Tag: 100-200

Isomerism of hydroxyurea. XI. Absorption spectra in the infrared was written by Kofod, Helmer. And the article was included in Acta Chemica Scandinavica in 1959.Name: Methyl 2-chloro-6-methylbenzoate This article mentions the following:

A survey of the Raman and infrared spectroscopy of urea and hydroxyurea isomers is presented, and assignment of the principal absorption frequencies is attempted. Although no rigorous proof has been furnished, the results are compatible with the proposed constitutions, carbamhydroxamic acid and O-carbamoylhydroxylamine, resp. In the experiment, the researchers used many compounds, for example, Methyl 2-chloro-6-methylbenzoate (cas: 99585-14-5Name: Methyl 2-chloro-6-methylbenzoate).

Methyl 2-chloro-6-methylbenzoate (cas: 99585-14-5) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Name: Methyl 2-chloro-6-methylbenzoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Role of Cl• • •Cl halogen bonds in tuning the crystals of Uranyl-Dicholorothiophene carboxylate based hybrid cluster materials through N-donor counter ions was written by Jennifer, Samson Jegan;Razak, Ibrahim Abdul;Ebenezer, Cheriyan;Solomon, Rajadurai Vijay. And the article was included in Journal of Molecular Structure in 2022.SDS of cas: 36157-41-2 This article mentions the following:

Hydrothermal synthesis has afforded eight uranyl bearing hybrid materials with various ancillary ligands such as 2,5-Dichlorothiophene-3-carboxylate (CTDC) as the main ligand and 4,4′-bipyridine (4BPY), 4,4′-Trimethylenedipyridine (4TBY), trans-1-(2-pyridyl)-2-(4-pyridyl)ethylene (TTPY), 1,10-Phenanthroline (PHEN), or 2,2′-Dipyridylamine (2DPY). These uranyl complexes; (UO₂) _0.5 (CTDC)(4BPY)_0.5 (I), UO₂(CTDC)₂(4BPY)_0.5, (II); [(UO₂)₄(μ₃-O)₂(μ₂-OH)₂(CTDC)₄(4TBY)₂].(H₂4TBY).2H₂O (III); [(UO₂)₂(μ3-O)(CTDC)₃].(HTTPY).H₂O (IV); [(UO₂)(CTDC)₂(PHEN)]₂ (V); [(UO₂)(μ₂-OH)(CTDC)(PHEN)] (VI); [UO₂(CTDC)₃]₂ (H2DPY)₂ (VII); [UO₂(CTDC)₃]₂ (H4TBY)₂ (VIII) were characterized by single-crystal X-ray diffraction, powder X-ray diffraction, elemental anal., FT-IR spectroscopy, thermogravimetric anal. and by their uranyl emission spectra. The complexes (I) and (II) are the first examples of uranyl complexes with aromatic carboxylates formed in the presence of a coordinated 4,4′-bipyridine ligand. Here, the complexes (V) and (VI) were concomitant polymorphs while (II) and (VIII) are polymorphs of (I) and (III) resp. and were obtained by varying the pH in synthetic procedures. Halogen bonding (Cl···Cl) interactions were found to play a strong role in expanding their dimensionality into 3D and defining their crystal packing patterns. To gain insights into the Cl···Cl interactions, a detailed QTAIM study is taken up. The photocatalytic properties of (I-VIII) for degradation of various organic dyes under Hg-lamp irradiation were performed. Interestingly, complexes (I, II, V) which are mononuclear uranyl clusters possess the highest efficiency in degradation of organic dyes than the tetranuclear uranyl clusters (III, IV). Thus, this work sheds light on the structural features of these uranyl complexes to extend our knowledge and understanding of uranyl chem. In the experiment, the researchers used many compounds, for example, 2,5-Dichlorothiophene-3-carboxylic acid (cas: 36157-41-2SDS of cas: 36157-41-2).

2,5-Dichlorothiophene-3-carboxylic acid (cas: 36157-41-2) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.SDS of cas: 36157-41-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and antifungal activities of 2-(2,4- difluorophenyl)-3-(N-methyl-N-substituted acylamino)-1-(1H-1,2,4- triazol-1-yl)-2-propanol was written by Zhong, Wu;Zhang, Wannian;Li, Ke;Zhou, Youjun;Zhu, Ju;Lu, Jiaguo. And the article was included in Yaoxue Xuebao in 1999.Recommanded Product: 6834-42-0 This article mentions the following:

Twenty one new triazole compounds were designed and synthesized as potential inhibitors of the fungal cytochrome P 450 14α-demethylase, and their antifungal activities were determined by biol. tests in vitro. All compounds had antifungal activities especially against Candida albicans and Candida parapsilosis. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Recommanded Product: 6834-42-0).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Recommanded Product: 6834-42-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chromium(II)-Mediated Reformatskii Reactions of Carboxylic Esters with Aldehydes was written by Wessjohann, Ludger;Gabriel, Tobias. And the article was included in Journal of Organic Chemistry in 1997.Formula: C9H9ClO2 This article mentions the following:

Chromium dichloride reacts with α-halo esters and aldehydes in a Barbier-type reaction to give β-hydroxy esters in good to excellent yield. The reaction is of excellent reproducibility and chemoselectivity and suitable for microscale preparations and the construction of quaternary centers. The simple diastereoselectivity is preferentially anti and contrasts with that of comparable Reformatskii reactions. The effects of substituents, temperature, halogen, and additives are discussed briefly. In the experiment, the researchers used many compounds, for example, Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6Formula: C9H9ClO2).

Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Formula: C9H9ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Design and synthesis of aminothiazole based Hepatitis B Virus (HBV) capsid inhibitors was written by Pan, Ting;Ding, Yanchao;Wu, Liyang;Liang, Liting;He, Xin;Li, Qianwen;Bai, Chuan;Zhang, Hui. And the article was included in European Journal of Medicinal Chemistry in 2019.Recommanded Product: 3-Cyanobenzoyl chloride This article mentions the following:

The capsid assembly is an essential step for Hepatitis B Virus (HBV) life cycle and is an important target for anti-HBV drug development. In this report, we identified a hit compound with aminothiazole structure by the high throughput screening (HTS) which inhibited the interaction of HBV capsid protein within the cells. The structure hopping and SAR studies of the hit compound afforded compound 79 with potent anti-HBV replication activity and good basic drug-like properties. The working mechanism studies showed that compound 79 could bind to the similar binding site of known HBV capsid inhibitor with heteroaryldihydropyrimidine (HAP) scaffold, through similar hydrophobic interactions but with a different hydrogen bond. This compound exerted potent inhibitory effect upon HBV production, either in cell culture or in mice with no obvious acute toxicity. We propose that further development of this compound could lead to novel potent anti-HBV inhibitors that target HBV capsid assembly. In the experiment, the researchers used many compounds, for example, 3-Cyanobenzoyl chloride (cas: 1711-11-1Recommanded Product: 3-Cyanobenzoyl chloride).

3-Cyanobenzoyl chloride (cas: 1711-11-1) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Recommanded Product: 3-Cyanobenzoyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Benzimidazole scaffold based hybrid molecules for various inflammatory targets: Synthesis and evaluation was written by Kaur, Gaganpreet;Silakari, Om. And the article was included in Bioorganic Chemistry in 2018.Recommanded Product: 1-(Chloromethyl)-3-methylbenzene This article mentions the following:

Designing of hybrid drugs with specific multitarget profile is a promising line of attack against inflammation. In light of this, a series of benzimidazole scaffold based hybrid mols. were designed by integrating benzimidazoles (containing pharmacophoric elements for COXs and LOXs inhibitors) with phthalimide subunit of thalidomide (pharmacophore element for TNF-α inhibitor) under one construct via mol. hybridization strategy. The designed mols. were synthesized and evaluated for their inhibitory activity against COXs (COX-1, COX-2), LOXs (5-LOX, 15-LOX) enzymes as well as TNF-α inhibitory effect. The results revealed that, compounds (3a-l) obtained showed inhibition in submicromolar range against COXs and LOXs targets whereas milder inhibitory activity was obtained against lipopolysaccharides (LPS)-induced TNF-α secretion by murine macrophage-like cells (RAW264.7). Within this class of compounds, I emerged as having alluring multiple inhibitory effects on set of COX-1/2 and 5-/15-LOX enzymes (COX-1 IC₅₀ = 9.85 μM; COX-2 IC₅₀ = 1.00 μM; SI = 9.85; 5-LOX IC₅₀ = 0.32 μM; 15-LOX IC₅₀ = 1.02 μM) in conjunction with a good anti-inflammatory and analgesic activities. Addnl., compound I showed gastrointestinal safety with reduced lipid peroxidation Docking results of compound I with COX-2 and 5-LOX were also consistent with the in vivo anti-inflammatory results. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9Recommanded Product: 1-(Chloromethyl)-3-methylbenzene).

1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Recommanded Product: 1-(Chloromethyl)-3-methylbenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Structure and absolute configuration of some 5-chloro-2-methoxy-N-phenylbenzamide derivatives was written by Galal, Alaaeldin M. F.;Shalaby, Elsayed M.;Abouelsayed, Ahmed;Ibrahim, Medhat A.;Al-Ashkar, Emad;Hanna, Atef G.. And the article was included in Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy in 2018.Safety of 5-Chloro-2-methoxybenzoic acid This article mentions the following:

The absolute configuration of 5-chloro-2-methoxy-N-phenylbenzamide single crystal [compound (1)] and the effect of introducing -[CH₂]_n-, n = 1,2 group adjacent to the amide group [compounds (2) and (3)], were studied. Furthermore, the replacement of the methoxy group with a hydroxy group [compound (4)] was defined. Proton and carbon-13 NMR spectrometer were used to record the structural information of the prepared compounds X-ray single crystal diffractometer were used to elucidate the 3D structural configurations. Intensity data for the studied compounds were collected at room temperature The X-ray data prove that compound (1) is almost planar, with maximum r.m.s. deviations of 0.210(3) Å corresponds to C13. This planarity starts to disturb by adding -[CH₂]_n-, n = 1,2 groups between the NH group and the Ph ring in compounds (2) and (3), resp. By replacing the OCH₃ group by an OH group in compound (4), the plane of the chlorophenyl moiety is nearly perpendicular to that of the Ph ring. Such new structural configurations were further illustrated by the IR, and UV-visible spectroscopy measurements in the frequency range 400-4000 cm ^-1 and 190-1100 nm, resp. Spectroscopic analyses were verified with the help of mol. modeling using d. functional theory. The estimated total dipole moment for the prepared compounds reflects its ability to interact with its surrounding mols. The higher dipole moment for a given structures is combined with the higher reactivity for potential use in medicinal applications. In the experiment, the researchers used many compounds, for example, 5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2Safety of 5-Chloro-2-methoxybenzoic acid).

5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Safety of 5-Chloro-2-methoxybenzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Combinatorial Approach to N-Substituted Amino-Cyclitol Libraries by Solution-Phase Parallel Synthesis and Preliminary Evaluation as Glucocerebrosidase Inhibitors was written by Serrano, Pedro;Casas, Josefina;Zucco, Martine;Emeric, Gilbert;Egido-Gabas, Meritxell;Llebaria, Amadeu;Delgado, Antonio. And the article was included in Journal of Combinatorial Chemistry in 2007.Name: 2-(3-Methoxyphenyl)acetyl chloride This article mentions the following:

Libraries of N-substituted amino-cyclitol derivatives of the scyllo and racemic chiro series by means of parallel solution-phase methodol. with the help of robotic technol. are described. Chem. diversity has been introduced by reaction of selected scaffolds with a set of aldehydes, acyl chlorides, sulfonyl chlorides, chloroformates, and amines to afford the corresponding amines, amides, sulfonamides, carbamates and ureas, resp. The optimized methodol. has proven excellent, in terms of overall purity of the resulting libraries, for the production of amides. Sulfonamides and carbamates have been obtained in slightly lower purity, while amines afforded modest results. Selected library members have been evaluated as inhibitors of recombinant glucocerebrosidase with K_i values ranging in the low micromolar scale for the most active members. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Name: 2-(3-Methoxyphenyl)acetyl chloride).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Name: 2-(3-Methoxyphenyl)acetyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Nickel-catalyzed decarboxylative arylation of azoles with perfluoro- and nitrobenzoates was written by Crawford, Jennifer M.;Shelton, Kyle E.;Reeves, Emily K.;Sadarananda, Bryce K.;Kalyani, Dipannita. And the article was included in Organic Chemistry Frontiers in 2015.Recommanded Product: 225104-76-7 This article mentions the following:

This manuscript describes a Ni-catalyzed method for the direct arylation of azoles using benzoates. Perfluorophenyl and 2-nitrobenzoates participate in these reactions to afford the corresponding products, e.g., I, in modest to good yields. The efficiency of the arylations with perfluorobenzoates is highly dependent on both the degree and position of fluorine atoms in the benzoates. In the experiment, the researchers used many compounds, for example, 3-Chloro-2,6-difluorobenzoic acid (cas: 225104-76-7Recommanded Product: 225104-76-7).

3-Chloro-2,6-difluorobenzoic acid (cas: 225104-76-7) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Recommanded Product: 225104-76-7

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Maximizing ER-α Degradation Maximizes Activity in a Tamoxifen-Resistant Breast Cancer Model: Identification of GDC-0927 was written by Kahraman, Mehmet;Govek, Steven P.;Nagasawa, Johnny Y.;Lai, Andiliy;Bonnefous, Celine;Douglas, Karensa;Sensintaffar, John;Liu, Nhin;Lee, KyoungJin;Aparicio, Anna;Kaufman, Josh;Qian, Jing;Shao, Gang;Prudente, Rene;Joseph, James D.;Darimont, Beatrice;Brigham, Daniel;Heyman, Richard;Rix, Peter J.;Hager, Jeffrey H.;Smith, Nicholas D.. And the article was included in ACS Medicinal Chemistry Letters in 2019.Application In Synthesis of 2-(3-Methoxyphenyl)acetyl chloride This article mentions the following:

The further optimization of ER-α degradation efficacy of a series of ER modulators by refining side-chain substitution led to efficacious selective estrogen receptor degraders (SERDs). A fluoromethyl azetidine group was found to be preferred and resulted in the identification of bis-phenol chromene 17ha. In a tamoxifen-resistant breast cancer xenograft model, 17ha (ER-α degradation efficacy = 97%) demonstrated tumor regression, together with robust reduction of intratumoral ER-α levels. However, despite superior oral exposure, 5a (ER-α degradation efficacy = 91%) had inferior activity. This result suggests that optimizing ER-α degradation efficacy leads to compounds with robust effects in a model of tamoxifen-resistant breast cancer. Compound 17ha (GDC-0927) was evaluated in clin. trials in women with metastatic estrogen receptor-pos. breast cancer. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Application In Synthesis of 2-(3-Methoxyphenyl)acetyl chloride).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Application In Synthesis of 2-(3-Methoxyphenyl)acetyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics