Tag: 100-200

On October 19, 2017, Kumoi, Hirofumi; Tanaka, Masato published a patent.Formula: C7H6ClF The title of the patent was Production method of phthalocyanine crystals and process for producing electrophotographic photoreceptor using the same. And the patent contained the following:

Title production method of phthalocyanine crystal includes mixing of phthalocyanine compound obtained by the acid pasting method with an organic compound and subjecting it to crystal transformation to obtain phthalocyanine crystal, which comprises a rotatable rotor and a jacket covering the rotor, at least the rotor has a flow path of a coolant or a heat medium therein and a gap between the rotor and the inner wall of the jacket has a portion forming an annular space, the rotor and the inner wall of the jacket both have a smooth surface and a crystal transformation is performed using a disperser having a structure in which a mixture of the phthalocyanine compound and the organic compound passes through the space filled with media particles. Thus, 0.3 parts of hydroxygallium phthalocyanine pigment powder (prepared by reacting chlorogallium phthalocyanine pigment with sulfuric acid), 9.7 parts of N,N-dimethylformamide were mixed in stainless steel container and then the mixed solution was subjected to dispersion treatment using glass beads as media particles and then the mixture was dispersed by using a dispersion machine to obtain hydroxygallium phthalocyanine crystals. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Formula: C7H6ClF

The Article related to phthalocyanine crystal organic compound electrophotog photoreceptor, Dyes, Organic Pigments, Fluorescent Brighteners, and Photographic Sensitizers: Phthalocyanines and other aspects.Formula: C7H6ClF

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On June 10, 2021, Yao, Hong; Uras, Giuseppe; Zhang, Pengfei; Xu, Shengtao; Yin, Ying; Liu, Jie; Qin, Shuai; Li, Xinuo; Allen, Stephanie; Bai, Renren; Gong, Qi; Zhang, Haiyan; Zhu, Zheying; Xu, Jinyi published an article.Formula: C7H6ClNO2 The title of the article was Discovery of Novel Tacrine-Pyrimidone Hybrids as Potent Dual AChE/GSK-3 Inhibitors for the Treatment of Alzheimer’s Disease. And the article contained the following:

Based on a multitarget strategy, a series of novel tacrine-pyrimidone hybrids were identified for the potential treatment of Alzheimer’s disease (AD). Biol. evaluation results demonstrated that these hybrids exhibited significant inhibitory activities toward acetylcholinesterase (AChE) and glycogen synthase kinase 3 (GSK-3). The optimal compound 27g (I) possessed excellent dual AChE/GSK-3 inhibition both in terms of potency and equilibrium (AChE: IC50 = 51.1 nM; GSK-3β: IC50 = 89.3 nM) and displayed significant amelioration on cognitive deficits in scopolamine-induced amnesia mice and efficient reduction against phosphorylation of tau protein on Ser-199 and Ser-396 sites in glyceraldehyde (GA)-stimulated differentiated SH-SY5Y cells. Furthermore, compound 27g exhibited eligible pharmacokinetic properties, good kinase selectivity, and moderate neuroprotection against GA-induced reduction in cell viability and neurite damage in SH-SY5Y-derived neurons. The multifunctional profiles of compound 27g suggest that it deserves further investigation as a promising lead for the prospective treatment of AD. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Formula: C7H6ClNO2

The Article related to tacrine pyrimidone hybrid ache gsk3 inhibitor alzheimer disease, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Formula: C7H6ClNO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On August 12, 2022, Wang, Tao; Chen, Xuling; Li, Pengfei published an article.Computed Properties of 89-77-0 The title of the article was One-Pot Divergent Synthesis of Benzoxazines and Dihydroquinolines from Morita-Baylis-Hillman Alcohols. And the article contained the following:

Benzoxazines and hydroquinolines was prepared by a one-pot process via catalyst-controlled divergent annulations of Morita-Baylis-Hillman (MBH) alcs. In the presence of diazabicyclo[2.2.2]octane, MBH alcs. reacted with Boc2O to form MBH carbonates, followed by intramol. annulation to give 4H-benzo[d][1,3]oxazines. Divergently, the combination of Bu4NBr and NaOH enabled the formation of 1,2-dihydroquinolines from the same starting materials. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Computed Properties of 89-77-0

The Article related to hydroxy carboxypropylene benzamide intramol heterocyclization, carboxyethylene benzoxazine preparation, acyl dihydroquinoline carboxylate preparation, Heterocyclic Compounds (More Than One Hetero Atom): Other 6-Membered Rings, Two Hetero Atoms and other aspects.Computed Properties of 89-77-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zhang, Min; Hao, Erhong; Xu, Yajun; Zhang, Shengzhou; Zhu, Hongnian; Wang, Qi; Yu, Changjiang; Jiao, Lijuan published an article in 2012, the title of the article was One-pot efficient synthesis of pyrrolylBODIPY dyes from pyrrole and acyl chloride.Quality Control of Methyl 6-chloro-6-oxohexanoate And the article contains the following content:

A facile one-pot synthesis of pyrrolylBODIPY dyes from acid chloride and excess pyrrole was developed through oxidative nucleophilic substitution of in situ formed dipyrromethene with pyrrole. Fluorescence imaging of living cells by using selected dyes was successfully demonstrated. The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).Quality Control of Methyl 6-chloro-6-oxohexanoate

The Article related to pyrrolylbodipy dye pyrrole acyl chloride synthesis fluorescent imaging, Dyes, Organic Pigments, Fluorescent Brighteners, and Photographic Sensitizers: Heterocyclics and other aspects.Quality Control of Methyl 6-chloro-6-oxohexanoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On September 18, 2015, Zhou, Xin; Yu, Changjiang; Feng, Zeya; Yu, Yang; Wang, Jun; Hao, Erhong; Wei, Yun; Mu, Xiaolong; Jiao, Lijuan published an article.Name: Methyl 6-chloro-6-oxohexanoate The title of the article was Highly Regioselective α-Chlorination of the BODIPY Chromophore with Copper(II) Chloride. And the article contained the following:

A general and efficient method for α-chlorination of 4,4′-difluoro-4-bora-3a,4a-diaza-s-indacenes (BODIPYs) was developed using CuCl2 as chlorination reagent. The reaction is characterized by complete 3/5-positions of BODIPY regioselectivity. This unusual highly regioselective α-halogenation of BODIPY is in sharp contrast to previously reported halogenation methods which preferred to occur first at the 2,6-positions of BODIPY. This approach provides a straightforward, facile, and economical route to 3- and/or 5-chloroBODIPYs with various meso-groups (H, alkyl, and aryl) and their derivatives The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).Name: Methyl 6-chloro-6-oxohexanoate

The Article related to regioselective chlorination bodipy copper chloride, Dyes, Organic Pigments, Fluorescent Brighteners, and Photographic Sensitizers: Heterocyclics and other aspects.Name: Methyl 6-chloro-6-oxohexanoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Furuya, Takeru; Kaiser, Hanns Martin; Ritter, Tobias published an article in 2008, the title of the article was Palladium-mediated fluorination of arylboronic acids.Name: 4-Chloro-2-fluorotoluene And the article contains the following content:

Novel palladium complexes allow mild, two-step fluorination of aryl boronic acids. The reaction is regiospecific, functional-group tolerant, has a broad substrate scope, and is ideally suited for the introduction of fluorine substituents at a late stage for aryl fluoride synthesis. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Name: 4-Chloro-2-fluorotoluene

The Article related to aryl boronic acid palladium acetate complex transmetallation, complex aryl palladium preparation electrophilic fluorination, regioselective aryl fluoride preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Halides and Halonium Compounds and other aspects.Name: 4-Chloro-2-fluorotoluene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On September 4, 1990, Lai, J. S.; Wu, Rey F.; Lin, Ivan J. B.; Cheng, M. C.; Wang, Yu published an article.Product Details of 5034-06-0 The title of the article was Preparation of sulfur ylide complexes of platinum by phase transfer catalysis. And the article contained the following:

Various sulfur ylide complexes of Pt were prepared by the phase transfer catalysis (PTC). Thus, reaction of Pt(PR3)2Cl2 (R = Me, Ph) in CH2Cl2 with [S(O)(CH3)3]I under PTC/OH- conditions give complexes {Pt(PR3)2[(CH2)2S(O)(CH3)]}I, which contain a bidentate double sulfur ylide. With Pt(dppe)Cl2 [dppe = Ph2P(CH2)2PPh2] as starting material, a similar product was obtained. But when Pt(dppm)Cl2 [dppm = Ph2PCH2PPh2] was treated with [S(O)(CH3)3]Cl under PTC/OH- conditions, an unexpected product {Pt(PPh2CH3)(PPh2OH)[(CH2)2S(O)(CH3)]}Cl was obtained. This compound contains a bidentate double sulfur ylide and two unsym. phosphines resulting from the base hydrolysis of dppm. Compound {Pt(PPh3)2[(CH2)2S(O)(CH3)]}I, was subjected to an x-ray diffraction study. The experimental process involved the reaction of trimethyloxosulphonium chloride(cas: 5034-06-0).Product Details of 5034-06-0

The Article related to phase transfer catalyzed sulfur ylide platinum, crystal structure platinum sulfur ylide complex, mol structure platinum sulfur ylide complex, Organometallic and Organometalloidal Compounds: Group Viii – Co, Ni, Ru, Rh, Pd, Os, Ir, Pt and other aspects.Product Details of 5034-06-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zhang, Yong; Lai, Guo-Wei; Nie, Long-Jun; He, Qifang; Lin, Mei-Juan; Chi, Rong; Lu, Dong-Liang; Fan, Xiaolin published an article in 2022, the title of the article was Organocatalytic difluorobenzylation of 1,2-diketones via mild cleavage of carbon-carbon bonds.Name: 2-Chloro-4-methyl-1-nitrobenzene And the article contains the following content:

α-Aryl-α,α-difluoroacetophenones (DFAPs) RCF2C(O)Ph [R = 2,4-di-O2NC6H3, 2-O2NC6H4, 3-Cl-4-O2NC6H3, etc.] were developed as a new class of difluorobenzylation reagents that could be facilely prepared from readily available and cheap starting materials. In situ carbon-carbon bond cleavage of electron-deficient DFAPs gave difluorobenzyl carbanions that underwent base-catalyzed nucleophilic addition to isatins, unsaturated-α-ketoesters and cyclic 1,2-diketones. This organocatalytic difluorobenzylation reaction provided a new and efficient protocol to prepare various valuable building blocks such as I [R1 = H, 5-F, 7-Cl, etc.; R2 = H, Me, Ph, etc.; R3 = 2,4-di-O2NC6H3, 2-O2NC6H4, 3-Cl-4-O2NC6H3, etc.] containing the electron-deficient difluorobenzyl group. The experimental process involved the reaction of 2-Chloro-4-methyl-1-nitrobenzene(cas: 38939-88-7).Name: 2-Chloro-4-methyl-1-nitrobenzene

The Article related to difluorobenzylated compound preparation, aryl difluoroacetophenone diketone nucleophilic difluorobenzylation dbu catalyst, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Name: 2-Chloro-4-methyl-1-nitrobenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On February 11, 1999, Wingert, Horst; Gotz, Norbert; Keil, Michael; Muller, Bernd published a patent.Electric Literature of 452-75-5 The title of the patent was Manufacture of substituted benzyl bromides. And the patent contained the following:

Benzyl bromides ring-substituted with ≥1 electron-withdrawing group and optionally with ≥1 Me group are prepared by bromination of correspondingly substituted toluenes with a brominating agent at 20-95° in the presence of an oxidizing agent and either an azodinitrile or an azodicarboxylate ester. Thus, (1) a solution of 26.2 g AIBN in 548 g o-MeC6H4NO2 and (2) 725 g 15% aqueous H2O2 were sep. added simultaneously over 2-2.5 h to a mixture of AIBN 6.6, PhCl 1350, and 47% HBr 620 g at 75° and the mixture was stirred 2 h addnl. at 75° to give an organic phase containing (excluding solvent) o-BrCH2C6H4NO2 60.4, o-MeC6H4NO2 21.5, and o-Br2CHC6H4NO2 18.2%, corresponding to a 58.1% yield of the desired product. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Electric Literature of 452-75-5

The Article related to bromination methylbenzene derivative oxidizing agent, radical generator bromination methylbenzene derivative, Industrial Organic Chemicals, Leather, Fats, and Waxes: Manufacture Of Industrial Organic Chemicals and other aspects.Electric Literature of 452-75-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Patel, Hiren; Chuckowree, Irina; Coxhead, Peter; Guille, Matthew; Wang, Minghua; Zuckermann, Alexandra; Williams, Robin S. B.; Librizzi, Mariangela; Paranal, Ronald M.; Bradner, James E.; Spencer, John published an article in 2014, the title of the article was Synthesis of hybrid anticancer agents based on kinase and histone deacetylase inhibitors.Reference of Methyl 6-chloro-6-oxohexanoate And the article contains the following content:

Fragments based on the VEGFR2i Semaxanib (SU5416, vascular endothelial growth factor receptor-2 inhibitor) and the HDACi (histone deacetylase inhibitor) SAHA (suberanilohydroxamic acid) have been merged to form a range of low mol. weight dual action hybrids. Vindication of this approach is provided by SAR, docking studies, in vitro cancer cell line and biochem. enzyme inhibition data as well as in vivo Xenopus data for the lead mol. I. The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).Reference of Methyl 6-chloro-6-oxohexanoate

The Article related to oxoindoline zinc binding group hybrid preparation anticancer docking, kinase histone deacetylase inhibitor, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Reference of Methyl 6-chloro-6-oxohexanoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics