Tag: 100-200

Base-Promoted Metal-/Oxidant-Free Three-Component Tandem Annulation: A Strategy for the Construction of 2,4,5-Trisubstituted Thiazoles via C-N Bond Cleavage of Amidines was written by Guo, Wei;Zhao, Mingming;Tan, Wen;Zheng, Lvyin;Tao, Kailiang;Chen, Luyan;Wang, Mingfeng;Chen, Deliang;Fan, Xiaolin. And the article was included in Asian Journal of Organic Chemistry in 2018.HPLC of Formula: 18637-02-0 This article mentions the following:

A base-promoted and metal-/oxidant-free one-pot three-component tandem annulation of amidines, aryl/alkyl isothiocyanates, and α-bromoesters/ketones to 2,4,5-trisubstituted thiazoles I (R¹ = Ph, 4-FC₆H₄, 3-BrC₆H₄, etc.; R² = 4-FC₆H₄, 4-EtC₆H₄, 2-ClC₆H₄, etc.; R³ = OEt, 4-NCC₆H₄, 3-FC₆H₄, etc.) is described. This operationally simple protocol involves a base-promoted C-N bond cleavage of amidines and features readily available starting materials, excellent functional group tolerance, and high step-economy. It leads to the preparation of 2,4,5-trisubstituted thiazoles efficiently and has potential applications in the field of drug screening and modification. In the experiment, the researchers used many compounds, for example, 2-Chloro-benzamidine hydrochloride (cas: 18637-02-0HPLC of Formula: 18637-02-0).

2-Chloro-benzamidine hydrochloride (cas: 18637-02-0) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.HPLC of Formula: 18637-02-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Design, synthesis, antifungal evaluation, and molecular docking of novel 1,2,4-triazole derivatives containing oxime ether and cyclopropyl moieties as potential sterol demethylase inhibitors was written by Sun, Sheng-Xin;Yan, Jing-Hua;Zuo, Jiang-Tao;Wang, Xiao-Bin;Chen, Min;Lu, Ai-Min;Yang, Chun-Long;Li, Guo-Hua. And the article was included in New Journal of Chemistry in 2021.SDS of cas: 620-19-9 This article mentions the following:

In the search for novel sterol demethylase inhibitors (DMIs), a series of 1,2,4-triazole derivatives containing oxime ether and cyclopropyl moieties I (R = Ph, 2,4,6-trichlorophenyl, 2-(1,3-dimethoxy-3-oxoprop-1-en-2-yl)benzen-1-yl, etc.) were designed using the bioactive substructure combination assisted by virtual mol. docking. The antifungal evaluation against Rhizoctonia solani (Rs), Fusarium graminearum (Fg), and Botrytis cinerea (Bc) indicated that most of the target compounds exhibited remarkable inhibitory activities against the above-mentioned tested fungi. Significantly, the compound I (R = 2,6-dichlorophenyl) exhibited outstanding anti-Fg activity with an EC₅₀ value of 1.22μg mL^-1 in vitro, and a protective effect of 59.45% in vivo at 200μg mL^-1. Further investigation revealed that compound I (R = 2,6-dichlorophenyl) evidently inhibited Fg spore germination and caused some wrinkles and dents on the surface of mycelia. Mol. docking showed that compound I (R = 2,6-dichlorophenyl) bound with the target protein FgCYP51 via coordination, hydrogen bonding and stacking interactions that were similar, but slightly different from the interactions of tebuconazole with FgCYP51. These research results suggested that the target compounds I are valuable for the further structural optimization of novel triazole fungicides. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9SDS of cas: 620-19-9).

1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.SDS of cas: 620-19-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Novel spirosuccinimides with incorporated isoindolone and benzisothiazole 1,1-dioxide moieties as aldose reductase inhibitors and antihyperglycemic agents was written by Wrobel, Jay;Dietrich, Arlene;Woolson, Shiela A.;Millen, Jane;McCaleb, Michael;Harrison, Maria C.;Hohman, Thomas C.;Sredy, Janet;Sullivan, Donald. And the article was included in Journal of Medicinal Chemistry in 1992.Computed Properties of C8H6ClFO2 This article mentions the following:

Compounds from two novel series of spirosuccinimides were prepared Analogs I (R = alkyl, aralkyl; R¹ = H, 4-, 5-, 6-, 7-Cl, 5,6-Cl₂, 6-F, 5-Br, 4-, 5-Me, 6-Co₂Me, 5,6-benzo, 5-Ph, 5-MeO, 5-MeS, 6-O₂N) possessed a spiro-fused isoindolone moiety while analogs II (R = alkyl, aralkyl) contained a spiro-fused benzisothiazole S,S-dioxide group. I and II were evaluated as aldose reductase inhibitors (ARI) in vitro by their ability to inhibit glyceraldehyde reduction using a partially purified bovine lens aldose reductase preparation and in vivo as inhibitors of galactitol accumulation in the lens, sciatic nerve, and diaphragm of galactose-fed rats. Many members from the isoindolone series I, particularly those with R = Me, showed good in vitro and in vivo potency. The most potent member, I (R = Me, R¹ = 6-Cl) (III), was resolved, and aldose reductase activity was found to reside almost exclusively in the (+)-enantiomer. III was approx. equipotent in the sciatic nerve of the galactose-fed rat to other cyclic imide ARI’s of similar in vitro activity, namely sorbinil and ADN-138 and also to tolrestat, an acetic acid-based ARI (ED₅₀ = 4-8 mg/kg). Compounds from both series I and II also lower plasma glucose levels of genetically obese db/db and ob/ob mice with potency similar to that of ciglitazone. However, members from these series failed to lower insulin levels of the ob/ob mouse at the doses tested. In the experiment, the researchers used many compounds, for example, Methyl 2-chloro-4-fluorobenzoate (cas: 85953-29-3Computed Properties of C8H6ClFO2).

Methyl 2-chloro-4-fluorobenzoate (cas: 85953-29-3) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Computed Properties of C8H6ClFO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

ROCK inhibitors 3: Design, synthesis and structure-activity relationships of 7-azaindole-based Rho kinase (ROCK) inhibitors was written by Bandarage, Upul K.;Cao, Jingrong;Come, Jon H.;Court, John J.;Gao, Huai;Jacobs, Marc D.;Marhefka, Craig;Nanthakumar, Suganthi;Green, Jeremy. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2018.Safety of 2-(3-Methoxyphenyl)acetyl chloride This article mentions the following:

Rho kinase (ROCK) inhibitors are potential therapeutic agents for the treatment of a variety of disorders including hypertension, glaucoma and erectile dysfunction. Here we disclose a series of potent and selective ROCK inhibitors based on a substituted 7-azaindole scaffold. Substitution of the 3-position of 7-azaindole led to compounds such as 37, which possess excellent ROCK inhibitory potency and high selectivity against the closely related kinase PKA. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Safety of 2-(3-Methoxyphenyl)acetyl chloride).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Safety of 2-(3-Methoxyphenyl)acetyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Exploring the readthrough of nonsense mutations by non-acidic Ataluren analogues selected by ligand-based virtual screening was written by Pibiri, Ivana;Lentini, Laura;Tutone, Marco;Melfi, Raffaella;Pace, Andrea;Di Leonardo, Aldo. And the article was included in European Journal of Medicinal Chemistry in 2016.Reference of 1711-11-1 This article mentions the following:

Ataluren, also known as PTC124, is a 5-(fluorophenyl)-1,2,4-oxadiazolyl-benzoic acid suggested to suppress nonsense mutations by readthrough of premature stop codons in the mRNA. Potential interaction of PTC124 with mRNA has been recently studied by mol. dynamics simulations highlighting the importance of H-bonding and stacking π-π interactions. A series of non-acidic analogs of PTC124 were selected from a large database via a ligand-based virtual screening approach. Eight of them were synthesized and tested for their readthrough activity using the Fluc reporter harboring the UGA premature stop codon. The most active compound was further tested for suppression of the UGA nonsense mutation in the bronchial epithelial IB3.1 cell line carrying the W1282X mutation in the CFTR gene. In the experiment, the researchers used many compounds, for example, 3-Cyanobenzoyl chloride (cas: 1711-11-1Reference of 1711-11-1).

3-Cyanobenzoyl chloride (cas: 1711-11-1) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Reference of 1711-11-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Metabolism of 2,4-, 2,5-, and 3,4-dichloronitrobenzene in the rabbit was written by Bray, H. G.;James, Sybil P.;Thorpe, W. V.. And the article was included in Biochemical Journal in 1957.Application In Synthesis of 5-Amino-2,4-dichlorophenol This article mentions the following:

The metabolism of 2,4-, 2,5-, and 3,4-dichloronitrobenzene has been studied in the rabbit. The main products excreted in urine are mercapturic acids (corresponding to 30-50% of the dose) and phenols conjugated with glucuronic and sulfuric acids. Smaller amounts of dichloroanilines are excreted. The mercapturic acids have been isolated and their structure has been confirmed by synthesis. In each case they are formed by substitution of the labile Cl. 2-Bromo-4-chloro-, 2-bromo-5-chloro-, and 4-bromo-3-chloronitrobenzene when fed to rabbits yield the same mercapturic acids as do the corresponding dichloronitrobenzenes. The following nitro- and aminodichlorophenols excreted have been identified: N-acetyl-S-(5-chloro-2-nitrophenyl)-L-cysteine, m. 192°, [α]_D²⁰ in EtOH + 63 ± 3°, absorption maximum 253 mμ, 375, N-acetyl-S-(4-chloro-2-nitrophenyl)-L-cysteine 161-2, 104 ± 7, 249, 390; N-acetyl-S-(2-chloro-4-nitrophenyl)-L-cysteine 192-194, -4 ± 4, 345; 2,4-, 2,5- and 3,4-dichloroaniline, 2,4-dichloro-5-nitrophenol, 3,5-dichloro-2-nitrophenol, 2-amino-3,5-dichlorophenol, 3-amino-2,6-dichlorophenol, 5-amino-2,4-dichlorophenol, 2,5-dichloro-4-nitrophenol, 3-amino-2,5-dichlorophenol, 4-amino-2,5-dichlorophenol, 2-aminodichlorophenol, 5-amino-2,3-dichlorophenol. R_f values in 3 solvents have been determined for the various possible metabolites of the dichloronitrobenzenes. 3,3′,4,4′-Tetrachloroazoxybenzene has been isolated from the urine of rabbits given 3,4-dichloronitrobenzene. The difference between the metabolic fates of the dichloronitrobenzenes and those of the monochloronitrobenzenes are discussed. Mercapturic acid formation provides the major metabolite pathway for the dichloro compounds and hydroxylation is the principal metabolite process for the monochloro compounds In the experiment, the researchers used many compounds, for example, 5-Amino-2,4-dichlorophenol (cas: 39489-79-7Application In Synthesis of 5-Amino-2,4-dichlorophenol).

5-Amino-2,4-dichlorophenol (cas: 39489-79-7) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Application In Synthesis of 5-Amino-2,4-dichlorophenol

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Immobilization of copper(II) on mesoporous MCM-41: A highly efficient and recyclable catalyst for tandem oxidative annulation of amidines and methylarenes was written by Jiang, Minhua;Tuo, Yuxin;Cai, Mingzhong. And the article was included in Journal of Porous Materials in 2020.Formula: C7H8Cl2N2 This article mentions the following:

A new 3-(2-aminoethylamino)propyl-functionalized MCM-41-immobilized copper(II) complex [MCM-41-2N-Cu(OAc)₂] was easily prepared from com. available and inexpensive 3-(2-aminoethylamino)propyltrimethoxysilane via immobilization on MCM-41, followed by reaction with copper(II) acetate and characterized by various physico-chem. techniques. It was found that this heterogeneous copper complex is a highly efficient catalyst for the tandem oxidative annulation of amidine hydrochlorides RC(=NH)NH₂·HCl (R = Me, 4-fluorophenyl, cyclopropyl, 2-pyridinyl, etc.) and methylarenes ArCH₃ (Ar = 3,4-dichlorophenyl, 1-naphthyl, 3-thienyl, 4-pyridinyl, etc.) with tert-Bu hydroperoxide as oxidant to give 3,5-disubstituted 1,2,4-oxadiazoles I and can be reused at least eight consecutive trials with almost consistent activity. In the experiment, the researchers used many compounds, for example, 2-Chloro-benzamidine hydrochloride (cas: 18637-02-0Formula: C7H8Cl2N2).

2-Chloro-benzamidine hydrochloride (cas: 18637-02-0) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Formula: C7H8Cl2N2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Organic sulfur compounds. XXII. 2,5-Diaryl-1,6,6aS(super IV)trithia-3,4-diazapentalenes was written by Derocque, Jean Luc;Perrier, Michel;Vialle, Jean. And the article was included in Bulletin de la Societe Chimique de France in 1968.Quality Control of 2-Chloro-benzamidine hydrochloride This article mentions the following:

Ureas RNHC(:NR1)SMe(Ia) → R1NHC(:NR)SMe(Ib) are treated with P2S5 to give II compounds; the II are treated with NH3 to give IIIa → IIIb which are oxidized to amides IVa → IVb. Thus, BzNHCONHBz, m. 219°, and the following I are prepared according to known methods (R, R1, and m.p. given): Bz, Bz, 148°; p-ClC6H4CO, p-ClC6H4CO, 182°; p-MeOC6H4CO, p-MeOC6H4CO, 164°; H, Bz, – (methosulfate m. 160°); Bz, o-ClC6H4CO, 173°; Bz, p-ClC6H4CO, 164°; Bz, p-MeOC6H4CO, 144°; Bz, tert-BuCO, 109°. A mixture of I (R = R1 = Bz) and P2S5, 2:1 P2S5-I weight ratio is refluxed 0.5 hr. in xylene to give 60% 2,5-diphenyl-1,6,-6aSIV-trithia-3,4-diazepentalene (V), m. 211°. Similarly prepared are the following II (R, R1, m.p., and % yield given): p-ClC6H4, p-ClC6H4, 215°, 55; p-MeOC6H4, p-MeOC6H4, 232°, 55; Ph, o-ClC6H4, 184°, 45; Ph, p-ClC6H4, 181°, 50; Ph, p-MeOC6H4, 179°, 60; Ph, tert-Bu, 109°, 40. A solution of V in a 50:50 C6H6-alc. mixture is boiled and NH3 introduced 4-5 hrs. to give N-(3-phenyl-1,2,4-thiadiazol-5-yl)thiobenzimidic acid (VI), m. 198°. Similarly prepared are (m.p. given): III (R = R1 = p-ClC6H4), 227°; IIIa (R = Ph, R1 = o-ClC6H4), 209°; IIIb (R = Ph, R1 = o-ClC6H4), 83°; IIIa (R = Ph, R1 = p-ClC6H4), 190°; IIIb (R = Ph, R1 = p-ClC6H4), 215°. A solution of VI in a 50:50 HOAc-Me2CO mixture containing water is treated with Hg(OAc)2, [1:1 Hg(OAc)2-VI weight ratio] and the mixture is agitated overnight to give 60% N-(4-phenyl-1,3,5-thiadiazol-2-yl)benzamide (VII), m. 172°. 3-Phenyl-5-amino-1,2,4-thiadiazole is treated with BzCl to give 55% VII. Similarly prepared are [m.p., % yield Hg(OAc)2 method, and % yield aroylation method given]: IVa (R = Ph, R1 = o-ClC6H4), 166°, 60, 50; IVb (R = Ph, R1 = o-ClC6H4), 180°, 60, 80; IVa (R = Ph, R1 = p-ClC6H4), 266°, 60, 65; IVb (R = Ph, R1 = p-ClC6H4), 244°, 60, 75. In the experiment, the researchers used many compounds, for example, 2-Chloro-benzamidine hydrochloride (cas: 18637-02-0Quality Control of 2-Chloro-benzamidine hydrochloride).

2-Chloro-benzamidine hydrochloride (cas: 18637-02-0) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Quality Control of 2-Chloro-benzamidine hydrochloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and biological evaluation of novel 5(H)-phenanthridin-6-ones, 5(H)-phenanthridin-6-one diketo acid, and polycyclic aromatic diketo acid analogs as new HIV-1 integrase inhibitors was written by Patil, Shivaputra;Kamath, Shantaram;Sanchez, Tino;Neamati, Nouri;Schinazi, Raymond F.;Buolamwini, John K.. And the article was included in Bioorganic & Medicinal Chemistry in 2007.Quality Control of 3-Cyanobenzoyl chloride This article mentions the following:

A new series of phenanthridinone derivatives, and diketo acid analogs, as well as related phenanthrene and anthracene diketo acids have been synthesized and evaluated as HIV integrase (IN) inhibitors. Several new β-diketo acid analogs with the phenanthridinone scaffold replaced by phenanthrene, anthracene or pyrene exhibited the highest IN inhibitory potency. There is a general selectivity against the integrase strand transfer step. The most potent IN was 2,4-dioxo-4-phenanthren-9-yl-butyric acid (27f) with an IC₅₀ of 0.38 μM against integrase strand transfer. The phenanthrene diketo acids 27d-f were more potent (IC₅₀ = 2.7-0.38 μM) than the corresponding phenanthridinone diketo acid 16 (IC₅₀ = 65 μM), suggesting that the polar amide bridge in the phenanthridinone system decreases inhibitory activity relative to the more lipophilic phenanthrene system. This might have to do with the possible binding of the aryl group of the compounds binding to a lipophilic pocket at the integrase active site as suggested by the docking simulations. Mol. modeling also suggested that effectiveness of chelation of the active site Mg²⁺ contributes to IN inhibitory potency. Finally, some of the potent compounds inhibited HIV-1 replication in human peripheral blood mononuclear cells (PBMC) with EC₅₀ down to 8 μM for phenanthrene-3-(2,4-dioxo)butyric acid (27d), with a selectivity index of 10 against PBMCs. In the experiment, the researchers used many compounds, for example, 3-Cyanobenzoyl chloride (cas: 1711-11-1Quality Control of 3-Cyanobenzoyl chloride).

3-Cyanobenzoyl chloride (cas: 1711-11-1) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Quality Control of 3-Cyanobenzoyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Syntheses and Structures of Ag(I)-Containing Coordination Polymers and Co(II)-Containing Supramolecular Complex Based on Novel Fulvene Ligands was written by Dong, Yu-Bin;Wang, Peng;Huang, Ru-Qi;Smith, Mark D.. And the article was included in Inorganic Chemistry in 2004.Computed Properties of C8H4ClNO This article mentions the following:

Three new rigid conjugated fulvene ligands L1-L3 were synthesized. L1 and L3 were prepared by an aroylation reaction of cyclohexyl-substituted cyclopentadienyl anions. L2 was prepared by the reaction of L1 with PhNHNH₂ in hot ethanol. Six new coordination polymers, [Ag(C₂₅H₂₀N₂O₂)(ClO₄)]·3.5C₆H₆ (1), [Ag₂(μ-C₃₁H₂₄N₄)(η²-C₆H₆)(H₂O)](ClO₄)₂·(C₆H₆)·(H₂O)_0.5 (3), [Ag(C₃₁H₂₄N₄)]SbF₆·solvate (4), [Ag(C₃₁H₂₄N₄)](SbF₆)·2C₆H₆·CH₂Cl₂ (5), [Ag(C₂₅H₂₀N₂O₂)₂]SbF₆ (6), and [Ag(C₂₅H₂₀N₂O₂)₂]SbF₆ (7), and one seven-membered cobaltacycle-containing complex, Co(C₂₅H₂₀N₂O₂)₂(EtOH)₂ (2), were obtained through self-assembly based on these three new fulvene ligands. L2-L3 and compounds 1-7 were fully characterized by IR spectroscopy, elemental anal., and single-crystal x-ray diffraction. The coordination chem. of new fulvene ligands is versatile. They can bind metal ions not only through the terminal N-donors and fulvene C atoms into organometallic coordination polymers but also through the two chelating carbonyl groups into unusual seven-membered metallo-ring supramol. complexes. In the solid state, ligands L1-L3 are luminescent. A blue-shift in the emission was observed between the free ligand L1 and the one incorporated into Co(II)-containing complex 2, and a red shift in the emission was observed between the free ligand L3 and the one incorporated into Ag(I)-containing polymeric compounds 6 and 7. In the experiment, the researchers used many compounds, for example, 3-Cyanobenzoyl chloride (cas: 1711-11-1Computed Properties of C8H4ClNO).

3-Cyanobenzoyl chloride (cas: 1711-11-1) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Computed Properties of C8H4ClNO

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics