Chlorides-buliding-blocks

Haszeldine, Robert N. published the artcilePerfluoroalkyl derivatives of sulfur. Part XIX. Reaction of fluoroolefins with fluoride ion in the presence of dimethyl disulfide, and related reactions, Category: chlorides-buliding-blocks, the publication is Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) (1976), 1178-82, database is CAplus.

F2C:CF2 reacted with CsF in the presence of MeS2Me to give 15% CF3CFRSMe (I; R = F), 77% MeSCF2CFRSMe (II; R = F), and 2% CF3CF2H, whereas F2C:CFCl gave 15% I (R = Cl), 56% II (R = Cl) and 13% of a mixture (III) of cis- and trans-MeSCF:CFR (R = Cl. Under similar conditions CF3CF:CF2 gave 38% I (R = CF3) and 12-21% III (R = CF3) together with olefin telomers. F2C:CF2 with CsF in the presence of Me2S gave only CF3CF2H. F2C:CFCl and CF3CF:CF2 reacted with NaSMe in Et2O at -196° to give 77 and 90% III, resp.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about 1002-41-1. 1002-41-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1,2-Bis(2-chloroethyl)disulfane, and the molecular formula is C4H8Cl2S2, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kosmalski, Tomasz published the artcileThe Oxime Ethers with Heterocyclic, Alicyclic and Aromatic Moiety as Potential Anti-Cancer Agents, HPLC of Formula: 939-99-1, the publication is Molecules (2022), 27(4), 1374, database is CAplus and MEDLINE.

Chemotherapy is one of the most commonly used methods of cancer disease treatment. Due to the acquisition of drug resistance and the possibility of cancer recurrence, there is an urgent need to search for new mols. that would be more effective in destroying cancer cells. In this study, 1-(benzofuran-2-yl)ethan-1-one oxime and 26 oxime ethers containing heterocyclic, alicyclic or aromatic moiety were screened for their cytotoxicity against HeLa cancer cell line. The most promising derivatives with potential antitumor activity were 2-(cyclohexylideneaminoxy)acetic acid (18) and (E)-acetophenone O-2-morpholinoethyl oxime (22), which reduced the viability of HeLa cells below 20% of control at concentrations of 100-250 μg/mL. Some oxime ethers, namely thiazole and benzothiophene derivatives (24-27), also reduced HeLa cell viability at similar concentrations but with lower efficiency. Further cytotoxicity evaluation confirmed the specific toxicity of (E)-acetophenone O-2-morpholinoethyl oxime (22) against A-549, Caco-2, and HeLa cancer cells, with an EC₅₀ around 7 μg/mL (30 μM). The most potent and specific compound was (E)-1-(benzothiophene-2-yl)ethanone O-4-methoxybenzyl oxime (27), which was selective for Caco-2 (with EC₅₀ 116 μg/mL) and HeLa (with EC₅₀ 28 μg/mL) cells. Considering the bioavailability parameters, the tested derivatives meet the criteria for good absorption and permeation. The presented results allow us to conclude that oxime ethers deserve more scientific attention and further research on their chemotherapeutic activity.

Molecules published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H6ClF3, HPLC of Formula: 939-99-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Boutevin, B. published the artcileSynthesis of phosphonic compounds with chlorofluorinated chains. Part I, Formula: C5H10Cl3O3P, the publication is Phosphorus and Sulfur and the Related Elements (1981), 11(3), 373-81, database is CAplus.

The redox catalysis and free-radical telomerizations of di- and trichloromethylphosphonyl dichlorides and their esters with chlorotrifluoroethylene (I) [79-38-9] were studied. Also investigated was phosphonation of telomers of I and CCl₄ using Kinnear-Perren and Michaelis-Arbuzov methods. Phosphonic compounds containing chlorofluorinated blocks are obtained with these two methods. By-products are described and explained using known mechanisms.

Phosphorus and Sulfur and the Related Elements published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Formula: C5H10Cl3O3P.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Albrecht, Steffen published the artcileDirect synthesis of dialkyl N,N-diorganophosphoramidates from trialkyl phosphites, Application In Synthesis of 866-23-9, the publication is Phosphorus, Sulfur and Silicon and the Related Elements (1991), 62(1-4), 189-92, database is CAplus.

Amidation of (RO)₃P (R = Et, Bu) with secondary amines R¹R²NH (R¹ = R² = Bu, Et; R¹ = Ph, R² = Me, Et) in the presence of amine hydrochloride catalysts and CCl₄ in MeCN as solvent gave title compounds, (RO)₂P(O)(NR¹R²). The mechanism is discussed.

Phosphorus, Sulfur and Silicon and the Related Elements published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Application In Synthesis of 866-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Steinbach, J. published the artcileReaction of the two-component system trialkyl phosphite/carbon tetrachloride with nucleophiles containing hydrogen. 2. Reaction with ammonia and amines, Name: Diethyltrichloromethylphosphonate, the publication is Zeitschrift fuer Anorganische und Allgemeine Chemie (1985), 180-6, database is CAplus.

RNH₂ (R = H, Pr, Bu, PhCH₂, Ph) reacted 1:1 with (R¹O)₃P (R¹ = Et, Bu) and CCl₄ to give (R¹O)₂P(O)NHR. If excess RNH₂ was used, R¹OP(O)(NHR)₂ and OP(NHR)₃ also formed. The reaction of (R¹O)₃P/CCl₄ in the presence of secondary and tertiary amines gave (R¹O)₂P(O)CCl₃, which reacted with the amine to give [Cl₃CP(O)(O^–)(OR¹)][⁺NRR²R³R⁴].

Zeitschrift fuer Anorganische und Allgemeine Chemie published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C14H10O4S2, Name: Diethyltrichloromethylphosphonate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Albrecht, S. published the artcileReaction of the two-component system trialkyl phosphite/carbon tetrachloride with nucleophiles. 3. Reaction in presence of trialkylammonium salts, SDS of cas: 866-23-9, the publication is Zeitschrift fuer Anorganische und Allgemeine Chemie (1987), 132-46, database is CAplus.

Alkali pseudohalides (KSCN, NaN₃, KCN) react with the 2-component system trialkyl phosphite/carbon tetrachloride in the presence of trialkylammonium halides. Isothiocyanates of dialkylphosphoric acid, N-alkyl phosphoric acid diester amides, N-dialkoxyphosphoryl trialkoxyphosphazenes and tricyanophosphine oxide resp., are obtained. In the system (RO)₃P/CCl₄/R₃NHI the dialkoxyphosphoryl chloride is formed.

Zeitschrift fuer Anorganische und Allgemeine Chemie published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, SDS of cas: 866-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Albrecht, S. published the artcileReactions of chloro-substituted methanephosphonic acid dialkyl esters with dialkyl phosphites, trialkyl phosphites, or alcohol/sodium alcoholate, Quality Control of 866-23-9, the publication is Zeitschrift fuer Anorganische und Allgemeine Chemie (1986), 207-11, database is CAplus.

(RO)₂P(O)CCl₃ (R = Et, Bu) react with dialkyl phosphites and alc. in the presence of tertiary amines or with trialkyl phosphites and alc. yielding diesters of dichloromethanephosphonic acids and triesters of phosphoric acid. When esters of trichloromethane- or dichloromethanephosphonic acid react with alcs. in the presence of sodium alcoholates, a quant. cleavage of P-C bond occurs, and triesters of phosphoric acid and CHCl₃ or CH₂Cl₂ are formed.

Zeitschrift fuer Anorganische und Allgemeine Chemie published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Quality Control of 866-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ballari, Maria Sol published the artcileOne-pot sequential synthesis and antifungal activity of 2-(benzylsulfonyl)benzothiazole derivatives, Category: chlorides-buliding-blocks, the publication is RSC Advances (2019), 9(50), 29405-29413, database is CAplus.

A series of 2-(benzylsulfonyl)benzothiazoles I [R = H, 4-F, 2-I, etc.; X = S] was synthesized by an environmentally friendly method, using water as reaction medium via one-pot and two-step procedure, starting from 2-mercaptobenzothiazole and benzyl halides. Few compounds of 2-(benzylsulfonyl)benzoxazoles I [X = O] were successfully synthesized via oxidation of 2-(benzoxazolyl)benzylsulfides. The potential fungicides were tested against a panel of phytopathogenic fungi, with many of them showing a significant improvement compared to the non-oxidized analogs and the com. antifungal Captan. The new derivatives I [R = 4-Me, 2-Cl; X = S] presented remarkable properties, being able to inhibit the growth of two resistant molds (A. fumigatus and A. ustus). Compounds I [R = 4-Me, 2-Cl; X = S] could be classified as broad-spectrum fungicides, emerging as possible candidates for the control of these molds, which had neg. impact in food production

RSC Advances published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H6ClF3, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Serrano, Jose S. published the artcileCompared efficacy of quinidine, GABA and N-trimethyl GABA upon a model of ventricular automaticity, Recommanded Product: 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, the publication is Methods and Findings in Experimental and Clinical Pharmacology (1983), 5(4), 251-4, database is CAplus and MEDLINE.

The effects of GABA  [56-12-2], its quaternary derivative N-trimethyl-GABA  [10329-41-6], and quinidine  [56-54-2] were studied in a model of ventricular automaticity induced in the isolated ventricle of the rat. GABA showed low antiautomatic activity. N-Trimethyl-GABA and quinidine were, however, very effective drugs in the reduction of the automatic ventricular rate. The efficacies of the latter 2 drugs at 5 × 10^-5 M were not significantly different. Thus, N-trimethyl-GABA has antiautomatic activity in this exptl. model similar to that of the classic antidysrhythmic drug quinidine.

Methods and Findings in Experimental and Clinical Pharmacology published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C10H7NO3, Recommanded Product: 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Bailey, William J. published the artcilePyrolysis of esters. XXII. Synthesis of bisdienes from 2-hydroxymethyl-1,3-butadiene, Quality Control of 866-23-9, the publication is Journal of Organic Chemistry (1962), 2732-6, database is CAplus.

cf. CA 57, 4529d. A new synthesis of 2-hydroxymethyl-1,3-butadiene was developed, starting from commercially available 2-amino-2-ethyl-1,3-propanediol and involving a pyrolysis of an amine oxide as well as the pyrolysis of an ester. Hydroxymethylbutadiene treated with vinyl acetate in the presence of a mercuric oxide-boron trifluoride etherate mixture gave 38% bis(2-butadienylmethyl) acetal. Treatment of the hydroxymethylbutadiene with hexamethylene diisocyanate gave 76% solid bis(2-butadienylmethyl) hexamethylenecarbamate, while treatment with m-xylylene diisocyanate gave 91% solid bis(2-butadienylmethyl) m-xylylenecarbamate.

Journal of Organic Chemistry published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Quality Control of 866-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics