Chlorides-buliding-blocks

DeShong, Philip published the artcileIntermolecular and intramolecular azomethine ylide [3 + 2] dipolar cycloadditions for the synthesis of highly functionalized pyrroles and pyrrolidines, Safety of 2,3-Dibromopropionylchloride, the publication is Journal of Organic Chemistry (1985), 50(13), 2309-15, database is CAplus.

N-Alkyl and N-arylaziridines carrying a single carboxy ester function, e.g., I, undergo thermally induced electrocyclic ring opening to produce azomethine ylides, which subsequently react with acetylenes or olefins to yield substituted pyrroles, e.g., II, or pyrrolidines, e.g., III, resp. The [3 + 2] dipolar cycloaddition reaction can be performed in either an intermol. or intramol. mode and displays high regioselectivity and stereoselectivity with a variety of dipolarophiles. The yield of cycloadducts depends on the electronic characteristics and the substitution pattern of the dipolarophile, and on the mode of cycloaddition employed. In the intermol. reaction, the yield of adducts is poor unless the dipolarophile is activated. Intramol. cycloadditions with monosubstituted olefins or acetylenes give adducts in yields of 45-70%. Although the yields of adducts in these instances are moderate, the starting materials are readily prepared and the method is an effective means for the assembly of a structurally complex heterocyclic system with high regiochem. and stereochem. control of peripheral substituents. When the dipolarophilic component is disubstituted, the cycloaddition gives synthetically useful yields if the dipolarophile carries an electron-withdrawing functionality.

Journal of Organic Chemistry published new progress about 18791-02-1. 18791-02-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 2,3-Dibromopropionylchloride, and the molecular formula is C3H3Br2ClO, Safety of 2,3-Dibromopropionylchloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Patel, Daksha published the artcileThe cell labeling efficacy, cytotoxicity and relaxivity of copper-activated MRI/PET imaging contrast agents, Safety of 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, the publication is Biomaterials (2010), 32(4), 1167-1176, database is CAplus and MEDLINE.

A new class of nanoparticle-based dual-modality positron emission tomog./magnetic resonance imaging (PET/MRI) contrast agents has been developed. The probe consists of a superparamagnetic iron oxide (SPIO) or manganese oxide core coated with 3,4-dihydroxy-D,L-phenylalanine (dl-DOPA). The chelator 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) was conjugated to DOPA termini. The DOTA modified nanoparticles allow chelation of copper for PET imaging. These surface functionalized nanoparticle-based probes have been characterized by various anal. techniques. The cell-labeling efficacy, cytotoxicity and relaxivity of these nanoparticles have been evaluated and compared with the same properties of one of the most commonly utilized MRI contrast agents, Feridex. Evidently, this new nanoparticle has a great potential for use in cell tracking with MRI and PET in the absence of transfecting agent. It is noteworthy that there is a sharp increase in r₂ relaxivity of these nanoparticles on coordination with Cu²⁺ ions. Thus these iron oxide nanoparticles can also be explored as the smart magnetic resonance (MR) sensor for the detection of micromolar changes in copper concentration for neurodegenerative diseases such as Alzheimer’s disease, Menkes and Wilson’s diseases, amyotrophic lateral sclerosis and prion diseases.

Biomaterials published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Safety of 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Agelis, George published the artcileFacile and efficient syntheses of a series of N-benzyl and N-biphenylmethyl substituted imidazole derivatives based on (E)-urocanic acid, as angiotensin II AT1 receptor blockers, Computed Properties of 42074-68-0, the publication is Molecules (2013), 7510-7532, database is CAplus and MEDLINE.

In the present work, a facile and efficient route for the synthesis of a series of N-substituted imidazole derivatives is described. Docking studies have revealed that N-substituted imidazole derivatives based on (E)-urocanic acid may be potential antihypertensive leads. Therefore, new AT1 receptor blockers bearing either the benzyl or the biphenylmethyl moiety at the N-1 or N-3 position, either the (E)-acrylate or the propanoate fragment and their related acids at the C-4 position as well as a halogen atom at the C-5 position of the imidazole ring [I; R = CH:CHCO₂H, CH:CHCO₂Me, CH₂CH₂ CO₂H, CH₂CH₂CO₂Me] and [II; X = H, R = CH:CHCO₂R¹ or CH₂CH₂CO₂R¹, R¹ = H, Me, Q; X = Cl, Br, or iodo, R = CH₂CH₂R¹, R¹ = H or Q] were synthesized. The newly synthesized analogs were evaluated for binding to human AT1 receptor. The biol. results showed that this class of mols. possesses moderate or no activity, thus not always confirming high docking scores. Nonetheless, important conclusions can be derived for their mol. basis of their mode of action and help medicinal chemists to design and synthesize more potent ones. An aliphatic group as in losartan seems to be important for enhancing binding affinity and activity.

Molecules published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C19H14Cl2, Computed Properties of 42074-68-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Hagemann, Justin P. published the artcileDesigner ligands. Part 4. Synthesis of acyclic and macrocyclic platinum group metal-specific ligands, Quality Control of 1002-41-1, the publication is Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1999), 341-348, database is CAplus.

Synthetic pathways to a range of novel, polydentate, sulfur-containing, mono-amide ligands, e.g. mercaptoacetanilides I (R = H, MeO), designed to coordinate platinum group metals, have been developed. Access to the tetradentate systems was facilitated by the extensive use of disulfide linkages as a protection strategy.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry published new progress about 1002-41-1. 1002-41-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1,2-Bis(2-chloroethyl)disulfane, and the molecular formula is C4H8Cl2S2, Quality Control of 1002-41-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sato, Masakazu published the artcileSynthesis and evaluation of novel thiazolidine derivatives as thromboxane A₂ receptor antagonists, Related Products of chlorides-buliding-blocks, the publication is Chemical & Pharmaceutical Bulletin (1994), 42(3), 521-9, database is CAplus and MEDLINE.

3-Benzoyl or 3-phenylsulfonyl-2-substituted thiazolidine derivatives were prepared, and evaluated for their thromboxane A₂ (TXA₂) receptor-antagonizing effect on (15S)-15-hydroxy-11α,9α-(epoxymethano)prostathiazolidine derivative, 3-benzoyl-2-(4-hydroxy-3-methoxyphenyl)thiazolidine, showed mild TXA₂ receptor antagonist activity. Modification of the compound led to 2-chloro-4-[3-(4-chlorophenylsulfonyl)thiazolidin-2-ylmethyl]phenoxyacetates I (X = H, Cl; R² = H, OMe, halo; n = 0-2), one of which showed TXA₂ receptor antagonist activity.

Chemical & Pharmaceutical Bulletin published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C8H7ClO3, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Suzuki, Nobutaka published the artcilePhotochemical type I and II elimination reactions of dialkyl (trichloromethyl)phosphonates, Computed Properties of 866-23-9, the publication is Bulletin of the Chemical Society of Japan (1980), 53(5), 1421-4, database is CAplus.

Irradiation of CCl₃P(O)(OR)₂ (I; R = Et, Pr, CH₂CHMe₂) in MeCN gave the corresponding monoesters and olefins via photochem. type-II elimination. In addition, products via type-I elimination were obtained from I (R = Me, CH₂CHMe₂).

Bulletin of the Chemical Society of Japan published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H6BNO2, Computed Properties of 866-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Tamao, Kohei published the artcileCoupling of (amino)alkylchlorosilanes with lithium: new access to symmetrical di- and tetrafunctional alkyldisilanes, Product Details of C7H16Cl2Si, the publication is Organometallics (1993), 12(2), 580-2, database is CAplus.

Homocoupling reactions of amino- and diaminoalkylchlorosilanes with Li metal proceed readily in THF at room temperature to form the corresponding sym. diamino- and tetraaminoalkyldisilanes, resp., in high yields, which are transformed into chloroalkyldisilanes by the action of acyl chloride or dry HCl and into ethoxyalkyldisilanes by ethanolysis under mild conditions. The following are the compounds prepared in this study: XR¹R²SiSiR¹R²X where R¹ = R² = Me, X = Et₂N and Cl; R¹ = R² = iso-Pr, X = Et₂N and Cl; R¹ = Me,R² = n-hexyl, X = Et₂N, Cl and EtO, and X₂MeSiSiMeX₂ where X = Et₂N and EtO.

Organometallics published new progress about 14799-94-1. 14799-94-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(hexyl)(methyl)silane, and the molecular formula is C38H74Cl2N2O4, Product Details of C7H16Cl2Si.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Okawara, Tadashi published the artcileFacile synthesis of four-, five-, six-, and seven-membered heterocyclic compounds by the reaction of hydrazines and thiosemicarbazides with α- and β-halogenoacyl halides in a two-phase system, Application of 2,3-Dibromopropionylchloride, the publication is Journal of Chemical Research, Synopses (1987), 254-5, database is CAplus.

Phase-transfer cyclization of RNHNHR (I, R = Ph, Me) with R¹CHXCOCl (II, R¹ = H, X = Cl; R¹ = Me, Et, Ph, X = Br) in the presence of PhCH₂N⁺Et₃ Cl^– gave diazetidinones III (R² = R) in 20-45% yields. Cyclization of thiosemicarbazides R³NHCSNHNH₂ (R³ = Bu, cyclohexyl, PhCH₂, Ph) with ClCH₂COCl gave diazetidinones III [R = R¹ = H, R² = C(:NR³)SCOCH₂Cl] in 52-84% yields. Similar cyclization of R⁴NHCSNMeNHMe (R⁴ = Ph, cyclohexyl, 1-naphthyl) with II gave thiadiazinone derivatives IV in 52-81% yields. Cyclization of I (R = Ph) with XCH₂CR⁵R⁶COCl (V, R⁵ = H, Me, R⁶ = X = Br; R⁵ = R⁶ = Me, X = Cl) gave diphenylpyrazolinones VI. Phase-transfer cyclization of R⁷NHCSNR⁸NH₂ (R⁷ = cyclohexyl, R⁸ = H, Me) with V (R⁵ = R⁶ = Me, X = Cl) gave 1,3,4-thiadiazepines, e.g. VII, along with azetidinone derivatives

Journal of Chemical Research, Synopses published new progress about 18791-02-1. 18791-02-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 2,3-Dibromopropionylchloride, and the molecular formula is C3H3Br2ClO, Application of 2,3-Dibromopropionylchloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Jankowiak, Aleksandra published the artcile4-Substituted 1-Acyloxypyridine-2(1 H)-thiones: Experimental and Computational Studies of the Substituent Effect on Electronic Absorption Spectra, SDS of cas: 6313-54-8, the publication is Journal of Organic Chemistry (2009), 74(19), 7441-7448, database is CAplus and MEDLINE.

A series of eight 4-substituted 1-(adamantane-1-carbonyloxy)-4-X-pyridine-2(1H)-thiones (1, X = H, OC₇H₁₅, Me, CF₃, SC₃H₇, CN, COOMe, and Cl) was prepared and characterized by UV-vis spectroscopy in MeCN and cyclohexane. The observed lowest energy transition, designated as π_CS → π*_ring, exhibits a substantial substituent effect and λ_max ranges from 333 (X = OC₇H₁₅) to 415 nm (X = CN). Exptl. λ_max values for all esters except for 1b (X = OC₇H₁₅) correlate with the σ_p^– parameter (ρ = 0.41 ± 0.03, r² = 0.95). In contrast, the energy of the absorption band at about 295 nm, designated as π_CS → π*_CS, is practically substituent independent. Both absorption bands exhibit a modest neg. solvatochromic effect. The exptl. absorption energies correlate better with excitation energies calculated for N-acetyloxy analogs 2 with the ZINDO//DFT than with the TD-DFT//DFT method. Calculations for a series of 12 N-acetates 2 predict the most blue-shifted π → π* transition for the alkoxy substituent and most red-shifted for the NO₂ group relative to the parent 2a (X = H).

Journal of Organic Chemistry published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, SDS of cas: 6313-54-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Mandour, A. H. published the artcileSynthesis of N-(Coumarinsulfonyl)thiohydantoin and -hydantoin derivatives, Product Details of C9H5ClO4S, the publication is Afinidad (2000), 57(489), 344-348, database is CAplus.

Acylation of glycine with 6-coumarinylsulfonyl chloride or (6-nitro-3-coumarinyl)sulfonyl chloride gave N-[(coumarinyl)sulfonyl]glycine derivatives Treatment of the latter compounds with ammonium thiocyanate and acetic anhydride afforded N-[(coumarinyl)sulfonyl]-3-thiohydantoins. The key intermediates thus prepared were 1-[(2-oxo-2H-1-benzopyran-6-yl)sulfonyl]-2-thioxo-4-imidazolidinone and 1-[(6-nitro-2-oxo-2H-1-benzopyran-3-yl)sulfonyl]-2-thioxo-4-imidazolidinone. Hydrolysis of these intermediates using aqueous chloroacetic acid gave N-[(coumarinyl)sulfonyl]hydantoins. Thus, the above (thioxo)imidazolidinones were transformed into the resp. diones, 1-[(2-oxo-2H-1-benzopyran-6-yl)sulfonyl]-2,4-imidazolidinedione and 1-[(6-nitro-2-oxo-2H-1-benzopyran-3-yl)sulfonyl]-2,4-imidazolidinedione. Condensation of N-[(coumarinyl)sulfonyl]-3-thiohydantoins and N-[(coumarinyl)sulfonyl]-3-hydantoins with (arylidene)malononitrile in piperidine gave the corresponding pyrano[2,3-d]imidazolidines. Also, the condensation of the above intermediates with aromatic aldehyde led to the formation of 5(arylidene)thiohydantoins and 5-(arylidene)hydantoins. The condensation of the latter compounds with malononitrile was also carried out.

Afinidad published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C9H5ClO4S, Product Details of C9H5ClO4S.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics