Tag: 100-200

On June 26, 2003, Koppitz, Marcus; Muhn, Hans Peter; Shaw, Ken; Hess-Stumpp, Holger; Paulini, Klaus published a patent.Application of 59833-69-1 The title of the patent was Synthesis of tetrahydrocarbazole derivatives for use as ligands for G-protein coupled receptors and antagonists of gonadotropin-releasing hormone for treatment of disease. And the patent contained the following:

The invention relates to novel tetrahydrocarbazole derivatives [e.g., (I)] which act as ligands for G-protein coupled receptors (GPCR), especially as antagonists of gonadotropin-releasing hormone (GnRH), and pharmaceutical composition containing them. Furthermore, the invention relates to the administration of tetrahydrocarbazole derivatives for the treatment of pathol. conditions mediated by GPCR, especially for the inhibition of GnRH, to mammals, especially humans, requiring such treatment, and to the use of tetrahydrocarbazole derivatives for producing a pharmaceutical agent for treating pathol. conditions mediated by GPCR, especially for the inhibition of GnRH. Limited synthesis of intermediate materials is given, with many tables of products exemplified by general synthesis steps. Thus, beginning from 4,4-ethylenedioxycyclohexanone and phenylhydrazine, I was prepared in seven generalized steps. In in vitro tests with alpha T3-1 cells, I had IC50 for human GnRH of 1.5 x 10-8 M, with Ca2+ release of 4.5 x 10-8 M. The experimental process involved the reaction of Methyl 2-(3-amino-4-chlorophenyl)acetate(cas: 59833-69-1).Application of 59833-69-1

The Article related to protein receptor antagonist tetrahydrocarbazole derivative preparation infertility conception therapy, heterocyclic compound peptide derivative preparation solid phase tumor therapy and other aspects.Application of 59833-69-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On October 1, 1987, Fukuoka, Shinsuke published a patent.Product Details of 452-75-5 The title of the patent was Preparation of aryl fluoro-substituted aromatic carboxylates as intermediates for agrochemicals, pharmaceuticals, and monomers. And the patent contained the following:

The title esters, useful as intermediates for agrochems., pharmaceuticals, and monomers, are prepared by aryloxycarbonylation. Heating a mixture of 22.2 g p-FC6H4I, 11.3 g PhOH, 22.2 g Bu3N, and 40 mg PdCl2 at 200° and 30 kg/cm2 CO gave 98% p-FC6H4CO2Ph. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Product Details of 452-75-5

The Article related to fluoroarenecarboxylate intermediate agrochem pharmaceutical monomer, aryl fluoroarenecarboxylate intermediate agrochem pharmaceutical monomer, aryloxycarbonylation fluoroaryl halide and other aspects.Product Details of 452-75-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On October 9, 2013, Peng, Bo; Geerdink, Danny; Maulide, Nuno published an article.SDS of cas: 35444-44-1 The title of the article was Electrophilic Rearrangements of Chiral Amides: A Traceless Asymmetric α-Allylation. And the article contained the following:

A one-pot protocol for the asym. α-allylation reaction is reported relying on a key efficient asym. Claisen rearrangement, triggered by electrophilic activation of chiral pseudoephedrine amides. Subsequent reduction or hydrolysis of the resulting iminium ions provides highly enantioenriched α-allylic aldehydes or carboxylic acids in a traceless manner. Compared to traditional alternatives which make use of strongly basic conditions, the work presented herein displays unprecedented functional group tolerance. The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).SDS of cas: 35444-44-1

The Article related to chiral pseudoephedrine amide electrophilic claisen rearrangement asym allylation, allylic aldehyde stereoselective preparation, carboxylic acid allylic stereoselective preparation and other aspects.SDS of cas: 35444-44-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On April 10, 2002, Busch, Brett B.; Paz, Manuel M.; Shea, Kenneth J.; Staiger, Chad L.; Stoddard, Jonathan M.; Walker, James R.; Zhou, Xian-Zhi; Zhu, Huide published an article.Synthetic Route of 5034-06-0 The title of the article was The Boron-Catalyzed Polymerization of Dimethylsulfoxonium Methylide. A Living Polymethylene Synthesis. And the article contained the following:

Trialkyl and aryl organoboranes catalyze the polymerization of dimethylsulfoxonium methylide (1). The product of the polymerization is a tris-polymethylene organoborane. Oxidation affords linear telechelic α-hydroxy polymethylene. The polymer mol. weight was found to be directly proportional to the stoichiometric ratio of ylide/borane, and polydispersities as low as 1.01-1.03 have been realized. Although oligomeric polymethylene has been the most frequent synthetic target of this method, polymeric star organoboranes with mol. weights of 1.5 million have been produced. The average turnover frequency at 120° in 1,2,4,5-tetrachlorobenzene/toluene is estimated at >6 × 106 g of polymethylene (mol boron)-1 h-1. The mechanism of the polyhomologation reaction involves initial formation of a zwitterionic organoborane-ylide complex which breaks down in a rate-limiting 1,2-alkyl group migration with concomitant expulsion of a mol. of DMSO. The reaction was found to be first order in the borane catalyst and zero order in ylide. DMSO does not interfere with the reaction. The temperature dependence of the reaction rate yielded the following activation energy parameters (toluene, ΔH⧧ = 23.2 kcal/mol, ΔS⧧ = 12.6 cal deg/mol, ΔG⧧ = 19.5 kcal/mol; THF, ΔH⧧ = 26.5 kcal/mol, ΔS⧧ = 21.5 cal deg/mol, ΔG⧧ = 20.1 kcal/mol). The experimental process involved the reaction of trimethyloxosulphonium chloride(cas: 5034-06-0).Synthetic Route of 5034-06-0

The Article related to dimethylsulfoxonium methylide living polymerization boron catalyst kinetics mechanism, polymethylene preparation dimethylsulfoxonium methylide living polymerization boron catalyst and other aspects.Synthetic Route of 5034-06-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On September 11, 2017, Ocasio, Cory A.; Sansook, Supojjanee; Jones, Rhiannon; Roberts, Justin M.; Scott, Thomas G.; Tsoureas, Nikolaos; Coxhead, Peter; Guille, Matthew; Tizzard, Graham J.; Coles, Simon J.; Hochegger, Helfrid; Bradner, James E.; Spencer, John published an article.SDS of cas: 35444-44-1 The title of the article was Pojamide: An HDAC3-Selective Ferrocene Analogue with Remarkably Enhanced Redox-Triggered Ferrocenium Activity in Cells. And the article contained the following:

A ferrocene containing ortho-aminoanilide, N1-(2-aminophenyl)-N8-ferrocenyloctanediamide, 2b (Pojamide) displayed nanomolar potency vs. HDAC3. Compared to RGFP966, a potent and selective HDAC3 inhibitor, Pojamide displayed superior activity in HCT116 colorectal cancer cell invasion assays; however, TCH106 and Romidepsin, potent HDAC1 inhibitors, outperformed Pojamide in cellular proliferation and colony formation assays. Together, these data suggest that HDAC 1 and 3 inhibition is desirable to achieve maximum anticancer benefits. Addnl., the authors explored Pojamide-induced redox-pharmacol. Indeed, treating HCT116 cells with Pojamide, SNP (Na nitroprusside) and glutathione (GSH) led to greatly enhanced cytotoxicity and DNA damage attributed to activation to an Fe(III) species. The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).SDS of cas: 35444-44-1

The Article related to pojamide ferrocene analog preparation cellular ferrocenium activity anticancer agent, ferrocenyloctanediamide ferrocene containing ortho aminoanilide preparation anticancer agent and other aspects.SDS of cas: 35444-44-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Weber, Lothar published an article in 1976, the title of the article was Bis(dimethyl sulfoxoniummethylide) tetracarbonyl complexes of chromium, molybdenum and tungsten.Recommanded Product: 5034-06-0 And the article contains the following content:

From the photochem. reaction of M(CO)6 (M = Cr, Mo, W) and Me2S(O):CH2 in ether, yellow solids of [Me2S(O)CH2]2M(CO)4 are obtained in good yields. [Me2S(O)CH2]2M(CO)4 (M = Cr, Mo) are also accessible by the displacement of olefin from LM(CO)4 (L = norbornadiene) by excess ylide in ether. Pale insoluble [Me2S(O)CH2]3Mo(CO)3 is the sole product from the reaction of L1Mo(CO)3 (L1 = cycloheptatriene) and excess ylide in ether. The experimental process involved the reaction of trimethyloxosulphonium chloride(cas: 5034-06-0).Recommanded Product: 5034-06-0

The Article related to sulfoxonium methylide metal complex, chromium sulfoxonium methylide complex, molybdenum sulfoxonium methylide complex, tungsten sulfoxonium methylide complex, ylide metal complex and other aspects.Recommanded Product: 5034-06-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On February 15, 2022, Sun, Bin; Ding, Hao; Tian, Hai-Xia; Huang, Pan-Yi; Jin, Can; Wu, Chun-Lei; Shen, Run-Pu published an article.Product Details of 89-77-0 The title of the article was Photo-Triggered Self-Induced Homolytic Dechlorinative Sulfonylation/Cyclization of Unactivated Alkenes: Synthesis of Quinazolinones Containing a Sulfonyl Group. And the article contained the following:

A self-photocatalyzed sulfonylation/cyclization of quinazolinones containing unactivated alkenes with various sulfonyl chlorides was developed. The protocol provided access to sulfonyl radicals via energy transfer from quinazolinone skeleton to sulfonyl chloride. Notably, transformations proceeded without any external photocatalysts, additives, or oxidants, providing an alternative method for fabricating sulfonylated compounds I [R = Et, cyclopropyl, Ph, etc.; R1 = H, 3-F, 2-MeO, etc.; n = 0, 1]. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Product Details of 89-77-0

The Article related to quinazolinone containing sulfonyl group regioselective preparation photochem green chem, sulfonyl chloride quinazolinone tandem sulfonylation heterocyclization energy transfer photocatalyst and other aspects.Product Details of 89-77-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On May 31, 2022, Ma, Jiajia; Chen, Shuming; Bellotti, Peter; Wagener, Tobias; Daniliuc, Constantin; Houk, Kendall N.; Glorius, Frank published an article.Quality Control of 2-Amino-4-chlorobenzoic acid The title of the article was Facile access to fused 2D/3D rings via intermolecular cascade dearomative [2+2] cycloaddition/rearrangement reactions of quinolines with alkenes. And the article contained the following:

Two types of energy-transfer-mediated cascade dearomative [2+2] cycloaddition/rearrangement reactions of quinoline derivatives with alkenes, which provide a straightforward avenue to 2D/3D pyridine-fused 6-5-4-3- and 6-4-6-membered ring systems are reported. Notably, this energy-transfer-mediated strategy features excellent diastereoselectivity that bypasses the general reactivity and selectivity issues of photochem. [2+2] cycloaddition of various other aromatics Tuning the aza-arene substitutions enabled selective diversion of the iridium photocatalyzed energy transfer manifold towards either cyclopropanation or cyclobutane-rearrangement products. D. functional theory calculations revealed a cascade energy transfer scenario to be operative. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Quality Control of 2-Amino-4-chlorobenzoic acid

The Article related to quinoline alkene iridium photochem diastereoselective intermol dearomative cycloaddition rearrangement, azatetracyclododecatriene preparation, tetrahydro benzocyclobutapyridine preparation and other aspects.Quality Control of 2-Amino-4-chlorobenzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On May 24, 2012, Lundgren, Rylan J.; Stradiotto, Mark published a patent.Product Details of 452-75-5 The title of the patent was Preparation of amines, hydrazones, hydrazines, and indazoles by hydroamination or cross-coupling reactions catalyzed by palladium or gold in the presence of a phosphine ligand. And the patent contained the following:

The invention provides compounds and ligands of formula I that are useful in transition metal catalyzed cross-coupling reactions. Compounds of formula I wherein R1 and R2 are independently t-Bu, cyclohexyl, 2-tolyl, 1-adamantyl; R3 and R4 are independently C1-5 alkyl; R3R4 taken together to form a 4- to 10-membered heterocyclyl; each X is independently N and CR5; each X1 is independently N and CR6; R5 is H, Me, OME, halo, and CF3; R6 is H, Me, OMe, NMe2, halo and CF3; vicinal R5R6 may be taken together to form a 5- to 7-membered heterocyclic or carbocyclic ring; provided that no more than one of each X and X1 is N; are claimed. For example, the compounds and ligands of the invention are useful in palladium or gold catalyzed cross-coupling reactions. Ligand II was used in the palladium-catalyzed cross-coupling of chlorobenzene with hydrazine followed by condensation to give diphenylhhydrazone. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Product Details of 452-75-5

The Article related to aryl halide amine cross coupling palladium phosphine, arylamine preparation, indazole preparation, hydrazone preparation, hydrazine preparation, palladium phosphine cross coupling catalyst and other aspects.Product Details of 452-75-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On August 6, 2008, Sone, Toshihiko; Yamaguchi, Akitake; Matsunaga, Shigeki; Shibasaki, Masakatsu published an article.Category: chlorides-buliding-blocks The title of the article was Catalytic Asymmetric Synthesis of 2,2-Disubstituted Terminal Epoxides via Dimethyloxosulfonium Methylide Addition to Ketones. And the article contained the following:

Catalytic asym. Corey-Chaykovsky epoxidation of ketones with dimethyloxosulfonium methylide using an La-Li3-tris(binaphthoxide) + Ar3P:O (Ar = 2,4,6-trimethoxyphenyl) complex proceeded smoothly at room temperature, and 2,2-disubstituted terminal epoxides were obtained with high enantioselectivity (91-97%) and yield (>88-99%) from a broad range of Me ketones with 1-5 mol% catalyst loading. The use of achiral additive Ar3P:O was important to achieve high enantioselectivity. The experimental process involved the reaction of trimethyloxosulphonium chloride(cas: 5034-06-0).Category: chlorides-buliding-blocks

The Article related to corey chaykovsky epoxidation ketone dimethyloxosulfonium methylide lanthanum binaphthoxide catalyst, asym epoxidation ketone dimethyloxosulfonium methylide lanthanum binaphthoxide catalyst and other aspects.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics