Chlorides-buliding-blocks

Zhang, Hui published the artcileAltering intercomponent interactions in a photochromic multi-state [2]rotaxane, Quality Control of 219537-97-0, the publication is Organic & Biomolecular Chemistry (2011), 9(11), 4051-4056, database is CAplus and MEDLINE.

Rotaxanes have attracted much attention because of their challenging constructions and potential applications. In this paper, a multi-state [2]rotaxane, in which a dithienylethene-functionalized dibenzo-24-crown-8 macrocycle was interlocked onto a thread component bearing a 4-morpholin-naphthalimide fluorescent stopper and two distinct recognition sites, namely, dibenzylammonium and N-methyltriazolium recognition sites, was prepared and studied. By introducing a dithienylethene photochrome into the macrocycle component, multi-mode alteration of the intercomponent interactions, such as energy transfer, electron transfer, and charge transfer interaction between the photochrome and the fluorescent naphthalimide stopper could be altered in this multi-state rotaxane system in response to the combination of chem. and photochem. stimuli.

Organic & Biomolecular Chemistry published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C20H21ClN4O4, Quality Control of 219537-97-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ogris, Manfred published the artcileNovel biocompatible cationic copolymers based on polyaspartylhydrazide being potent as gene vector on tumor cells, COA of Formula: C7H16ClNO2, the publication is Pharmaceutical Research (2007), 24(12), 2213-2222, database is CAplus and MEDLINE.

The reaction between α,β-poly(aspartylhydrazide) (PAHy), a water soluble synthetic polymer and 3-(carboxypropyl)trimethyl-ammonium chloride (CPTACl) produced copolymers bearing permanent pos. charges (PAHy-CPTA) with mol. weight of 10 kDa and PAHy-CPTA copolymers differing in pos. charge amount (18-58%) were chosen for biol. investigations. Biophys. properties of DNA/PAHy-CPTA polyplexes were evaluated in terms of DNA condensation, zeta potential and size distribution. Cytotoxicity studies on Neuro2A murine neuroblastoma cells evidenced absence of toxicity of these copolymers up to 300 μg/mL unlike linear polyethylenimine (LPEI) that was highly toxic already at 20 μg/mL. PAHy-CPTA copolymers did not induce any erythrocyte aggregation up to 1 mg/mL. Cellular interaction studies of PAHy-CPTA polyplexes evidenced a faster binding of these polyplexes with cells compared to DNA/LPEI polyplexes. The in vitro transfection ability of PAHy-CPTA polyplexes was strongly affected by exptl. conditions reaching about 10% of the transfection efficiency of optimized LPEI polyplexes. Finally, in vivo application studies confirmed the biocompatibility of PAHy-CPTA copolymers. With LPEI, clear signs of microvesicular fatty liver were observed and with LPEI polyplexes significant weight loss. In strong contrast, PAHy-CPTA did not induce histopathol. changes or weight loss.

Pharmaceutical Research published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, COA of Formula: C7H16ClNO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Majewski, Piotr published the artcileSynthesis of Dichloromethylphosphonates, SDS of cas: 866-23-9, the publication is Phosphorus, Sulfur and Silicon and the Related Elements (2009), 184(4), 956-962, database is CAplus.

Efficient synthesis of O,O-dialkyl, O-alkyl-N,N-dialkylamido and N,N,N’,N’-tetraalkyldiamido dichloromethylphosphonates via treatment of O,O-dialkyl, O-alkyl-N,N-dialkylamido, and N,N,N’,N’-tetraalkyldiamido trichloromethylphosphonates with di-Et phosphite in the presence of triethylamine in ethanol has been described.

Phosphorus, Sulfur and Silicon and the Related Elements published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, SDS of cas: 866-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Merchant, Jaysukhlal R. published the artcileSynthesis of sulfones with antitubercular activity, Application of Coumarin-6-sulfonyl chloride, the publication is Chemistry & Industry (London, United Kingdom) (1982), 955, database is CAplus.

6-Coumarylsulfonyl chlorides underwent Friedel-Crafts reaction with aromatic compounds to give 6-coumaryl aryl sulfones in 30-40% yield. E.g., treatment of sulfonyl chloride I (R = Cl) with PhEt for 4 h at 100° in the presence of AlCl₃ gave I (R = C₆H₄Et-p) (II). The sulfones were generally active against Mycobacterium tuberculosis.

Chemistry & Industry (London, United Kingdom) published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C9H5ClO4S, Application of Coumarin-6-sulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Takahashi, Hidehiko published the artcileRelation between the hypotensive activity and chemical structure of γ-aminobutyric acid in the rabbit, Application of 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, the publication is Japan. J. Physiol. (1962), 97-105, database is CAplus.

γ-Aminobutyric acid applied intrathecalty gave a stronger and longer depressor response than that given intravenously. Me esters and N-substitution of γ-aminobutyric acid gave little response when applied intrathecally.

Japan. J. Physiol. published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C18H19ClN4, Application of 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Pashynska, Vlada A. published the artcileOn the stability of the organic dication of the bisquaternary ammonium salt decamethoxinum under liquid secondary ion mass spectrometry, Recommanded Product: N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, the publication is Rapid Communications in Mass Spectrometry (2005), 19(6), 785-797, database is CAplus and MEDLINE.

In the course of a liquid secondary ion mass spectrometric (SIMS) investigation on a bisquaternary ammonium antimicrobial agent, decamethoxinum, unusual pathways of fragmentation of the organic dication M²⁺ of this bisquaternary salt, with preservation of the doubly charged state of the fragments, were observed To reveal the structural and electronic parameters of decamethoxinum, which are responsible for the stabilization of its organic dication in the gas phase, a comprehensive SIMS study using metastable decay, collision-induced dissociation and kinetic energy release techniques complemented by ab initio quantum chem. calculations was performed. Pathways of fragmentation of two main precursors originating from decamethoxinum – organic dication M²⁺ and its cluster with a Cl^– counterion [M·Cl]⁺ – and a number of their primary fragments were established and systematized. Differences in the pathways of fragmentation of M²⁺ and [M·Cl]⁺ were revealed: the main directions of [M·Cl]⁺ decay involve dequaternization similar to thermal degradation of this compound, while in M²⁺ fragmentation via loss of one and two terminal radicals with preservation of the doubly charged state of the fragments dominates over charge separation processes. It was shown that pairing of the dication with a Cl^– anion does not preserve the complex from fragmentation via separation of two pos. charged centers or neutralization (dequaternization) of one such center. At the same time the low abundance of M²⁺ in the SIMS spectra is to a larger extent controlled by a probability of M²⁺ association with an anion than by the decay of the dication per se. Quantum chem. calculations of the structural and electronic parameters of the decamethoxinum dication have revealed at least three features which can provide stabilization of the doubly charged state. Firstly, in the most energetically favorable stretch conformation the distance between the quaternary nitrogens (r_N1-N2 = 1.39 nm) is relatively large. Secondly, an intramol. solvation of quaternary groups by carbonyl oxygens of the adjacent groups of the dication occurs, which contribute to structural stabilization. Thirdly, an important feature of the electronic structure of the dication is the presence of a partial neg. charge on the nitrogen atoms and smearing of a pos. charge mainly over the hydrogens of alkyl groups attached to the quaternary nitrogens, which reduces the net repulsion between the quaternary groups. The possible influence of charge smearing on the kinetic energy released on the dication fragmentation is discussed.

Rapid Communications in Mass Spectrometry published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Recommanded Product: N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sukhodub, L. F. published the artcileMass spectrometry of decamethoxine, an antimicrobial drug, Quality Control of 38146-42-8, the publication is Antibiotiki i Khimioterapiya (1989), 34(11), 823-7, database is CAplus and MEDLINE.

Desorption mass spectrometry was a suitable method for identification and determination of a novel antimicrobial drug; decamethoxine (I). Thermal decomposition and mass spectrometric fragmentation of I under various ionization conditions are discussed.

Antibiotiki i Khimioterapiya published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C15H12O6, Quality Control of 38146-42-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Pokrovskii, V. A. published the artcileMatrix-assisted laser desorption/ionization mass spectrometric study of bisquaternary ammonium antimicrobial agent decamethoxinum in 2,5-dihydroxybenzoic acid, Safety of N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, the publication is Mass-Spektrometriya (2005), 2(3), 183-192, database is CAplus.

The results of investigation of decamethoxinum on matrix-assisted laser desorption/ionization (MALDI) time-of-flight mass spectrometer using 2,5-dihydroxybenzoic acid (DHB) matrix were presented. The MALDI mass spectra were obtained in the linear, reflectron and post source decay (PSD) modes. The spectra reveal diagnostic quasimol. ions of the decamethoxinum [Cat·Cl]⁺ and [Cat-H]⁺. The PSD data confirm that the pathways of unimol. decay of the [Cat·Cl]⁺ ions in the gas phase coincide with those of the salt thermal degradation via dequaternization; this agrees with the data obtained earlier with the use of secondary ion mass spectrometry. Abundant clusters containing Cat²⁺ and anions those originate from the DHB matrix were observed, and it was suggested that they were stabilized either by the electrostatic interactions with the carboxylic group (carboxylate anion) of DHB or due to the cation-π interactions with the DHB aromatic ring.

Mass-Spektrometriya published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Safety of N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Pashynskaya, V. A. published the artcileMechanistic investigation of the interaction between bisquaternary antimicrobial agents and phospholipids by liquid secondary ion mass spectrometry and differential scanning calorimetry, Formula: C38H74Cl2N2O4, the publication is Rapid Communications in Mass Spectrometry (2002), 16(18), 1706-1713, database is CAplus and MEDLINE.

Mechanisms of interaction between the antimicrobial drugs decamethoxinum and aethonium, which are based on bisquaternary ammonium compounds, and a phospholipid component of biol. membranes, dipalmitoylphosphatidylcholine, were studied by means of liquid secondary ion mass spectrometry (LSIMS) and differential scanning calorimetry (DSC). Supramol. complexes of the drugs with this phospholipid were recorded under secondary ion mass spectrometric conditions. The dependence of the structures of these complexes on structural parameters of the dications of the bisquaternary ammonium compounds was demonstrated. Tandem mass spectrometric investigations of the metastable decay of doubly charged ions of decamethoxinum and aethonium complexes with dipalmitoylphosphatidylcholine allowed estimation of structural parameters of these complexes in the gas phase. Interactions of decamethoxinum and aethonium with model membrane assemblies built from hydrated dipalmitoylphosphatidylcholine were studied using DSC. It was shown that while both drugs can interact with model membranes, the mechanisms of such interactions for decamethoxinum and aethonium differ. The correlation between the nature of these interactions and structural and electronic parameters of the dications of the two bisquaternary agents is discussed. Interpretation of combined mass spectrometric and calorimetric exptl. data led to proposals that the mol. mechanisms of antimicrobial action of bisquaternary ammonium compounds are related to their effect on the membrane phospholipid components of microbial cells.

Rapid Communications in Mass Spectrometry published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Formula: C38H74Cl2N2O4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Pashynska, V. A. published the artcileStudy of non-covalent complexes formation between the bisquaternary ammonium antimicrobial agent decamethoxinum and membrane phospholipids by electrospray ionization and collision-induced dissociation mass spectrometry, Category: chlorides-buliding-blocks, the publication is Visnik Kharkivs’kogo Natsional’nogo Universitetu im. V. N. Karazina (2004), 123-130, database is CAplus.

The noncovalent complex formation between the membrane phospholipid, dipalmitoylphosphatidylcholine, and the bisquaternary ammonium antimicrobial agent, decamethoxinum, which is related to its biol. activity, was studied by electrospray ionization (ESI) mass spectrometry and collision-induced dissociation (CID) tandem mass spectrometry. Stable doubly-charged complexes of the drug dication with phospholipid mol. assemblies containing up to nine phospholipid mols., which model drug-phospholipid interactions in biol. membrane systems, were registered. For examination of the structure and the stability characteristics of the drug-phospholipid noncovalent complexes, their CID spectra were examined The developed ESI mass spectrometry methodol. is proposed for fast screening of bisquaternary ammonium compounds with antimicrobial activity.

Visnik Kharkivs’kogo Natsional’nogo Universitetu im. V. N. Karazina published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics