Tag: 100-200

Synthesis of the new morphine partial structure – 15,16-secomorphinan was written by Revesz, Laszlo. And the article was included in Helvetica Chimica Acta in 1984.Safety of 2-(3-Methoxyphenyl)acetyl chloride This article mentions the following:

1-Methylcyclohexene was cyclized with p-MeOC₆H₄CH₂COCl in CH₂Cl₂ containing AlCl₃ followed by oximation to give the phenanthrenone oxime I, which was reduced to give the phenanthrenamines II and III (R = R¹ = H). II and III (R = R¹ = H) were converted to II and III (R = H, R¹ = F₃CCO, cyclopropylcarbonyl; R = H, Me, R¹ = cyclopropylmethyl). (±)-15,16-Secocyclorphan (III, R = Me, R¹ = cyclopropylmethyl) has the analgesic potency of morphine and exhibites good binding to the opiate receptor. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Safety of 2-(3-Methoxyphenyl)acetyl chloride).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Safety of 2-(3-Methoxyphenyl)acetyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Copper immobilized on biomimetic assembled calcium carbonate/carboxymethylcellulose hybrid: a highly active recoverable catalyst for CuAAC reactions was written by Zhang, Mingjuan;Xu, Jinxi;Zhang, Tianzhu;Li, Yiqun. And the article was included in Research on Chemical Intermediates in 2021.SDS of cas: 620-19-9 This article mentions the following:

A novel copper immobilized on biomimetic assembled CM-cellulose/calcium carbonate hybrid (Cu^II@CMC/CaCO₃) as an efficient heterogeneous catalyst for the synthesis of 1,2,3-triazoles has been described herein. The fabrication of Cu^II@CMC/CaCO₃ is accomplished through a bioinspired mineralization process using sodium CM-cellulose (CMC-Na) as the template and ion exchange agent, while the metathesis, nucleation, assemble, hybridization, and immobilization of Cu(II) occurred by successful treatment with CaCl₂, Na₂CO₃, and CuSO₄ in water at room temperature The resultant Cu^II@CMC/CaCO₃ hybrid was well characterized by various analyses such as FT-IR, XRD, SEM, EDX, EDX-mapping, TEM, and TGA techniques. In the presence of low copper loading of Cu^II@CMC/CaCO₃ hybrid, benzylic halides, azide, and alkynes proceeded smoothly to afford 1,4-disubstituted 1,2,3-triazoles in high yields. The catalyst can be conveniently recovered from the reaction mixture by filter and reused for at least 5 consecutive runs with a slight drop in its catalytic activity. The remarkable activity and stability of the catalyst may be attributed to the coordination of both carboxyl and hydroxyl groups of the hybrid of CMC/CaCO₃. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9SDS of cas: 620-19-9).

1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.SDS of cas: 620-19-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Small-molecule Ca_Vα₁·Ca_Vβ antagonist suppresses neuronal voltage-gated calcium-channel trafficking was written by Chen, Xingjuan;Liu, Degang;Zhou, Donghui;Si, Yubing;Xu, David;Stamatkin, Christopher W.;Ghozayel, Mona K.;Ripsch, Matthew S.;Obukhov, Alexander G.;White, Fletcher A.;Meroueh, Samy O.. And the article was included in Proceedings of the National Academy of Sciences of the United States of America in 2018.Computed Properties of C8H4ClNO This article mentions the following:

Extracellular calcium flow through neuronal voltage-gated CaV2.2 calcium channels converts action potential-encoded information to the release of pronociceptive neurotransmitters in the dorsal horn of the spinal cord, culminating in excitation of the postsynaptic central nociceptive neurons. The CaV2.2 channel is composed of a pore-forming α1 subunit (CaVα1) that is engaged in protein-protein interactions with auxiliary α2/δ and β subunits. The high-affinity CaV2.2α1-CaVβ3 protein-protein interaction is essential for proper trafficking of CaV2.2 channels to the plasma membrane. Here, structure-based computational screening led to small mols. that disrupt the CaV2.2α1-CaVβ3 protein-protein interaction. The binding mode of these compounds reveals that three substituents closely mimic the side chains of hot-spot residues located on the α-helix of CaV2.2α1. Site-directed mutagenesis confirmed the critical nature of a salt-bridge interaction between the compounds and CaVβ3 Arg-307. In cells, compounds decreased trafficking of CaV2.2 channels to the plasma membrane and modulated the functions of the channel. In a rodent neuropathic pain model, the compounds suppressed pain responses. Small-mol. α-helical mimetics targeting ion channel protein-protein interactions may represent a strategy for developing nonopioid analgesia and for treatment of other neurol. disorders associated with calcium-channel trafficking. In the experiment, the researchers used many compounds, for example, 3-Cyanobenzoyl chloride (cas: 1711-11-1Computed Properties of C8H4ClNO).

3-Cyanobenzoyl chloride (cas: 1711-11-1) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Computed Properties of C8H4ClNO

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

From alcohol to 1,2,3-triazole via a multi-step continuous-flow synthesis of a rufinamide precursor was written by Borukhova, Svetlana;Noel, Timothy;Metten, Bert;de Vos, Eric;Hessel, Volker. And the article was included in Green Chemistry in 2016.Quality Control of 2-(Chloromethyl)-1,3-difluorobenzene This article mentions the following:

Rufinamide can be synthesized from 2,6-difluorobenzyl chloride in three steps. The microreactor flow networks have better sustainability profiles in terms of life-cycle assessment than the resp. consecutive processing in a batch. The anal. is based on the results of a single step conversion from batch to continuous mode. An uninterrupted continuous process towards rufinamide is developed, starting from 2,6-difluorobenzyl alc. precursor, which is converted to the corresponding 2,6-difluorobenzyl chloride with hydrogen chloride gas. The chloride is then converted to the corresponding 2,6-difluorobenzyl azide that yields the rufinamide precursor I via cycloaddition to the greenest and cheapest dipolarophile available on the market. The current process demonstrates chem. and process-design intensification aspects encompassed by novel process windows. Single reaction steps are chem. intensified via a wide range of conditions available in a microreactor environment. Meanwhile, the connection of reaction steps and separations results in process-design intensification. With two in-line separations the process consists of five stages resulting in a total yield of 82% and productivity of 9 g h^-1 (11.5 mol h^-1L^-1). The process minimizes the isolation and handling of strong alkylating or energetic intermediates, while minimizing water and organic solvent consumption. In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4Quality Control of 2-(Chloromethyl)-1,3-difluorobenzene).

2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Quality Control of 2-(Chloromethyl)-1,3-difluorobenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Structural Insights of Benzenesulfonamide Analogues as NLRP3 Inflammasome Inhibitors: Design, Synthesis, and Biological Characterization was written by Fulp, Jacob;He, Liu;Toldo, Stefano;Jiang, Yuqi;Boice, Ashley;Guo, Chunqing;Li, Xia;Rolfe, Andrew;Sun, Dong;Abbate, Antonio;Wang, Xiang-Yang;Zhang, Shijun. And the article was included in Journal of Medicinal Chemistry in 2018.COA of Formula: C8H7ClO3 This article mentions the following:

NLRP3 inflammasome plays critical roles in a variety of human diseases and represents a promising drug target. In this study, we established the in vivo functional activities of JC124, a previously identified NLRP3 inflammasome inhibitor from our group, in mouse models of Alzheimer’s disease and acute myocardial infarction. To understand the chem. space of this lead structure, a series of analogs were designed, synthesized, and biol. characterized. The results revealed the critical roles of the two substituents on the benzamide moiety of JC124. On the other hand, modifications on the sulfonamide moiety of JC124 are well tolerated. Two new lead compounds, 14 and 17, were identified with improved inhibitory potency (IC₅₀ values of 0.55 ± 0.091 and 0.42 ± 0.080 μM, resp.). Further characterization confirmed their selectivity and in vivo target engagement. Collectively, the results strongly encourage further development of more potent analogs based on this chem. scaffold. In the experiment, the researchers used many compounds, for example, 5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2COA of Formula: C8H7ClO3).

5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.COA of Formula: C8H7ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Isoxazol-5(2H)-one: a new scaffold for potent human neutrophil elastase (HNE) inhibitors was written by Vergelli, Claudia;Schepetkin, Igor A.;Crocetti, Letizia;Iacovone, Antonella;Giovannoni, Maria Paola;Guerrini, Gabriella;Khlebnikov, Andrei I.;Ciattini, Samuele;Ciciani, Giovanna;Quinn, Mark T.. And the article was included in Journal of Enzyme Inhibition and Medicinal Chemistry in 2017.Formula: C8H4ClNO This article mentions the following:

Human neutrophil elastase (HNE) is an important target for the development of novel and selective inhibitors to treat inflammatory diseases, especially pulmonary pathologies. Here, the authors report the synthesis, structure-activity relationship anal., and biol. evaluation of a new series of HNE inhibitors with an isoxazol-5(2H)-one scaffold. The most potent compound (2o) (3-isopropyl-2-(4-methylbenzoyl)isoxazol-5(2H)-one) had a good balance between HNE inhibitory activity (IC₅₀ value =20 nM) and chem. stability in aqueous buffer (t_1/2=8.9 h). Anal. of reaction kinetics revealed that the most potent isoxazolone derivatives were reversible competitive inhibitors of HNE. Furthermore, since compounds (2o) and (2s) (3-isopropyl-2-(4-(trifluoromethyl)benzoyl)isoxazol-5(2H)-one) contain two carbonyl groups (2-N-CO and 5-CO) as possible points of attack for Ser 195, the amino acid of the active site responsible for the nucleophilic attack, docking studies allowed the authors to clarify the different roles played by these groups. In the experiment, the researchers used many compounds, for example, 3-Cyanobenzoyl chloride (cas: 1711-11-1Formula: C8H4ClNO).

3-Cyanobenzoyl chloride (cas: 1711-11-1) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Formula: C8H4ClNO

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

A new air-stable Si,S-chelating ligand for Ir-catalyzed directed ortho C-H borylation was written by Jiao, Jiao;Nie, Wenzheng;Song, Peidong;Li, Pengfei. And the article was included in Organic & Biomolecular Chemistry in 2021.Product Details of 85953-29-3 This article mentions the following:

A new air-stable Si,S-chelating ligand 1-(ⁱPrS)-2-(ⁱPr₂SiH)C₆H₄ (HL) has been developed and used in a directed ortho C-H borylation reaction of aromatic and heterocyclic compounds with B₂pin₂ catalyzed by [Ir(OMe)(cod)]₂/HL combination with a broad substrate scope, providing o-boryl-substituted aromatic and heterocyclic esters, amides and amines. This study provides the first example of using a sulfur-containing ligand in the catalytic C-H borylation process. It provides a rapid, efficient, and economical method for the preparation of organoboron compounds In the experiment, the researchers used many compounds, for example, Methyl 2-chloro-4-fluorobenzoate (cas: 85953-29-3Product Details of 85953-29-3).

Methyl 2-chloro-4-fluorobenzoate (cas: 85953-29-3) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Product Details of 85953-29-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and activity of substituted heteroaromatics as positive allosteric modulators for α4β2α5 nicotinic acetylcholine receptors was written by Jin, Zhuang;Khan, Pasha;Shin, Youseung;Wang, Jingyi;Lin, Li;Cameron, Michael D.;Lindstrom, Jon M.;Kenny, Paul J.;Kamenecka, Theodore M.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2014.COA of Formula: C8H4ClNO This article mentions the following:

The design and synthesis of a series of substituted heteroaromatic α4β2α5 pos. allosteric modulators is reported. The optimization and development of the heteroaromatic series was carried out from NS9283, and several potent analogs, such as 3-(5-(pyridin-3-yl)-2H-tetrazol-2-yl)benzonitrile and 3,3′-(2H-tetrazole-2,5-diyl)dipyridine with good in vitro efficacy were discovered. In the experiment, the researchers used many compounds, for example, 3-Cyanobenzoyl chloride (cas: 1711-11-1COA of Formula: C8H4ClNO).

3-Cyanobenzoyl chloride (cas: 1711-11-1) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.COA of Formula: C8H4ClNO

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Linear relations between thermodynamic parameters. IV. Basicities of some substituted dimethylanilines was written by Lee, Ikchoon;Park, Yong Ja. And the article was included in Taehan Hwahakhoe Chi in 1964.Recommanded Product: 698-01-1 This article mentions the following:

Basicities of 9 dimethylanilines were determined in 50, 70, and 90 volume % EtOH, at 25, 30, 35, and 45°. Temperature coefficients are independent of solvent composition, while they show a linear correlation with basicities of the compounds Thermodynamic parameters obtained were used in the discussion of substituent and solvent effects in conjunction with the general equation derived in the preceding papers. In the experiment, the researchers used many compounds, for example, 2-Chloro-N,N-dimethylaniline (cas: 698-01-1Recommanded Product: 698-01-1).

2-Chloro-N,N-dimethylaniline (cas: 698-01-1) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Recommanded Product: 698-01-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Direct oxidative coupling of amidine hydrochlorides and methylarenes: TBHP-mediated synthesis of substituted 1,3,5-triazines under metal-free conditions was written by Guo, Wei. And the article was included in Organic & Biomolecular Chemistry in 2015.Name: 2-Chloro-benzamidine hydrochloride This article mentions the following:

Various 2,4,6-trisubstituted 1,3,5-triazines I (R = C₆H₅, 4-ClC₆H₄, cyclopropyl, etc.; Ar = 5-Br-2-H₃COC₆H₃, 1-naphthyl, thiophen-2-yl, etc.) were smoothly formed via TBHP-mediated direct oxidative coupling of amidine and methylarenes. This tandem oxidation-imination-cyclization transformation exhibits a straightforward protocol to prepare 1,3,5-triazines I from easily available starting materials and green oxidants under metal-free conditions. In the experiment, the researchers used many compounds, for example, 2-Chloro-benzamidine hydrochloride (cas: 18637-02-0Name: 2-Chloro-benzamidine hydrochloride).

2-Chloro-benzamidine hydrochloride (cas: 18637-02-0) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Name: 2-Chloro-benzamidine hydrochloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics