Tag: 100-200

On September 15, 2021, Chai, Xin-Yue; Xu, Hui-Bei; Dong, Lin published an article.SDS of cas: 35444-44-1 The title of the article was Cascade Reaction to Selectively Synthesize Multifunctional Indole Derivatives by IrIII-Catalyzed C-H Activation. And the article contained the following:

An effective and condition-controlled way to synthesize with high selectivity a variety of functionalized indoles with potent biol. properties has been developed. Notably, 2,4-dialkynyl indole products were obtained by direct double C-H bond alkynylation, whereas alkynyl at the C4 position could convert to carbonyl to generate 2-alkynyl-3,4-diacetyl indoles fast and effectively. Addnl., a one-pot relay catalytic reaction led to 2,5-di-alkynyl-3,4-diacetyl indoles when using a carbonyl group as the directing group and by controlling the type and quantity of additives. A possible mechanism was proposed based on many studies including deuterium-exchange experiments, the necessary conditions of product conversion, and the effect of water on the reaction. The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).SDS of cas: 35444-44-1

The Article related to indole preparation, acyl indole bromoalkyne alkynylation carbonylation iridium catalyst, alkynylation, carbonylation, cascade reactions, iridium, multifunctional indole derivatives, multistep c−h activation and other aspects.SDS of cas: 35444-44-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On November 7, 2007, Kakei, Hiroyuki; Sone, Toshihiko; Sohtome, Yoshihiro; Matsunaga, Shigeki; Shibasaki, Masakatsu published an article.HPLC of Formula: 5034-06-0 The title of the article was Catalytic Asymmetric Cyclopropanation of Enones with Dimethyloxosulfonium Methylide Promoted by a La-Li3-(Biphenyldiolate)3 + NaI Complex. And the article contained the following:

Catalytic asym. cyclopropanation of enones with dimethyloxosulfonium methylide using a La-Li3-(biphenyldiolate)3 + NaI complex is described. The present method is complementary to the previously reported catalytic enantioselective methods in terms of ylides used, and trans products, e.g., I, were exclusively obtained in good yield (96-73%) and high enantioselectivity (99-84% ee). Use of biphenyldiol and NaI additive was essential to achieve high enantioselectivity. The experimental process involved the reaction of trimethyloxosulphonium chloride(cas: 5034-06-0).HPLC of Formula: 5034-06-0

The Article related to enone dimethyloxosulfonium methylide lanthanium chiral biphenyldiol complex asym cyclopropanation, cyclopropyl ketone derivative stereoselective preparation, asym cyclopropanation catalyst lanthanium chiral biphenyldiol complex and other aspects.HPLC of Formula: 5034-06-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On December 31, 1979, Corley, L. S.; Vogl, O. published an article.Application In Synthesis of trimethyloxosulphonium chloride The title of the article was Haloaldehyde polymers. 16. Stabilization of anionically-prepared polychloral by end-capping with decomposable cations and other additives. And the article contained the following:

Completely or partially stable polychloral [25154-92-1] was obtained by anionic cryotachensic polymerization of Cl3CCHO in the presence of alkylating or acylating agents, e.g. Me2SO4 [77-78-1]. Stabilization was also effected by polymerization using salts with easily decomposed cations as anionic initiators. Sulfonium salts, e.g. Me3S+Cl- [3086-29-1] and [Me2S+CH2Ph]Br- [14182-15-1], and iodonium salts, e.g. Ph2I+Cl- [1483-72-3], were effective although quant. stabilization was not achieved. Polychloral with improved stability was also obtained using certain amide acetals, e.g. Me2NCH(OMe)2 [4637-24-5], as initiators. The experimental process involved the reaction of trimethyloxosulphonium chloride(cas: 5034-06-0).Application In Synthesis of trimethyloxosulphonium chloride

The Article related to polychloral stabilization, chloral anionic polymerization stability, sulfonium catalyst chloral polymerization, iodonium initiator chloral polymerization, amide acetal chloral polymerization, end capping polychloral stability and other aspects.Application In Synthesis of trimethyloxosulphonium chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On July 20, 2020, Plaza, Manuel; Jandl, Christian; Bach, Thorsten published an article.COA of Formula: C7H11ClO3 The title of the article was Photochemical Deracemization of Allenes and Subsequent Chirality Transfer. And the article contained the following:

Trisubstituted allenes with a 3-(1′-alkenylidene)-pyrrolidin-2-one motif were successfully deracemized (13 examples, 86-98% ee) employing visible light (λ=420 nm) and a chiral triplet sensitizer as the catalyst (2.5 mol %). The photocatalyst likely operates by selective recognition of one allene enantiomer via hydrogen bonds and by a triplet-sensitized racemization process. Even a tetrasubstituted allene (45% ee) and a seven-membered 3-(1′-alkenylidene)-azepan-2-one (62% ee) could be enantiomerically enriched under the chosen conditions. It was shown that the axial chirality of the allenes can be converted into point chirality by a Diels-Alder (94-97% ee) or a bromination reaction (91% ee). Ring opening of the five-membered pyrrolidin-2-one was achieved without significantly compromising the integrity of the chirality axis (92% ee). The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).COA of Formula: C7H11ClO3

The Article related to allene deracemization chiral resolution chiral triplet sensitizer enantioselectivity light, chiral trisubstituted allene preparation, allenes, chiral resolution, enantioselectivity, hydrogen bonds, photochemistry, sensitizers and other aspects.COA of Formula: C7H11ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On March 31, 2021, Faraji, Aram; Motahari, Rasoul; Hasanvand, Zaman; Oghabi Bakhshaiesh, Tayebeh; Toolabi, Mahsa; Moghimi, Setareh; Firoozpour, Loghman; Boshagh, Mohammad Amin; Rahmani, Roya; Ketabforoosh, Shima H. M. E.; Bijanzadeh, Hamid Reza; Esmaeili, Rezvan; Foroumadi, Alireza published an article.Application of 89-77-0 The title of the article was Quinazolin-4(3H)-one based agents bearing thiadiazole-urea: Synthesis and evaluation of anti-proliferative and antiangiogenic activity. And the article contained the following:

A series of quinazolin-4(3H)-one based agents containing thiadiazole-urea I [X = H, Cl; R1 = H, Me, Cl, etc.; R2 = H, Me, F, MeO, Cl] were designed, synthesized and biol. evaluated. The proliferation rate of PC3 cells were moderately reduced by compound I [X = R2 = H, R1 = Me] (IC50 = 17.7μM) which was comparable with sorafenib (IC50 = 17.3μM). There was also a significant reduction in the number of HUVEC cells, when they were exposed to compound I [X = R1 = Cl, R2 = Me] (IC50 = 6.1μM). To test the potential of compounds I in inducing apoptosis, Annexin V-FITC/propidium iodide double staining assay was used. After the treatment of HUVEC cells with compound I [X = R2 = H, R1 = Me], they underwent apoptotic effects. A substantial effort was dedicated to gathering comprehensive data across CAM assay. These data showed that compound I [X = R2 = H, R1 = Me] moderately inhibited the growth of corresponding blood vessels. Finally, the outcomes of Western blotting proposed a mechanism of action, by which the phosphorylation of VEGFR-2 was inhibited by compounds I [X = R2 = H, R1 = Me; X = R1 = Cl, R2 = Me]. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Application of 89-77-0

The Article related to phenylureido thiadiazolylthiomethyl dihydroquinazolinone preparation, antitumor cytotoxicity sar antiangiogenic mol docking apoptosis induction, apoptotic effects, cam assay, pc3 cells, sorafenib, vegfr-2, western blotting and other aspects.Application of 89-77-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Wang, Haiyang; Guo, Chang published an article in 2019, the title of the article was Enantioselective γ-Addition of Pyrazole and Imidazole Heterocycles to Allenoates Catalyzed by Chiral Phosphine.Name: Methyl 6-chloro-6-oxohexanoate And the article contains the following content:

Chiral phosphines were found to catalyze the enantioselective asym. γ-addition of heteroaromatic compounds to allenoates in good yields with high enantiomeric ratios and regioselectivity in the presence of (S)-BINOL. Both pyrazole and imidazole could be employed in this process. The synthetic value of these γ-addition products was demonstrated by the preparation of biol. relevant mols. and structural scaffolds. Remarkably, the synthetic utility of this strategy was demonstrated through a two-step synthesis of a Janus kinase (JAK) inhibitor. The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).Name: Methyl 6-chloro-6-oxohexanoate

The Article related to heterocycle substituted alkenoate enantioselective preparation, heteroaromatic compound allenoate enantioselective addition chiral phosphine catalyst, allenoates, asymmetric catalysis, heterocycles, phosphines, γ-addition and other aspects.Name: Methyl 6-chloro-6-oxohexanoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Ladelta, Viko; Zapsas, George; Abou-hamad, Edy; Gnanou, Yves; Hadjichristidis, Nikos published an article in 2019, the title of the article was Tetracrystalline Tetrablock Quarterpolymers: Four Different Crystallites under the Same Roof.Recommanded Product: trimethyloxosulphonium chloride And the article contains the following content:

Multicrystalline block polymers having three or more crystalline segments are essential materials for the advancement of physics in the field of crystallinity. The challenging synthesis of multicrystalline polymers has resulted in only a limited number of tricryst. terpolymers having been reported to date. We report, for the first time, the synthesis of polyethylene-b-poly(ethylene oxide)-b-poly(ε-caprolactone)-b-poly(L-lactide) (PE-b-PEO-b-PCL-b-PLLA), a tetracryst. tetrablock quarterpolymer, by combining polyhomologation, ring-opening polymerization, and an organic/metal “catalyst switch” strategy. 1H NMR spectroscopy and gel-permeation chromatog. confirmed the formation of the tetrablock quarterpolymer, while differential scanning calorimetry, X-ray diffraction, and wide-line separation solid-state NMR spectroscopy revealed the existence of four different crystalline domains. The experimental process involved the reaction of trimethyloxosulphonium chloride(cas: 5034-06-0).Recommanded Product: trimethyloxosulphonium chloride

The Article related to polyethylene oxide polycaprolactone polylactide tetrablock quarterpolymer synthesis characterization, catalyst switch, multicrystalline polymers, polyhomologation, ring-opening polymerization, tetrablock quarterpolymers and other aspects.Recommanded Product: trimethyloxosulphonium chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On January 1, 2016, MacLean, Mark A.; Diez-Cecilia, Elena; Lavery, Christopher B.; Reed, Mark A.; Wang, Yanfei; Weaver, Donald F.; Stradiotto, Mark published an article.HPLC of Formula: 452-75-5 The title of the article was Diversification of edaravone via palladium-catalyzed hydrazine cross-coupling: Applications against protein misfolding and oligomerization of beta-amyloid. And the article contained the following:

N-Aryl derivatives of edaravone were identified as potentially effective small mol. inhibitors of tau and beta-amyloid aggregation in the context of developing disease-modifying therapeutics for Alzheimer’s disease (AD). Palladium-catalyzed hydrazine monoarylation protocols were then employed as an expedient means of preparing a focused library of 21 edaravone derivatives featuring varied N-aryl substitution, thereby enabling structure-activity relationship (SAR) studies. On the basis of data obtained from two functional biochem. assays examining the effect of edaravone derivatives on both fibril and oligomer formation, it was determined that derivatives featuring an N-biaryl motif were four-fold more potent than edaravone. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).HPLC of Formula: 452-75-5

The Article related to edaravone derivative preparation palladium catalyzed protein misfolding beta amyloid, alzheimers treatment edaravone derivative beta amyloid tau aggregation inhibitor, alzheimer’s disease, beta-amyloid, hydrazine, palladium-catalyzed aminations and other aspects.HPLC of Formula: 452-75-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Wei, Hao-Zhao; Yu, Liu-Zhu; Shi, Min published an article in 2020, the title of the article was Lewis or Bronsted acid-catalysed reaction of propargylic alcohol-tethered alkylidenecyclopropanes with indoles and pyrroles for the preparation of polycyclic compounds tethered with indole or pyrrole motif.Product Details of 89-77-0 And the article contains the following content:

A facile synthetic method to access cyclopenta[b]naphthalene derivatives I (R1 = H, 3-Me, 5-Me, 4-CF3, 5-OMe, 4-MeO, 4-Cl; R2 = Ph, 4-MeOC6H4, 3-thienyl; R3 = H, Me, OMe, Cl, F; R4 = H, Me, OMe, Cl; R5 = N-methylpyrrol-2-yl, indol-3-yl, N-phenylindol-3-yl, etc.) via the Lewis or Bronsted acid catalyzed cascade nucleophilic addition, electronic cyclization, ring-opening rearrangement of propargylic alc.-tethered alkylidenecyclopropanes II (R6 = H, 5-MeO, 5-Cl, 6-Me, etc.) with indole and pyrrole derivatives was developed. The reaction exhibited a broad substrate scope and good functional group tolerance under metal-free conditions, affording the desired products in moderate to good yields. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Product Details of 89-77-0

The Article related to cyclopenta naphthalene indole preparation, propargylic alc alkylidenecyclopropane indole cyclization lewis acid catalyst, naphthalene cyclopenta pyrrole preparation, pyrrole propargylic alc alkylidenecyclopropane cyclization lewis acid catalyst and other aspects.Product Details of 89-77-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On February 28, 2022, Rastegari, Arezoo; Safavi, Maliheh; Vafadarnejad, Fahimeh; Najafi, Zahra; Hariri, Roshanak; Bukhari, Syed Nasir Abbas; Iraji, Aida; Edraki, Najmeh; Firuzi, Omidreza; Saeedi, Mina; Mahdavi, Mohammad; Akbarzadeh, Tahmineh published an article.Related Products of 89-77-0 The title of the article was Synthesis and evaluation of novel arylisoxazoles linked to tacrine moiety: in vitro and in vivo biological activities against Alzheimer’s disease. And the article contained the following:

Focusing on the efficient cholinesterase inhibitory activity of tacrine, design and synthesis of arylisoxazole-tacrine analogs, I [R = H, 4-F, 4-O2N, etc.; X = H, Cl] was developed. In-vitro acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibition assay confirmed high potency of the title compds I. Among them, compounds I [R = 3-MeO, X = Cl; R = 4-Cl, X = H] demonstrated high activity toward AChE and BChE with IC50 values of 0.050 and 0.039μM, resp. Both compounds I [R = 3-MeO, X = Cl; R = 4-Cl, X = H] showed very good self-induced Aβ aggregation and AChE-induced inhibitory activity (79.4 and 71.4% for compound I [R = 3-MeO, X = Cl] and 61.8 and 58.6% for compound I [R = 4-Cl, X = H], resp.). Also, I [R = 3-MeO, X = Cl] showed good anti-BACE1 activity with IC50 value of 1.65μM. The metal chelation test indicated the ability of compounds I [R = 3-MeO, X = Cl; R = 4-Cl, X = H] to chelate biometals (Zn2+, Cu2+, and Fe2+). However, they showed no significant neuroprotectivity against Aβ-induced damage in PC12 cells. Evaluation of in-vitro hepatotoxicity revealed comparable toxicity of compounds I [R = 3-MeO, X = Cl; R = 4-Cl, X = H] with tacrine. In-vivo studies by Morris water maze (MWM) task demonstrated that compound I [R = 3-MeO, X = Cl] significantly reversed scopolamine-induced memory deficit in rats. Finally, mol. docking studies of compounds I [R = 3-MeO, X = Cl; R = 4-Cl, X = H] confirmed establishment of desired interactions with the AChE, BChE, and BACE1 active sites. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Related Products of 89-77-0

The Article related to phenyl tetrahydroacridinyl aminoethyl isoxazole preparation cholinesterase bace1 inhibition neuroprotection, mol docking sar metal chelation, alzheimer’s disease, bace1, cholinesterase, isoxazole, metal chelating, morris water maze, tacrine and other aspects.Related Products of 89-77-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics