Tag: 100-200

On September 30, 2021, Asada, Masaki; Higuchi, Satonori; Naganawa, Atsushi; Hanada, Keisuke; Takeda, Yasuhiro published a patent.HPLC of Formula: 59833-69-1 The title of the patent was Preparation of phenylacetic acid compound as DP receptor antagonist. And the patent contained the following:

Title compound I [R1 = H, alkyl or benzyl; R2-R4 = independently halo, alkyl (optionally substituted with halo) or alkoxy (optionally substituted with halo); J = bond, -O- or -S-; L = bond, alkylene, alkenylene, etc.; R5 = H, carbocyclyl or heterocyclyl (wherein the carbocycle and heterocycle are optionally substituted with R7); when L is a bond, R5 cannot be H; R7 = halo, alkyl (optionally substituted with halo) or alkoxy (optionally substituted with halo); R11 = H, halo or alkyl (optionally substituted with halo); R12 = H, halo or alkyl (optionally substituted with halo); R11 and R12, together with the carbon atom to which they are attached, may be combined to form a saturated carbocycle; n = 0-4; m = 0-3; or a pharmaceutically acceptable salt thereof] was prepared For example, treatment of Me (4-chloro-3-[2,6-dimethyl-4-[2-(oxan-2-yl)ethoxy]benzamido]phenyl)acetate with Lawesson’s reagent, chiral separation and hydrolsis afforded compound II. The phenylacetic acid compound in the present invention shows high antagonistic activity for DP receptor, e.g., IC50 value of II was 0.0048μM. Compound I is claimed useful for the treat,ent of allergic disease, inflammation, sleep disorder, etc. The experimental process involved the reaction of Methyl 2-(3-amino-4-chlorophenyl)acetate(cas: 59833-69-1).HPLC of Formula: 59833-69-1

The Article related to phenylacetic acid preparation dp receptor antagonist, allergy inflammation sleep disorder treatment phenylacetic acid, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.HPLC of Formula: 59833-69-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Tanini, Damiano; Dalia, Camilla; Capperucci, Antonella published an article in 2021, the title of the article was The polyhedral nature of selenium-catalyzed reactions: Se(IV) species instead of Se(VI) species make the difference in the on water selenium-mediated oxidation of arylamines.SDS of cas: 38939-88-7 And the article contains the following content:

On water selenium mediated oxidation of anilines was reported. In the presence of di-Ph diselenide or benzeneseleninic acid, anilines reacted with hydrogen peroxide, providing direct and selective access to nitroarenes. On the other hand, the use of selenium dioxide or sodium selenite lead to azoxyarenes. Careful mechanistic anal. and 77Se NMR studies revealed that only Se(IV) species, such as benzeneperoxyseleninic acid, were the active oxidants involved in the catalytic cycle operating in water and leading to nitroarenes. While other selenium-catalyzed oxidations occurring in organic solvents were recently demonstrated to proceed through Se(VI) key intermediates, the on water oxidation of anilines to nitroarenes does not. These findings shed new light on the multifaceted nature of organoselenium-catalyzed transformations and open new directions to exploit selenium-based catalysis. The experimental process involved the reaction of 2-Chloro-4-methyl-1-nitrobenzene(cas: 38939-88-7).SDS of cas: 38939-88-7

The Article related to aryl amine water selenium catalyst oxidation, nitroarene preparation, arylamide preparation, azoxyarene preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.SDS of cas: 38939-88-7

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Iwahashi, Maki; Takahashi, Eiji; Tanaka, Motoyuki; Matsunaga, Yoko; Okada, Yutaka; Matsumoto, Ryoji; Nambu, Fumio; Nakai, Hisao; Toda, Masaaki published an article in 2011, the title of the article was Design and synthesis of new prostaglandin D2 receptor antagonists.Safety of Methyl 2-(3-amino-4-chlorophenyl)acetate And the article contains the following content:

To identify new cost-effective prostaglandin D2 (DP) receptor antagonists, a series of novel 3-benzoylaminophenylacetic acids containing a benzoxazine moiety were synthesized and biol. evaluated. Among those tested, some representative compounds, e.g., I, were found to be orally available. Receptor selectivity and rat PK profiles were also evaluated. The structure-activity relationship (SAR) study is presented. The experimental process involved the reaction of Methyl 2-(3-amino-4-chlorophenyl)acetate(cas: 59833-69-1).Safety of Methyl 2-(3-amino-4-chlorophenyl)acetate

The Article related to benzoylaminophenylacetic acid benzoxazine derivative preparation prostaglandin receptor antagonist sar, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Safety of Methyl 2-(3-amino-4-chlorophenyl)acetate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On March 26, 2020, Asada, Masaki; Hanada, Keisuke; Higuchi, Satonori; Naganawa, Atsushi; Takeda, Yasuhiro published a patent.Application of 59833-69-1 The title of the patent was Preparation of benzamide compound as DP antagonist. And the patent contained the following:

The present invention relates to a compound I [R1 = H, alkyl or benzyl; R2-R4 = independently halo, alkyl (optionally substituted with halo) or alkoxy (optionally substituted with halo); when plural R2 or R4 groups exist, they, at each occurrence, are the same or different; J = bond, -O- or -S-; L = bond, alkylene, alkenylene, etc.; R5 = H or carbocyclyl or heterocyclyl (wherein carbocycle and heterocycle are optionally substituted with R7); when L is a bond, R5 cannot be H; R7 = halo, alkyl (optionally substituted with halo) or alkoxy (optionally substituted with halo); Q = oxygen atom or sulfur atom; R6 = H or alkyl; R11 = H, halo or alkyl (optionally substituted with halo); R12 = H, halo or alkyl (optionally substituted with halo); R11 and R12, together with the carbon atom to which they are attached, may combine to form a saturated carbocycle; n = 0-4; m = 0-3; or a pharmaceutically acceptable salt thereof]. For example, compound II was prepared via reaction of Me [4-chloro-3-(4-hydroxy-2,6-dimethylbenzamido)phenyl]acetate with N,N-bis(trifluoromethylsulfonyl)aniline and coupling reaction with 2-[(E)-3-cyclohexylpropen-1-yl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane. Compound I exhibits high DP antagonistic activity, has excellent ability to migrate to the central nervous system, and therefore is useful for the treatment of disease involving DP receptors located in the central nervous system among DP-receptor-mediated diseases (i.e., sleep-wake disorder). The experimental process involved the reaction of Methyl 2-(3-amino-4-chlorophenyl)acetate(cas: 59833-69-1).Application of 59833-69-1

The Article related to benzamide preparation dp receptor antagonist, sleep wake disorder treatment benzamide, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Application of 59833-69-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On May 12, 2022, Sharma, Swagat; Peng, Qi; Vadukoot, Anish K.; Aretz, Christopher D.; Jensen, Aaron A.; Wallick, Alexander I.; Dong, Xinzhong; Hopkins, Corey R. published an article.Application of 89-77-0 The title of the article was Synthesis and Biological Characterization of a Series of 2-Sulfonamidebenzamides as Allosteric Modulators of MrgX1. And the article contained the following:

The present study describes the continued efforts in the discovery and characterization of a series of 2-sulfonamidebenzamides e.g., 3-(Cyclopropanesulfonamido)-N-(2-ethoxyphenyl)-2-naphthamide as allosteric modulators of MrgX1. MrgX1 has been shown to be an attractive target as a nonopioid receptor for the potential treatment of chronic pain. Working from the original compound, ML382, and utilizing iterative medicinal chem., key halogen substituents that improve MrgX1 potency by ~8-fold were identified. In addition, the compounds in Tier 1 drug metabolism and pharmacokinetics assays were evaluated and the key compounds that impart improved potency and microsomal stability were identified. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Application of 89-77-0

The Article related to sulfonamidebenzamide preparation allosteric modulator protein coupled receptor, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Application of 89-77-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On January 17, 2020, Guru, Murali Mohan; Thorve, Pradip Ramdas; Maji, Biplab published an article.Related Products of 89-77-0 The title of the article was Boron-Catalyzed N-Alkylation of Arylamines and Arylamides with Benzylic Alcohols. And the article contained the following:

A sustainable boron-based catalytic approach for chemoselective N-alkylation of primary and secondary aromatic amines and amides with primary, secondary, and tertiary benzylic alcs. have been presented. The metal-free protocol operates at low catalyst loading, tolerates several functional groups and generates H2O as the sole byproduct. Preliminary mechanistic studies were performed to demonstrate the crucial role of boron catalyst for the activation of the intermediate dibenzyl ether and to identify the rate-determining step. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Related Products of 89-77-0

The Article related to arylamine arylamide benzylic alc chemoselective alkylation boron green chem, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Related Products of 89-77-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On January 31, 2011, Ramalingam, S.; Periandy, S.; Elanchezhian, B.; Mohan, S. published an article.Related Products of 452-75-5 The title of the article was FT-IR and FT-Raman spectra and vibrational investigation of 4-chloro-2-fluorotoluene using ab initio HF and DFT (B3LYP/B3PW91) calculations. And the article contained the following:

FT-IR (4000-100 cm-1) and FT-Raman (4000-100 cm-1) spectra of solid sample of 4-chloro-2-fluorotoluene (4Cl2FT) have been recorded using Bruker IFS 66 V spectrometer. Ab initio-HF (HF/6-311++G (d, p)) and DFT (B3LYP/6-311++G and B3PW91/6-311++G (d, p)) calculations have been performed giving energies, optimized structures, harmonic vibrational frequencies, depolarization ratios, IR intensities, Raman activities. The vibrational frequencies are calculated and scaled values are compared with FT-IR and FT-Raman exptl. values. The isotropic HF and DFT analyses showed good agreement with exptl. observations. The differences between the observed and scaled wave number values of most of the fundamentals are very small in B3LYP than HF. Comparison of the simulated spectra provides important information about the ability of the computational method (B3LYP) to describe the vibrational modes. The influences of substitutions on the geometry of mol. and its normal modes of vibrations have also been discussed. The changes made by substitutions on the benzene are much responsible for the non-linearity of the mol. This is an attractive entity for the future studies of non-linear optics. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Related Products of 452-75-5

The Article related to chlorofluorotoluene ir raman spectra hf dft, Physical Organic Chemistry: Absorption, Emission, Reflection, and Scattering Spectra (Ultraviolet and Visible, Infrared and Fourier Transform Infrared, Raman, Microwave, Photoelectron, Fluorescence, Phosphorescence, etc.) and other aspects.Related Products of 452-75-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On June 7, 2007, Wada, Mitsuo; Ida, Kazutaka published a patent.COA of Formula: C7H6ClF The title of the patent was Charge-generating phthalocyanine crystals and electrophotographic photoconductors using them. And the patent contained the following:

The crystals having main diffraction peaks at Bragg angle (2θ±0.2°) 27.2° to CuKa x ray (wavelength 1.541 Å) are manufactured by treatment of amorphous or low-crystalline phthalocyanines with fluorinated aromatic compounds bearing substituents with Hammett constant ≤0.48. Electrophotog. photoconductor cartridges and electrophotog. apparatus are also claimed. The electrophotog. photoconductors show high sensitivity to LED or semiconductor lasers, and low dark decay. Thus, low-crystalline oxytitanylphthalocyanine was treated with 2,4-dichlorofluorobenzene. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).COA of Formula: C7H6ClF

The Article related to charge generator phthalocyanine crystal electrophotog photoconductor, fluoroarene crystallization phthalocyanine electrophotog photoconductor, Radiation Chemistry, Photochemistry, and Photographic and Other Reprographic Processes: Electrophotography, Electrography, and Photoelectrophoretic Imaging and other aspects.COA of Formula: C7H6ClF

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Li, Yiming; Wang, Yuhong; Yang, Tilong; Lin, Zhenyang; Jiang, Xuefeng published an article in 2021, the title of the article was Selenium-catalyzed intramolecular atom- and redox-economical transformation of o-nitrotoluenes into anthranilic acids.Computed Properties of 89-77-0 And the article contains the following content:

Herein, a straightforward strategy to transform abundant o-nitrotoluenes into biol. and pharmaceutically significant AAs without any extra reductants, oxidants and protecting groups was demonstrated. Various sensitive groups, such as halogens, sulfide, aldehyde, pyridines, quinolines, etc., can be tolerated in this transformation. A hundred-gram-scale operation was realized efficiently with almost quant. selenium recycling. Further mechanistic studies and DFT calculations disclosed the proposed atom-exchange processes and the key roles of the selenium species. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Computed Properties of 89-77-0

The Article related to nitrotoluene selenium catalyst redox reaction mechanism, anthranilic acid preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Carboxylic Acids and Peroxycarboxylic Acids and Their Sulfur-Containing Analogs and Salts and other aspects.Computed Properties of 89-77-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On August 20, 2021, Zeng, Rong; Zhang, Guoxiang published a patent.Electric Literature of 452-75-5 The title of the patent was Preparation of aromatic acids by oxidation of alkyl substituted aromatic compounds. And the patent contained the following:

The invention discloses a preparation of aromatic acids by oxidation of alkyl substituted aromatic compounds, which has high safety and low cost. The aromatic acids of the invention were prepared via oxidation of aromatic compounds The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Electric Literature of 452-75-5

The Article related to aromatic acid preparation alkyl substituted aromatic oxidation iron catalysis, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Carboxylic Acids and Peroxycarboxylic Acids and Their Sulfur-Containing Analogs and Salts and other aspects.Electric Literature of 452-75-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics