The canonical Wnt/β-catenin signaling pathway facilitates pseudorabies virus proliferation and enhances virus-induced autophagy was written by Wang, Chongyang;Hu, Ruochen;Duan, Liuyuan;Hou, Qili;Yang, Mengqing;Wang, Ting;Liu, Haijin;Xiao, Sa;Dang, Ruyi;Wang, Juan;Wang, Xinglong;Zhang, Shuxia;Yang, Zengqi. And the article was included in Veterinary Microbiology in 2022.Product Details of 7447-41-8 The following contents are mentioned in the article:
Pseudorabies virus (PRV) is a swine herpesvirus with a broad host range that causes significant economic losses worldwide. The Wnt/β-catenin signaling pathway is reportedly involved in multiple virusesâ?proliferation. In this study, we demonstrated that PRV infection significantly activated the Wnt/β-catenin signaling and promoted the nuclear translocation of β-catenin. Applying specific chem. inhibitors (FH535 and iCRT14) caused a remarkable decrease in PRV titers in various cell lines. Knockdown of β-catenin by siRNA also reduced the proliferation of PRV. On the contrary, treatment with lithium chloride (LiCl), an inhibitor of GSK3β, stimulated the Wnt/β-catenin signaling pathway and enhanced the PRV proliferation. Similarly, overexpression of β-catenin promoted PRV proliferation and reversed the antiviral effect of FH535. Moreover, LiCl promoted PRV-induced autophagy, whereas FH535 and iCRT14 showed converse effects. These findings suggest that PRV infection stimulates the canonical Wnt/β-catenin signaling pathway, facilitating PRV proliferation and regulating virus-induced autophagy. These data also provide potential targets for developing antiviral agents against PRV. This study involved multiple reactions and reactants, such as Lithium chloride (cas: 7447-41-8Product Details of 7447-41-8).
Lithium chloride (cas: 7447-41-8) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Product Details of 7447-41-8
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics