Tag: 100-200

Chen, Mao; Buchwald, Stephen L. published an article in 2013, the title of the article was Continuous-flow synthesis of 1-substituted benzotriazoles from chloronitrobenzenes and amines in a C-N bond formation/hydrogenation/diazotization/cyclization sequence.Product Details of 38939-88-7 And the article contains the following content:

We have developed an efficient and regiospecific synthesis of 1-substituted benzotriazoles from chloronitrobenzenes and amines by a C-N bond formation/hydrogenation/diazotization/cyclization sequence under continuous-flow conditions. Two approaches beginning either with an SnAr reaction or Pd catalysis were developed to prepare unsym. substituted benzotriazoles with a range of substituents. Of particular note is that benzotriazoles that bear various N-substituted groups, including alkyl, aryl, and heteroaryl, can all be efficiently and regiospecifically accessed with the described method. This protocol represents a successful example of a continuous-flow method with consecutive multiphase processes. The experimental process involved the reaction of 2-Chloro-4-methyl-1-nitrobenzene(cas: 38939-88-7).Product Details of 38939-88-7

The Article related to benzotriazoles regioselective synthesis continuous flow, chloronitrobenzene amine tandem reaction cn coupling hydrogenation diazotization cyclization, Heterocyclic Compounds (More Than One Hetero Atom): Triazines and other aspects.Product Details of 38939-88-7

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On January 17, 2021, Polina, Saibabu; Putta, V. P. Rama Kishore; Gujjarappa, Raghuram; Singh, Virender; Pujar, Prasad Pralhad; Malakar, Chandi C. published an article.Application of 89-77-0 The title of the article was P(III)-Mediated Cascade C-N/C-S Bond Formation: A Protocol Towards the Synthesis of N,S-Heterocycles and Spiro Compounds. And the article contained the following:

A P(III)-mediated entry towards construction of C-N/C-S bond has been devised. The developed heterocyclization method was applied to the synthesis of a diverse range of N,S-heterocycles and related spiro mols. P(NMe2)3 showed the maximum efficacies under the aerobic reaction conditions, and a range of bis-nucleophiles and isothiocyanates were tolerated well to serve the access of manifold immense mols. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Application of 89-77-0

The Article related to isothiocyanate amine heterocyclization phosphine mediated, thiazine benzothiazine thiazole preparation, spiro heterocycle preparation, Heterocyclic Compounds (More Than One Hetero Atom): Thiazines and other aspects.Application of 89-77-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On October 5, 1978, Henrick, Clive A.; Garcia, Barbara A. published a patent.Product Details of 452-75-5 The title of the patent was Amino acid esters and thiol esters. And the patent contained the following:

RR1NCR2R3COXR4 [R = cycloalkyl, cycloalkenyl, substituted Ph; R1 = H, alkyl, haloalkylcarbonyl, HCO; R2 = C2-5-alkyl, C2-5-alkenyl, C1-4-haloalkyl, C2-4-haloalkenyl, C3-4-cycloalkyl; R3 = H, F; X = O, S; R4 = CHR5R6 [R5 = H, CN, Me, CF3, CCH, CSNH2; R6 = substituted Ph, Q (R8 = H, alkyl; R9 = alkenyl, alkynyl, aralkyl; X1 = O, S)], CH2R10 [R10 = Q1 (R12R13 = alkylene, alkenylene; X2 = O, S), Q2 (R15 = H, alkyl, alkenyl, alkynyl, aralkyl; R16 = H, alkyl)], CH2CR17:CR18CH2R19 (R17 and R18 = H, Cl, F, Me; R17R18 = bond; R19 = Ph, OPh), CH(CCH)CR20:CHR21 (R20 = H, halo, Me, Et; R21 = allyl, propargyl, 3-butenyl, 3-butynyl, Ph, CH2Ph)] and their salts were prepared as pesticides. Thus, Me2CHCHBrCO2H was treated with SOCl2 to give the acid chloride, which was esterified with HOCH2C6H4OPh-m to give Me2CHCHBrCO2CH2C6H4OPh-m, which was aminated with PhNH2 to give PhNHCH(CHMe2)CO2CH2C6H4OPh-m. A great number of other N-substituted valine esters were also prepared Pesticide activity data are given. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Product Details of 452-75-5

The Article related to amino acid ester, pesticide amino acid ester, thioester amino acid, valine ester preparation pesticide, Synthesis of Amino Acids, Peptides, and Proteins: Amino Acids and other aspects.Product Details of 452-75-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On November 11, 1993, Cantegril, Richard; Croisat, Denis; Desbordes, Philippe; Guigues, Francois; Mortier, Jacques; Peignier, Raymond; Vors, Jean Pierre published a patent.Formula: C7H6ClF The title of the patent was Fungicidal arylpyrazoles and their preparation, compositions, and use. And the patent contained the following:

The invention relates to new derivatives of the family of 3-arylpyrazoles, their methods of preparation, compositions containing them, and their utilization for the protection of plants against fungal diseases. The invention relates more particularly to 3-arylpyrazole derivatives having the formula I [X1-X5 = H, halo, OH, cyano, NO2, alkyl, amino, etc.; or 2 adjacent X may form carbon chain with optional heteroatoms or substituents; Y = H, halo, NO2, cyano, alkoxy, amino, etc.; Z = H, halo, cyano, OH, NO2, alkoxy, alkylthio, amino, C(Z1)Z2, etc.; Z1 = O, S, alkylamino, imino, arylamino; Z2 = H, halo, OH, SH, cyano, amino, alkyl, alkoxy, etc.]. For example, condensation of 3,5-dichloroacetophenone with DMF di-Me acetal gave 77% 3,5-Cl2C6H3COCH:CHNMe2, which was cyclized with hydrazine hydrate in EtOH give 90% 3-(3,5-dichlorophenyl)-1H-pyrazole (II; Y = H). Chlorination of this with N-chlorosuccinimide in CH2Cl2 gave 57% II (Y = Cl), which as a 1-g/L suspension gave good (≥75%) protection of tomato leaves from Botrytis cinerea. Over 330 compounds, including products and/or intermediates, were prepared Addnl. tests and formulations are described. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Formula: C7H6ClF

The Article related to arylpyrazole preparation fungicide, pyrazole aryl preparation fungicide, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Formula: C7H6ClF

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chen, Xiulei; Zhou, Zhen; Li, Zhong; Xu, Xiaoyong published an article in 2020, the title of the article was Synthesis and nematicidal activities of 1,2,3-benzotriazin-4-one containing 4,5-dihydrothiazole-2-thiol derivatives against Meloidogyne incognita.Synthetic Route of 89-77-0 And the article contains the following content:

A series of novel 1,2,3-benzotriazin-4-one derivatives containing 4,5-dihydrothiazole-2-thiol I (R = H, 5-OMe, 7-F, 8-NO2, etc.) was synthesized. The bioassay results showed that compounds I (R = 7-OMe, 6-NO2, 7-Cl (A)) exhibited good control efficacy against the cucumber root-knot nematode disease caused by Meloidogyne incognita at the concentration of 10.0 mg L-1 in vivo. Compound (A) showed excellent nematicidal activity with inhibition 68.3% at a concentration of 1.0 mg L-1. It suggested that the structure of 1,2,3-benzotriazin-4-one containing 4,5-dihydro-thiazole-2-thiol could be optimized further. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Synthetic Route of 89-77-0

The Article related to benzotriazinone dihydrothiazole thiol preparation nematocidal activity, Heterocyclic Compounds (More Than One Hetero Atom): Triazines and other aspects.Synthetic Route of 89-77-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On August 15, 2013, Ji, Haitao; Yu, Binxun; Zhang, Min; Guo, Wenxing published a patent.COA of Formula: C7H6ClNO2 The title of the patent was Preparation of substituted 1H-indazol-1-ol analogs as inhibitors of beta-catenin/Tcf protein-protein interactions. And the patent contained the following:

The invention relates to substituted 1H-benzo[d][1,2,3]triazol-1-ol analogs of formula I, synthetic methods for making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating disorders, e.g. various tumors and cancers, associated with β-catenin/Tcf protein-protein interaction dysfunction using the compounds and compositions Compounds of formula I wherein A1 is N, NH and CR2a; A2 is N, CO, CS and CR2b; A3 is NOH and O; L is CH2, CH2CH2, CH2CH2CH2, OCH2, NHCH2, etc.; B1 is N, O and S; B2 is N, CO, CS, and SO; R11, R1b and R1c are independently H, halo, OH, NH2, C1-3 alkyl, etc.; R2a and R2b are independently H, halo, OH, NH2, C1-3 haloalkyl, etc.; and pharmaceutically acceptable salts, esters, hydrates, solvates, or polymorphs thereof, are claimed. Example compound II was prepared by a multistep procedure (procedure given). The invention compounds were evaluated for their inhibitory activity of β-catenin/Tcf protein-protein interaction. From the assay, it was determined that compound II exhibited Ki value of 1304 ± 2.03 μM. The experimental process involved the reaction of 2-Chloro-4-methyl-1-nitrobenzene(cas: 38939-88-7).COA of Formula: C7H6ClNO2

The Article related to substituted indazole preparation beta catenin tcf protein interaction, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.COA of Formula: C7H6ClNO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On December 31, 2019, Yan, Jingbo; Li, Song; Zhong, Wu; Xiao, Junhai; Wang, Gang published a patent.Electric Literature of 38939-88-7 The title of the patent was Preparing method and application of Quetiapine analog. And the patent contained the following:

The title Quetiapine analog is shown in formula (I), wherein, m, n and p are independently integers of 0, 1, 2, 3 and 4; R1 and R2 are independently selected from H, halogen, nitro, cyano, hydroxy, etc.; R3 is 3-10-membered cycloalkyl, 3-membered heterocycloalkyl, etc.; R4 is H, cyano, C1-6 alkyl, etc.; R5 is H, C1-6 alkyl, C1-6 alkoxy, etc. The invented Quetiapine analog shows higher bioactivity than Quetiapine. The experimental process involved the reaction of 2-Chloro-4-methyl-1-nitrobenzene(cas: 38939-88-7).Electric Literature of 38939-88-7

The Article related to quetiapine antidepressant anxiolytic analgesic preparation, Heterocyclic Compounds (More Than One Hetero Atom): Eight- and Higher-Membered Rings and other aspects.Electric Literature of 38939-88-7

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On January 31, 2022, Tatevosyan, Stepan S.; Kotovshchikov, Yury N.; Latyshev, Gennadij V.; Lukashev, Nikolay V.; Beletskaya, Irina P. published an article.Synthetic Route of 89-77-0 The title of the article was Facile Access to Triazole-Fused 3,1-Benzoxazines Enabled by Metal-Free Base-Promoted Intramolecular C-O Coupling. And the article contained the following:

A convenient approach to assemble 1,2,3-triazole-fused 4 H-3,1-benzoxazines I (R = H, 6-Me, 7-I, 7,8-dimethoxy, etc.; R1 = H, Me, Ph; R2 = Bu, cyclopropyl, Ph, etc.) has been developed. Diverse alc.-tethered 5-iodotriazoles II (R3 = H, 6-Me, 5-I, 4,5-dimethoxy, etc.), readily accessible by a modified protocol of Cu-catalyzed (3+2)-cycloaddition, were utilized as precursors of the target fused heterocycles I. The intramol. C-O coupling proceeded efficiently under base-mediated transition-metal-free conditions, furnishing cyclization products I in yields up to 96%. Suppression of the competing reductive cleavage of the C-I bond was achieved by the use of Na2CO3 in acetonitrile at 100°C. This practical and cost-effective procedure features a broad substrate scope and valuable functional group tolerance. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Synthetic Route of 89-77-0

The Article related to triazole benzoxazine preparation, iodotriazolyl benzyl alc preparation intramol coupling, Heterocyclic Compounds (More Than One Hetero Atom): Oxazines (Including Morpholine) and other aspects.Synthetic Route of 89-77-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On December 18, 2008, Akatsuka, Hidenori; Sugama, Hiroshi; Awai, Nobumasa; Kawaguchi, Takayuki; Takahashi, Yoichi; Iijima, Toru; Shen, Jingkang; Xia, Guangxin; Xie, Jianshu published a patent.Recommanded Product: 3-Chloro-5-hydroxy-4-methoxybenzaldehyde The title of the patent was Preparation of morpholine derivatives as renin inhibitors. And the patent contained the following:

The title compounds I [R1 = alkyl (substituted with a group selected from (un)substituted alkoxy, OH, halo, etc.), (un)substituted aryl, (un)substituted heterocyclic group, etc.; R2 = alkyl (substituted with a group selected from (un)substituted alkoxy, OH, halo, etc.), (un)substituted aryl, (un)substituted heterocyclic group, etc.; T = methylene, carbonyl; R3 – R6 = H, (un)substituted carbamoyl, (un)substituted alkyl] are prepared Thus, (2R)-N-cyclopropyl-N-([4-(3-methoxypropoxy)-2-naphthyl]methyl)morpholine-2-carboxamide hydrochloride (II) was prepared in a multistep process starting from 4-hydroxy-2-naphthalenecarboxylic acid. II showed IC50 value of 30.2 nM against human renin. The experimental process involved the reaction of 3-Chloro-5-hydroxy-4-methoxybenzaldehyde(cas: 54246-06-9).Recommanded Product: 3-Chloro-5-hydroxy-4-methoxybenzaldehyde

The Article related to morpholine derivative preparation renin inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Oxazines (Including Morpholine) and other aspects.Recommanded Product: 3-Chloro-5-hydroxy-4-methoxybenzaldehyde

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kachbi Khelfallah, S.; Monteil, M.; Deschamp, J.; Gager, O.; Migianu-Griffoni, E.; Lecouvey, M. published an article in 2015, the title of the article was Synthesis of novel polymerizable molecules bearing bisphosphonate.Application In Synthesis of Methyl 6-chloro-6-oxohexanoate And the article contains the following content:

In recent years, bisphosphonate chem. has undergone an exponential growth due to the potential applications of these compounds in medicine and nanobiomaterial research. In this paper authors describe the synthesis methods of different families of methacrylic monomers bearing a bisphosphonate with varying lengths of the chain, PEG linkers and more or less hydrolyzable functions such as ester, carbamate or amide. The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).Application In Synthesis of Methyl 6-chloro-6-oxohexanoate

The Article related to methacrylic monomer bisphosphonate nanobiomaterial ester carbamate amide, Chemistry of Synthetic High Polymers: Monomers and Reagents Used In Polymerization and other aspects.Application In Synthesis of Methyl 6-chloro-6-oxohexanoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics