Tag: 100-200

Moselage, Marc; Li, Jie; Kramm, Frederik; Ackermann, Lutz published an article in 2017, the title of the article was Ruthenium(II)-Catalyzed C-C Arylations and Alkylations: Decarbamoylative C-C Functionalizations.Computed Properties of 452-75-5 And the article contains the following content:

Ruthenium(II)biscarboxylate catalysis enabled selective C-C functionalizations by means of decarbamoylative C-C arylations. The versatility of the ruthenium(II) catalysis was reflected by widely applicable C-C arylations and C-C alkylations of aryl amides, as well as acids with modifiable pyrazoles, through facile organometallic C-C activation. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Computed Properties of 452-75-5

The Article related to arylindazole decarbamoylative arylation alkylation ruthenium, arylpyrazole decarbamoylative arylation alkylation, ruthenium decarbamoylative arylation alkylation catalyst, c−c activation, amides, arylation, reaction mechanisms, ruthenium and other aspects.Computed Properties of 452-75-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On November 13, 2003, Heppner, Philip D.; Charles, Leslie J.; Dellaria, Joseph F.; Merrill, Bryon A.; Mickelson, John W. published a patent.Recommanded Product: 2-Chloro-4-methyl-1-nitrobenzene The title of the patent was Preparation of aryl ether substituted imidazoquinolines as immune response modifiers. And the patent contained the following:

The title compounds [I; X = (CH2)2, CHEtCH2, etc.; R1 = alkenyl, aryl, R4-aryl; R2 = H, alkyl, alkenyl, etc.; R4 = alkyl, alkenyl which may be interrupted by one or more O atoms; R3 = H, alkyl; n = 0-4; R = alkyl, alkoxy, OH, etc.] that contain ether and aryl or alkenyl functionality at the 1-position, and are useful as immune response modifiers, were prepared E.g., a multi-step synthesis of I [X = (CH2)2; R1 = CH2CCH; R2 = H; n = 0] which showed the lowest effective concentration of 0.12 μM and 1.11 μM to induce biosynthesis of interferon α and TNFα in human cells, resp., was given. The compounds I can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases. The pharmaceutical composition comprising the compound I is claimed. The experimental process involved the reaction of 2-Chloro-4-methyl-1-nitrobenzene(cas: 38939-88-7).Recommanded Product: 2-Chloro-4-methyl-1-nitrobenzene

The Article related to imidazoquinoline aryl ether preparation immunomodulator antiviral antitumor, cytokine interferon tnf alpha biosynthesis inducer imidazoquinoline preparation, tumor necrosis factor alpha biosynthesis inducer imidazoquinoline preparation and other aspects.Recommanded Product: 2-Chloro-4-methyl-1-nitrobenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On November 27, 1975, Tomari, Masazumi; Miyamatsu, Hiroki; Kiyota, Keiichi; Yasuno, Akio published a patent.Product Details of 59833-69-1 The title of the patent was 2-(Alkoxycarbonylmethylphenyl)-1,3-dihydroisoindoles. And the patent contained the following:

Dihydroisoindoles I (X = H, halo; R = H, Me; R1 = C1-4 alkyl) or their salts are prepared by cyclizing o-(ClCH2)2C6H4 (II) with aminophenylacetate esters III (R2 = C1-4 alkyl). I have antiinflammatory and analgesic effects (no data). Thus, 5.24 g II was refluxed with 6 g III (X = 2-Cl, x = 5, R = H, R2 = Me) (IV) and 6.36 g Na2CO3 in DMF 4 hr to give 70% I (X = 2-Cl, x = 5, R = H, R1 = Me). The ester was hydrolyzed with KOH in MeOH to give 51.5% I (X = 2-Cl, x = 5, R = R1 = H), also prepared in 80% yield by heating II and IV with NaOH in MeOH. Similarly prepared were I (X, x, R, R1 given): 2-Cl, 5, Me, Me; 2-Cl, 5, Me, H; H, 4, H, Me; H, 4, H, H. The experimental process involved the reaction of Methyl 2-(3-amino-4-chlorophenyl)acetate(cas: 59833-69-1).Product Details of 59833-69-1

The Article related to analgesic isoindole, antiinflammatory isoindole, isoindole carboxyalkylphenyl, cyclization bischloromethylbenzene carboxyalkylaniline, chloromethylbenzene dicyclization aniline, aminophenylalkanoate cyclization bischloromethylbenzene and other aspects.Product Details of 59833-69-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On January 3, 2022, Gui, Qing-Wen; Teng, Fan; Yang, Hao; Xun, Changping; Huang, Wen-Jie; Lu, Zi-Qin; Zhu, Meng-Xue; Ouyang, Wen-Tao; He, Wei-Min published an article.Electric Literature of 89-77-0 The title of the article was Visible-Light Photosynthesis of CHF2/CClF2/CBrF2-Substituted Ring-fused Quinazolinones in Dimethyl Carbonate. And the article contained the following:

With eco-friendly and sustainable CO2-derived di-Me carbonate as the sole solvent, the visible-light-induced cascade radical reactions have been established as a green and efficient tool for constructing various CHF2/CClF2/CBrF2-substituted ring-fused quinazolinones. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Electric Literature of 89-77-0

The Article related to ring fused quinazolinone preparation, alkenyl quinazolinone visible light cascade difluoromethylation cyclization green chem, cascade radical reactions, difluoromethylation, dimethyl carbonate, metal-free, ring-fused quinazolinones and other aspects.Electric Literature of 89-77-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On September 3, 2021, Li, Ling; Zhang, Shiqi; Deng, Xiongfei; Li, Guangxun; Tang, Zhuo; Zhao, Gang published an article.Quality Control of 2-Amino-4-chlorobenzoic acid The title of the article was Preparation and Application of α-Imino Ketones through One-Pot Tandem Reactions Based on Heyns Rearrangement. And the article contained the following:

A metal-free and operationally simple strategy was developed to generate α-imino ketones with high regioselectivity. Meanwhile, the method allowed for the preparation of various N,O-ketals with high regioselectivities and diastereoselectivities through cascade reactions in one pot. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Quality Control of 2-Amino-4-chlorobenzoic acid

The Article related to amine hydroxyketone regioselective diastereoselective tandem heyns rearrangement oxidation, imino ketone preparation, hydroxyketone aminoalc regioselective diastereoselective tandem heyns rearrangement oxidation, ketal preparation and other aspects.Quality Control of 2-Amino-4-chlorobenzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On February 21, 2022, Nonami, Reina; Morimoto, Yusei; Kanemoto, Kazuya; Yamamoto, Yasunori; Shirai, Tomohiko published an article.Name: 2-Amino-4-chlorobenzoic acid The title of the article was Cationic Iridium-Catalyzed Asymmetric Decarbonylative Aryl Addition of Aromatic Aldehydes to Bicyclic Alkenes. And the article contained the following:

An unprecedented catalytic protocol for the enantioselective decarbonylative transformation of aryl aldehydes. In this process, the decarbonylation of aldehydes catalyzed by chiral iridium complexes enabled the formation of asym. C-C bonds through the formation of an aryl-iridium intermediate. The decarbonylative aryl addition to bicyclic alkenes were fluidly performed without a stoichiometric aryl-metal reagent, such as aryl boronic acid, with a cationic iridium complex generated in-situ from Ir(cod)2(BArF4) and the sulfur-linked bis(phosphoramidite) ligand ((R,R)-S-Me-BIPAM). This reaction has broad functional group compatibility and no waste was generated, except carbon monoxide. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Name: 2-Amino-4-chlorobenzoic acid

The Article related to formylphenyl acetamide norbornene iridium catalyst enantioselective decarbonylation, norbornanyl phenyl acetamide preparation, c−h bond activation, asymmetric catalysis, cationic iridium, decarbonylation, decarbonylative arylation and other aspects.Name: 2-Amino-4-chlorobenzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On March 3, 2016, Baum, Erich W.; Fischer, Lindsey G.; Crouse, Gary D.; Sparks, Thomas C. published a patent.SDS of cas: 38939-88-7 The title of the patent was Preparation of 5-(1,2,4-triazol-3-yl)indan-2-ylurea and 6-(1,2,4-triazol-3-yl)-1,2,3,4-tetrahydronaphthalen-2-ylurea derivatives as pesticides, and intermediates, compositions, and processes related thereto. And the patent contained the following:

This disclosure relates to the field of mols. having pesticidal utility against pests such as Phylum nematoda, Arthropoda, and/or Mohusca, processes to produce such mols. and intermediates used in such processes, compositions containing such mols., and processes of using such mols. against such pests. More specifically the title compounds I [R1, R2, R3, R4, R5, R6, R7, R9 = independently H, F, Cl, Br, iodo, cyano, NO2, OH, or each (un)substituted C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1-4 haloalkyl, C1-4 alkoxy, C1-4 haloalkoxy, C3-6cycloalkyl, or C3-6cycloalkoxy; R8 = H; L = (un)substituted C1-4 alkyl; R10 = H or each (un)substituted C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1-4 haloalkyl, (C1-4 alkyl)(C3-6 cycloalkyl), C1-4 alkylphenyl, C1-4 alkylheterocyclyl, (C1-4 alkyl)O(C1-4 alkyl), (C1-4 alkyl)OC(O)(C1-4 alkyl), (C1-4 alkyl)OC(O)O(C1-4 alkyl), C(O)(C1-4 alkyl), or C(O)phenyl, wherein each alkyl, alkenyl, alkynyl, haloalkyl, cycloalkyl; R11, R12, R13, R14, R15 = each independently H, F, Cl, Br, iodo, cyano, NO2, OH, C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1-4 haloalkyl, C1-4 alkoxy, C1-4 haloalkoxy, C3-6 cycloalkyl, or C3-6 cycloalkoxy; R16, R17 = independently group (G), H, or each (un)substituted C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1-4 haloalkyl, (C1-4 alkyl)(C3-6 cycloalkyl), C1-4 alkylphenyl, C1-4 alkylheterocyclyl, (C1-4 alkyl)C(O)(C1-4 alkyl), or (C1-4 alkyl)C(O)O(C1-4 alkyl); group (G) = (un)substituted 4 to 8 membered heterocyclyl ring formed by taking R16 and R17 together with (S)-Cx(Nx)] are prepared The compounds I may be used, for example, as nematicides, acaricides, insecticides, miticides, and/or molluscicides. Thus, dichloromethane (4 mL), water (2 mL), and sodium bicarbonate (0.271 g, 3.22 mmol) were added 5-[1-[4-(trifluoromethoxy)phenyl]-1H-1,2,4-triazol-3-yl]-2,3-dihydro-1H-inden-2-amine dihydrochloride (0.279 g, 0.645 mmol) in a vial (25 mL) equipped with a stir bar under nitrogen. The resulting mixture was cooled in an ice water bath, followed by adding triphosgene (0.0770 g, 0.258 mmol) in one portion and the resulting reaction was stirred vigorously until the conversion of the starting material was observed After workup, the solid obtained was suspended in acetonitrile (6 mL) in a round-bottomed flask (100 mL) equipped with a stir bar under nitrogen, treated with cesium carbonate (0.231 g, 0.709 mmol) and 1-(2-isopropyl-5-methylphenyl)thiourea (0.134 g, 0.645 mmol), and stirred overnight at room temperature to give, after workup and flash chromatog., 39% 1-[(2-isopropyl-5-methylphenyl)carbamothioyl]-3-[5-[1-[4-(trifluoromethoxy)phenyl]-1,2,4-triazol-3-yl]indan-2-yl]urea (II). II controlled 50-100% beet armyworm (Spodoptera exigua) and cabbage looper (Thchoplusia ni) and 80-100% yellow fever mosquito (Aedes aegypti) eggs. The experimental process involved the reaction of 2-Chloro-4-methyl-1-nitrobenzene(cas: 38939-88-7).SDS of cas: 38939-88-7

The Article related to triazolylindanylurea triazolyltetrahydronaphthalenylurea preparation pesticide, nematicide acaricide insecticide triazolylindanylurea triazolyltetrahydronaphthalenylurea preparation, miticides molluscicide triazolylindanylurea triazolyltetrahydronaphthalenylurea preparation and other aspects.SDS of cas: 38939-88-7

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On April 15, 2020, Liu, Jian; Zhou, Jingxian; He, Fengjun; Gao, Liang; Wen, Yu; Gao, Lina; Wang, Ping; Kang, Di; Hu, Lihong published an article.Application of 35444-44-1 The title of the article was Design, synthesis and biological evaluation of novel indazole-based derivatives as potent HDAC inhibitors via fragment-based virtual screening. And the article contained the following:

Based on fragment-based virtual screening and bioisosterism strategies, novel indazoles I [R = C6H5, 4-C5H4N, 3-C4H3S etc.; X = C; Y = (CH2)3, (CH2)4, (CH2)6, etc.] and pyrazolo[3,4-b] pyridine derivatives I [R = 3-MeO-C6H4, 4-MeO-C6H4; X = N; Y = (CH2)6] as HDACs inhibitors were synthesized and evaluated. Most of these compounds displayed good to excellent inhibitory activities against HDACs, especially compounds I [R = 4-MeO-C6H4, 4-Cl-C6H4; X = C; Y = (CH2)6] were identified as potent inhibitors of HDAC1 (IC50 = 2.7 nM and IC50 = 3.1 nM), HDAC2 (IC50 = 4.2 nM and IC50 = 3.6 nM) and HDAC8 (IC50 = 3.6 nM and IC50 = 3.3 nM). Further anti-proliferation assays revealed that compounds I [R = 4-MeO-C6H4, 4-Cl-C6H4; X = C; Y = (CH2)6] showed better anti-proliferative activities against HCT-116 and HeLa cells than pos. control SAHA. The western blot anal. results indicated that compounds I [R = 4-MeO-C6H4, 4-Cl-C6H4; X = C; Y = (CH2)6] noticeably up-regulated the level of acetylated α-tubulin and histone H3. In addition, the two compounds I [R = 4-MeO-C6H4, 4-Cl-C6H4; X = C; Y = (CH2)6] could arrest cell cycle in G2/M phase and promote cell apoptosis, which was similar as the reference compound SAHA. Through the mol. docking and dynamic studies, the potent HDAC inhibitory activities mainly caused by van der Waals and electrostatic interactions with the HDACs. The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).Application of 35444-44-1

The Article related to arylindazolyl hydroxy alkanediamide preparation antitumor hdac inhibition sar docking, phenylpyrazolopyridinyl hydroxy alkanediamide preparation antitumor hdac inhibition sar docking, antitumor activity, fragment-based drug design, hdac, hdac inhibitors, indazole scaffold and other aspects.Application of 35444-44-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Seno, Manabu; Tsuchiya, Shinji published an article in 1977, the title of the article was Preparation, properties, and x-ray photoelectron spectra of palladium(II) and platinum(II) complexes of amine imides aminimides and sulfur ylides.Synthetic Route of 5034-06-0 And the article contains the following content:

Amine imides RMe2N+N-COR1 (R = PhCH2, p-O2NC6H4CH2; R1 = Me, Et, Ph) and the S ylides Me2S+(O)C-HCOPh with Pd(II) and Pt(II) halides gave ylide-metal complexes PdCl2L2 (L = amine imide), PtCl2[Me2S+(O)C-HCOPh]SEt2, and MCl2[Me2S+(O)C-HCOPh]2 (M = Pd, Pt). IR, 1H and 13C NMR, and x-ray photoelectron spectra indicated that the coordination of the ylide to the metal was through the nucleophilic N+ or C- atom as simple terminal ligands. Cis-PtCl2[Me2S+(O)C-HCOPh]SEt2 released SEt2 in Me2SO giving PtCl2[Me2S+(O)C-HCOPh] which was chelated through the carbanion C and the sulfonium O of the ylide. The thermal properties of the complexes were examined by thermal gravimetric anal. and the nature of the bonding was discussed. The experimental process involved the reaction of trimethyloxosulphonium chloride(cas: 5034-06-0).Synthetic Route of 5034-06-0

The Article related to amine imide metal complex, sulfur ylide metal complex, palladium amine imide ylide complex, platinum sulfur ylide complex, ir metal ylide complex, nmr metal ylide complex, photoelectron spectra metal ylide, elec conductivity metal ylide, coordination metal ylide complex and other aspects.Synthetic Route of 5034-06-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Komar, Mario; Kraljevic, Tatjana Gazivoda; Jerkovic, Igor; Molnar, Maja published an article in 2022, the title of the article was Application of Deep Eutectic Solvents in the Synthesis of Substituted 2-Mercaptoquinazolin-4(3H)-Ones: A Comparison of Selected Green Chemistry Methods.Electric Literature of 89-77-0 And the article contains the following content:

In this study, deep eutectic solvents (DESs) were used as green and eco-friendly media for the synthesis of substituted 2-mercaptoquinazolin-4(3H)-ones I [R1 = H, 6-I, 6-Br, 7-Cl, 6,8-dichloro; R2 = Me, Ph, Bn, etc.] from different anthranilic acids and aliphatic or aromatic isothiocyanates. A model reaction on anthranilic acid and Ph isothiocyanate was performed in 20 choline chloride-based DESs at 80 °C to find the best solvent. Based on the product yield, choline chloride:urea (1:2) DES was found to be the most effective, while DESs acted both as solvents and catalysts. Desired compounds were prepared with moderate to good yields using stirring, microwave-assisted, and ultrasound-assisted synthesis. Significantly higher yields were obtained with mixing and ultrasonication (16-76%), while microwave-induced synthesis showed lower effectiveness (13-49%). The structures of the synthesized compounds were confirmed by 1H and 13C NMR spectroscopy. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Electric Literature of 89-77-0

The Article related to mercaptoquinazolinone green preparation, anthranilic acid isothiocyanate microwave ultrasound choline chloride urea catalyst, 2-mercaptoquinazolin-4(3h)-one, deep eutectic solvents, green chemistry, microwave-assisted synthesis, ultrasound-assisted synthesis and other aspects.Electric Literature of 89-77-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics