Chlorides-buliding-blocks

Cid, Jose Maria published the artcileDiscovery of 1,4-Disubstituted 3-Cyano-2-pyridones: A New Class of Positive Allosteric Modulators of the Metabotropic Glutamate 2 Receptor, Category: chlorides-buliding-blocks, the publication is Journal of Medicinal Chemistry (2012), 55(5), 2388-2405, database is CAplus and MEDLINE.

The discovery and characterization of compound 48, a selective and in vivo active mGlu2 receptor pos. allosteric modulator (PAM), are described. A key to the discovery was the rational exploration of the initial HTS hit 13 guided by an overlay model built with reported mGlu2 receptor PAM chemotypes. The initial weak in vitro activity of the hit 13 was quickly improved, although compounds still had suboptimal druglike properties. Subsequent modulation of the physicochem. properties resulted in compounds having a more balanced profile, combining good potency and in vivo pharmacokinetic properties. Final refinement by addressing cardiovascular safety liabilities led to the discovery of compound (I). Besides good potency, selectivity, and ADME properties, I displayed robust in vivo activity in a sleep-wake EEG (sw-EEG) assay consistent with mGlu2 receptor activation, in accordance with previous work from our laboratories

Journal of Medicinal Chemistry published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C6H3ClFNO2, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Lesuisse, Dominique published the artcileRational design of potent GSK3β inhibitors with selectivity for Cdk1 and Cdk2, SDS of cas: 766549-26-2, the publication is Bioorganic & Medicinal Chemistry Letters (2010), 20(6), 1985-1989, database is CAplus and MEDLINE.

From an HTS hit, a series of potent and selective aminoindazole inhibitors of GSK3β have been designed based on a Cdk2-homol. model and with the help of several crystal structures of the compounds within Cdk2.

Bioorganic & Medicinal Chemistry Letters published new progress about 766549-26-2. 766549-26-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Phenol,Boronic Acids,Boronic acid and ester, name is 2-Chloro-4-hydroxyphenylboronic acid, and the molecular formula is C6H6BClO3, SDS of cas: 766549-26-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wawrzynczak, Agata published the artcileHydrosilylation of n-alkenes and allyl chloride over platinum supported on styrene-divinylbenzene copolymer, Safety of Dichloro(methyl)(octyl)silane, the publication is Catalysis Today (2011), 169(1), 69-74, database is CAplus.

Catalytic performance of styrene-divinylbenzene copolymer-supported platinum catalyst of high crosslinking degree and high surface area was studied in reactions of hydrosilylation of allyl chloride, 1-octene and 1-butene. The catalyst has shown considerably greater stability of catalytic activity than classical active carbon-supported catalyst. In experiments on repeated use of catalysts, the decrease in catalytic activity for hydrosilylation of liquid double bond-containing compounds proceeding in the presence of the copolymer-supported and carbon-supported platinum was considerably smaller in the case of the former catalyst. Bimetallic Pt-Cu catalyst on polymeric support appeared to be considerably less active than monometallic catalyst.

Catalysis Today published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C10H20O2, Safety of Dichloro(methyl)(octyl)silane.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Alkayal, Nazeeha published the artcileWell-defined polyethylene-based graft terpolymers by combining nitroxide-mediated radical polymerization, polyhomologation and azide/alkyne “click” chemistry, Quality Control of 5034-06-0, the publication is Polymer Chemistry (2016), 7(17), 2986-2991, database is CAplus.

Novel well-defined polyethylene-based graft terpolymers were synthesized via the “grafting onto” strategy by combining nitroxide-mediated radical polymerization (NMP), polyhomologation and copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) “click” chem. Three steps were involved in this approach: (i) synthesis of alkyne-terminated polyethylene-b-poly(ε-caprolactone) (PE-b-PCL-alkyne) block copolymers (branches) by esterification of PE-b-PCL-OH with 4-pentynoic acid; the PE-b-PCL-OH was obtained by polyhomologation of dimethylsulfoxonium methylide to afford PE-OH, followed by ring opening polymerization of ε-caprolactone using PE-OH as a macroinitiator, (ii) synthesis of random copolymers of styrene (St) and 4-chloromethylstyrene (4-CMS) with various CMS contents, by nitroxide-mediated radical copolymerization (NMP), and conversion of chloride to azide groups by reaction with sodium azide (NaN₃) (backbone) and (iii) “click” linking reaction to afford the PE-based graft terpolymers. All intermediates and final products were characterized by high-temperature size exclusion chromatog. (HT-SEC), Fourier transform IR spectroscopy (FTIR), proton NMR spectroscopy (¹H NMR) and differential scanning calorimetry (DSC).

Polymer Chemistry published new progress about 5034-06-0. 5034-06-0 belongs to chlorides-buliding-blocks, auxiliary class Salt,Aliphatic hydrocarbon chain, name is trimethyloxosulphonium chloride, and the molecular formula is C3H9ClOS, Quality Control of 5034-06-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Topolski, M. published the artcileChiral carbenoids: their formation and reactions, HPLC of Formula: 866-23-9, the publication is Journal of Organic Chemistry (1993), 58(3), 546-55, database is CAplus.

Carbenoids, generated by metalation or halogen-metal exchange reactions, have been prepared from chiral vinyl and cyclopropyl halides. The reactivity and stereochem. observed in the reaction of these carbenoids has been interpreted as being due to metal-assisted ionization.

Journal of Organic Chemistry published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C7H8BNO4, HPLC of Formula: 866-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kemp, Laura R. published the artcileThe transcriptional regulator CprK detects chlorination by combining direct and indirect readout mechanisms, Computed Properties of 33697-81-3, the publication is Philosophical Transactions of the Royal Society, B: Biological Sciences (2013), 368(1616), 20120323/1-20120323/8, database is CAplus and MEDLINE.

The transcriptional regulator CprK controls the expression of the reductive dehalogenase CprA in organohalide-respiring bacteria. Desulfitobacterium hafniense CprA catalyzes the reductive dechlorination of the terminal electron acceptor o-chlorophenol acetic acid, generating the phenol acetic acid product. It has been shown that CprK has ability to distinguish between the chlorinated CprA substrate and the de-halogenated end product, with an estimated an estimated 10⁴-fold difference in affinity. Using a green fluorescent protein GFP_UV-based transcriptional reporter system, we establish that CprK can sense o-chlorophenol acetic acid at the nanomolar level, whereas phenol acetic acid leads to transcriptional activation only when approaching micromolar levels. A structure-activity relationship study, using a range of o-chlorophenol acetic-acid-related compounds and key CprK mutants, combined with pK_a calculations on the effector binding site, suggests that the sensitive detection of chlorination is achieved through a combination of direct and indirect readout mechanisms. Both the phys. presence of the bulky chloride substituent as well as the accompanying electronic effects lowering the inherent phenol pK_a are required for high affinity. Indeed, transcriptional activation by CprK appears strictly dependent on establishing a phenolate-K133 salt bridge interaction, rather than on the presence of a halogen atom per se. As K133 is strictly conserved within the CprK family, our data suggest that physiol. function and future applications in biosensing are probably restricted to phenolic compounds

Philosophical Transactions of the Royal Society, B: Biological Sciences published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C8H7ClO3, Computed Properties of 33697-81-3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Drake, R. published the artcilePolymethacrylate and polystyrene-based resin-supported Pt catalysts in room temperature, solvent-less, oct-1-ene hydrosilylations using trichlorosilane and methyldichlorosilane, Product Details of C9H20Cl2Si, the publication is Journal of Molecular Catalysis A: Chemical (2001), 177(1), 49-69, database is CAplus.

A first group of methacrylate-based resins have been prepared with different amine ligands each co-ordinating Pt(II). Evaluation of each of these as room temperature catalysts in the solvent-less hydrosilylation of oct-1-ene by trichlorosilane has identified a supported ethylenediamine-derived ligand as providing the most active and stable Pt catalyst. A second group of methacrylate-based resins and third group of styrene-based resins have also been prepared with a variety of morphologies. Each of these was chem. modified to introduce the same ethylenediamine-derived ligand and subsequently Pt(II) coordinated to each of these. Both groups of resin catalysts were evaluated for activity, selectivity, Pt leaching and recyclability in the hydrosilylation of oct-1-ene by trichlorosilane and methyldichlorosilane. Specific samples of resin catalysts have been recycled up to 11 times in successive batch reactions. The styrene-based resins have been shown to be more active than the methacrylate-based ones, almost certainly because as a group they are more hydrophobic. Gel-type morphologies in the support are totally unsuitable and appear to provide severe mass transport limitations. The various macroporous resin based species are very attractive catalysts and the most likely optimum design criteria are discussed.

Journal of Molecular Catalysis A: Chemical published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C9H20Cl2Si, Product Details of C9H20Cl2Si.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Drake, R. published the artcileOptimization of polystyrene resin-supported Pt catalysts in room temperature, solvent-less, 1-octene hydrosilylation using methyldichlorosilane, Category: chlorides-buliding-blocks, the publication is Combinatorial Chemistry and High Throughput Screening (2002), 5(3), 201-209, database is CAplus and MEDLINE.

Six precursor resins with systematic variation of porous parameters were prepared by suspension polymerization using specific compositions of divinylbenzene, styrene vinylbenzyl chloride (VBC) and 2-ethylhexan-1-ol (a porogen) and the surface areas from N₂ sorption and BET anal. were ∼2-170 m²·g^-1. The VBC content in each case was 38 mol% and these groups were aminated using the sodium salt of trimethylethylenediamine and Pt was introduced onto each resin at three different loadings (∼0.03, ∼ 0.2 and ∼ 0.4 mmol·g^-1) by appropriate manipulation of K₂PtCl₄. The matrix of 18 resin-supported Pt complexes was then assessed for catalytic activity in the room temperature, solvent-less, hydrosilylation of 1-octene using methyldichlorosilane such that alkene:silane:Pt ratio was fixed as 2:1:1×10^-3. Though all the catalysts showed activity lower than that of homogeneous Speier’s catalyst, most were sufficiently active to be potentially valuable heterogeneous catalysts in the laboratory, and indeed the plant. The most lightly loaded resins proved to be the least active and the remainders were recycled 5 times, and the best performers, the most highly loaded species, a further 5 times making 10 consecutive uses in all. A strong dependence on the porous structure of the resins was demonstrated with the activity rising systemically with the surface area. The two highest surface area highest loaded species displayed good activity even when used for the tenth time. The level of concurrent alkene isomerization observed was low throughout (<1%) making these heterogeneous species selective and highly active. Overall the derived catalysts are excellent candidates for use in the research laboratory, and with further development could also be valuable in continuous processes.

Combinatorial Chemistry and High Throughput Screening published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C9H20Cl2Si, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Tunc, Sibel published the artcileInvestigation of interactions between some anionic dyes and cationic surfactants by conductometric method, COA of Formula: C19H34ClN, the publication is Fluid Phase Equilibria (2007), 251(1), 1-7, database is CAplus.

The interactions of cationic surfactants with anionic dyes were studied by conductometric method. Benzyltrimethylammonium chloride (BTMACl), benzyltriethylammonium chloride (BTEACl) and benzyltributylammonium chloride (BTBACl) were used as cationic surfactants and indigo carmine (IC) and amaranth (Amr) were chosen as anionic dyes. The specific conductance of dye-surfactant mixtures was measured at 25, 35 and 45 °C. A decrease in measured specific conductance values of dye-surfactant mixture was caused by the formation of non-conducting or less-conducting dye-surfactant complex. The equilibrium constants, K₁, the standard free energy changes, ΔG°₁ the standard enthalpy changes, ΔH°₁ and the standard entropy changes, ΔS°₁ for the first association step of dye-surfactant complex formation were calculated by a theor. model. The results showed that the equilibrium constants and the neg. standard free energy change values for all systems decreased as temperature increased. Also these values decreased for all systems studied with increasing alkyl chains of surfactants due to the steric effect. When the equilibrium constant values, K₁, for the first association step of IC-surfactant and Amr-surfactant systems with the same surfactant were compared, the values of K₁ for IC-surfactant system were higher than that of Amr-surfactant system.

Fluid Phase Equilibria published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C8H19NO2, COA of Formula: C19H34ClN.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Shen, Hui published the artcileSynthesis of 3-substituted 2-oxindoles from secondary α-bromo-propionanilides via palladium-catalyzed intramolecular cyclization, Name: 3-(2,6-Dichlorophenyl)propanoic acid, the publication is Organic & Biomolecular Chemistry (2022), 20(17), 3589-3597, database is CAplus and MEDLINE.

A palladium-catalyzed intramol. cyclization of α-bromo-propionanilides was developed, delivering a series of 3-substituted 2-oxindoles in high yields. The method features easy to prepare starting materials, broad substrate scope and excellent functional group tolerance. A detailed mechanistic investigation was performed.

Organic & Biomolecular Chemistry published new progress about 51656-68-9. 51656-68-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene, name is 3-(2,6-Dichlorophenyl)propanoic acid, and the molecular formula is C10H10O2, Name: 3-(2,6-Dichlorophenyl)propanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics