Chlorides-buliding-blocks

Design, synthesis and mode of action of some benzothiazole derivatives bearing an amide moiety as antibacterial agents was written by Singh, Meenakshi;Singh, Sudhir K.;Gangwar, Mayank;Nath, Gopal;Singh, Sushil K.. And the article was included in RSC Advances in 2014.Synthetic Route of C8H7ClO3 This article mentions the following:

In this study ten benzothiazole derivatives bearing the amide moiety were designed, synthesized and evaluated for their antibacterial activity and possible mode of action. Structures of the synthesized compounds were elucidated by spectral data. Four different Gram-neg. and two different Gram-pos. bacterial strains were used in antibacterial activity tests. Among all the synthesized compounds, compound A07 displayed the most potent inhibitory activity with min. inhibitory concentration (MIC) values of 15.6, 7.81, 15.6, 3.91 μg ml^-1 against S. aureus, E. coli, S. typhi and K. pneumoniae resp. Structure-activity relationship (SAR) studies revealed that electronic and lipophillic factors of the Ph ring had a significant effect on the antimicrobial activity of the designed compounds The benzothiazole bearing amide (A01-A10) series exhibited different modes of action based on aryl group substitution as revealed by studies on intact bacterial cells and plasmid DNA. The present study provides us two active compounds (A07 and A10) with a membrane perturbing mode of action, and an intracellular mode of action due to binding with DNA along with potent activity against clin. relevant pathogens E. coli and S. aureus. In the experiment, the researchers used many compounds, for example, 5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2Synthetic Route of C8H7ClO3).

5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Synthetic Route of C8H7ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and biological evaluation of ethacrynic acid derivatives bearing sulfonamides as potent anti-cancer agents was written by El Abbouchi, Abdelmoula;El Brahmi, Nabil;Hiebel, Marie-Aude;Bignon, Jerome;Guillaumet, Gerald;Suzenet, Franck;El Kazzouli, Said. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2020.COA of Formula: C8H9ClO4S This article mentions the following:

A series of ethacrynic acid (2-[2,3-dichloro-4-(2-methylidenebutanoyl)phenoxy]acetic acid) (EA, Edecrin) containing sulfonamides linked via three types of linkers namely 1,2-ethylenediamine, piperazine and 4-aminopiperidine was synthesized and subsequently evaluated in vitro against HL60 and HCT116 cancer cell lines. All the EA analogs, excluding two derivs, showed anti-proliferative activity with IC_50s in the micromolar range (less than 4 uM). Three derivatives I–III were selected for their interesting dual activity on HL60 cell line in order to be further evaluated against a panel of cancer cell lines (HCT116, A549, MCF7, PC3, U87-MG and SKOV3) as well as on MRC5 as a normal cell line. These compounds displayed IC₅₀ values in nanomolar range against A549, MCF7, PC3 and HCT116 cell lines, deducing the discovery that piperazine or 4-aminopiperidine is the linker’s best choice to develop EA analogs with highly potent anti-proliferative activities own up to 24 nM. Besides, in terms of selectivity, those linkers are more suitable offering safety ratios of up to 63.8. In the experiment, the researchers used many compounds, for example, 2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2COA of Formula: C8H9ClO4S).

2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.COA of Formula: C8H9ClO4S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Substituent effects in substrates on activation parameters in the bimolecular nucleophilic reactions in solution was written by Vlasov, Vladislav M.. And the article was included in New Journal of Chemistry in 2010.Recommanded Product: Ethyl 4-chloro-3-nitrobenzoate This article mentions the following:

Changes of the activation parameters, ΔH^≠ and ΔS^≠, in the S_N2, S_NAr and acyl-transfer reactions with charged and neutral nucleophiles in various solvents were correlated with σ constants of the substituents in the aromatic ring of the substrates. The resultant δΔH^≠ and δΔS^≠ reaction constants are linearly related for variations of substituents at the substrate. Correlation of δΔH^≠ vs. δΔS^≠ allows one to estimate the contribution of changes of the internal enthalpy, δΔH^≠_int, to the enthalpy reaction constant, δΔH^≠, which gives a single linear dependence on the Hammett ρ reaction constants for all bimol. nucleophilic reactions. The deviations from dependence of δΔH^≠_int vs. ρ can be interpreted in terms of changes of the transition state structure or reaction mechanism. The results obtained show that the substituent effects in the substrates and nucleophiles on the charge development in the transition state are governed by the magnitude of δΔH^≠_int. In the experiment, the researchers used many compounds, for example, Ethyl 4-chloro-3-nitrobenzoate (cas: 16588-16-2Recommanded Product: Ethyl 4-chloro-3-nitrobenzoate).

Ethyl 4-chloro-3-nitrobenzoate (cas: 16588-16-2) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Recommanded Product: Ethyl 4-chloro-3-nitrobenzoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Intramolecular reactions of N-nitrenes: oxidation of 3-amino-2-(arylalkyl)quinazolin-4(3H)-ones was written by Atkinson, Robert S.;Malpass, John R.;Woodthorpe, Katherine L.. And the article was included in Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) in 1982.Synthetic Route of C9H9ClO2 This article mentions the following:

Oxidation of quinazolines I (R = OMe; R¹ = H, OMe; R² = NH₂; n = 2) with Pd(OAc)₄ in CH₂Cl₂ at room temperature gave I (same R, R¹, n; R² = H) (II) and the diazepines III (R = H, OMe; R¹ ≠ R² = H, OMe) via the corresponding N-nitrene intermediates. On oxidation under analogous conditions I (n = 2, R = H, R¹ = OMe; n = 1, R ≠ R¹ = H, OMe; R² = NH₂) gave only the deamination products II. Azepine formation involves electrophilic aromatic substitution by the nitrene on the aromatic ring via a 7-membered transition state. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Synthetic Route of C9H9ClO2).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Synthetic Route of C9H9ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Preparation, characterization and catalytic study of a nano-inorganic composite of CuO/NiO for the regioselective synthesis of 1,4-disubstituted-1,2,3-triazoles in water was written by Beni, Zohreh Hashemi;Albadi, Jalal;Kiyani, Hamzeh. And the article was included in Inorganic and Nano-Metal Chemistry.Application of 620-19-9 This article mentions the following:

In this research, a nano-inorganic composite of CuO/NiO is prepared by co-precipitation method as an efficient recyclable nanocatalyst for the regioselective synthesis of 1,4-disubstituted-1,2,3-triazoles in water. The catalyst was characterized by several techniques such as the field emission SEM (FESEM), energy dispersive spectroscopy (EDS), x-ray diffraction (XRD), transmission electron microscopy (TEM), thermogravimetric anal. (TGA), x-ray fluorescence, inductively coupled plasma at. emission spectroscopy (ICP-OES), and brunauer-emmett-teller (BET) surface area anal. The regioselective synthesis of 1,4-disubstituted-1,2,3-triazoles was carried out from reaction of various benzyl halides or alkyl halides with Ph acetylene and sodium azide in water under reflux condition in high yields. The CuO/NiO nanocatalyst can be simply recovered and reused 6 runs without a significant slight in activity. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9Application of 620-19-9).

1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Application of 620-19-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

5-HT_2C receptor selectivity and structure-activity relationship of N-methyl-N-(1-methylpiperidin-4-yl)benzenesulfonamide analogs was written by Jang, Jae Wan;Baek, Je-sook;Choi, Gil Don;Park, Woo-Kyu;Cho, Yong Seo;Baek, Du-Jong;Pae, Ae Nim. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2012.Category: chlorides-buliding-blocks This article mentions the following:

Agonists of the 5-HT_2C receptor have attracted much attention as therapeutic agents for the treatment of obesity. Subtype selectivity against other 5-HT₂ receptors is one of the most important prerequisites for reducing side effects. We present the synthesis of N-methyl-N-(1-methylpiperidin-4-yl)benzenesulfonamide analogs and their structure-activity relationship studies on 5-HT_2A and 5-HT_2C receptors. Although the compounds showed nanomolar activity to the 5-HT_2C receptor, their selectivity against the 5-HT_2A receptor was modest to low. Mol. modeling studies using homol. modeling and docking simulation revealed that selectivity originated from subtype specific residues. The observed binding modes and receptor-ligand interactions provided us a clue for optimizing the selectivity against the 5-HT_2A receptor. In the experiment, the researchers used many compounds, for example, 4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3Category: chlorides-buliding-blocks).

4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Concise synthesis of 3,4-dihydro-1,4-benzoxazines by three-component reactions of acyl chlorides, o-aminophenols and 1,2-dichloroethane was written by Liu, Yunyun;Chen, Xuwen. And the article was included in Tetrahedron in 2018.Product Details of 6834-42-0 This article mentions the following:

The Cu(OAc)₂-catalyzed three-component reactions of o-aminophenols R¹-2-NH₂C₆H₃OH (R¹ = H, 4-CH₃, 5-CH₃), acyl chlorides R²C(O)Cl (R² = C₆H₅, furan-2-yl, (E)-C₆H₅CH=CH, etc.) and 1,2-dichloroethane (DCE) have been established for the efficient synthesis of 3,4-dihydro-2H-benzo[b][1,4]oxazines (3,4-dihydro-1,4-benzoxazines) I (R³ = H, 6-CH₃, 7-CH₃). This method features advantages of the one-pot operation enabling N-acylation, C-Cl bond amidation and etherification, as well as the structural divergence of the synthesized products. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Product Details of 6834-42-0).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Product Details of 6834-42-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of functionalized 5-(4-arylpiperazin-1-yl)-N-arylpentanamides and their evaluation as D₃ receptor ligands was written by Blass, Benjamin E.;Chen, Peng-Jen;Gordon, John C.. And the article was included in Medicinal Chemistry Research in 2022.COA of Formula: C19H15Cl This article mentions the following:

Cocaine use disorder (CUD) is a major, unmet medical need. This tropane alkaloid is one of the most commonly abused recreational drugs. In 2018, there were over 5.5 million cocaine users. Therapeutic options capable of addressing this issue are limited, as there are no approved pharmacotherapies. The D₃ dopamine receptor is a potential CUD therapeutic target that remains under active investigation. We have recently disclosed a series of functionalized 5-(4-arylpiperazin-1-yl)-N-arylpentanamides typified by I that are potent D₃ ligands that have moderate to high selectivity for D₃ over D₂. We have continued our exploration of this series of compounds in an effort to identify compounds with improved microsomal stability such as II. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5COA of Formula: C19H15Cl).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.COA of Formula: C19H15Cl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and fungicidal activity of phenazine-1-carboxylic triazole derivatives was written by Li, Xu-Jun;Zhang, Wei;Zhao, Chi-Na;Wu, Qing-Lai;Li, Jun-Kai;Xu, Zhi-Hong. And the article was included in Journal of Asian Natural Products Research in 2021.Recommanded Product: 1-(Chloromethyl)-3-methylbenzene This article mentions the following:

A total of 15 novel-substituted 3-(benzylsulfanyl)-1H-1,2,4-triazol-5-ylamines I [R = 3-MeC₆H₄, 2-FC₆H₄, 2,4-Cl₂C₆H₃, etc.] and 10 novel-substituted 3-benzylmercapto-1,2,4-triazole derivatives II were synthesized based on the natural product phenazine-1-carboxylic acid (PCA). Their structures were confirmed by ¹H-NMR, ¹³C-NMR, HRMS and X-ray. Most substituted 3-benzylmercapto-1,2,4-triazole derivatives II displayed very strong fungicidal activity against one or multiple plant pathogens in vitro and in vivo. Compounds II [R = 4-MeC₆H₄, 4-iPrC₆H₄, 4-tBuC₆H₄, etc.] showed a broad spectrum of fungicidal activity. Further field experiments indicated that compounds II [R = 4-MeC₆H₄, 2-FC₆H₄, 4-iPrC₆H₄, etc.] displayed better efficacy against rice blast (Pyricularia oryzae) than PCA. These data demonstrated that compounds II [R = 4-MeC₆H₄, 2-FC₆H₄, 4-iPrC₆H₄, etc.] were promising fungicidal candidates, deserving further studies. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9Recommanded Product: 1-(Chloromethyl)-3-methylbenzene).

1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Recommanded Product: 1-(Chloromethyl)-3-methylbenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Nanofiltration membranes with enhanced performance by constructing an interlayer integrated with dextran nanoparticles and polyethyleneimine coating was written by Chen, Yuhao;Sun, Haixiang;Tang, Sihui;Feng, Huimei;Zhang, Hongbin;Chen, Kuo;Li, Peng;Niu, Q. Jason. And the article was included in Journal of Membrane Science in 2022.Recommanded Product: 4422-95-1 This article mentions the following:

The thin-film composite (TFC) nanofiltration (NF) membrane is a novel kind of membrane that has been extensively studied in recent years and broadly applied in desalination and wastewater treatment. The improvement of separation performance by optimizing the structure and morphol. of NF membranes can significantly reduce energy consumption and bring more economic benefits. In this work, glutaraldehyde (GA) was used to crosslink polyethyleneimine (PEI) and dextran nanoparticles (DNPs) to construct an interfacial coating interlayer on polysulfone (PSF) ultrafiltration (UF) substrate. Subsequently, the polyamide (PA) NF membranes were fabricated by interfacial polymerization (IP) between piperazine (PIP) and trimesoyl chloride (TMC). DNPs were semi-encapsulated in the PEI coating and the exposed nanoparticles would be embedded in the PA layer for forming interfacial channels after IP. The interlayer not only affected the adsorption and diffusion of aqueous phase monomers to form a thin membrane, but also improved the membrane d. to prevent selective defects associated with the incorporation of nanoparticles. The pure water permeance of the interlayered-TFC NF membrane was determined as 313.3 Lm^-2h^-1MPa^-1, which was approx. four-fold that of the pristine membrane. The retention rate of various divalent salts of the NF membrane also significantly improved, and the retention rate of Na₂SO₄ exceeded 99%. This innovative method of interlayer modification has exhibited great potential in rapid desalination and wastewater recovery, providing new possibilities for the preparation of industrial high-performance NF membranes. In the experiment, the researchers used many compounds, for example, Trimesoylchloride (cas: 4422-95-1Recommanded Product: 4422-95-1).

Trimesoylchloride (cas: 4422-95-1) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Recommanded Product: 4422-95-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics