Tag: 100-200

On December 31, 1990, Anchordoguy, Thomas J.; Carpenter, John F.; Cecchini, Christine A.; Crowe, John H.; Crowe, Lois M. published an article.Name: trimethyloxosulphonium chloride The title of the article was Effects of protein perturbants on phospholipid bilayers. And the article contained the following:

Series of alcs., amides, ureas, and sulfoxides with increasingly longer hydrocarbon chains lower progressively the thermal denaturation temperature of proteins. Several classes of compounds were investigated for effects on the stability of phospholipid vesicles. Many compounds that are known to perturb protein function also destabilize phospholipid bilayers as reflected by solute-induced loss of vesicle contents. The experimental process involved the reaction of trimethyloxosulphonium chloride(cas: 5034-06-0).Name: trimethyloxosulphonium chloride

The Article related to phospholipid membrane permeability solute perturbant structure, urea membrane destabilization, amide membrane destabilization, alc membrane destabilization, sulfoxide membrane destabilization and other aspects.Name: trimethyloxosulphonium chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On March 6, 2015, Jagadeesh, Rajenahally V.; Natte, Kishore; Junge, Henrik; Beller, Matthias published an article.Formula: C7H6ClNO2 The title of the article was Nitrogen-Doped Graphene-Activated Iron-Oxide-Based Nanocatalysts for Selective Transfer Hydrogenation of Nitroarenes. And the article contained the following:

Nanoscaled iron oxides on carbon were modified with nitrogen-doped graphene (NGr) and found to be excellent catalysts for the chemoselective transfer hydrogenation of nitroarenes to anilines. Under standard reaction conditions, a variety of functionalized and structurally diverse anilines, which serve as key building blocks and central intermediates for fine and bulk chems., were synthesized in good to excellent yields. The experimental process involved the reaction of 2-Chloro-4-methyl-1-nitrobenzene(cas: 38939-88-7).Formula: C7H6ClNO2

The Article related to nitroarene nitrogen doped graphene activated iron chemoselective transfer hydrogenation, aniline preparation, nitrogen doped graphene activated iron oxide transfer hydrogenation nanocatalyst and other aspects.Formula: C7H6ClNO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On July 31, 2020, Cieslikiewicz-Bouet, Monika; Naldi, Marina; Bartolini, Manuela; Perez, Belen; Servent, Denis; Jean, Ludovic; Araoz, Romulo; Renard, Pierre-Yves published an article.Application In Synthesis of 2-Amino-4-chlorobenzoic acid The title of the article was Functional characterization of multifunctional ligands targeting acetylcholinesterase and alpha 7 nicotinic acetylcholine receptor. And the article contained the following:

Alzheimer’s disease (AD) is a neurodegenerative disorder associated with cholinergic dysfunction, provoking memory loss and cognitive dysfunction in elderly patients. The cholinergic hypothesis provided over the years with mol. targets for developing palliative treatments for AD, acting on the cholinergic system, namely, acetylcholinesterase and α7 nicotinic acetylcholine receptor (α7 nAChR). In our synthetic work, we used “click-chem.” to synthesize two Multi Target Directed Ligands (MTDLs) MB105 and MB118 carrying tacrine and quinuclidine scaffolds which are known for their anticholinesterase and α7 nAChR agonist activities, resp. Both, MB105 and MB118, inhibit human acetylcholinesterase and human butyrylcholinesterase in the nanomolar range. Electrophysiol. recordings on Xenopus laevis oocytes expressing human α7 nAChR showed that MB105 and MB118 acted as partial agonists of the referred nicotinic receptor, albeit, with different potencies despite their similar structure. The different substitution at C-3 on the 2,3-disubstituted quinuclidine scaffold may account for the significantly lower potency of MB118 compared to MB105. Electrophysiol. recordings also showed that the tacrine precursor MB320 behaved as a competitive antagonist of human α7 nAChR, in the micromolar range, while the quinuclidine synthetic precursor MB099 acted as a partial agonist. Taken all together, MB105 behaved as a partial agonist of α7 nAChR at concentrations where it completely inhibited human acetylcholinesterase activity paving the way for the design of novel MTDLs for palliative treatment of AD. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Application In Synthesis of 2-Amino-4-chlorobenzoic acid

The Article related to preparation tacrine quinuclidine derivative ache nicotinic receptor, acetylcholinesterase, alpha 7 nicotinic acetylcholine receptor, alzheimer’s disease, butyrylcholinesterase, multi-target directed ligand and other aspects.Application In Synthesis of 2-Amino-4-chlorobenzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Rodriguez-Aristegui, Sonsoles; Clapham, Kate M.; Barrett, Lauren; Cano, Celine; Desage-El Murr, Marine; Griffin, Roger J.; Hardcastle, Ian R.; Payne, Sara L.; Rennison, Tommy; Richardson, Caroline; Golding, Bernard T. published an article in 2011, the title of the article was Versatile synthesis of functionalised dibenzothiophenes via Suzuki coupling and microwave-assisted ring closure.Related Products of 38939-88-7 And the article contains the following content:

Amino-substituted biphenyls were obtained by Suzuki cross-coupling of 2,6-dibromoaniline with a phenylboronic acid (substituted with Me, NO2, OH, OMe or Cl) preferably assisted by microwave irradiation Conversion of the amino group into a thiol preceded a base-induced intramol. substitution, also facilitated by microwave heating, to generate the second C-S bond of the target dibenzothiophene, e.g. I (R1 = MeO, R2 = R3 = R4 = H; R1 = R2 = R4 = H, R3 = Cl; R1 = R3 = R4 = H, R2 = OH). The 1-, 2-, 3- or 4-substituted 6-halodibenzothiophenes obtained were subjected to a palladium-mediated coupling with 2-morpholin-4-yl-8-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4H-chromen-4-one to give the resp. 6-, 7-, 8- or 9-substituted dibenzothiophen-4-ylchromenones, e.g. II (R1 = MeO, R2 = R3 = R4 = H; R1 = R2 = R4 = H, R3 = Cl; R1 = R3 = R4 = H, R2 = OH). These compounds were evaluated as inhibitors of DNA-dependent protein kinase (DNA-PK) and compared to the parent 8-(dibenzo[b,d]thiophen-4-yl)-2-morpholin-4-yl-4H-chromen-4-one. Notably, derivatives bearing hydroxy or methoxy substituents at C-8 or C-9 retained activity, whereas substitution at C-7 lowered activity. Substitution with chloro at C-6 was not detrimental to activity, but a chloro group at C-7 or C-8 reduced potency. The data indicate permissive elaboration of hydroxyl at C-8 or C-9, enabling the possibility of improved pharmaceutical properties, while retaining potency against DNA-PK. The experimental process involved the reaction of 2-Chloro-4-methyl-1-nitrobenzene(cas: 38939-88-7).Related Products of 38939-88-7

The Article related to dibenzothiophenylchromenone preparation structure activity relationship dna protein kinase inhibiting, suzuki coupling intramol substitution microwave irradiation dibenzothiophenylchromenone preparation and other aspects.Related Products of 38939-88-7

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On April 25, 1986, Matsuda, Akira; Ueda, Tohru published an article.Formula: C3H9ClOS The title of the article was Nucleosides and nucleotides. LXVI. Synthesis of 8,6′-cyclo-6′-deoxyhexofuranosyladenines: adenosines fixed in an anti-conformation. And the article contained the following:

For studies of the conformation of nucleosides around the glycosyl linkages, the carbon-bridged cycloadenosines I (R = OH, R1 = H; R = H, R1 = OH) were prepared by the following route. Treatment of N6-benzoyl-2′,3′-O-isopropylideneadenosine 5′-aldehyde with dimethyloxosulfonium methylide afforded the 5′,6′-anhydrohexofuranosyladenine II, which was treated with thiophenoxide to give the diastereomeric 6′-phenylthio derivatives III. Photoirradiation of III followed by 5′-O-acetylation afforded III. Attempted synthesis of a 8,7′-cycloheptofuranosyl derivative by way of photolysis of a 7′-phenylthioheptofuranosyladenine resulted in the formation of 5′,6′,7′-trideoxy-2′,3′-O-isopropylidene-β-D-ribo-heptofuranosyladenine. The nature of the CD spectra of I is discussed. The experimental process involved the reaction of trimethyloxosulphonium chloride(cas: 5034-06-0).Formula: C3H9ClOS

The Article related to cyclo deoxyhexofuranosyladenine, carbon bridged cycloadenosine, nucleoside carbon bridged cyclo, cd cyclo deoxyhexofuranosyladenine, conformation nucleoside, photochem cyclization phenylthio nucleoside and other aspects.Formula: C3H9ClOS

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On March 17, 2021, Li, Xiaoyu; Golden, Jennifer E. published an article.HPLC of Formula: 89-77-0 The title of the article was Construction of N-Boc-2-Alkylaminoquinazolin-4(3H)-Ones via a Three-Component, One-Pot Protocol Mediated by Copper(II) Chloride that Spares Enantiomeric Purity. And the article contained the following:

A multicomponent procedure integrating anthranilic acids, N-Boc-amino acids and amines in the presence of methanesulfonyl chloride, N-methylimidazole, and copper(II) chloride was developed to mildly afford N-Boc-2-alkylaminoquinazolin-4(3H)-ones, e.g., I, with excellent preservation of enantiomeric purity (>99% ee). Copper(II) chloride was essential to retaining enantiopurity and reaction component structural changes were well tolerated, resulting in an efficient, all-in-one procedure that promoted sequential coupling, lactonization, aminolysis and cyclization in good yields. The method was applied to the rapid assembly of four key intermediates used in the synthesis of high profile quinazolinones, including several PI3K inhibitor drugs. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).HPLC of Formula: 89-77-0

The Article related to boc alkylaminoquinazolinone preparation enantioselective, anthranilic acid amino aniline copper chloride mediated multicomponent, pi3 kinase, copper-mediated, enantiopurity, quinazolinone, racemization and other aspects.HPLC of Formula: 89-77-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Fernandez, Gabriela A.; Castro, Eliana F.; Rosas, Rocio A.; Fidalgo, Daniela M.; Adler, Natalia S.; Battini, Leandro; Espana de Marco, Maria J.; Fabiani, Matias; Bruno, Ana M.; Bollini, Mariela; Cavallaro, Lucia V. published an article in 2020, the title of the article was Design and optimization of quinazoline derivatives: new non-nucleoside inhibitors of bovine viral diarrhea virus.Application of 89-77-0 And the article contains the following content:

In a previous work, potential mols. that dock into an allosteric binding pocket of BVDV RdRp via a structure-based virtual screening approach was identified. One of them, N-(2-morpholinoethyl)-2-phenylquinazolin-4-amine I [R2 = Ph; R4 = 2-morpholinoethylamino; R7 = H] [50% effective concentration (EC50) = 9.7 ± 0.5μM], was selected to perform different chem. modifications. Among synthesized derivatives I [R2 = H, Ph, 4-MeC6H4, etc.; R4 = 4-methylpiperazin-1-yl, HN(CH2)5CH3, 4-methoxyanilino, etc.; R7 = H, Cl], compound I [R2 = H, Ph, 4-(Me)2NC6H4; R4 = 4-methylpiperazin-1-yl, 3-(dimethylamino)propylamino, 4-(2-hydroxyethyl)piperazin-1-yl, (2-morpholinoethylamino), 2-(1-piperidyl)ethylamino, 2-(1-piperidyl)ethylamino, (2,2,6,6-tetramethyl-4-piperidyl)amino, ; R7 = H, Cl] of them showed considerable antiviral activity. Mol. modeling of the most active compounds I [R2 = H, Ph, 4-MeC6H4, 4-MeOC6H4, 4-O2NC6H4, 4-(Me)2NC6H4; R4 = 4-methylpiperazin-1-yl, 3-(dimethylamino)propylamino, 4-(2-hydroxyethyl)piperazin-1-yl, 2-morpholinoethylamino, 2-(1-piperidyl)ethylamino, (2,2,6,6-tetramethyl-4-piperidyl)amino; R7 = H, Cl] showed that they bind to a pocket located in the fingers and thumb domains in BVDV RdRp, which was different than that identified for other non-nucleoside inhibitors (NNIs) such as thiosemicarbazone (TSC). Compound 2-[4-(2-phenylquinazolin-4-yl)piperazin-1-yl]ethanol I [R2 = Ph; R4 = 4-(2-hydroxyethyl)piperazin-1-yl; R7 = H] ( EC50 = 1.7 ± 0.4μM) was selected for further anal. Compound I [R2 = Ph; R4 = 4-(2-hydroxyethyl)piperazin-1-yl; R7 = H] was found to inhibit the in vitro replication of TSC-resistant BVDV variants, which carry the N264D mutation in the RdRp. In addition, I [R2 = Ph; R4 = 4-(2-hydroxyethyl)piperazin-1-yl; R7 = H] presented adequate solubility in different media and a high-stability profile in murine and bovine plasma. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Application of 89-77-0

The Article related to quinazolinyl amine preparation antiviral docking cytotoxicity pharmacokinetic stability, bvdv inhibitors, rdrp protein, molecular dynamics, pharmacokinetics in vitro properties, quinazoline derivatives and other aspects.Application of 89-77-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On January 17, 2022, Ouyang, Yao; Xu, Xiu-Hua; Qing, Feng-Ling published an article.Product Details of 38939-88-7 The title of the article was Electrochemical Trifluoromethoxylation of (Hetero)aromatics with a Trifluoromethyl Source and Oxygen. And the article contained the following:

A conceptually new and operationally simple protocol for the direct C-H trifluoromethoxylation of (hetero)aromatics by the combination of the readily available trifluoromethylating reagent and oxygen under electrochem. reaction conditions was discussed. This reaction proceeded through the initial generation of CF3 radical followed by conversion to CF3O radical, addition to (hetero)aromatics and rearomatization. The utility of this electrochem. trifluoromethoxylation was illustrated by the direct incorporation of CF3O group into a variety of (hetero)aromatics as well as bio-relevant mols. The experimental process involved the reaction of 2-Chloro-4-methyl-1-nitrobenzene(cas: 38939-88-7).Product Details of 38939-88-7

The Article related to trifluoromethoxyarene preparation, arene trifluoromethyl pyridylsulfone electrochem trifluoromethoxylation, electrochemistry, oxygen, radical reactions, trifluoromethoxylation, trifluoromethyl groups and other aspects.Product Details of 38939-88-7

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On November 21, 2012, Yu, Juntian; Zhang, Ling; Sun, Zhiguo; Luan, Xiuli published a patent.Quality Control of 4-Chloro-2-fluorotoluene The title of the patent was Method for preparing 4-chloro-2-fluorotoluene. And the patent contained the following:

The invention relates to the method for preparation of 4-chloro-2-fluorotoluene. 4-Chloro-2-fluorotoluene was prepared via salt formation of 5-chloro-2-methylaniline with hydrofluoric acid; the resulting 5-chloro-2-methylaniline hydrofluoric acid salt underwent diazotization to give 5-chloro-2-methylphenyldiazonium fluoride, which underwent denitrogenation to give the title compound The method has few steps, high yield and high product purity. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Quality Control of 4-Chloro-2-fluorotoluene

The Article related to chloro methyl aniline salt formation, hydrofluoric acid salt chloro methyl aniline preparation diazotization, phenyl diazonium fluoride preparation denitrogenation, fluoro methyl toluene preparation and other aspects.Quality Control of 4-Chloro-2-fluorotoluene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Jurga, Stefan published an article in 1980, the title of the article was Nuclear magnetic relaxation studies in solids.Recommanded Product: trimethyloxosulphonium chloride And the article contains the following content:

Spin-lattice relaxation times in the laboratory and in the rotating frame are reported for trimethyloxosulfonium fluoride, chloride, bromide and iodide as well as for Me2SO and Me2SO2 over a wide temperature range. A model was developed that makes it possible to analyze the exptl. data on the basis of 4 independent reorientations around 3 3-fold axis and around center of gravity . The following conclusions consistent with the 2nd moment and spin-lattice relaxation results are drawn about reorientational state of cations and mols. The Me group is reorienting about its 3-fold axis at random between 3 equilibrium positions separated by 120° in all the compounds A 3-fold reorientation of all cations around the C3 axis (designed by S → O bond) occurs. There is dynamical inequivalence of Me groups within the Me2SO mol. and trimethyloxosulfonium chloride with 1:2 ratio. There is observed translational diffusion in Me2SO2. The activation energies for C3 and C’3 reorientations decrease with an increase of an anion ionic radius (with exception of the iodide salt for the last motion). The experimental process involved the reaction of trimethyloxosulphonium chloride(cas: 5034-06-0).Recommanded Product: trimethyloxosulphonium chloride

The Article related to spin lattice relaxation solid, dimethyl sulfone spin lattice relaxation, sulfoxide dimethyl spin lattice relaxation, trimethyloxosulfonium halide spin lattice, sulfonium salt spin lattice relaxation and other aspects.Recommanded Product: trimethyloxosulphonium chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics