Chlorides-buliding-blocks

The effects of methyl jasmonate and salicylic acid on the production of secondary metabolites in organ culture of Ziziphora persica was written by Zare-Hassani, Elham;Motafakkerazad, Rouhollah;Razeghi, Jafar;Kosari-Nasab, Morteza. And the article was included in Plant Cell, Tissue and Organ Culture in 2019.COA of Formula: C18H37Cl This article mentions the following:

Ziziphora persica (Lamiaceae) has been used as infusions and decoctions in traditional medicine for various purposes such as sedative, carminative, and stomach pain. In the proliferation stage of shoot culture, MS medium was treated with different concentrations of Me jasmonate (MJ) and salicylic acid (SA) (50, 100 and 150渭M) either individually or in combination with various concentrations (25渭M SA + 25渭M MJ, 25渭M SA + 50渭M MJ, 50渭M SA + 25渭M MJ, 50渭M SA + 50渭M MJ). In the present study, we investigated the quant. changes in pigments, growth parameters, and volatile compounds in the shoot culture of nodal segments. Volatile compounds were extracted and subsequently analyzed using GC-mass spectrometry. The highest amounts of chlorophyll a and carotenoids were detected in SA₂₅ + MJ₂₅ treatment, whereas chlorophyll b was highly found in the control treatment. Besides, significant amounts of detected volatile compounds belonged to alkane hydrocarbons, whereas mono and sesquiterpenes were found in low amounts In the experiment, the researchers used many compounds, for example, 1-Chlorooctadecane (cas: 3386-33-2COA of Formula: C18H37Cl).

1-Chlorooctadecane (cas: 3386-33-2) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.COA of Formula: C18H37Cl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Control of ER-positive breast cancer by ER伪 expression inhibition, apoptosis induction, cell cycle arrest using semisynthetic isoeugenol derivatives was written by Nafie, Mohamed S.;Elghazawy, Nehal H.;Owf, Salma M.;Arafa, Kholoud;Abdel-Rahman, Mohamed A.;Arafa, Reem K.. And the article was included in Chemico-Biological Interactions in 2022.Name: 1-(Chloromethyl)-3-methylbenzene This article mentions the following:

New semi-synthetic effective and safe anticancer agents isoeugenol derivatives were synthesized, characterized, and screened for their cytotoxic activity against MCF-7. Moreover, their selective cytotoxicity was assessed against MCF-10A. Three derivatives, 2, 8 and 10 were significantly more active than the reference drug 5-FU with IC50 values of 6.59, 8.07 and 9.63 and 30.93 渭M, resp. Also interestingly, these derivatives demonstrated some degree of selectivity to cancer cells over normal cells. Furthermore, derivative 2 was subjected to other in vitro experiments against MCF-7 where it inhibited colony formation by 87.5% and lowered ER伪 concentration to 395.7 pg/mL compared to 1129 pg/mL in untreated control cells. In continuation of the investigation, the apoptotic activity of compound 2, was assessed where it significantly enhanced total apoptotic cell death by 9.16-fold (18.70% compared to 1.64% for the untreated MCF-7 control cells) and arrested the cell cycle at the G2/M phase. Furthermore, the mol. mechanism of apoptotic activity was investigated at both the gene (RT-PCR) and protein (western plotting) levels where upregulation of pro-apoptotic and down regulation of anti-apoptotic genes was detected. Addnl., compound 2 treatment enhanced the antioxidant (GSH, CAT, SOD) activities. Finally, in vivo experiments verified the effective anticancer activity of compound 2 through inhibition of tumor proliferation by 47.6% compared to 22.9% for 5-FU and amelioration of the hematol., biochem., and histopathol. examinations near normal. In effect, compound 2 can be viewed as a promising semi-synthetic derivative of isoeugenol with some degree of selectivity for management of breast cancer through apoptotic induction and ER伪 downregulation. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9Name: 1-(Chloromethyl)-3-methylbenzene).

1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Name: 1-(Chloromethyl)-3-methylbenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Evaluation of indole-picolinamide hybrid molecules as carbonic anhydrase-II inhibitors: Biological and computational studies was written by Zaib, Sumera;Khan, Imtiaz;Anbar, Hanan S.;Zaraei, Seyed-Omar;Sbenati, Rawan M.;Maryam, Hafiza Taha;Shah, Hamid Saeed;El-Gamal, Mohammed I.. And the article was included in Journal of Molecular Structure in 2022.Category: chlorides-buliding-blocks This article mentions the following:

The present study reported the successful synthesis and evaluation of a series of indole-picolinamide hybrids I, II [Ar = Ph, 3-CF₃C₆H₄, 3,4-di-ClC₆H₃], III, IV and V as potent inhibitors of bovine carbonic anhydrase II, a promising therapeutic target for the treatment of neurol. disorders, osteoporosis, glaucoma, cancer and obesity. Various multistep synthetic approaches were utilized to access the desired structures having exclusive sites for chem. modifications and diverse spots for biol. interactions between the ligand and enzyme. Compound I was observed as a potent inhibitor of the bovine CA-II with an IC₅₀ value of 0.0440 卤 0.009渭M. The inhibition potency was about 22-fold higher than the standard drug acetazolamide (IC₅₀ = 0.9618 卤 0.180渭M). Several relevant structure-activity relationships were deduced that enlighten the crucial role of substituents as well as the key pharmacophores involved in the inhibition process. Mol. docking tools reinforced the in vitro assay results. The most active compound I was also investigated for anticancer potential using sulforhodamine B assay and results showed two-fold efficacy against HeLa cells when compared to standard drug cisplatin (IC₅₀ = 8.045 卤 3.791渭g/mL and 4.128 卤 1.473渭g/mL, resp.). These findings were also confirmed by flow cytometry and comet tests. Moreover, fluorescence microscopy with DAPI staining revealed apoptosis as a mechanism of cancer cell death. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Category: chlorides-buliding-blocks).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and biological evaluation of novel sulfonamide derivatives of tricyclic thieno[2,3-d]pyrimidin-4(3H)-ones on melanin synthesis in murine B16 cells was written by Nie, Li Fei;Bozorov, Khurshed;Niu, Chao;Huang, Guozheng;Aisa, Haji Akber. And the article was included in Research on Chemical Intermediates in 2017.COA of Formula: C7H4ClF3O2S This article mentions the following:

A series of novel sulfonamide derivatives containing tricyclic thieno[2,3-d]pyrimidinones I (R = Ph, 4-FC₆H₄, 2-F₃CC₆H₄, 3,5-Cl₂C₆H₃, etc.) was synthesized and evaluated for melanin synthesis in murine B16 cells. All new compounds were characterized by ¹H NMR, ¹³C NMR, IR and HRMS. Among them, 6 compounds demonstrated excellent activity than pos. control (8-methoxylpsoralen, 8-MOP) with more than 1.5-fold potency. Compound I (R = 3,5-Cl₂C₆H₃) was the most potent one (658.3 卤 8.7%), exhibiting 5.0-fold stronger activity than 8-MOP (130.9 卤 8.6%). The compound I (R = 3,5-F₂C₆H₃) increased melanin synthesis in murine B16 cells with a 4.35-fold potency as compared to 8-MOP. These compounds may serve as lead compounds for further drug discoveries for the treatment of vitiligo. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6COA of Formula: C7H4ClF3O2S).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.COA of Formula: C7H4ClF3O2S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Occurrence of pharmaceutical and personal care products in Cau River, Vietnam was written by Ngo, Thanh Huy;Van, Dieu-Anh;Tran, Hoai Le;Nakada, Norihide;Tanaka, Hiroaki;Huynh, Trung Hai. And the article was included in Environmental Science and Pollution Research in 2021.Safety of 1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea This article mentions the following:

Abstract: This study evaluated the occurrence of PPCPs in Cau River (Vietnam). Surface water and sediment samples were collected to determine PPCP concentrations The anal. results showed the presence of 36 out of 56 investigated PPCPs in samples. The total concentration of PPCPs in water samples ranged from 8.21 to 529 ng/L and the value observed in sediment was from 17.4 to 172.8 渭g/kg. Along the Cau River, there was a trend of accumulation of PPCPs at the downstream. The highest level of PPCP was observed after the river flows through Thai Nguyen and Bac Ninh provinces. Among detected PPCPs, the ones detected with high frequency (over 70%) and high concentration were caffeine, sulfamethoxazole, and lincomycin in water and triclocarban, levofloxacin, and griseofulvin in sediment. The water-sediment partition coefficient (K_d) was estimated to explore the fate of PPCP in the river, and the observed K_d mean values for lincomycin, sulfamethoxazole, and griseofulvin were 223.0, 7.6, and 997.0 kg/L, resp. Risk assessment was initially conducted by applying a semi-quant. assessment risk quotient (RQ); the potential ecol. risk to the aquatic organism of PPCPs posed a moderate risk. In the experiment, the researchers used many compounds, for example, 1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea (cas: 101-20-2Safety of 1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea).

1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea (cas: 101-20-2) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Safety of 1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Symmetrical biaryls from diazotized amines. Scope of the reaction. Unsymmetrical biaryls was written by Atkinson, Edward R.;Morgan, C. R.;Warren, H. H.;Manning, T. J.. And the article was included in Journal of the American Chemical Society in 1945.Recommanded Product: 5344-49-0 This article mentions the following:

The reducing agent was prepared by-reducing Cu₂SO₄ in NH₄OH with NH₂OH; the exptl. conditions were those reported in C.A. 35, 2879.8. The yields of R₂ and (:NR)₂ are given (%), as well as other products isolated. PhNH₂, small, 45, ROH; o-MeC₆H₄NH₂, 0, 45, ROH, RCl; m-MeC₆H₄NH₂, 0, 27, ROH; p-MeC₆H₄NH₂, 0, 50, ROH, RCl; o-O₂NC₆H₄NH₂, 45, 3, RCl (14%); m-O₂NC₆H₄NH₂, 45, 3, RCl (13%); p-O₂NC₆H₄Me (at 30-5掳), 12, small, RCl (14%); 2,6-Me(O₂N)C₆H₃NH₂, 24, 16; 2,4-isomer, 31, -; 2,4-O₂N(MeO)C₆H₃NH₂, 64, small; p-HOC₆H₄NH₂, 0, 45; p-AcNHC₆H₄NH₂, 0, 28; o-H₂NC₆H₄CO₂H, 85-90, 0, RNHR; 4,2-Cl(H₂N)C₆H₃CO₂H, 75, 0, RX, R₂O, ROH; 5-Cl isomer, 50, 0, RX, ROH; 6-Cl isomer, 80, 0; 3,5,2-Cl₂(H₂N)C₆H₂CO₂H, 50, 0, RCl, RNH₂; 3,5,2-Br₂(H₂N)C₆H₂CO₂H, 40, 0, RCl, RNH₂; 2,4-H₂N(O₂N)C₆H₃CO₂H, 61, -; 6-NO₂ isomer, 40, -, RCl; m-H₂NC₆H₄CO₂H, 0, 31, RCl; p-isomer, 0, 35; o-H₂NC₆H₄SO₃H gives 20% of (2-C₆H₄SO₃H)₂; aminonaphthalenecarboxylic acid gives high yields of R₂. A mixture of the diazo solutions from 10 g. of 3,5,2-Cl₂(H₂N)C₆H₂CO₂H and 10 g. of o-H₂NC₆H₄CO₂H gives 2 g. of 4,4′,6,6′-tetrachlorodiphenic acid and 0.5 g. of 4,6-dichlorodiphenic acid (II), m. 216-17掳. II (0.3 g.) and 2 g. concentrated H₂SO₄, heated 10 min. at 150掳 and for 2 days at 80掳, give 2,4-dichlorofluorenone-5-carboxylic acid (III), yellow, m. 240-2掳. The formation of III is a convenient method for estimating II in a mixture of diphenic acid and its tetra-Cl derivative A mixture of the diazo solutions from o-O₂NC₆H₄NH₂ and o-H₂NC₆H₄CO₂H gives the same reduction products as are obtained from their reduction sep. In the experiment, the researchers used many compounds, for example, 2-Chloro-6-nitrobenzoic acid (cas: 5344-49-0Recommanded Product: 5344-49-0).

2-Chloro-6-nitrobenzoic acid (cas: 5344-49-0) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Recommanded Product: 5344-49-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Discovery of novel indole derivatives that inhibit NEDDylation and MAPK pathways against gastric cancer MGC803 cells was written by Fu, Dong-Jun;Cui, Xin-Xin;Zhu, Ting;Zhang, Yan-Bing;Hu, Yang-Yang;Zhang, Li-Rong;Wang, Sheng-Hui;Zhang, Sai-Yang. And the article was included in Bioorganic Chemistry in 2021.Reference of 620-19-9 This article mentions the following:

A series of novel indole derivatives were synthesized and evaluated for their antiproliferative activity against three selected cancer cell lines (MGC803, EC-109 and PC-3). Among these analogs, 2-(5-methoxy-1H-indol-1-yl)-N-(4-methoxybenzyl)-N-(3,4,5-trimethoxyphenyl)acetamide (I) showed the best inhibitory activity against MGC803 cells with an IC₅₀ value of 1.59渭M. Cellular mechanisms elucidated that I inhibited colony formation, induced apoptosis and arrested cell cycle at G2/M phase. Importantly, indole analog I inhibited NEDDylation pathway and MAPK pathway against MGC803 cells. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9Reference of 620-19-9).

1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Reference of 620-19-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and central nervous system depression properties of 3-[(1′-pyrazolyl)phenyl]sydnones was written by Havanur, Shambhuling B.;Badami, Bharati V.;Puranik, Gurubasav S.. And the article was included in Archiv der Pharmazie (Weinheim, Germany) in 1981.HPLC of Formula: 7476-66-6 This article mentions the following:

Sydnones I [R = R² (R³ = H, Me); R¹ = H, Me, Ph] were prepared by the reaction of 2-RC₆H₄NH₂ and ClCHR¹CO₂Me and subsequent nitrosation and cyclization of 2-RC₆H₄NHCHR¹CO₂H. I [R = R² (R³ = H), R¹ = H] had central nervous system depressant activity and considerable toxicity. In the experiment, the researchers used many compounds, for example, Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6HPLC of Formula: 7476-66-6).

Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.HPLC of Formula: 7476-66-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and properties of 2-guanidinopurines was written by Cesnek, Michal;Masojidkova, Milena;Holy, Antonin;Solinova, Veronika;Koval, Dusan;Kasicka, Vaclav. And the article was included in Collection of Czechoslovak Chemical Communications in 2006.Recommanded Product: 203436-45-7 This article mentions the following:

2-Guanidinopurines were prepared as derivatives of 2,6-diamino-9-[2-(phosphonomethoxy)ethyl]-9H-purine (PMEDAP) (I), which shows an important antiviral activity. It completes earlier described synthesis of 6-guanidinopurine derivatives The title compounds were obtained by the reaction of the corresponding 2-chloropurines with guanidine. 2- And 6-guanidinopurines were used as model compounds for determination of dissociation constants (pK_a) of their ionogenic groups by capillary zone electrophoresis. The pK_a values of ionogenic groups of the above compounds were compared with those of the corresponding aminopurines. The pK_a of guanidino group at the purine moiety varies from 7.77 to 10.32. There is no protonation of N¹-position in contrast to aminopurines. None of these compounds showed any antiviral activity. In the experiment, the researchers used many compounds, for example, 2,6-Dichloro-9-isopropyl-9H-purine (cas: 203436-45-7Recommanded Product: 203436-45-7).

2,6-Dichloro-9-isopropyl-9H-purine (cas: 203436-45-7) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Recommanded Product: 203436-45-7

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics