Tag: 100-200

On December 15, 2010, Wang, Kai; Zhou, Zhiming; Song, Jinhong; Bi, Lixue; Shen, Ning; Wu, Yukai; Chen, Fuxue; Wen, Hongliang published an article.Quality Control of 2-Chloro-4-methyl-1-nitrobenzene The title of the article was A metal-free aerobic oxidation of nitrotoluenes catalyzed by N,N’,N”-trihydroxyisocyanuric acid (THICA) and a novel approach to the catalyst. And the article contained the following:

A metal-free catalytic system with N,N’,N”-trihydroxyisocyanuric acid (THICA) as the catalyst for the oxidation of nitrotoluenes is introduced, and a novel Pd-free approach for the synthesis of THICA was developed. In a solution of acetic acid, THICA and concentrated nitric acid, nitrotoluenes especially polynitrotoluenes such as 2,4,6-trinitrotoluene (TNT), were converted into the desired carboxylic acids under 0.2 MPa of O2 at 100 °C with yields up to 99%. THICA was synthesized from N-hydroxyphtalimide through a four-step synthesis in a total yield of 46%. A possible mechanism of this catalytic process was proposed where NO2 and nitric acid first induced a radical of THICA, which then abstracts a hydrogen atom from the Me on the aromatic ring to form a benzyl radical. This radical then initiates subsequent reactions. The production of the benzyl radical was supported by ESR measurements. The experimental process involved the reaction of 2-Chloro-4-methyl-1-nitrobenzene(cas: 38939-88-7).Quality Control of 2-Chloro-4-methyl-1-nitrobenzene

The Article related to nitrotoluene oxidation nitrobenzoic acid trihydroxycyanuric acid catalyst, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Carboxylic Acids and Peroxycarboxylic Acids and Their Sulfur-Containing Analogs and Salts and other aspects.Quality Control of 2-Chloro-4-methyl-1-nitrobenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On January 26, 2004, Yang, Fan; Sun, Jing; Zheng, Rui; Qiu, Wenwei; Tang, Jie; He, Mingyuan published an article.Recommanded Product: 4-Chloro-2-fluorotoluene The title of the article was Oxidation of toluenes to benzoic acids by oxygen in non-acidic solvents. And the article contained the following:

Oxidation of substituted toluenes by mol. oxygen to the corresponding benzoic acids has been investigated. Oxidation of halo-, methoxy-, and cyanotoluenes using Co(C18H35O2)2/NH4Br or Co(OAc)2/NaBr/AcOH as catalysts, in the presence of a radical initiator, gave the benzoic acids in good yields. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Recommanded Product: 4-Chloro-2-fluorotoluene

The Article related to substituted toluene oxygen oxidation, benzoic acid preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Carboxylic Acids and Peroxycarboxylic Acids and Their Sulfur-Containing Analogs and Salts and other aspects.Recommanded Product: 4-Chloro-2-fluorotoluene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On September 10, 2019, Hong, Hao; Zhang, Enxuan; Lu, Jiangping; Liu, Zhiqing; Li, Chao; Tan, Yang published a patent.Recommanded Product: 452-75-5 The title of the patent was Continuous synthesis method of substituted benzoic acid organic matter by oxygen gas oxidation. And the patent contained the following:

The title continuous synthesis method includes reacting compound (such as 2,4-difluoroacetophenone) and oxygen gas under catalysis of catalyst (cobalt acetate, cobalt acetylacetonate, etc.) in presence of metal halide (sodium bromide, lithium chloride, etc.) and initiator (azobisisobutyronitrile, N-hydroxyphthalimide, etc.) in organic solvent (formic acid, glacial acetic acid, etc.) at 130-180°C and 1-2.5 MPa for 90-240 min to obtain the title compounds (such as 2,4-difluorobenzoic acid). The invention has cheap and easily available oxygen gas, no three wastes, improved utilization rate of oxygen gas, simplified operation, and improved reaction safety and product yield. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Recommanded Product: 452-75-5

The Article related to benzoic acid preparation oxidation acetophenone methylbenzene, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Carboxylic Acids and Peroxycarboxylic Acids and Their Sulfur-Containing Analogs and Salts and other aspects.Recommanded Product: 452-75-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On December 17, 2020, Hong, Hao; Lu, Jiangping; Zhang, Enxuan; Liu, Zhiqing; Li, Chao published a patent.Synthetic Route of 452-75-5 The title of the patent was Continuous synthesis method for substituted benzoate organic matter. And the patent contained the following:

The present invention provides a continuous synthesis method for a substituted benzoate organic matter. Oxygen is a green reagent, and is cheap and easy to obtain; the present invention would not produce a large amount of waste gas, waste water, and waste residues after the completion of reaction, and the system is easy to handle. The use of continuous reaction operation can reduce the risk of solvent flash evaporation explosion due to high concentration oxygen in batch reactions. Under the same oxidation conditions, the use of a continuous preparation process can reduce the escape of oxygen, greatly increase the utilization of oxygen, simplify the operation, and improve the reaction safety and the yield of substituted benzoate organic matters. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Synthetic Route of 452-75-5

The Article related to benzoate preparation oxidation carboxylation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Carboxylic Acids and Peroxycarboxylic Acids and Their Sulfur-Containing Analogs and Salts and other aspects.Synthetic Route of 452-75-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Tripathi, G. N. R.; Tewari, B. N.; Verma, R. M.; Ram, Sita published an article in 1974, the title of the article was Electronic absorption spectrum of 2-chloro-6-fluorotoluene in vapor phase.Electric Literature of 452-75-5 And the article contains the following content:

The near-uv absorption spectrum of 2-chloro-6-fluorotoluene was investigated. The bands were observed at 2553-2722 Å. The (0,0) band was identified at 2700.7 Å. The vibrational anal. of the bands is proposed in terms of the ground state fundamental 262 cm-1 and the excited state fundamentals 352, 600, 755, 982, 1087, 1175, and 1580 cm-1. The fundamentals identified are correlated with the ir and Raman frequencies. A blue shift in the (0,0) band of 2-chloro-6-fluorotoluene with respect to ο-chlorotoluene is noted. The (0,0) bands of chlorofluorotoluenes and a few other related compounds are calculated with the help of Platt’s spectroscopic moments. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Electric Literature of 452-75-5

The Article related to uv chlorofluorotoluene vibrational analysis, fluorochlorotoluene uv, toluene chlorofluoro uv, Spectra by Absorption, Emission, Reflection, or Magnetic Resonance, and Other Optical Properties: Absorption, Emission, Reflection, and Scattering and other aspects.Electric Literature of 452-75-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Lundgren, Rylan J.; Stradiotto, Mark published an article in 2010, the title of the article was Palladium-Catalyzed Cross-Coupling of Aryl Chlorides and Tosylates with Hydrazine.Application In Synthesis of 4-Chloro-2-fluorotoluene And the article contains the following content:

The cross-coupling of aryl chlorides and tosylates with hydrazine in presence of cinnamylpalladium chloride dimer and 4-[2-(bis(1-adamantanyl)phosphinyl)phenyl]morpholine proceeds rapidly with excellent chemoselectivity under mild conditions. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Application In Synthesis of 4-Chloro-2-fluorotoluene

The Article related to coupling aryl chloride tosylate hydrazine palladium adamantylphosphinylphenylmorpholine catalyst, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Hydroxylamines, Hydrazines, Triazenes, Azides, Azines, and Azo and Diazo Compounds and other aspects.Application In Synthesis of 4-Chloro-2-fluorotoluene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On November 30, 2010, Sinisi, Riccardo; Sun, Jianwei; Fu, Gregory C. published an article.Recommanded Product: 35444-44-1 The title of the article was Phosphine-catalyzed asymmetric additions of malonate esters to γ-substituted allenoates and allenamides. And the article contained the following:

Because carbonyl groups are ubiquitous in organic chem., the ability to synthesize functionalized carbonyl compounds, particularly enantioselectively, is an important objective. We have developed a straight forward and versatile method for catalytic asym. carbon-carbon bond formation at the γ-position of carbonyl compounds, specifically, phosphine-catalyzed additions of malonate esters to γ-substituted allenoates and allenamides. Mechanistic studies have provided insight into the reaction pathway. The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).Recommanded Product: 35444-44-1

The Article related to malonate ester phosphine catalysis asym addition allenoate allenamide, Physical Organic Chemistry: Stereochemistry and Stereochemical Relationships, Including Conformational Inversions and Rotational Isomerization and other aspects.Recommanded Product: 35444-44-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chen, Jinying; Sang, Zitai; Jiang, Youjun; Yang, Chao; He, Linhong published an article in 2019, the title of the article was Design, synthesis, and biological evaluation of quinazoline derivatives as dual HDAC1 and HDAC6 inhibitors for the treatment of cancer.Application of 35444-44-1 And the article contains the following content:

Fifty-eight quinazoline-based compounds were designed and synthesized based on the structural optimizations from the lead compound 23bb in an attempt to search for more potent dual HDAC1 and HDAC6 inhibitors. Among them, 32c (HDAC1, IC50 = 31.10 ± 0.37 nM; HDAC6, IC50 = 16.15 ± 0.62 nM) and 32d (HDAC1, IC50 = 37.00 ± 0.24 nM; HDAC6, IC50 = 35.00 ± 0.71 nM) were not only identified as potent dual-acting HDAC1 and HDAC6 inhibitors with over 10-fold selectivity to the other HDACs, but also displayed activities in tubulin acetylation and histone H3 acetylation induction. Importantly, both of them displayed strong antiproliferative activities against various tumor cell lines in vitro with IC50 values <40 nM, especially for hematol. tumors cells (U266 and RPMI8226, IC50 < 1 nM), which were even better than 23bb and SAHA. Furthermore, 32c showed a significant tumor growth inhibition (antitumor rate = 63.98%, p < 0.05) in the resistant MCF-7/ADR xenograft model without any obvious body weight changes and abnormal behaviors. The authors' findings validate that 32c is a potent dual inhibitor of HDAC1/6 that can be an efficacious treatment for breast cancer with Adriamycin resistance. The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).Application of 35444-44-1

The Article related to quinazoline derivative hdac1 hdac6 inhibitor anticancer agent, design synthesis biol evaluation quinazoline derivative dual hdac1 hdac6, hdac, sar study, cancer, dual inhibitors and other aspects.Application of 35444-44-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On February 28, 1981, Goh, Swee Hock; Kam, Toh Seok published an article.Reference of 2-Chloro-4-methyl-1-nitrobenzene The title of the article was Comparative reactivity of substituted 4-nitrobenzylidene dichlorides with alkali. And the article contained the following:

A comparative study of the reactions of RCHCl2 [R = 3,4- and 2,4-Cl(O2N)C6H3, 4-O2NC6H4, 4,3,5-O2N(Me)2C6H2, 2,4-Me(O2N)C6H3] with aqueous-alc. alkali showed that Cl substitution enhances the electron-transfer radical mechanism, whereas Me substitution favors the solvolysis path. The mechanism of the reaction is discussed. The experimental process involved the reaction of 2-Chloro-4-methyl-1-nitrobenzene(cas: 38939-88-7).Reference of 2-Chloro-4-methyl-1-nitrobenzene

The Article related to nitrobenzylidene chloride reactivity alkali, solvolysis nitrobenzylidene chloride, substituent effect reactivity nitrobenzylidene chloride, benzylidene chloride nitro reactivity and other aspects.Reference of 2-Chloro-4-methyl-1-nitrobenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On August 13, 2009, Ritter, Tobias; Furuya, Takeru; Kaiser, Hanns M. published a patent.Reference of 4-Chloro-2-fluorotoluene The title of the patent was System for fluorinating organic compounds using palladium complexes and fluorinating agents. And the patent contained the following:

Described herein are fluorinated organic compounds and methods of making fluorinated organic compounds, for example, using palladium complexes of formula I. Also described herein are compositions and kits containing compounds and palladium complexes described herein. Palladium complexes of formula I wherein Pd has valence +2; R11 and R12 are independently (un)substituted aliphatic, (un)substituted heteroaliph., (un)substituted aryl, etc.; when W is C and CRd, Z is a bond, O, S, (un)substituted methylene, (un)substituted ethenylene, N- joined via L to R11, etc.; and L is CO, CO2, SO2, etc.; when W is N and NH and derivatives, Z is a bond, (un)substituted methylene, (un)substituted ethenylene, etc.; Rd is H, (un)substituted aliphatic, (un)substituted heteroaliph., etc.; R1, R2, R3 and R4 are independently (un)substituted aliphatic, (un)substituted heteroaliph., (un)substituted aryl; R1R2 R2R3, and R3R4 are independently taken together to form (un)substituted 5- to 7-membered aryl, heteroaryl, heterocyclic and carbocyclic ring; dashed bon is single and double bond; provided that at least one of R11 and R12 is neg. charged moiety or the complex further comprises of a neg. charged counter ion; are claimed. Fluorobenzene was prepared by transmetalation of II with phenylboronic acid, the resulting phenylpalladium sulfamidate complex underwent electrophilic fluorination to give fluorobenzene. The fluorinated organic compounds may be useful as imaging agents. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Reference of 4-Chloro-2-fluorotoluene

The Article related to arylboronic acid palladium acetate sulfamidate complex transmetalation, arylpalladium sulfamidate preparation electrophilic fluorination, fluoro arene preparation imaging agent and other aspects.Reference of 4-Chloro-2-fluorotoluene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics