Tag: 100-200

On March 15, 2014, Xiao, Dong; Zhu, Xiaohong; Yu, Younong; Shao, Ning; Wu, Jie; McCormick, Kevin D.; Dhondi, Pawan; Qin, Jun; Mazzola, Robert; Tang, Haiqun; Rao, Ashwin; Siliphaivanh, Phieng; Qiu, Hongchen; Yang, Xiaoxin; Rivelli, Maria; Garlisi, Charles G.; Eckel, Steve; Mukhopadhyay, Gitali; Correll, Craig; Rindgen, Diane; Aslanian, Robert; Palani, Anandan published an article.Electric Literature of 35444-44-1 The title of the article was Quality by design (QbD) of amide isosteres: 5,5-Disubstituted isoxazolines as potent CRTh2 antagonists with favorable pharmacokinetic and drug-like properties. And the article contained the following:

Isoxazoles are frequently used amide isosteres, as shown in the context of discovery of CRTh2 antagonists from amide I to isoxazole II. However, persistent agonism and poor solubility in isoxazole series presented challenges to its further development. Based on the concept of quality by design (QbD), 5,5-disubstituted isoxazolines III (R1, R2 = alkyl, aryl) were introduced. The chirality at 5 position of isoxazolines controlled the switch between two modes of actions, which led to a novel series of pure antagonists. This non-planar motif also conferred a change of shape of these mols., which avoided flat structures and improved their phys. properties. The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).Electric Literature of 35444-44-1

The Article related to isoxazoline amide isostere crth2 antagonist design, agonism/antagonism switch, amide isostere, crth(2) antagonists, drug-like properties, isoxazolines, quality by design (qbd) and other aspects.Electric Literature of 35444-44-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On April 16, 2021, Fairuz Binte Sheikh Ismail, Siti Nur; Yang, Binmiao; Zhao, Yu published an article.Application In Synthesis of 2-Amino-4-chlorobenzoic acid The title of the article was Access to 5,6-Spirocycles Bearing Three Contiguous Stereocenters via Pd-Catalyzed Stereoselective [4 + 2] Cycloaddition of Azadienes. And the article contained the following:

We present herein a highly diastereo- and enantioselective Pd-catalyzed [4 + 2] cycloaddition of benzofuran-derived azadienes with vinyl benzoxazinanones, which represents a rare highly stereoselective cycloaddition of this class of fused azadienes as a two-atom synthon. The use of a phosphoramidite ligand bearing a chiral secondary amine with a simple biphenyl backbone proved to be the key to construct the novel spirocyclic tetrahydroquinoline scaffold containing three contiguous stereocenters in high enantioselectivity. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Application In Synthesis of 2-Amino-4-chlorobenzoic acid

The Article related to vinyl benzoxazinanone azadiene palladium phosphoramidite ligand diastereoselective enantioselective cycloaddition, spirocyclic tetrahydroquinoline stereoselective preparation and other aspects.Application In Synthesis of 2-Amino-4-chlorobenzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On August 24, 2011, Ano, Yusuke; Tobisu, Mamoru; Chatani, Naoto published an article.Quality Control of Methyl 6-chloro-6-oxohexanoate The title of the article was Palladium-catalyzed direct ethynylation of C(sp3)-H bonds in aliphatic carboxylic acid derivatives. And the article contained the following:

The first catalytic alkynylation of unactivated C(sp3)-H bonds has been accomplished. The method allows for the straightforward introduction of an ethynyl group into aliphatic acid derivatives under palladium catalysis. This new reaction can be applied to the rapid elaboration of complex aliphatic acids, for example, via azide/alkyne cycloaddition The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).Quality Control of Methyl 6-chloro-6-oxohexanoate

The Article related to quinolinyltriisopropylsilylpentynamide derivative preparation, quinolinylamide preparation bromoalkyne alkynylation palladium catalyst, acid chloride aminoquinoline amidation and other aspects.Quality Control of Methyl 6-chloro-6-oxohexanoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On June 18, 2020, Conway, Lorna; Riccio, Anna; Santoro, M. Gabriella; Evans, Paul published an article.Related Products of 35444-44-1 The title of the article was Synthesis of the 4-aza cyclopentenone analogue of Δ12,14-15-deoxy-PGJ2 and S-cysteine adducts. And the article contained the following:

The synthesis of a series of 4-aza cross-conjugated cyclopentenones, inspired by the natural prostaglandin Δ12,14-15-deoxy-PGJ2 (5, I) is described. Using the 4-aza cyclopentenone 7 (II), the installation of the α-side chain was performed using N-functionalization, following a Boc-deprotection. The ω-side chain was then installed through a Baylis-Hillman type aldol reaction with trans-2-octenal. This afforded 11 (III), the aza-analog of 5. With this prostaglandin analog in hand, a series of thiol adducts (14-16, IV: R = NHAc, R’ = CO2Me; R = NHAc, R’ = CO2Et; R = NHBoc, R’ = CO2Me, resp.) were prepared Included are activities for compounds 11 and 14-16 in relation to inhibition of the transcription factor NF-κB. The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).Related Products of 35444-44-1

The Article related to aza cyclopentenone prostaglandin deoxy pgj2 analog synthesis, thiol analog prostaglandin deoxy pgj2 analog synthesis, nf kappa b inhibitor prostaglandin analog thiol adduct and other aspects.Related Products of 35444-44-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On April 30, 1998, Gerstenberger, Ina; Hansen, Martin; Mauvais, Antony; Wartchow, Rudolf; Winterfeldt, Ekkehard published an article.Application of 5034-06-0 The title of the article was Regioselective and stereoselective transformations of enantiopure para-benzoquinone equivalents. And the article contained the following:

The selectivities of typical transformations of the 1,4-benzoquinone Diels-Alder adduct I (RR1 = bond) and its dihydro derivative I (R, R1 = H) are highly dependent on the mechanistic path followed. To avoid ambiguities and to make sure of clearly defined regioselectivity, 1,4-benzoquinone monoethylene ketal was examined and proven not only to be an excellent dienophile but, of course, also to lead to reliable regioselectivity in subsequent transformations. This led to the correction of an earlier provisional assignment of alkylation products. The experimental process involved the reaction of trimethyloxosulphonium chloride(cas: 5034-06-0).Application of 5034-06-0

The Article related to diels alder adduct benzoquinone selective reaction, benzoquinone equivalent regioselective stereoselective addition substitution, retro diels alder benzoquinone equivalent and other aspects.Application of 5034-06-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Spinozzi, Eleonora; Bauer, Adriano; Maulide, Nuno published an article in 2019, the title of the article was A Mild Synthesis of Bicyclic Alkoxyoxazolium Salts from Proline and Pipecolic Acid Derivatives.Reference of Methyl 6-chloro-6-oxohexanoate And the article contains the following content:

A regio- and chemoselective preparation of bicyclic alkoxyoxazolium salts from amide derivatives of proline and pipecolic acid by electrophilic amide activation is reported. Mechanistic NMR experiments suggest an unusual role for the base and highlight the effect of substitution pattern of the substrates. The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).Reference of Methyl 6-chloro-6-oxohexanoate

The Article related to bicyclic alkoxyoxazolium salt preparation proline pipecolic electrophilic amide activation, amide activation, chemoselectivity, cycloaddition, oxazolium, synthesis design and other aspects.Reference of Methyl 6-chloro-6-oxohexanoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On December 15, 2021, Nair, K. P. Rajappan; Herbers, Sven; Grabow, Jens-Uwe; Nguyen, Ha Vinh Lam published an article.Electric Literature of 452-75-5 The title of the article was Neighborhood matters: Steric effects on methyl internal rotation and chlorine nuclear quadrupole coupling in 2-fluoro-4-chlorotoluene. And the article contained the following:

The rotational spectrum of 2-fluoro-4-chlorotoluene was studied in the frequency range 4 to 24 GHz by Fourier transform microwave spectroscopy. Fine torsional splittings into doublets were found for all rotational transitions due to Me internal rotation hindered with a barrier of about 230 cm-1. In combination with the quadrupole coupling hyperfine splittings on the same order of magnitude originating from the chlorine nucleus, rich spectral features were observed Rotational and quadrupole coupling constants for the 35Cl and 37Cl isotopologues studied in natural abundance were precisely determined Results from the experiment were supported by quantum chem. calculations at several levels of theory for the rotational constants and by Bailey’s semi-exptl. method for the quadrupole coupling constants The χcc quadrupole coupling tensor element and the barrier to Me internal rotation were compared with those of other halogen-substituted toluene derivatives The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Electric Literature of 452-75-5

The Article related to fluoro chlorotoluene internal rotation nuclear quadrupole coupling, Physical Organic Chemistry: Absorption, Emission, Reflection, and Scattering Spectra (Ultraviolet and Visible, Infrared and Fourier Transform Infrared, Raman, Microwave, Photoelectron, Fluorescence, Phosphorescence, etc.) and other aspects.Electric Literature of 452-75-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On December 20, 2013, Chae, Sang Youl; Yoon, Young Wook; Lee, Sang Kuk published an article.Synthetic Route of 452-75-5 The title of the article was Vibronic spectroscopy of jet-cooled benzyl-type radicals produced from 2-fluoro-4-chlorotoluene by corona discharge. And the article contained the following:

A home-made pinhole-type glass nozzle was employed to generate vibronically excited but jet-cooled benzyl-type radicals from precursor 2-fluoro-4-chlorotoluene with a large amount of carrier gas He, from which the visible vibronic emission spectrum was recorded with a long-path monochromator. From an anal. of the spectrum observed, it was found that two benzyl-type radicals, 2-fluorobenzyl and 2-fluoro-4-chlorobenzyl radicals, were formed from the precursor in corona discharge. The possible pathway for the production of benzyl-type radicals that can explain the spectroscopic observation is herein proposed. In addition, the electronic energy of the D1 → D0 transition and the vibrational mode frequencies in the D0 state of the 2-fluoro-4-chlorobenzyl radical were determined for the first time. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Synthetic Route of 452-75-5

The Article related to benzyl type radical corona discharge reaction mechanism, Physical Organic Chemistry: Absorption, Emission, Reflection, and Scattering Spectra (Ultraviolet and Visible, Infrared and Fourier Transform Infrared, Raman, Microwave, Photoelectron, Fluorescence, Phosphorescence, etc.) and other aspects.Synthetic Route of 452-75-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On July 1, 2021, Mezeiova, Eva; Hrabinova, Martina; Hepnarova, Vendula; Jun, Daniel; Janockova, Jana; Muckova, Lubica; Prchal, Lukas; Kristofikova, Zdena; Kucera, Tomas; Gorecki, Lukas; Chalupova, Katarina; Kunes, Jiri; Hroudova, Jana; Soukup, Ondrej; Korabecny, Jan published an article.Synthetic Route of 89-77-0 The title of the article was Huprine Y – Tryptophan heterodimers with potential implication to Alzheimer’s disease treatment. And the article contained the following:

The search for novel and effective therapeutics for Alzheimers disease (AD) is the main quest that remains to be resolved. The goal is to find a disease-modifying agent able to confront the multifactorial nature of the disease pos. Herewith, a family of huprineY-tryptophan heterodimers was prepared, resulting in inhibition of cholinesterase and neuronal nitric oxide synthase enzymes, with effect against amyloid-beta (Aβ) and potential ability to cross the blood-brain barrier. Their cholinesterase pattern of behavior was inspected using kinetic anal. in tandem with docking studies. These heterodimers exhibited a promising pharmacol. profile with strong implication in AD. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Synthetic Route of 89-77-0

The Article related to hupriney tryptophan heterodimer neuroprotective agent alzheimer disease, acetylcholinesterase, alzheimer’s disease, amyloid-beta, multi-target directed ligands, huprine y, l-tryptophan and other aspects.Synthetic Route of 89-77-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Nguyen, Thanh Binh; Ermolenko, Ludmila; Retailleau, Pascal; Al-Mourabit, Ali published an article in 2014, the title of the article was Elemental Sulfur Disproportionation in the Redox Condensation Reaction between o-Halonitrobenzenes and Benzylamines.Formula: C7H6ClNO2 And the article contains the following content:

The disproportionation of elemental sulfur at moderate temperatures is investigated in the redox condensation involving o-halonitrobenzenes 1 and benzylamines 2. As a redox moderator, elemental sulfur plays the dual role of both electron donor and acceptor, generating its lowest and highest oxidation states: S-2 (sulfide equivalent) in benzothiazole 3 and S+6 (sulfate equivalent) in sulfamate 4, and filling the electron gap of the global redox condensation process. Along with this process, a cascade of reactions of reduction of the nitro group of 1, oxidation of the aminomethyl group of 2, metal-free aromatic halogen substitution, and condensation finally led to 2-arylbenzothiazoles 3. The experimental process involved the reaction of 2-Chloro-4-methyl-1-nitrobenzene(cas: 38939-88-7).Formula: C7H6ClNO2

The Article related to sulfur disproportionation redox condensation halonitrobenzene benzylamine preparation, benzothiazoles, multicomponent reactions, redox condensation, sulfur, sulfur disproportionation and other aspects.Formula: C7H6ClNO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics