Chlorides-buliding-blocks

Tsuchida, Kouhei published the artcileConstruction of Chiral Tri- and Tetra-Arylmethanes Bearing Quaternary Carbon Centers: Copper-Catalyzed Enantioselective Propargylation of Indoles with Propargylic Esters, Application In Synthesis of 21286-54-4, the publication is Angewandte Chemie, International Edition (2016), 55(33), 9728-9732, database is CAplus and MEDLINE.

Copper-catalyzed enantioselective propargylation of indoles with propargylic esters and sequential Huisgen cycloaddition with azides lead to the construction of chiral triarylmethanes, bearing a quaternary carbon center, with high to excellent enantioselectivities. The result described herein can be used in the enantioselective preparation of a tetraarylmethane.

Angewandte Chemie, International Edition published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C8H10O2, Application In Synthesis of 21286-54-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kodolov, V. I. published the artcileFrequency shift of the phosphorus:oxygen bond in organophosphorus compounds, Recommanded Product: Diethyltrichloromethylphosphonate, the publication is Trudy Instituta Khimii, Akademiya Nauk SSSR, Ural’skii Filial (1966), 99-101, database is CAplus.

Ir spectra were examined in the 1150-1350-cm.-1 region for (EtO)2PHO, MeP(O)(OEt)2, CH2:CHCH2P(O)(OEt)2, PhP(O)(OEt)2, CCl3P(O)(OEt)2, and PhPOCl2. The exptl. found values of vibrational frequencies of the P(O) bond agreed better with the values calculated by the L. C. Thomas equation (1964) than those calculated according to Griffin (1960).

Trudy Instituta Khimii, Akademiya Nauk SSSR, Ural’skii Filial published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Recommanded Product: Diethyltrichloromethylphosphonate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kodolov, V. I. published the artcilePossibilities for calculating stretching vibrational frequencies of the phosphorus=oxygen-group for some alkyl(aryl) phosphonates and aryl phosphates, Name: Diethyltrichloromethylphosphonate, the publication is Zhurnal Prikladnoi Spektroskopii (1967), 7(3), 382-6, database is CAplus.

Spectra of alkyl and aryl phosphates and of arylphosphates were measured in the liquid phase and in Nujol in the region 900-1900 cm.-1 The exptl. P:O group frequencies γPO were compared with values obtained by the calculation of γPO from Griffin (γPO = 1198 + 16.8 Σπ) and Thomas (γPO = 930 + 40 Σσ*) equations, where σ* = Taft constant and π = the electronegativity of the substituent. The comparison of exptl. and calculated γPO showed in phosphonates a better agreement if the Thomas equation were applied. The lower difference is explained by higher accuracy owing to π value application. The σ* is not precise because the interaction mass substituent is not taken into account. Tables give the charges, bond lengths and angles, electrostatic forces, and σk values for H, Me, CCl3, CHCl2, CH2Cl, Et, and Ph substituents. The differences between exptl. and calculated γPO were the same by the application of both equations in arylphosphates because only an insignificant effect of substituent polarity can occur in the neighborhood of the phosphate group.

Zhurnal Prikladnoi Spektroskopii published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Name: Diethyltrichloromethylphosphonate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Katsev, A. M. published the artcileStudy of interactions between cationic surface-active antiseptics and serum albumin by bacterial bioluminescence, Application of N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, the publication is Klinicheskaya Laboratornaya Diagnostika (2002), 39-41, database is CAplus and MEDLINE.

Human serum albumin binding of cationic surface-active antiseptics was studied using a Photobacterium phosphoreum K3 strain isolated in the Black Sea. Binding of cationic surface-active proteins to serum albumin led to disappearance of toxic and antibacterial characteristics of miramistin, ethonium, and decametoxin, but not chlorhexidine. The activity of chlorohexidine was reduced by 45-8% in the presence of albumin. Albumin binding capacity towards miramistin was 7.0-8.7%, towards ethonium 8.2-10%, and towards decametoxin 2.4-3%.

Klinicheskaya Laboratornaya Diagnostika published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Application of N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Su, Helen C. F. published the artcileSynthesis of possible cancer chemotherapeutic compounds based on enzyme approach. III. 1,2,3-Oxadithiolane 2-oxide, Product Details of C4H8Cl2S2, the publication is Journal of Organic Chemistry (1961), 4993-5, database is CAplus.

1,2,3-Oxadithiolane 2-oxide (I) was prepared from mercaptoethanol (II) and SOCl₂ in CHCl₃. The 5-Me derivative (III) was prepared by this method. Attempted preparation of the 5-Ph derivative under the same conditions led only to 2,5-diphenyl-p-dithiane (IV). Treatment of I with K₂CO₃ gave CO₂, SO₂, and ethylene sulfide. Bromination of I with Br yielded bis(2-bromoethyl) disulfide (V) and with N-bromosuccinimide, yielded N-(2-bromoethylthio)succinimide (VI). II (156 g.) in 150 ml. CHCl₃ and 262 g. SOCl₂ added dropwise into 200 ml. CHCl₃ at room temperature and stirred 5 hrs. gave 176 g. I, b₃ 77-9°, n²⁰_D 1.5771, 22.3% 2-chloro-2′-mercaptodiethyl sulfide, b₄ 91-4°, n²⁰_D 1.5653, 1.5% p-dithiane, flakes, m. 111-12°, and a residual paste which, treated with hot concentrated H₂SO₄-HNO₃, gave a gray sponge. Isopropenyl acetate (20 g.) treated dropwise with 16.7 g. thiolacetic acid and the mixture heated 2 hrs. gave 74% 1-acetoxythioisopropyl acetate (VII), b_0.65-0.70 56.5-8.0°, n³³_D 1.4635. VII refluxed with 1% MeOH-HCl for 7 hrs. and evaporated gave 2-hydroxypropyl mercaptan, b_46-7 75-9°, n³⁰_D 1.4818. III, prepared in 3 hrs. at 28-30° by the same method used for I, b_1.7-2.1 72-85°, m. 39-9.5°; distillation of the residue gave a dark liquid, b_1.6-2.1 82-120°. Attempted redistillation of this product led to severe decomposition Styrene oxide (36 g.) added in 5 hrs. to 30 g. Ba(OH)₂ in 75% alc. saturated with H₂S below 30°, H₂S passed in for 1 hr. longer and the mixture saturated with CO₂ and extracted gave 76.8% 1-phenyl-2-mercaptoethanol (VIII), b_3.7-4.1 124.5-7.0°, n²⁷_D 1.5803. VIII (31.5 g.) and 35.7 g. SOCl₂ added simultaneously to CHCl₃ at 25-30°, stirred 5 hrs., evaporated, and the liquid treated with C in CHCl₃, concentrated, and triturated with Et₂O gave IV, flakes, m. 212-14°. The solvent filtrate further concentrated gave rhombic crystals of S, m. 113-15°. Equimolar amounts of I and K₂CO₃ heated to the point where gas was evolved gave almost quant. yields of CO₂ and SO₂ and 2.3 ml. ethylene sulfide, b. 55-6°, n²⁰_D 1.4821. I (12.4 g.) was added dropwise to a preheated flask at 270°/130-5 mm. and the products distilled to give S and unchanged I, H₂O and a rubbery substance, and a mixture of SO₂, H₂O, and more rubbery product. I (12.4 g.) in 100 ml. CCl₄ treated at -5° with 16 g. Br in 20 ml. CCl₄, and the mixture stirred 5 hrs. at room temperature and distilled gave 4.5 g. V, b_0.5-.055 103-6°, n¹⁹_D 1.6190. N-Bromosuccinimide (17.8 g.) added portionwise to 12.4 g. I in 100 ml. CCl₄ at 15-20° and the mixture heated 6 hrs. at 25-30° gave 8 g. VI, m. 89-90.5°. The liquid was evaporated to give a small amount of V. I (28.3 g.) containing 0.1 g. Bz₂O₂ treated at -5° with Cl, stirred 3 hrs. at 0°, then overnight at room temperature, and distilled gave 63% V. I (12.4 g.) and 13.4 g. N-chlorosuccinimide refluxed 8 hrs. in 100 ml. CCl₄ gave succinimide. The CCl₄ solution afforded some I and 1.5 g. bis(2-chloroethyl) disulfide, b_0.8 80-7°, n²⁰_D 1.5634. III treated with Br in CCl₄ as above gave bis(g-bromopropyl) disulfide, b_0.8 113-14°, n²²_D 1.5805. Infrared spectra were given for the above compounds

Journal of Organic Chemistry published new progress about 1002-41-1. 1002-41-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1,2-Bis(2-chloroethyl)disulfane, and the molecular formula is C8H5F3O2S, Product Details of C4H8Cl2S2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Akapo, S. O. published the artcileThe production of stable, uniform reverse phases for liquid chromatography by oligomeric synthesis, Related Products of chlorides-buliding-blocks, the publication is Journal of Liquid Chromatography (1991), 14(2), 217-36, database is CAplus.

The use of oligomeric synthesis for the preparation of reverse phases by a fluidized bed technique is described. Reverse phases comprising 1-10 oligomers were synthesized and the phys. and chromatog. properties of each phase examined The nature of the interactions were investigated by measuring the excess free enthalpies of absorption of a homologous series of aromatic hydrocarbons and aromatic esters from retention measurements taken at different temperatures It is shown that a reverse phase comprising ≥5 oligomers behaves as a true dispersive phase, has consistent and predictable retentive properties, and is far more stable to acid conditions than the normal type reverse phase.

Journal of Liquid Chromatography published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C9H20Cl2Si, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sonoshita, Masahiro published the artcileA whole-animal platform to advance a clinical kinase inhibitor into new disease space, Quality Control of 32333-53-2, the publication is Nature Chemical Biology (2018), 14(3), 291-298, database is CAplus and MEDLINE.

Synthetic tailoring of approved drugs for new indications is often difficult, as the most appropriate targets may not be readily apparent, and therefore few roadmaps exist to guide chem. Here, we report a multidisciplinary approach for accessing novel target and chem. space starting from an FDA-approved kinase inhibitor. By combining chem. and genetic modifier screening with computational modeling, we identify distinct kinases that strongly enhance (‘pro-targets’) or limit (‘anti-targets’) whole-animal activity of the clin. kinase inhibitor sorafenib in a Drosophila medullary thyroid carcinoma (MTC) model. We demonstrate that RAF-the original intended sorafenib target-and MKNK kinases function as pharmacol. liabilities because of inhibitor-induced transactivation and neg. feedback, resp. Through progressive synthetic refinement, we report a new class of ‘tumor calibrated inhibitors’ with unique polypharmacol. and strongly improved therapeutic index in fly and human MTC xenograft models. This platform provides a rational approach to creating new high-efficacy and low-toxicity drugs.

Nature Chemical Biology published new progress about 32333-53-2. 32333-53-2 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Sulfonyl chlorides,Benzene, name is 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride, and the molecular formula is C8H10S, Quality Control of 32333-53-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wang, Dengjin published the artcileOne-Carbon Chain Extension of Esters to α-Chloroketones: A Safer Route without Diazomethane, Name: trimethyloxosulphonium chloride, the publication is Journal of Organic Chemistry (2004), 69(5), 1629-1633, database is CAplus and MEDLINE.

The reaction of a variety of Me esters with dimethylsulfoxonium methylide at 0-25 °C affords the chain-extended β-keto dimethylsulfoxonium ylides. Subsequent treatment with hydrogen chloride in THF proceeds with loss of DMSO to afford the corresponding α-chloro ketones. This sequence has been utilized to convert the Me esters of CBZ-protected alanine and valine to the anti N-protected α-amino epoxides, which are important pharmaceutical intermediates. When the same protocol is applied to BOC-protected phenylalanine Me ester, epimerization occurs so that the use of a more reactive aryl ester is required. This chem. provides a practical route to α-chloroketones that avoids the use of toxic and explosive diazomethane.

Journal of Organic Chemistry published new progress about 5034-06-0. 5034-06-0 belongs to chlorides-buliding-blocks, auxiliary class Salt,Aliphatic hydrocarbon chain, name is trimethyloxosulphonium chloride, and the molecular formula is C11H14O2, Name: trimethyloxosulphonium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Spinnato, Davide published the artcileA Photochemical Organocatalytic Strategy for the α-Alkylation of Ketones by using Radicals, Formula: C8H6ClF3, the publication is Angewandte Chemie, International Edition (2020), 59(24), 9485-9490, database is CAplus and MEDLINE.

Reported herein is a visible-light-mediated radical approach to the α-alkylation of ketones. This method exploits the ability of a nucleophilic organocatalyst to generate radicals upon S_N2-based activation of alkyl halides and blue light irradiation The resulting open-shell intermediates are then intercepted by weakly nucleophilic silyl enol ethers, which would be unable to directly attack the alkyl halides through a traditional two-electron path. The mild reaction conditions allowed functionalization of the α position of ketones with functional groups that are not compatible with classical anionic strategies. In addition, the redox-neutral nature of this process makes it compatible with a cinchona-based primary amine catalyst, which was used to develop a rare example of enantioselective organocatalytic radical α-alkylation of ketones. Thus, e.g., treatment of acetophenone O-TBS silyl enol ether with chloroacetonitrile afforded I (91%) in presence of dithiocarbonyl catalyst II using blue LED irradiation and TFA or TBAF workup.

Angewandte Chemie, International Edition published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C9H10O3S, Formula: C8H6ClF3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Bourquin, J. P. published the artcileSyntheses in the phenothiazine family. II. N-Substituted phenothiazinethiol derivatives, Formula: C5H13Cl2N, the publication is Helvetica Chimica Acta (1958), 1072-108, database is CAplus.

cf. C.A. 52, 18423d. 2-(N-Methyl-2-pyrrolidyl)ethanol (31.0 g.) in 200 ml. CHCl₃ treated with HCl 10 min. at 10°, 59.0 g. SOCl₂ added, after 2 hrs. at 70° the mixture concentrated, treated with 160 ml. 3N NaOH, extracted with Et₂O, and the dried extracts distilled gave 90% 2-(N-methyl-2-pyrrolidyl)-1-chloroethane (I), b₁₁ 65-6°; picrate, m. 133-5° (EtOH). BuNHMe (60.9 g.) and 54.6 g. Br(CH₂)₃Cl in boiling Et₂O 24 hrs. gave 68% BuMeN(CH₂)₃Cl, b₁₃ 71-2°; picrate, m. 94-6° (EtOH). BrCH₂CHMeCH₂Cl (68.6 g.), 36.0 g. Me₂NH, and 20 ml. C₆H₆ heated in an autoclave at 110° 7 hrs., 100 ml. H₂O and 320 ml. 10% HCl added, and the mixture extracted with 250 ml. Et₂O and 140 ml. 30% NaOH gave 68% Me₂NCH₂CHMeCH₂Cl, b₁₁ 35-6°. To 50.0 g. N-methylpiperazine in 150 ml. MeOH was added 37.7 g. propylene oxide, the mixture boiled 3 hrs., and distilled giving 70% N-methyl-N’-(2-hydroxypropyl)piperazine (II), b₁₁ 91-3°. II (50.7 g.) in 250 ml. C₆H₆ saturated with HCl, 78.2 g. SOCl₂ added, the mixture refluxed 5 hrs. then concentrated, 100 ml. H₂O and 120 ml. 30% NaOH added, the mixture extracted with 600 ml. C₆H₆, and the extract distilled gave 60% N-methyl-N’-(2-chloropropyl)piperazine, b₁₁ 87-9°; di-HCl salt, m. 233-5° (EtOH). N-Methylpiperazine (46.8 g.) and 40 g. BrCH₂CHMeCH₂Cl in 120 ml. refluxing Et₂O 24 hrs. gave 30% N-methyl-N’-(3-chloro-2-methylpropyl)piperazine, b₁₁ 99-100°; di-HCl salt, m. 234-6° (MeOH). Similarly, 233 g. N-benzylpiperazine and 104 g. Br(CH₂)₃Cl in 370 ml. Et₂O 48 hrs. gave 75% N-benzyl-N’-(3-chloropropyl)piperazine, b_0.01 132-6°; di-HCl salt, m. 249-51° (absolute EtOH). 2-(Methylthio)phenothiazine (III) (16.65 g.), 3.18 g. NaNH₂, and 100 ml. absolute xylene refluxed 3 hrs., 10.0 g. I in 10 ml. absolute xylene added during 1.5 hrs., after refluxing 3 hrs. and cooling 5 g. NH₄Cl and 150 ml. H₂O added, the xylene layer extracted with 115 ml. 15% tartaric acid, 35 ml. concentrated NaOH added, and the freed base extracted with 100 ml. C₆H₆ gave 85% 10-[2-(N-methyl-2-pyrrolidyl)ethyl]-2-(methylthio)phenothiazine, b_0.008 209°; tartrate, sintered 70°, m. 115°. Similarly prepared were the following 10-[2-(N-methyl-2-pyrrolidyl)ethyl]-2-(alkylthio)phenothiazines (alkyl groups given): Et, b_0.01 213° (tartrate-0.5-H₂O, sintered 65°, m. 90°); iso-Pr, b_0.008 217° (tartrate-0.5H₂O, sintered 70°, m. 90°); Bu, b_0.01 225° (tartrate-0.5H₂O, sintered 60°, m. 75°). 10-[2-(N-Methyl-2-piperidyl)ethyl]-2-(alkylthio)phenothiazines (alkyl groups given): Et (IV) [80% from 18.89 g. 2-(ethylthio)phenothiazine (V) and 14.7 g. 2-(N-methyl-2-piperidyl)-1-chloroethane], b_0.008, m. 57-9° (iso-PrOH) (tartrate, sintered 70°, decompose 135°); Pr, b_0.01 247° (tartrate, sintered 70°, decompose 120°); iso-Pr, b_0.05 223°, m. 73-5° (tartrate, sintered 70°, decompose 120°); Bu, b_0.005 227°; iso-Bu, b_0.003 215°; sec-Bu, b_0.007 215°; n-hexyl, b_0.015 235°; PhCH₂ (VI), b_0.01 246° (tartrate-0.5-H₂O, sintered 75°, m. 105°). 10-(N-Methyl-3-piperidylmethyl)-2-alkylphenothiazines (alkyl groups given): Me [60% from 50.0 g. III and 33.8 g. N-methyl-3-(chloromethyl)piperidine], b_0.01 207° [HCl salt, sintered 110°, decompose 124-6° (Me₂CO); tartrate-0.5H₂O, sintered 75°, decompose 140° (EtOAc); oxalate, decompose 182-4° (absolute EtOH)]; Et, b_0.01 222° (tartrate, sintered 75°, m. 140°); Pr, b_0.01 225°, sintered 85°, m. 145°; iso-Pr, b_0.01 216° (tartrate-0.5H₂O, sintered 75°, decompose 140°); Bu, b_0.01 223° (tartrate, sintered 80°, decompose 100°); iso-Bu, b_0.005 207° (tartrate-0.5H₂O, sintered 85°, m. 120°); sec-Bu, b_0.005 206°, tartrate-0.5H₂O, sintered 80°, m. 110°); PhCH₂, b_0.007 236° (tartrate-H₂O, sintered 90°, m. 120°). 10-(3-Dimethylaminopropyl)-2-(alkylthio)phenothiazines (alkyl group given): Et (80-5% from 20.0 g. V and 11.3 g. Me₂N(CH₂)₃Cl), b_0.008 200° [tartrate, sintered 110°, m. 117-9° (absolute EtOH)]; Pr, b_0.02 227° (tartrate-0.5H₂O, sintered 55°, decompose 90°); iso-Pr, b_0.01 198° (tartrate-0.5H₂O, sintered 60°, decompose 90°; oxalate, decompose 206-8°); Bu, b_0.005 202°; iso-Bu, b_0.004 195°; sec-Bu, b_0.006 189°; PhCH₂, b_0.01 224° (tartrate, sintered 65°, m. 85°). 10-Dialkylaminoalkyl-2-(methylthio)phenothiazines (dialkylaminoalkyl groups given): Me₂NCH₂CH₂ (85% from 50.0 g. III and 22.0 g. Me₂NCH₂CH₂Cl), b_0.01 195-6°, m. 72-4° (iso-PrOH) [HCl salt, m. 175-7° (absolute EtOH)]; Et₂NCH₂CH₂, b_0.01 198° (HCl salt, m. 160-2°); Et₂NCHMeCH₂, b_0.01 182° (HCl salt, sintered 194°, m. 202-4°); 2-(N-pyrrolidyl)ethyl, b_0.01 219-21°, m. 73-5° (HCl salt, m. 170-2°); 2-(N-methyl-N’-piperazyl)ethyl, b_0.02 228-30°, m. 85-7° (di-HCl salt, decompose 243-5°); 3-(N-piperidyl)propyl, b_0.05 235-7° (tartrate, sintered 65°, decompose 100°; methobromide, sintered 165°, m. 178-80°); 3-(N-benzyl-N’-piperazyl)propyl, m. 82-4° (di-HCl salt, sintered 225°, decompose 236-8°); 3-(N-morpholyl)propyl, b_0.03 240-2°, m. 100-2° (HCl salt, sintered 146°, m. 152-4°); 2-(N-pyrrolidyl)propyl, b_0.015 204° (HCl salt, m. 177-9°); 2-(N-methyl-N’-piperazyl)propyl, b_0.01 211° (di-HCl salt-0.5H₂O, sintered 210°, m. 224-6°). 10-Dialkylaminoalkyl-2-(isopropylthio)phenothiazines: Me₂NCH₂CH₂, b_0.015 189° (HCl salt, m. 182-4°); Et₂NCH₂CH₂, b_0.01 187° (HCl salt, m. 162-4°);

Helvetica Chimica Acta published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C5H13Cl2N, Formula: C5H13Cl2N.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics