Chlorides-buliding-blocks

Wu, Jie published the artcileDesign, synthesis, and screening of novel ursolic acid derivatives as potential anti-cancer agents that target the HIF-1α pathway, Computed Properties of 620-20-2, the publication is Bioorganic & Medicinal Chemistry Letters (2019), 29(6), 853-858, database is CAplus and MEDLINE.

The transcription factor hypoxia-inducible factor-1α (HIF-1α) plays an important role in tumor angiogenesis, growth, and metastasis and is recognized as an important potential therapeutic target for cancer. Here, we designed and synthesized three novel series of ursolic acid derivatives containing an aminoguanidine moiety and evaluated them as HIF-1α inhibitors and anticancer agents using human cancer cell lines. Most of the compounds exhibited significant inhibition of HIF-1α transcriptional activity, as measured using a Hep3B cell-based luciferase reporter assay. Among these compounds, I was the most potent inhibitor of HIF-1α expression under hypoxic conditions (IC₅₀ 4.0 μM) and did not display significant cytotoxicity against any cell lines tested. The mechanism of action of I was investigated, we found that I downregulated HIF-1α protein expression, possibly by suppressing its synthesis, reduced production of vascular endothelial growth factor, and inhibited the proliferation of cancer cells.

Bioorganic & Medicinal Chemistry Letters published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C12H10FeO4, Computed Properties of 620-20-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Fu, Jun-Hao published the artcileEnantioselective vinylogous aldol/lactonization cascade reaction between β,γ-unsaturated amides and trifluoromethyl ketones: facile access to chiral trifluoromethyl dihydropyranones, Safety of 1-(2-Chlorophenyl)-2,2,2-trifluoroethanone, the publication is Organic & Biomolecular Chemistry (2020), 18(39), 7848-7851, database is CAplus and MEDLINE.

An efficient asym. vinylogous aldol/lactonization cascade reaction between β,γ-unsaturated amides I (R¹ = C₆H₅, 2-thienyl, 1-naphthyl, etc.) and trifluoromethyl ketones has R²C(O)CF₃ (R² = C₆H₅, 2-ClC₆H₄, CH=CHC₆H₅, etc.) been developed. Using a chiral cyclohexanediamine-based tertiary amine-thiourea catalyst II [Ar = 3,5-(CF₃)₂C₆H₃], optically active trifluoromethyl dihydropyranones (S)-III have been constructed in moderate-to-excellent yields (up to 99%) with excellent stereoselectivities (96-> 99.5% ee).

Organic & Biomolecular Chemistry published new progress about 5860-95-7. 5860-95-7 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Benzene,Ketone, name is 1-(2-Chlorophenyl)-2,2,2-trifluoroethanone, and the molecular formula is C8H4ClF3O, Safety of 1-(2-Chlorophenyl)-2,2,2-trifluoroethanone.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Lin, Runfeng published the artcileThe development of HEC-866 and its analogues for the treatment of idiopathic pulmonary fibrosis, Name: 3-Chloro-4-fluoronitrobenzene, the publication is RSC Medicinal Chemistry (2021), 12(7), 1222-1231, database is CAplus and MEDLINE.

Idiopathic pulmonary fibrosis (IPF) is a chronic progressive lung disease with a typical survival time between three to five years. Two drugs, pirfenidone and nintedanib have been approved for the treatment of IPF, but they have limited efficacy. Thus, the development of new drugs to treat IPF is an urgent medical need. In this paper we report the discovery of a series of orally active pyrimidin-4(3H)-one analogs which exhibit potent activity in in vitro assays. Among them, HEC-866 showed promising efficacy in rat IPF models. Since HEC-866 also had good oral bioavailability, a long half-life and favorable long-term safety profiles, it was selected for further clin. evaluation.

RSC Medicinal Chemistry published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C6H3ClFNO2, Name: 3-Chloro-4-fluoronitrobenzene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Du, Qiuyao published the artcileSimultaneous determination and quantitation of hypolipidemic drugs in fingerprints by UPLC-Q-TRAP/MS, Formula: C12H15ClO3, the publication is Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences (2021), 122496, database is CAplus and MEDLINE.

An ultra-performance liquid chromatog. tandem triple quadrupole compound linear ion trap mass spectrometry (UPLC-Q-TRAP/MS) method was developed and validated for the detection of hypolipidemic drugs in fingerprints. 13 Hypolipidemic drugs were well separated by the gradient elution of 0.01% formic acid in water and methanol at a flow rate of 0.4 mL/min within 11 min. The analytes were detected in pos. (ESI⁺) and neg. (ESI^–) modes and scanned using scheduled multiple reaction monitoring-information dependent acquisition-enhanced product ion (SMRM-IDA-EPI) for best selectivity and sensitivity. The calibration curves showed good linearity in the range of 0.050-50.000 ng/patch with coefficients (r²) higher than 0.9904 for all analytes. Meantime, the LODs and LLOQs were in ranges of 0.001-0.034 and 0.003-0.050 ng/patch. The accuracies, intra-day and inter-day precision ranged from -13.3 to 0.3%, 1.1-10.4% and 3.7-14.5%, resp. The recoveries ranged from 79.9 to 114.8%, while the absolute and relative matrix effects were in the range of 83.0-107.2% and 2.2-9.7%. By comparing the non-spiked fingerprints from healthy volunteers with the fingerprints obtained from patients, demonstrated that the method was competent for determination and quantitation of hypolipidemic drugs in fingerprints.

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C12H15ClO3, Formula: C12H15ClO3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Li, Yuanfeng published the artcileAsymmetric Epoxidation of α,β-Unsaturated Ketones Catalyzed by Chiral Iron Complexes of (R,R)-3,4-Diaminopyrrolidine Derived N4-Ligands with Camphorsulfonyl Sidearms, Recommanded Product: ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, the publication is Asian Journal of Organic Chemistry (2020), 9(4), 616-621, database is CAplus.

Three (R,R)-3,4-diaminopyrrolidine-based chiral N₄ ligands and corresponding iron complexes were synthesized. The complexes were applied to the asym. epoxidation of various α,β-unsaturated ketones with H₂O₂ as an oxidant and carboxylic acid as an auxiliary. Good to excellent enantioselectivity (up to 97%) was achieved in the case of 2,2-dimethylbutyric acid as an auxiliary.

Asian Journal of Organic Chemistry published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Recommanded Product: ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Leimbacher, Markus published the artcileDiscovery of Small-Molecule Interleukin-2 Inhibitors from a DNA-Encoded Chemical Library, Recommanded Product: 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, the publication is Chemistry – A European Journal (2012), 18(25), 7729-7737, S7729/1-S7729/120, database is CAplus and MEDLINE.

Libraries of chem. compounds individually coupled to encoding DNA tags (DNA-encoded chem. libraries) hold promise to facilitate exceptionally efficient ligand discovery. We constructed a high-quality DNA-encoded chem. library comprising 30 000 drug-like compounds; this was screened in 170 different affinity capture experiments High-throughput sequencing allowed the evaluation of 120 million DNA codes for a systematic anal. of selection strategies and statistically robust identification of binding mols. Selections performed against the tumor-associated antigen carbonic anhydrase IX (CA IX) and the pro-inflammatory cytokine interleukin-2 (IL-2) yielded potent inhibitors with exquisite target specificity. The binding mode of the revealed pharmacophore against IL-2 was confirmed by mol. docking. Our findings suggest that DNA-encoded chem. libraries allow the facile identification of drug-like ligands principally to any protein of choice, including mols. capable of disrupting high-affinity protein-protein interactions.

Chemistry – A European Journal published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Recommanded Product: 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Li, He published the artcileAn improved method for the synthesis of phenylacetic acid derivatives via carbonylation, HPLC of Formula: 620-20-2, the publication is Journal of Chemical Research (2019), 43(11-12), 548-552, database is CAplus.

A series of phenylacetic acid derivatives RCH₂CO₂H [R = 2-ClC₆H₄, 4-MeC₆H₄, 2,4-Cl₂C₆H₃, etc.] was synthesized via bistriphenylphosphine palladium dichloride catalyzed carbonylation reaction of benzyl chloride derivatives in presence of tetraethylammonium chloride and sodium hydroxide as reagents and xylene as solvent at 80°C under a CO atm. 2,4-Dichlorophenylacetic acid was obtained in a maximum yield of 95% from 2,4-dichlorobenzyl chloride using the same reaction system.

Journal of Chemical Research published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, HPLC of Formula: 620-20-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Deng, Yu published the artcileRecovery of rare earths in different media with novel dicarboxylate based ionic liquid and application to recycle SmCo magnets, Recommanded Product: N-Benzyl-N,N-dibutylbutan-1-aminium chloride, the publication is Hydrometallurgy (2022), 105844, database is CAplus.

Recovery and separation of rare earth elements was highly crucial but difficult. In this study, a well-designed new ionic liquid named as benzyltributylammonium decanedioate ([N_444Bn]₂[SA]) was developed to extract rare earths and sep. Sm(III) from the spent SmCo magnets in acetate medium for the first time. To exhibit the superiority of acetate medium, the extraction of Nd(III) and La(III) in three different media were comparatively investigated under different conditions, including equilibrium time, initial pH of aqueous solution, rare earth concentration, extractant concentration, salting-out agent concentration and extraction temperature The results revealed that the better extractabilities of La(III) were observed in acetate medium rather than those in chloride medium (i.e., 97.6% vs. 78.6%), which may be attributed to the low-hydrated nature of acetate ions. Importantly, the back-extraction experiments indicated that 91.4% Nd(III) can be stripped from [N_444Bn]₂[SA] by using 1.5 mol/L HOAc, revealing the outstanding reusability of ionic liquid in the industrial separation-stripping cycles. Furthermore, the ion association mechanism was proposed to describe the extraction behavior and confirmed by the slope anal. and FT-IR characterizations in three media. In terms of the SmCoCu mixture separation, the maximal separation factor of Sm(III)/Co(II) was calculated as 3078 in simulated solution Impressively, the recovery of Sm(III) from the actual SmCo magnets by our dicarboxylate-type ionic liquid was also successfully achieved with a recycling rate of 96.8% and a Sm(III)/Co(II) selectivity of 148, which exhibited the potential application in the separation of Sm(III) from the spent SmCo magnets.

Hydrometallurgy published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C19H34ClN, Recommanded Product: N-Benzyl-N,N-dibutylbutan-1-aminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wang, Dan published the artcileSupport vector machine and KStar models predict the o-dealkylation reaction mediated by cytochrome P450, Computed Properties of 33697-81-3, the publication is Wuli Huaxue Xuebao (2011), 27(2), 343-351, database is CAplus.

Nested prediction model was constructed based on support vector machines (SVM) and the KStar method. The models consisted of a mol. shape discriminative model for metabolites, which was used to predict the o-dealkylation reaction mediated by cytochrome P 450, in addition to the metabolic site discriminative model, which was used to judge C-O bond breaking in mols. 1280 Mol. descriptors including topol. descriptors, 2D autocorrelation descriptors, and geometric descriptors were calculated and to characterize the physicochem. properties of 272 mols. A mol. shape discriminative model, represented by the classification models, was constructed by machine learning methods including SVM, decision tree, Bayesian network, and k nearest neighbors method. The results showed that the SVM model was superior to the other methods. Twenty-six quantum chem. features including charge-related, valency-related, and energy-related features were calculated for the 538 metabolism sites for the o-dealkylation reaction in the metabolic site discriminative model. Machine learning methods including decision tree, Bayesian network, KStar, and the artificial neural network method were also used to develop classification models. It showed that the KStar model with its prediction accuracy, sensitivity, and specificity of more than 90% outperformed the other classification models. Fifteen traditional Chinese medicine medicinal mols. were used to validate the model. The results showed that the nested models had certain accuracy and could contribute to the prediction of metabolites from traditional Chinese medicines.

Wuli Huaxue Xuebao published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C6H3ClFNO2, Computed Properties of 33697-81-3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhang, Wei published the artcileA hemicyanine fluorescent reactive cationic dye: synthesis and applications on wool fabrics, Name: 2,3-Dibromopropionylchloride, the publication is Coloration Technology (2015), 131(4), 316-321, database is CAplus.

A novel hemicyanine fluorescent reactive cationic dye was synthesized by the reaction between the free amino group of a hemicyanine fluorescent dye and 2,3-dibromopropionyl chloride. The dye was characterised by proton NMR spectroscopy, high-resolution mass spectrometry, UV-visible absorption spectrometry, and single-photon fluorescence spectrometry. The prepared dye was applied to wool fabrics to give fluorescent orange shades. The color fastness of the dyed wool fabrics was tested. Results show that dyed fabrics using the novel hemicyanine fluorescent reactive cationic dye could be used as fluorescent clothing.

Coloration Technology published new progress about 18791-02-1. 18791-02-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 2,3-Dibromopropionylchloride, and the molecular formula is C13H9ClN2O4, Name: 2,3-Dibromopropionylchloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics