Chlorides-buliding-blocks

Wu, Bowen published the artcileDesign, synthesis and anticancer activity studies of novel trimethoxyphenyl-quinoline derivatives, Recommanded Product: 3-Chlorobenzylchloride, the publication is Youji Huaxue (2020), 40(4), 978-987, database is CAplus.

A series of novel trimethoxyphenyl-quinoline hybrids I [R = 4-MeC₆H₄, 4-FC₆H₄, 5-Cl-2-thienyl, etc.] were designed, synthesized and evaluated for antiproliferative activity against three human cancer cell lines. Compound I [R = 3-ClCH₂C₆H₄] showed the most potent antitumor activity against PC-3 cells with IC₅₀ value of 9.23μmol/L. Meanwhile, compound I [R = 3-ClCH₂C₆H₄] inhibited the cell viability and colony formation of PC-3 cells. Further mechanism studies revealed that compound I [R = 3-ClCH₂C₆H₄] could arrest PC-3 cells in G2/M phase and induce cell apoptosis via activating intrinsic and extrinsic apoptosis pathway.

Youji Huaxue published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C15H23BO2, Recommanded Product: 3-Chlorobenzylchloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Xing, Siyang published the artcileDiastereoselective synthesis of cis-1,3-disubstituted isoindolines via a highly site-selective tandem cyclization reaction, Safety of Sodium chloro(tosyl)amide trihydrate, the publication is Organic Chemistry Frontiers (2018), 5(12), 1950-1956, database is CAplus.

A highly site-selective tandem reaction involving regioselective ring opening of aziridines and Michael addition of electron-deficient alkenes was described. O-atom nucleophiles, produced by the reaction of aldehydes and NHCs in open air, preferred to attack the less hindered aziridine carbons, followed by further intramol. aza-Michael addition to afford a series of cis-1,3-disubstituted isoindolines in good yields with good diastereoselectivities. High selectivities, high efficiency and mild conditions made this tandem reaction very suitable for the rapid construction of libraries of isoindoline compounds

Organic Chemistry Frontiers published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C10H17N3O2, Safety of Sodium chloro(tosyl)amide trihydrate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Nuti, Elisa published the artcileSugar-Based Arylsulfonamide Carboxylates as Selective and Water-Soluble Matrix Metalloproteinase-12 Inhibitors, Application of (4-((4-Chlorobenzyl)oxy)phenyl)boronic acid, the publication is ChemMedChem (2016), 11(15), 1626-1637, database is CAplus and MEDLINE.

Matrix metalloproteinase-12 (MMP-12) can be considered an attractive target to study selective inhibitors useful in the development of new therapies for lung and cardiovascular diseases. .In this study, a new series of arylsulfonamide carboxylates, with increased hydrophilicity resulting from conjugation with a β-N-acetyl-D-glucosamine moiety, were designed and synthesized as MMP-12 selective inhibitors. Their inhibitory activity was evaluated on human MMPs by using the fluorimetric assay, and a crystallog. anal. was performed to characterize their binding mode. Among these glycoconjugates, a nanomolar MMP-12 inhibitor with improved water solubility, compound I was identified.

ChemMedChem published new progress about 870778-91-9. 870778-91-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic Acids,Boronic acid and ester,, name is (4-((4-Chlorobenzyl)oxy)phenyl)boronic acid, and the molecular formula is C13H12BClO3, Application of (4-((4-Chlorobenzyl)oxy)phenyl)boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Passos, Helena published the artcileSelective Sequential Recovery of Zinc and Copper from Acid Mine Drainage, Computed Properties of 23616-79-7, the publication is ACS Sustainable Chemistry & Engineering (2021), 9(10), 3647-3657, database is CAplus.

The observed imbalance between the unsustainable consumption of available natural metal resources and finite deposits makes the recovery and recycling of metals from metal-containing wastes an imperative. Here, ionic-liquid-based aqueous biphasic systems (IL-based ABSs) are proposed as an efficient alternative for selective metal recovery from real copper acid mine drainage (AMD) effluents. ABSs composed of different ILs and Na₂SO₄ were evaluated for Zn, Al, Cu, Co, and Ni extraction from both model solutions and AMD samples. It is shown that IL composed of thiocyanate anion ([SCN]^–) presented a remarkable ability to extract metals from AMD through the formation of stable metal complexes. The addition of NaSCN to ABSs composed of tetrabutylammonium chloride ([N₄₄₄₄]Cl) allowed to mimic the use of [SCN]-based IL with addnl. advantages: tunable metal selectivity by the concentration of [SCN]^– added to the ABS and a reduction in system cost and environmental impact. Furthermore, at the [SCN]^– concentration range studied here, the formation of a hydrophobic salt composed of IL cations and metal complex anions is observed, which allows the selective extraction and recovery of transition metals in a single step. The IL-rich phase recyclability in three extraction cycles is demonstrated, showing the possibility to recover two times more Zn than with a single extraction cycle while using the same amount of IL and thiocyanate. Salt-rich phases were also recycled in a new IL-based ABS for the subsequent Cu extraction and recovery. These results allow the development of a sustainable process for the selective sequential recovery of transition metals from AMD.

ACS Sustainable Chemistry & Engineering published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C19H34ClN, Computed Properties of 23616-79-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Capuano, Ben published the artcileSynthesis and preliminary pharmacological evaluation of 4′-arylmethyl analogues of clozapine. I. The effect of aromatic substituents, Formula: C13H9ClN2O4, the publication is Australian Journal of Chemistry (2002), 55(9), 565-576, database is CAplus.

As part of a research program to develop compounds with mixed dopamine D₄ and serotonin 5-HT_2A antagonist activity with potential for the treatment of schizophrenia, the preparation of 8-chloro-11-[4-(phenylmethyl)-1-piperazinyl]-5H-dibenzo[b,e][1,4]diazepine derivatives I (R = H, Br, Cl, F, Me, OMe, CF₃, OCF₃, etc.) based on a structural modification of the atypical antipsychotic clozapine was reported. Corresponding 8-chloro-11-[4-[(1H-indol-3-yl)methyl]-1-piperazinyl]-5H-dibenzo[b,e][1,4]diazepine derivatives, bioisosteric 8-chloro-11-[4-[(pyridinyl)methyl]-1-piperazinyl]-5H-dibenzo[b,e][1,4]diazepine derivatives, 4-[[4-(8-chloro-5H-dibenzo[b,e][1,4]diazepin-11-yl)-1-piperazinyl]methyl]-1,2-benzenediol and 3-[[4-(8-chloro-5H-dibenzo[b,e][1,4]diazepin-11-yl)-1-piperazinyl]methyl]-1H-indol-5-ol were also prepared The chem. synthesis, structural characterization and pharmacol. evaluation of a series 4′-arylmethyl analogs of clozapine are described. Preliminary receptor binding data are presented, examining primarily the electronic and positional effects of substituents on the introduced arylmethyl group, and secondarily the nature of the aryl ring.

Australian Journal of Chemistry published new progress about 60091-87-4. 60091-87-4 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Nitro Compound,Carboxylic acid,Amine,Benzene, name is 2-((4-Chloro-2-nitrophenyl)amino)benzoic acid, and the molecular formula is C13H9ClN2O4, Formula: C13H9ClN2O4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Guirado, Gonzalo published the artcileElectrochemical Remote Control for Dithienylethene-Ferrocene Switches, Recommanded Product: 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, the publication is Journal of Physical Chemistry C (2007), 111(6), 2770-2776, database is CAplus.

The electrochromic properties of dithienylethene derivatives is a field of great importance and interest. In this manuscript the authors describe a potential mol. remote control system, which can be electrochem. triggered. Diferrocenyl compounds containing a diethylenene photoelectrochromic core with perhydro- and perfluorocyclopentene ring were prepared to induce a change in the chromic properties via an intramol. electron-transfer reaction from the redox group to the photochromic core. The electrochem. behavior of open and closed isomers was thoroughly studied using photochem., electrochem., and spectroelectrochem. techniques. The 1st redox couple was typically assigned to the ferrocene for the open isomer. However, for the closed isomer, an electrocatalytic ring-opening process was observed for the perhydrocyclopentene ring, while a slightly different electrochem. process was observed for the perfluorocyclopentene system. Mechanistic studies revealed that an internal charge transfer is necessary to destabilize the closed bridge. Once opened, the bridge’s cation radical is a strong oxidant, and the charge eventually gets localized on the ferrocene. The charges then migrate throughout the solution by self-exchange reactions. Hence, the redox status of the Fc units triggers the photochrom’s reactivity playing the role of antenna that can temporarily store a charge and facilitate the transformation. This way to perform the transformation, i.e., by electrochem. rather than photochem., presents the great advantage of being much more local and, thus, would permit the ultimate stage of miniaturization at the scale of just one ol.

Journal of Physical Chemistry C published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C15H14Cl2S2, Recommanded Product: 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Pierson, R. M. published the artcileBis-type modifiers in polymerization. I. Behavior of various disulfides in bulk styrene polymerization, Recommanded Product: 1,2-Bis(2-chloroethyl)disulfane, the publication is Journal of Polymer Science (1955), 221-46, database is CAplus.

Studies were made of the effectiveness in low-conversion bulk styrene polymerizations of the modifiers, bis(2-ethylhexyl) disulfide, dibenzyl disulfide, bis(chlorobenzyl) disulfide, bis[2-(2-pyridyl)ethyl] disulfide, bis(2-chloroethyl)disulfide, bis(2-hydroxyethyl)disulfide, dithiodiacetic acid, esters of bis(2-carboxyethyl)disulfide, bis(2-chloroacetoxyethyl) disulfide, diphenyl disulfide, di-ο-tolyl disulfide, bis(2,6-xylyl) disulfide, bis(2,3,5,6-tetramethylphenyl) disulfide, bis(4-carboxyphenyl) disulfide, bis(4-carbethoxyphenyl) disulfide, bis(4-hydroxymethylphenyl)disulfide, bis(2-chloromethylphenyl) disulfide, bis(2-bromomethylphenyl)disulfide, bis(2-aminophenyl) disulfide, di-2-naphthyl disulfide, di-2-benzothiazolyl disulfide, bis(isopropylxanthogen) disulfide, 4,4′-dithiodimorpholine disulfide, carbonylbis(thioglycolic acid), thiocarbonylbis(thioglycolic acid), and tetraphenylhydrazine. Alkyl disulfides, even when substituted at C’s near the SS bond, had very low transfer constants The transfer constants of aryl disulfides were much higher and could be increased by substitutions, thereby incorporating desired groups into the polymer. They cleave to give one half the mol. to each end of the polymer as was shown by comparing end-group concentrations of styrene polymers containing various types of end groups with polymers modified by thiols containing similar groups.

Journal of Polymer Science published new progress about 1002-41-1. 1002-41-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1,2-Bis(2-chloroethyl)disulfane, and the molecular formula is C4H8Cl2S2, Recommanded Product: 1,2-Bis(2-chloroethyl)disulfane.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Paolino, D. published the artcilePolyaspartylhydrazide copolymer-based supramolecular vesicular aggregates as delivery devices for anticancer brugs, Quality Control of 6249-56-5, the publication is Biomacromolecules (2008), 9(4), 1117-1130, database is CAplus and MEDLINE.

In this paper we report on three different hydrophilic copolymers based on α,β-polyaspartylhydrazide (PAHy) bearing butyric groups in the side chain (C₄) (PAHy-C₄) or a combination of butyric groups and pos. charged residues ((carboxypropyl)trimethylammonium chloride, CPTACl) (PAHy-C₄-CPTA) that were synthesized and used for the preparation of new supramol. vesicular aggregates (SVAs) containing gemcitabine as an antitumor drug. Gemcitabine-loaded SVAs containing synthesized PAHy derivatives were characterized from the physicochem. and technol. point of view and the in vitro toxicity and anticancer activity on two different human cancer cell lines, i.e., CaCo-2 (human colon carcinoma) and ARO (human anaplastic thyroid carcinoma) cells, were also evaluated. Moreover, considering that carrier-cell interaction is an important factor to achieve an improvement of anticancer drug activity, confocal laser scanning microscopy and flow cytometric experiments were carried out on the two different cancer cell lines.

Biomacromolecules published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Quality Control of 6249-56-5.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Lahm, George P. published the artcile4-Azolylphenyl isoxazoline insecticides acting at the GABA gated chloride channel, Application of 1,3-Dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene, the publication is Bioorganic & Medicinal Chemistry Letters (2013), 23(10), 3001-3006, database is CAplus and MEDLINE.

Isoxazoline insecticides have been shown to be potent blockers of insect GABA receptors with excellent activity on a broad pest range, including Lepidoptera and Hemiptera. Herein we report on the synthesis, biol. activity and mode-of-action for a class of 4-heterocyclic aryl isoxazoline insecticides e. g., I.

Bioorganic & Medicinal Chemistry Letters published new progress about 864725-22-4. 864725-22-4 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Alkenyl,Benzene, name is 1,3-Dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene, and the molecular formula is C9H5Cl2F3, Application of 1,3-Dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Childress, Scott J. published the artcileElectronegative substitutions in local anesthetics of the benzoic acid ester type, Computed Properties of 5204-46-6, the publication is Journal of the American Chemical Society (1954), 3988-91, database is CAplus.

A series of substituted BzOH esters of various alkanolamines has been prepared and tested pharmacologically. Esters of the tertiary amino alcs. were prepared either by the condensation of the corresponding dialkylaminoalkyl chloride with the Na salt of the acid (method A) or by the condensation of the acid chloride with the amino alc. in the presence of excess base (method B). The esters of secondary amines were prepared by refluxing the HCl salt of the secondary amino alc. with the acid chloride (method C). The nitro esters were reduced to the amino esters by treating the HCl salts with Fe powder in H₂O or aqueous EtOH (method D). The topical and intradermal anesthetic activities of the resulting esters were measured on guinea pig wheal and rabbit cornea, resp.; comparisons were made with cocaine or procaine, to each of which the value 1 was assigned; the acute toxicities were determined in albino mice. Me₃CNH₂ (37 g.), 22 g. ethylene oxide, and 2 cc. MeOH refrigerated 3 days and the mixture fractionated gave 6.5 g. Me₃CNH(CH₂)₂OH, b. 176-7°; picrate, m. 159-60° (from H₂O). 2,4-Cl(H₂N)C₆H₃CO₂H (34.3 g.), 30 g. BuBr, and 13.2 g. KOH in 250 cc. 75% EtOH refluxed overnight, the mixture treated with 13.2 g. KOH and 30 g. BuBr, refluxed 8 hrs., concentrated in vacuo, made basic with KOH, extracted with Et₂O, and acidified, the solid precipitate (20 g.) extracted with 3 l. boiling H₂O, the solution let stand, the procedure repeated with the mother liquor, and the resulting crystals recrystallized 3 times from 95% EtOH yielded 7.5 g. 2,4-Cl(BuNH)C₆H₃CO₂H (I), white crystals, m. 112-14°; the residue from the H₂O extraction recrystallized twice from absolute EtOH gave 2,4-Cl(Bu₂N)C₆H₃CO₂H, white crystals, m. 127-9°. 2,6,4-Cl₂(O₂N)C₆H₂Me (12 g.) in 50 cc. pyridine and 40 cc. H₂O, the mixture heated to the b.p., treated at intervals with six 4.3-g. portions KMnO₄, and filtered, the filtrate concentrated in vacuo to 1/4 its original volume and treated with concentrated HCl, the precipitate dissolved in aqueous NaOH to remove 6 g. unreacted material, the solution acidified, and the yellow crystalline precipitate (2 g.) repeatedly recrystallized from H₂O and dried gave 2,6,4-Cl₂(O₂N)C₆H₂CO₂H (II), white crystals, m. 172-4° with sintering at 157°. II (7 g.) refluxed 4 hrs. with 25 g. SOCl₂, and the resulting crude acid chloride treated with EtOH gave a poor yield of the Et ester, but yielded some anhydride of II, yellow needles, m. 190-1.5° (from EtOH). II (1.9 g.) and 1.5 g. 5% Pd-C added to 60 cc. MeOH, the mixture treated with stirring during 5 min. with 1 g. N₂H₄ in 5 cc. MeOH, let stand over the weekend, filtered, concentrated to 10 cc., poured into 25 cc. H₂O, and acidified, and the precipitate recrystallized twice from H₂O yielded 0.4 g. 2,6,4-Cl₂(H₂N)C₆H₂CO₂H (III), cream-colored crystals, m. 178-9° (decomposition). The following alkyl ester of ο-ClC₆H₄CO₂H HCl salts [alkyl group, m.p., method of preparation, local anesthetic activity compared to cocaine (topical) and procaine (intradermal), and the subcutaneous and the intravenous LD₅₀ in mg./kg. given] were prepared: Et₂N(CH₂)₂, 127-8° (from 95% EtOH), A, 0, 0.4, >1000, 120; Me₂CHCH₂NH(CH₂)₂, 141-2° (from EtOH-Et₂O), C, 0, 1.5, >1000, 75; EtMeCHNH(CH₂)₂, 181-3° (95% EtOH), C, 0, 1.2, >1000, 91; β-cyclohexylaminoethyl, 203-5° (from 50% EtOH), C, 0.3, 1,2, >1000, 98; β-cyclohexylaminoisopropyl, 174-5°, C, 1.7, 1.1, 250, 36. The following ester HCl salts of 3,4-Cl₂C₆H₄CO₂H (same data given): Et₂N(CH₂)₂, 178.5-80° (from EtOAc-EtOH), B, 0, 0.6, 840, 84; EtMeCHNH(CH₂)₂, 180-2° (from 95% EtOH), C, 0.3, 0.8, 510, 120. The following ester HCl salts of 2,4-Cl(O₂N)C₆H₃CO₂H (m.p. and method given): Et₂NCHMeCH₂, 150.5-2.5°, B; Et₂NCH₂CHMe, 145-8° (from EtOH-Et₂O), B; Et₂N(CH₂)₃, 125-6° (from EtOH-Et₂O), B; Me₂CHNH(CH₂)₂, 188-9°, C; BuNH(CH₂)₂, 162-3.5°, C; Me₂CHCH₂NH(CH₂)₂, 172-4°, C; EtMeCHNH(CH₂)₂, 160-1°, C; Me₃CNH(CH₂)₂, 190-2°, C; Et₂CHNH(CH₂)₂, 162-4°, C; BuNH(CH₂)₃, 140-1°, C; EtMeCHNH(CH₂)₃, 160-3°, C; β-cyclohexylaminoethyl, 177-8°, C; 2-cyclohexylamino-1-propyl, 179-80.5°, C; 1-cyclohexyl-2-propyl, 171-2.5°, C; β-cyclohexylaminoisopropyl, 182.5-84°, C; 2-cyclohexylamino-1-phenylethyl, 196-8°, C. 2,4-Br(O₂N)C₆H₃CO₂(CH₂)₂NHCHEtMe.HCl, 157-8°, C. 2,4-(O₂N)₂C₆H₃CO₂(CH₂)₂NEt₂, 137-9° (from EtOH-Et₂O), B (all nitro esters, except where otherwise stated, were recrystallized from EtOH). The following alkyl ester HCl salts of 2,4-Cl(H₂N)C₆H₃CO₂H (all by method D) (alkyl group, m.p., activity, and toxicity given): Et₂NCHMeCH₂, 156.5-7.5° (from EtOH-EtOAc), 1.1, 2.2, 240, 44; Et₂NCH₂CHMe, 156-7°, 1.3, 3.1, 220, 55; Et₂N(CH₂)₃, 198.5-9.5°, 2.9, 2.5, 205, 50; Me₂CHNH(CH₂)₂(HCO₂H salt), 163-5°, 0.9, 1.0, 900, 84; BuNH(CH₂)₂, 161-3°, 0.9, 6.0, 320, 47; Me₂CHCH₂NH(CH₂)₂, 215-17°, 1.3, 4.4, 260, 50; EtMeCHNH(CH₂)₂, 195.5-97°, 2.6, 4.1, 570, 45; (HCO₂H salt), 152-2.5°, 2.3, 4.9, 670, 46) [0.5(CH₂CO₂H)₂ salt], 192-4°, -, 4.9, -, -]; Me₂CHNH(CH₂)₂, 270° (decomposition), 1.0, 1.0, 750, 63; Et₂CHNH(CH₂)₂(HCO₂H salt), 145-6.5°, 1.9, 1.3, 740, 37; BuNH(CH₂)₃, 168-70°, 1.8, 3.1, 140, 23; EtMeCH(CH₂)₃, 208-9.5°, 2.7, 1.4, 220, 29; β-cyclohexylaminoethyl, 224.5-26°, 2.4, 3.1, 280, 29; 2-cyclohexylaminopropyl (HCO₂H salt), 162.5-64°, 3.0, 2.1, 330, 24; β-cyclohexylamino-2-propyl, 159-61°, 3.4, 3.1, 57, 17; 3-cyclohexylaminoisopropyl, 188.5-9.5°, 2.2, 3.4, 120, 17; 2-cyclohexylamino-1-phenylethyl, 239-41° (decomposition), -, -, -, -; 2,4-Br(H₂N)C₆H₃CO₂(CH₂)₂NHCHEtMe, 202-4°, 2.5, 2.7, 450, 43. The following ester HCl salts of 4,2-H₂N(O₂N)C₆H₃CO₂H by method A (same data given): Et₂N(CH₂)₂, 177-9°, 0.2, 1.4, 850, 130; Et₂NCHMeCH₂, 182-5°, 0, 1.5, 800, 71; Et₂N(CH₂)₃, 221-3°, 0.5, 1.0, 430, 49. The following ester salts of I (same data given) by method A: Me₂N(CH₂)₂ HCl salt monohydrate, 84-6° (from EtOH-EtOAc), 0.1, 1.9, 1000, 72; Me₂N(CH₂)₂ di-HCl salt, 167-70° (decomposition), -, -, -, -; Et₂N(CH₂)₂ di-HCl salt, 151-4°, -, -, -, – (all previous ester salts were recrystallized from EtOH, except where otherwise indicated). The Et₂N(CH₂)₂ ester HCl salts of the following acids (m.p., method, activity, and toxicity given): 2,5-Cl(O₂N)C₆H₃CO₂H, 197-8° (from EtOH), B, -, -, -, -; 2,5-Cl(H₂N)C₆H₃CO₂H, 152.5-4.5° (from iso-PrOH), D, 0, 0.6, >1200, 110; 3,4-Cl(H₂N)C₆H₃CO₂H, 148-50° (from EtOH-EtOAc), A, 1.2, 0.7, >450, 45; II, 170-1° (from EtOH), A, -, -, -, -; III, 154-5.5° (from EtOH-EtOAc), D, 2.8, 3.5, 130, 31; 3,5,4-Cl₂(H₂N)C₆H₂CO₂H, 237-8° (from EtOH), A, 0.7, 2.0, 290, 44. The EtMeCHNH(CH₂)₂ ester HCl salts of the following acids (same data given): 2,5-Cl(O₂N)C₆H₃CO₂H, 158.5-9.5° (from EtOH), C, -, -, -, -; 2,5-Cl(H₂N)C₆H₃CO₂H, 121-3° (from iso-PrOH), D, 0, 2.0, >1200, 75; 3,4-Cl(O₂N)C₆H₃CO₂H, 174-5° (from EtOH), C, -, -, -, -; 3,4-Cl(H₂N)C₆H₃CO₂H HCO₂H salt, 108-9° (from EtOH-EtOAc), D, 0.8, 1.5, 490, 45; 4,3-Cl(O₂N)C₆H₃CO₂H, 185-7° (from EtOH), C, -, -, -, -; 4,3-Cl(H₂N)C₆H₃CO₂H, 179-80.5°, D, 0.3, 2.0, 570, 68. The amino alc. in the preparation of IV neutralized incompletely gave N-[2-(2-chloro-4-nitrobenzoxy)-1-propyl]-N-cyclohexyl-2-chloro-4-nitrobenzamide) cream-colored solid, m. 156.5-58° (from CHCl₃-Et₂O) as a by-product. 2,4-(O₂N)₂C₆H₃CO₂(CH₂)₂NEt₂ (0.6 g.) in 20 cc. EtOH and 1 cc. 3N NH₄OH treated at room temperature 0.5 hr. with H₂S, the mixture filtered, and the filtrate concentrated gave 0.2 g. 4,2-HONH(O₂N)C₆H₃CO₂(CH₂)₂NEt₂, m. 170-2° (from EtOH) having topical activity 0, intradermal activity 0.5, subcutaneous LD₅₀ 790, and intravenous LD₅₀ 55.

Journal of the American Chemical Society published new progress about 5204-46-6. 5204-46-6 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Amine,Benzene, name is 4-Amino-2,6-dichlorobenzoic acid, and the molecular formula is C7H5Cl2NO2, Computed Properties of 5204-46-6.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics