Chlorides-buliding-blocks

Iodine-mediated neutral and selective N-Boc deprotection was written by Kumar, G. Pavan;Rambabu, D.;Rao, M. V. Basaveswara;Pal, Manojit. And the article was included in Journal of Chemistry in 2013.Reference of 18437-66-6 This article mentions the following:

A simple, efficient, and alternative method was developed for the N-Boc deprotection of structurally diverse protected amines. Selective removal of N-Boc groups was achieved with excellent yields under solvent-free conditions or in a solvent using I₂ as a catalyst. The methodol. involving the use of iodine for N-Boc deprotection of protected amines represents an effective and useful alternative to previously reported methods. In the experiment, the researchers used many compounds, for example, tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6Reference of 18437-66-6).

tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Reference of 18437-66-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Polymer amino-protecting groups based on tert-butoxycarbonyl- and benzoylcarbonyl function-containing polymethacrylamides was written by Rehse, Henning;Ritter, Helmut. And the article was included in Makromolekulare Chemie in 1989.Related Products of 18437-66-6 This article mentions the following:

The synthesis of tert-butoxycarbonyl- and benzyloxycarbonyl-modified monomers was performed by the addition of p-ClC₆H₄NCO or PhCH₂NCO to the free OH groups of N-(2-hydroxy-2-methylpropyl)methacrylamide, N-(2-hydroxy-2-methylpropyl)-6-methylacrylamidohexanamide and N-β-hydroxyphenethylmethacrylamide. The monomers were homopolymerized and copolymerized with Me methacrylate. The kinetics of acidic-induced amine cleavage from the amino-protecting groups was followed by NMR spectroscopy, and the polymers were suitable amino-protecting groups. Ca²⁺ ions enhanced the rate of amine cleavage considerably. Neighboring group effects and the influence of comonomers and spacer groups on the reactivity of the urethane groups were also discussed. In the experiment, the researchers used many compounds, for example, tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6Related Products of 18437-66-6).

tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Related Products of 18437-66-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Selective Angiotensin II AT₂ Receptor Agonists: Arylbenzylimidazole Structure-Activity Relationships was written by Wu, Xiongyu;Wan, Yiqian;Mahalingam, A. K.;Murugaiah, A. M. S.;Plouffe, Bianca;Botros, Milad;Karlen, Anders;Hallberg, Mathias;Gallo-Payet, Nicole;Alterman, Mathias. And the article was included in Journal of Medicinal Chemistry in 2006.Recommanded Product: 4-Butoxybenzene-1-sulfonyl chloride This article mentions the following:

Structural alterations in the 2- and 5-positions of the first drug-like selective angiotensin II AT₂ receptor agonist I have been performed. The imidazole ring system was proven to be a strong determinant for the AT₂ selectivity, and with few exceptions all variations gave good AT₂ receptor affinities and with retained high AT₂/AT₁ selectivities. On the contrary to the findings with AT₁ receptor agonists, the impact of structural modifications in the 5-position of the AT₂ selective compounds were less pronounced regarding activation of the AT₂ receptor. The butyloxyphenyl (56) and the propylthienyl (50) derivatives were found to exert a high agonistic effect as deduced from their capacity to induce neurite elongation in neuronal cells, as does angiotensin II. In the experiment, the researchers used many compounds, for example, 4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3Recommanded Product: 4-Butoxybenzene-1-sulfonyl chloride).

4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Recommanded Product: 4-Butoxybenzene-1-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Highly heat-resistant NF membrane modified by quinoxaline diamines for Li⁺ extraction from the brine was written by Xie, Huan-Yin;Tang, Run-Hua;Chen, Gui-E.;Xu, Zhen-Liang;Mao, Hai-Fang. And the article was included in Journal of Industrial and Engineering Chemistry (Amsterdam, Netherlands) in 2022.SDS of cas: 4422-95-1 This article mentions the following:

The functional layers with excellent heat-resistance nanofiltration (HRN) property were designed by fixing thermal stabilized quinoxaline diamines (QHDA) on poly (m-phenyleneisophthalamide) (PMIA) substrate through interfacial polymerization QHDA was used as aqueous monomer while cinnamoyl chloride (CNC), isophthaloyl chloride (IPC) and trimesoyl chloride (TMC) were served as organic monomers to realize the immobilization of thermally stable N heterocycles. The exptl. results stated clearly that the compact package reaction of QHDA with TMC lead a raise of thermal stability and salts rejection at high temperature stream. With the optimal TMC and 0.5 weight% QHDA, the as-developed membrane achieved the excellent NF performance and thermal stability. The rejection of MgSO₄ reached to 94.6% at 30°C and hardly decrease at 90°C. The reduction in rejection was satisfactory at high temperatures The functional layer still showed highly stability after 10 h long-term operation at 90°C with only 2.8% reduction in MgSO₄ rejection. Besides, the excellent Mg²⁺ and poor Li⁺ rejection made this membrane have huge potential in the application of extracting Li⁺ from brine. The separation factor of Mg²⁺-Li⁺ at high temperature was satisfactory. Over all, this study offered a prospect technol. to exploit heat-resistant membranes for extraction lithium at high temperature In the experiment, the researchers used many compounds, for example, Trimesoylchloride (cas: 4422-95-1SDS of cas: 4422-95-1).

Trimesoylchloride (cas: 4422-95-1) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.SDS of cas: 4422-95-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Unprecedented Access to β-Arylated Selenophenes through Palladium-Catalyzed Direct Arylation was written by Skhiri, Aymen;Ben Salem, Ridha;Soule, Jean-Francois;Doucet, Henri. And the article was included in Chemistry – A European Journal in 2017.Category: chlorides-buliding-blocks This article mentions the following:

The Pd-catalyzed coupling of benzenesulfonyl chlorides RS(O)₂Cl (R = 4-H₃CC₆H₄, 3,5-Cl₂C₆H₃, naphthalen-1-yl, etc.) with selenophenes I (R¹ = H, 4-H₃COC₆H₄, 3-F₃CC₆H₄; R² = H, Br, 4-H₃CC₆H₄, etc.; R³ = H) affording regiospecific β-arylated selenophenes II is reported. The reaction proceeds with easily accessible catalyst, base and substrates, and tolerates a variety of substituents both on the benzene and selenophene moieties. This transformation allows the programmed synthesis of polyarylated selenophenes II (R = 4-F₃CC₆H₄, 4-H₃COC₆H₄; R¹ = H, 4-O₂NC₆H₄; R² = 4-H₃CC(O)C₆H₄, 4-NCC₆H₄; R³ = 4-ClC₆H₄, 4-NCC₆H₄) with potential applications in pharmaceutical and materials chem., as the installation of aryl groups at the desired positions can be achieved. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Category: chlorides-buliding-blocks).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

A mild and green method for the N-BOC protection of amines without assistant of catalyst under solvent-free conditions was written by Mojtahedi, Mohammad Majid;Niknejad, Nina;Veisi, Hojat. And the article was included in Letters in Organic Chemistry in 2013.Reference of 18437-66-6 This article mentions the following:

A facile, green and versatile method for the Boc protection of amines has been developed by a treatment with (Boc)₂O without any additive at room temperature The method is general for the preparation of N-Boc derivatives of aliphatic (acyclic and cyclic), aromatic, and heteroaromatic amines; primary and secondary amines. The advantages of this method are green, simplicity, short reaction times and excellent yields. In the experiment, the researchers used many compounds, for example, tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6Reference of 18437-66-6).

tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Reference of 18437-66-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Amyloid-based carbon aerogels for water purification was written by Peydayesh, Mohammad;Vogt, Julia;Chen, Xiulin;Zhou, Jiangtao;Donat, Felix;Bagnani, Massimo;Muller, Christoph R.;Mezzenga, Raffaele. And the article was included in Chemical Engineering Journal (Amsterdam, Netherlands) in 2022.Computed Properties of C16H18ClN3S This article mentions the following:

Water scarcity is a worldwide concern with various implications, such as widespread pollution with heavy metals and organic pollutants, resulting in global threats to the environment and human health, and calling for innovative remediation strategies. We show here that the capability of protein-based carbon aerogels for removing contaminants from water can be greatly improved by transforming proteins into amyloids before their hydrothermal carbonization. Amyloid fibrils were prepared from whey protein isolate, a byproduct of the dairy industry, and upon addition to different carbohydrates, the ensued mixtures were used for carbon aerogels production Furthermore, the generality of the approach for producing carbon aerogels was demonstrated using vegetable amyloids from soy protein. The carbon aerogels are able to adsorb Au(III), Pt(II), Fe(III), and Ag(I) with excellent removal efficiencies. Moreover, the amyloid whey lactose carbon aerogel has an adsorption capacity of 650.08 mg/g for Au(III), significantly higher than that of a carbon aerogel derived from monomer whey lactose. The reusability of the carbon aerogel is also proven over three continuous adsorption/regeneration cycles, with a stable performance in terms of removal efficiency indicating good long-term use. Taken together, the results demonstrate amyloid carbon aerogels′ capability as an efficient, sustainable, and inexpensive solution for water purification In the experiment, the researchers used many compounds, for example, 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride (cas: 61-73-4Computed Properties of C16H18ClN3S).

3,7-Bis(dimethylamino)phenothiazin-5-ium chloride (cas: 61-73-4) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Computed Properties of C16H18ClN3S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Gold-iron oxide dimers for magnetic hyperthermia: the key role of chloride ions in the synthesis to boost the heating efficiency was written by Guardia, P.;Nitti, S.;Materia, M. E.;Pugliese, G.;Yaacoub, N.;Greneche, J.-M.;Lefevre, C.;Manna, L.;Pellegrino, T.. And the article was included in Journal of Materials Chemistry B: Materials for Biology and Medicine in 2017.Application In Synthesis of 1-Chlorooctadecane This article mentions the following:

With the aim of producing Au-Fe_xO_y dimers with outstanding heating performances under magnetic hyperthermia conditions applicable to human patients, here we report two synthesis routes, a two-pot and a one-pot method. The addition of chloride ions and the absence of 1,2-hexadecanediol (HDDOL), a commonly used chem. in this synthesis, are the key factors that enable us to produce dimers at low temperature with crystalline iron oxide domains in the size range between 18-39 nm that is ideal for magnetic hyperthermia. In the case of two-pot synthesis, in which no chloride ions are initially present in the reaction pot, dimers are obtained only at 300 °C. In order to lower the reaction temperature to 200 °C and to tune the size of the iron oxide domain, the addition of chloride ions becomes the crucial parameter. In the one-pot method, the presence of chloride ions from the start of the synthesis (as counter ions of the gold salt precursor) enables a prompt formation of dimers directly at 200 °C. In this case, the reaction time is the main parameter used to tune the iron oxide size. A record value of specific absorption rates (SARs) up to 1300 W g_Fe^-1 at 330 kHz and 24 kA m^-1 was measured for dimers with an iron oxide domain of 24 nm in size. In the experiment, the researchers used many compounds, for example, 1-Chlorooctadecane (cas: 3386-33-2Application In Synthesis of 1-Chlorooctadecane).

1-Chlorooctadecane (cas: 3386-33-2) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Application In Synthesis of 1-Chlorooctadecane

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Design and Synthesis of Novel Insecticides Based on the Serotonergic Ligand 1-[(4-Aminophenyl)ethyl]-4-[3-(trifluoromethyl)phenyl]piperazine (PAPP) was written by Cai, Mingyi;Li, Zhong;Fan, Feng;Huang, Qingchun;Shao, Xusheng;Song, Gonghua. And the article was included in Journal of Agricultural and Food Chemistry in 2010.SDS of cas: 697-73-4 This article mentions the following:

1-[(4-Aminophenyl)ethyl]-4-[3-(trifluoromethyl)phenyl]piperazine (PAPP) is a 5-HT_1A agonist and was reported to display high affinity for serotonin (5-HT) receptor from the parasitic nematode Haemonchus contortus. The present investigation explored the possibility of using PAPP as a lead compound of new insecticides with novel mode of action. On the basis of the PAPP scaffold, a series of 1-arylmethyl-4-[(trifluoromethyl)pyridin-2-yl]piperazine derivatives were designed, synthesized, and evaluated for biol. activities against the armyworm Pseudaletia separata (Walker). Bioassays showed that most of the target compounds displayed certain growth-inhibiting activities or larvicidal activities against armyworm. The quant. structure-activity relationship (QSAR) for growth-inhibiting activities was also analyzed and established. In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4SDS of cas: 697-73-4).

2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.SDS of cas: 697-73-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Characterization of Conformationally Constrained Benzanilide Scaffolds for Potent and Selective HDAC8 Targeting was written by Hassan, Muhammad Murtaza;Israelian, Johan;Nawar, Nabanita;Ganda, Giovanni;Manaswiyoungkul, Pimyupa;Raouf, Yasir S.;Armstrong, David;Sedighi, Abootaleb;Olaoye, Olasunkanmi O.;Erdogan, Fettah;Cabral, Aaron D.;Angeles, Fabrizio;Altintas, Rabia;de Araujo, Elvin D.;Gunning, Patrick T.. And the article was included in Journal of Medicinal Chemistry in 2020.Category: chlorides-buliding-blocks This article mentions the following:

Histone deacetylases (HDACs) are an attractive therapeutic target for a variety of human diseases. Currently, all four FDA-approved HDAC-targeting drugs are nonselective, pan-HDAC inhibitors, exhibiting adverse side effects at therapeutic doses. Although selective HDAC inhibition has been proposed to mitigate toxicity, the targeted catalytic domains are highly conserved. Herein, a series of rationally designed, conformationally constrained, benzanilide foldamers which selectively bind the catalytic tunnel of HDAC8 is described. The series includes benzanilides, MMH371, MMH409, and MMH410, which exhibit potent in vitro HDAC8 activity (IC₅₀ = 66, 23, and 66 nM, resp.) and up to 410-fold selectivity for HDAC8 over the next targeted HDAC. Exptl. and computational analyses of the benzanilide structure docked with human HDAC8 enzyme showed the adoption of a low-energy L-shaped conformer that favors HDAC8 selectivity. The conformationally constrained HDAC8 inhibitors present an alternative biol. probe for further determining the clin. utility and safety of pharmacol. knockdown of HDAC8 in diseased cells. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Category: chlorides-buliding-blocks).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics