylglutaric acid with 4(R)-(methoxycarbonyl)-1,3-thiazolidine-2-thione [4(R)-MCTT] in the presence of DCC in pyridine, was subjected to aminolysis with 1 equiv of piperidine in CH2Cl2 at -30° to give a mixture of diastereomers II [R2N = piperidino, R12N = MCTT moiety (III)] and II (R2N = MCTT moiety, R12N = piperidino) in a 88:12 ratio. III was separated by silica gel column chromatog. and treated with various nucleophiles to give optically pure bifunctional synthons (II; R2N and R12N = nucleophilic group) in high yields. Highly selective chiral induction into cis-4-cyclohexen-1,2-ylenebis(acetic acid) was also performed. Aminolysis of IV (R2N and R12N = MCTT moiety) (V) with 1 equiv of piperidine gave 94% diastereomer IV (R2N = piperidino, R12N = MCTT moiety). Similar chiral induction into cis-cyclohexan-1,2-xylenebis(acetic acid) and aminolysis of its 4(R)-MCTT diamide (VI) with piperidine were also carried out; opposite selectivity was obtained. The conformations of V and VI in a solvent, the relationship between the susceptibility of their conformations and environmental temperature, and the diastereoselectivity of the reaction are discussed on the basis of the 400-MHz 1H NMR spectra. The experimental process involved the reaction of trimethyloxosulphonium chloride(cas: 5034-06-0).Reference of trimethyloxosulphonium chloride

The Article related to chiral induction methylglutaric cyclohexenebisacetic acid, thiazolidinethionecarboxylate amidation methylglutaric cyclohexenebisacetic acid, conformation thiazolidinethionecarboxylate diamide, aminolysis thiazolidinethionecarboxylate diamide stereochem and other aspects.Reference of trimethyloxosulphonium chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Jerhaoui, Soufyan; Djukic, Jean-Pierre; Wencel-Delord, Joanna; Colobert, Francoise published an article in 2017, the title of the article was Stereoselective Sulfinyl Aniline-Promoted Pd-Catalyzed C-H Arylation and Acetoxylation of Aliphatic Amides.Related Products of 35444-44-1 And the article contains the following content:

Stereoselective functionalization of aliphatic C-H bonds presents a great challenge. Following this target, we disclose herein an original strategy towards direct arylation of aliphatic chains at β-methylene position based on a use of amide-sulfoxide bicoordinating directing group. Although moderate to high chiral induction (up to 9:1 d.r.) is achieved, diastereomerically pure compounds may be afforded by simple separation of diastereomeric products by silica gel chromatog. Accordingly, this reaction allows preparation of a large scope of high-value scaffolds in synthetically useful yields while recyclable character of our chiral auxiliary brings an addnl. benefit. A potential of this methodol. to build up original mols. by sequential diarylation and expedient (two step) synthesis of a biol. active compound are further disclosed. Finally a first example of stereoselective direct acetoxylation of aliphatic chains is reported. Thus, e.g., treatment of valeric acid derivative I with 4-iodonitrobenzene in presence of Pd(OAc)2 and AgOAc in PhMe/HFIP afforded arylated product II (85% conversion, 3:2 d.r.). The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).Related Products of 35444-44-1

The Article related to stereoselective palladium catalyzed arylation acetoxylation aliphatic amide, sulfinyl aniline directing group chiral auxiliary stereoselective arylation acetoxylation, c−h activation, aliphatic substrates, bixoordinating dg, direct arylation, sulfoxide and other aspects.Related Products of 35444-44-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On September 2, 1987, Fukuoka, Shinsuke published a patent.Reference of 4-Chloro-2-fluorotoluene The title of the patent was A process for preparation of aryl fluorinated aromatic carboxylates by carbonylation of fluorinated aryl halides in the presence of phenols. And the patent contained the following:

The title compounds, useful as intermediates for heat-resistant polymers, agrochems., and pharmaceuticals, are prepared A mixture of p-IC6H4F 22.2, PhOH 11.3, Bu3N 22.2, and Ni(acac)2 0.77 g was autoclaved under CO at 50 kg/cm2 and 200-220° for 2 h to give 95% p-FC6H4CO2Ph. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Reference of 4-Chloro-2-fluorotoluene

The Article related to fluoroarom carboxylate aryl ester preparation, fluorobenzoate phenyl ester preparation, pharmaceutical agrochem intermediate aryl fluoroarom carboxylate, heat resistant polymer intermediate fluoroarycarboxylate ester, carbonylation fluoroaryl halide and other aspects.Reference of 4-Chloro-2-fluorotoluene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On March 3, 2016, Baum, Erich W.; Fischer, Lindsey G.; Crouse, Gary D.; Sparks, Thomas C. published a patent.SDS of cas: 38939-88-7 The title of the patent was Preparation of 5-(1,2,4-triazol-3-yl)indan-2-ylurea and 6-(1,2,4-triazol-3-yl)-1,2,3,4-tetrahydronaphthalen-2-ylurea derivatives as pesticides, and intermediates, compositions, and processes related thereto. And the patent contained the following:

This disclosure relates to the field of mols. having pesticidal utility against pests such as Phylum nematoda, Arthropoda, and/or Mohusca, processes to produce such mols. and intermediates used in such processes, compositions containing such mols., and processes of using such mols. against such pests. More specifically the title compounds I [R1, R2, R3, R4, R5, R6, R7, R9 = independently H, F, Cl, Br, iodo, cyano, NO2, OH, or each (un)substituted C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1-4 haloalkyl, C1-4 alkoxy, C1-4 haloalkoxy, C3-6cycloalkyl, or C3-6cycloalkoxy; R8 = H; L = (un)substituted C1-4 alkyl; R10 = H or each (un)substituted C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1-4 haloalkyl, (C1-4 alkyl)(C3-6 cycloalkyl), C1-4 alkylphenyl, C1-4 alkylheterocyclyl, (C1-4 alkyl)O(C1-4 alkyl), (C1-4 alkyl)OC(O)(C1-4 alkyl), (C1-4 alkyl)OC(O)O(C1-4 alkyl), C(O)(C1-4 alkyl), or C(O)phenyl, wherein each alkyl, alkenyl, alkynyl, haloalkyl, cycloalkyl; R11, R12, R13, R14, R15 = each independently H, F, Cl, Br, iodo, cyano, NO2, OH, C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1-4 haloalkyl, C1-4 alkoxy, C1-4 haloalkoxy, C3-6 cycloalkyl, or C3-6 cycloalkoxy; R16, R17 = independently group (G), H, or each (un)substituted C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1-4 haloalkyl, (C1-4 alkyl)(C3-6 cycloalkyl), C1-4 alkylphenyl, C1-4 alkylheterocyclyl, (C1-4 alkyl)C(O)(C1-4 alkyl), or (C1-4 alkyl)C(O)O(C1-4 alkyl); group (G) = (un)substituted 4 to 8 membered heterocyclyl ring formed by taking R16 and R17 together with (S)-Cx(Nx)] are prepared The compounds I may be used, for example, as nematicides, acaricides, insecticides, miticides, and/or molluscicides. Thus, dichloromethane (4 mL), water (2 mL), and sodium bicarbonate (0.271 g, 3.22 mmol) were added 5-[1-[4-(trifluoromethoxy)phenyl]-1H-1,2,4-triazol-3-yl]-2,3-dihydro-1H-inden-2-amine dihydrochloride (0.279 g, 0.645 mmol) in a vial (25 mL) equipped with a stir bar under nitrogen. The resulting mixture was cooled in an ice water bath, followed by adding triphosgene (0.0770 g, 0.258 mmol) in one portion and the resulting reaction was stirred vigorously until the conversion of the starting material was observed After workup, the solid obtained was suspended in acetonitrile (6 mL) in a round-bottomed flask (100 mL) equipped with a stir bar under nitrogen, treated with cesium carbonate (0.231 g, 0.709 mmol) and 1-(2-isopropyl-5-methylphenyl)thiourea (0.134 g, 0.645 mmol), and stirred overnight at room temperature to give, after workup and flash chromatog., 39% 1-[(2-isopropyl-5-methylphenyl)carbamothioyl]-3-[5-[1-[4-(trifluoromethoxy)phenyl]-1,2,4-triazol-3-yl]indan-2-yl]urea (II). II controlled 50-100% beet armyworm (Spodoptera exigua) and cabbage looper (Thchoplusia ni) and 80-100% yellow fever mosquito (Aedes aegypti) eggs. The experimental process involved the reaction of 2-Chloro-4-methyl-1-nitrobenzene(cas: 38939-88-7).SDS of cas: 38939-88-7

The Article related to triazolylindanylurea triazolyltetrahydronaphthalenylurea preparation pesticide, nematicide acaricide insecticide triazolylindanylurea triazolyltetrahydronaphthalenylurea preparation, miticides molluscicide triazolylindanylurea triazolyltetrahydronaphthalenylurea preparation and other aspects.SDS of cas: 38939-88-7

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On April 15, 2020, Liu, Jian; Zhou, Jingxian; He, Fengjun; Gao, Liang; Wen, Yu; Gao, Lina; Wang, Ping; Kang, Di; Hu, Lihong published an article.Application of 35444-44-1 The title of the article was Design, synthesis and biological evaluation of novel indazole-based derivatives as potent HDAC inhibitors via fragment-based virtual screening. And the article contained the following:

Based on fragment-based virtual screening and bioisosterism strategies, novel indazoles I [R = C6H5, 4-C5H4N, 3-C4H3S etc.; X = C; Y = (CH2)3, (CH2)4, (CH2)6, etc.] and pyrazolo[3,4-b] pyridine derivatives I [R = 3-MeO-C6H4, 4-MeO-C6H4; X = N; Y = (CH2)6] as HDACs inhibitors were synthesized and evaluated. Most of these compounds displayed good to excellent inhibitory activities against HDACs, especially compounds I [R = 4-MeO-C6H4, 4-Cl-C6H4; X = C; Y = (CH2)6] were identified as potent inhibitors of HDAC1 (IC50 = 2.7 nM and IC50 = 3.1 nM), HDAC2 (IC50 = 4.2 nM and IC50 = 3.6 nM) and HDAC8 (IC50 = 3.6 nM and IC50 = 3.3 nM). Further anti-proliferation assays revealed that compounds I [R = 4-MeO-C6H4, 4-Cl-C6H4; X = C; Y = (CH2)6] showed better anti-proliferative activities against HCT-116 and HeLa cells than pos. control SAHA. The western blot anal. results indicated that compounds I [R = 4-MeO-C6H4, 4-Cl-C6H4; X = C; Y = (CH2)6] noticeably up-regulated the level of acetylated α-tubulin and histone H3. In addition, the two compounds I [R = 4-MeO-C6H4, 4-Cl-C6H4; X = C; Y = (CH2)6] could arrest cell cycle in G2/M phase and promote cell apoptosis, which was similar as the reference compound SAHA. Through the mol. docking and dynamic studies, the potent HDAC inhibitory activities mainly caused by van der Waals and electrostatic interactions with the HDACs. The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).Application of 35444-44-1

The Article related to arylindazolyl hydroxy alkanediamide preparation antitumor hdac inhibition sar docking, phenylpyrazolopyridinyl hydroxy alkanediamide preparation antitumor hdac inhibition sar docking, antitumor activity, fragment-based drug design, hdac, hdac inhibitors, indazole scaffold and other aspects.Application of 35444-44-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Seno, Manabu; Tsuchiya, Shinji published an article in 1977, the title of the article was Preparation, properties, and x-ray photoelectron spectra of palladium(II) and platinum(II) complexes of amine imides aminimides and sulfur ylides.Synthetic Route of 5034-06-0 And the article contains the following content:

Amine imides RMe2N+N-COR1 (R = PhCH2, p-O2NC6H4CH2; R1 = Me, Et, Ph) and the S ylides Me2S+(O)C-HCOPh with Pd(II) and Pt(II) halides gave ylide-metal complexes PdCl2L2 (L = amine imide), PtCl2[Me2S+(O)C-HCOPh]SEt2, and MCl2[Me2S+(O)C-HCOPh]2 (M = Pd, Pt). IR, 1H and 13C NMR, and x-ray photoelectron spectra indicated that the coordination of the ylide to the metal was through the nucleophilic N+ or C- atom as simple terminal ligands. Cis-PtCl2[Me2S+(O)C-HCOPh]SEt2 released SEt2 in Me2SO giving PtCl2[Me2S+(O)C-HCOPh] which was chelated through the carbanion C and the sulfonium O of the ylide. The thermal properties of the complexes were examined by thermal gravimetric anal. and the nature of the bonding was discussed. The experimental process involved the reaction of trimethyloxosulphonium chloride(cas: 5034-06-0).Synthetic Route of 5034-06-0

The Article related to amine imide metal complex, sulfur ylide metal complex, palladium amine imide ylide complex, platinum sulfur ylide complex, ir metal ylide complex, nmr metal ylide complex, photoelectron spectra metal ylide, elec conductivity metal ylide, coordination metal ylide complex and other aspects.Synthetic Route of 5034-06-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Komar, Mario; Kraljevic, Tatjana Gazivoda; Jerkovic, Igor; Molnar, Maja published an article in 2022, the title of the article was Application of Deep Eutectic Solvents in the Synthesis of Substituted 2-Mercaptoquinazolin-4(3H)-Ones: A Comparison of Selected Green Chemistry Methods.Electric Literature of 89-77-0 And the article contains the following content:

In this study, deep eutectic solvents (DESs) were used as green and eco-friendly media for the synthesis of substituted 2-mercaptoquinazolin-4(3H)-ones I [R1 = H, 6-I, 6-Br, 7-Cl, 6,8-dichloro; R2 = Me, Ph, Bn, etc.] from different anthranilic acids and aliphatic or aromatic isothiocyanates. A model reaction on anthranilic acid and Ph isothiocyanate was performed in 20 choline chloride-based DESs at 80 °C to find the best solvent. Based on the product yield, choline chloride:urea (1:2) DES was found to be the most effective, while DESs acted both as solvents and catalysts. Desired compounds were prepared with moderate to good yields using stirring, microwave-assisted, and ultrasound-assisted synthesis. Significantly higher yields were obtained with mixing and ultrasonication (16-76%), while microwave-induced synthesis showed lower effectiveness (13-49%). The structures of the synthesized compounds were confirmed by 1H and 13C NMR spectroscopy. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Electric Literature of 89-77-0

The Article related to mercaptoquinazolinone green preparation, anthranilic acid isothiocyanate microwave ultrasound choline chloride urea catalyst, 2-mercaptoquinazolin-4(3h)-one, deep eutectic solvents, green chemistry, microwave-assisted synthesis, ultrasound-assisted synthesis and other aspects.Electric Literature of 89-77-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On February 19, 2020, Wang, Ze-Shu; Chen, Yang-Bo; Zhang, Hao-Wen; Sun, Zhou; Zhu, Chunyin; Ye, Long-Wu published an article.Reference of 2-Amino-4-chlorobenzoic acid The title of the article was Ynamide Smiles Rearrangement Triggered by Visible-Light-Mediated Regioselective Ketyl-Ynamide Coupling: Rapid Access to Functionalized Indoles and Isoquinolines. And the article contained the following:

Here, a novel and practical radical Smiles rearrangement triggered by photoredox-catalyzed regioselective ketyl-ynamide coupling is reported, which represents the first radical Smiles rearrangement of ynamides. This method enables facile access to a variety of valuable 2-benzhydrylindoles with broad substrate scope in generally good yields under mild reaction conditions. In addition, this chem. can also be extended to the divergent synthesis of versatile 3-benzhydrylisoquinolines through a similar ketyl-ynamide coupling and radical Smiles rearrangement, followed by dehydrogenative oxidation Moreover, such an ynamide Smiles rearrangement initiated by intermol. photoredox catalysis via addition of external radical sources is also achieved. By control experiments, the reaction was shown to proceed via key ketyl radical and α-imino carbon radical intermediates. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Reference of 2-Amino-4-chlorobenzoic acid

The Article related to cascade regioselective coupling smiles rearrangement iridium photocatalyst, benzoylbenzyl ethynylsulfonamide preparation coupling regioselective smiles rearrangement iridium photocatalyst, indole benzhydryl preparation, isoquinoline benzhydryl preparation and other aspects.Reference of 2-Amino-4-chlorobenzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On February 7, 2020, Yuen, Tsz Ying; Brown, Christopher J.; Tan, Yaw Sing; Johannes, Charles W. published an article.Application of 5034-06-0 The title of the article was Synthesis of chiral alkenyl cyclopropane amino acids for incorporation into stapled peptides. And the article contained the following:

α,α’-Disubstituted amino acids serve as important non-proteinogenic amino acids in the construction of stabilized helical peptides. To expand the repertoire of α,α’-disubstituted amino acids, chiral alkenyl-containing cyclopropane amino acids were synthesized via a two-step olefination and cyclopropanation procedure. Herein, we report the first example of the use of alkenyl cyclopropane building blocks to constrain MDM2-targeting helical peptides. The increased potency and efficacy associated with C-terminal cyclopropane substitution is postulated to be driven by a combined effect of net hydrophobicity and enhanced protein association rates. The experimental process involved the reaction of trimethyloxosulphonium chloride(cas: 5034-06-0).Application of 5034-06-0

The Article related to chiral cyclopropane alkenyl amino acid synthesis stapled peptide, solid phase peptide synthesis macrocyclization conformation helix, mdm2 binding fluorescence md simulation enthalpy free energy cluster, glycine derivative horner wadsworth emmons olefination alkenyl aldehyde, condensation reaction stereoselective cyclopropanation and other aspects.Application of 5034-06-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics