Chlorides-buliding-blocks

1996-29-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1996-29-8, name is 1-Bromo-4-chloro-2-fluorobenzene, A new synthetic method of this compound is introduced below.

1-Bromo-4-chloro-2-fluorobenzene (5.68 g, 27.11 mmol) was dissolved in a reaction flask containing anhydrous tetrahydrofuran (60 mL) under nitrogen. The reaction solution was cooled to -78 C.LDA (11.44 mL, slowly added dropwise with stirring)2M tetrahydrofuran solution). After the addition is continued for 1 hour,Pass dry carbon dioxide gas and slowly raise to room temperature.After the reaction is complete, cool again to 0 C,It was quenched with saturated aqueous NaHCO3 (EtOAc) (EtOAc)Discard the organic phase. After the aqueous phase is adjusted to pH 2 to 3 with 3N hydrochloric acid,It was extracted with ethyl acetate (100 mL¡Á3) and the combined organic phases were washed with saturated brine.Dry over anhydrous sodium sulfate, filter, and concentrate the filtrate under reduced pressure.3-Bromo-6-chloro-2-fluorobenzoic acid (3.4 g, yellow solid, yield 49.4%).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Beijing Yue Zhi Kangtai Bio-pharmaceutical Technology Co., Ltd.; Duan Maosheng; Xiong Yanlin; Liu Jiale; Tian Shihong; Dai Quan; (57 pag.)CN109232533; (2019); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 27139-97-5, name is 2-Bromo-4-chloro-1-methylbenzene, This compound has unique chemical properties. The synthetic route is as follows., 27139-97-5

The cooling pipe is attached, the container is again after replacing the argon, distilled water (30 ml), 2-bromo-4-chlorotoluene (5. 23g, 20. 5mmol), tetrakistriphenyl phosphinepalladium (0. 462g, 0. 40mmol), potassium carbonate (2. 76g, 20mmol), and toluene (100 ml) is added, which is circulated to 5 hours. After cooling to room temperature, transferring the liquid content scopolia, organic phase and aqueous phase is separated, the water phase is removed, washed with organic phase. By drying the organic phase is sodium sulfate. Thereafter, by filtration to remove sodium sulfate, organic phase is concentrated. The mixture is purified by silica gel column chromatography (developing solvent: Phenylbicyclohexane), and the purpose of the above chemical eq. (118) is obtained (yield 4. 14g, yield 82. 4percent)

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; NIPPON HOSO KYOKAI <NHK>; KANTO CHEM CO INC; FUKAGAWA HIROHIKO; SHIMIZU TAKAHISA; TAKAHASHI JUNPEI; SHINNAI SATONOBU; TSUCHIYA KAZUHIKO; (53 pag.)JP2015/160849; (2015); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2533-69-9 as follows. 2533-69-9

24. 55 mmol of PHENYLENEDIAMINE 1a-k, 1M, In were dissolved in 50 ml of acetic acid, AND 27 MMOL of methy 2, 2, 2-TRICHFOROACETIMIDATE 2 WERE added at 0C over the course of 0.5 hour under an N2 atmosphere. When the addition was complete, the reaction mixture was slowly warmed to room temperature and stirred at this temperature for 2 hours. The reaction mixture was poured into ice-water, and the resulting precipitate was filtered off with suction, washed with a little water and dried at 40C under reduced pressure. 3a: R = 5-Cl ; brown solid, yield : 82%

According to the analysis of related databases, 2533-69-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; MERCK PATENT GmbH; WO2005/4863; (2005); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6940-78-9 name is 1-Bromo-4-chlorobutane, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 6940-78-9

(1) 3.53 g (20.6 mmol) of 1-bromo-4-chlorobutane was dissolved in 50 ml of absolute ethanol, added to a 250 ml round bottom flask, stirred in an ice bath at 0 C. A constant pressure dropping funnel was slowly added dropwise to a solution containing 3.11 g (22.2 mmol, 1.08 times) of 50% sodium thiomethoxide in anhydrous ethanol, and the temperature was gradually raised to room temperature overnight. The total reaction time was 26 hours. Stirring was carried out, and the ethanol was removed by vacuum at low temperature and extracted three times with n-hexane. The mixture was washed with saturated sodium chloride and dried over anhydrous sodium sulfate. The insoluble material was filtered off. Vacuum at low temperature steaming to remove n-hexane, with a strong mustard odor of 2.69g of colorless oil. The intermediate content of GC-MS was about 81%, and the yield of intermediate was about 76.3%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Bromo-4-chlorobutane, and friends who are interested can also refer to it.

Reference:
Patent; Shenyang Pharmaceutical University; Sun, Lixin; Li, Binglong; Zhou, Hui; (10 pag.)CN106496086; (2017); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

14752-66-0, A common heterocyclic compound, 14752-66-0, name is Sodium 4-chlorobenzenesulfinate, molecular formula is C6H4ClNaO2S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A mixture of alkyne 1 (0.25 mmol), sodium sulfinate 2 (0.375 mmol), FeCl3 (20 mol %),K2S2O8 (20 mol %), and water (3 mL) was stirred at rt in an open flask for 6-9 h(Table 2). After completion of the reaction (monitored by TLC), the mixture was extracted with EtOAc (3 5 mL). The combined organic phases were dried over anhyd. Na2SO4, filtered, and concentrated under reduced pressure. The resulting crude product was purified by silica gel column chromatography using a mixture of EtOAc-n-hexane (1:4) as eluent to afford an analytically pure sample of beta-keto sulfones 3 (Table 2).

The synthetic route of 14752-66-0 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Singh, Atul K.; Chawla, Ruchi; Yadav, Lal Dhar S.; Tetrahedron Letters; vol. 55; 17; (2014); p. 2845 – 2848;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

1871-57-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1871-57-4 as follows.

A solution of methyl 3-cyclohexyl-2-(2-hydroxyphenyl)-lH-indole-6-carboxylate (prepared as described in International patent application WO2006/046030) (0.12 M) in DMF was treated with KO1Bu (2.1 eq) in one portion; the resulting mixture was stirred for 30 min at RT then treated dropwise with 3-chloro-2-(chloromethyl)prop-l-ene (1.1 eq). The resulting solution was stirred at RT overnight before being quenched by addition of HCl (IN) and extracted into EtOAc. The combined organic layers were washed with sat. aq. NaHCO3 and brine, before being dried (Na2SO4), filtered and concentrated in vacuo. The crude material was purified by FC (PE/EtOAc 85:15) affording the product as a yellow oil (97%). (ES+) m/z 402 (M+H)+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1871-57-4, and friends who are interested can also refer to it.

Reference:
Patent; ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA; WO2009/10783; (2009); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

19752-55-7, The chemical industry reduces the impact on the environment during synthesis 19752-55-7, name is 1-Bromo-3,5-dichlorobenzene, I believe this compound will play a more active role in future production and life.

Example S.3: Synthesis of 3,5-dichloro-2,2,2-trifluoro acetophenone (Compound example no.2 of table C.1 ); To 5.1 g (0.209 mol) Magnesium turnings was added 0.45 g of a 1 molar solution of DIBAL in hexane at 6O0C. After 15 min, 3,5-dichloro-bromobenzene (5.0 g, 0.022 mol) and 25 mL THF were added and the mixture was stirred. After start up of the reaction a mixture of 45g (0.2 mol) 3,5-dichloro-bromobenzene and 250 mL THF was added under reflux. After completion of the reaction the mixture was cooled to 00C and 31.1 g (0.219 mol) ethyl trifluoroacetate was added. After 2 h an aqueous solution of NH4CI was added an the mixture was separated between MTBE and aqueous NH4CI solution. The organic layer was separated and the solvent was removed in vacuum. (34.3g brown oil; purity 70percent ace. to g.c; yield 50percent)1H-NMR (360 MHz, CDCI3): delta = 7.7 (s, 1 H), 7.9 (s, 2H) ppm.

The chemical industry reduces the impact on the environment during synthesis 1-Bromo-3,5-dichlorobenzene. I believe this compound will play a more active role in future production and life.

Reference:
Patent; BASF SE; Rack, Michael; Koerber, Karsten; WO2010/125130; (2010); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

72934-36-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 72934-36-2 name is 1-(4-Chlorophenyl)cyclopropanamine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of methyl 4-(4-chloro-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-ylamino)-3-fluorobenzoate (0.93 g, 2.45 mmol) in THF (10 mL) was added 1-(4-chlorophenyl)cyclopropanamine (0.5 g, 2.45 mmol) and Hunig’s Base (1.71 mL, 9.8 mmol). The resulting mixture was refluxed at 80 C. for 16 hs. The precipitate was filtrated through a plug washing with THF to give a crude product that was purified by Biotage eluting with 4/1 to 3/2 hexane/ethyl acetate to give 1.2 g of methyl 4-(4-(1-(4-chlorophenyl)cyclopropylamino)-6-(2,2,2-trifluoro ethoxy)-1,3,5-triazin-2-ylamino)-3-fluorobenzoate as product.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-(4-Chlorophenyl)cyclopropanamine, and friends who are interested can also refer to it.

Reference:
Patent; Bristol-Myers Squibb Company; Wang, Tao; Scola, Paul Michael; Zhang, Zhongxing; Yin, Zhiwei; Zhao, Qian; US2013/203758; (2013); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

These common heterocyclic compound, 33786-89-9, name is 5-Chloro-m-phenylenediamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 33786-89-9

To a solution of 5-chloro-benzene-1,3-diamine (3 g, 21 mmol) and dimethylamino-acetic acid (2.2 g, 21 mmol) in CH2Cl2 (300 mL) was added EDC (5 g, 25 mmol), HOBt (2.9 g, 21 mmol), and DIEA (5 mL). The reaction mixture was stirred at RT for overnight. Solvent was removed in vacuum and the residue was purified through flash chromatography on silica gel (0-8% MeOH in EtOAc) to give the desired compound.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 33786-89-9.

Reference:
Patent; Amgen Inc.; US2003/225106; (2003); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

A common heterocyclic compound, 870-24-6, name is 2-Chloroethanamine hydrochloride, molecular formula is C2H7Cl2N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 870-24-6.

Preparation of 2-aminoethylazide 2-chloroethylamine hydrochlorate (Sigma Aldrich) is solubilized in water (133 g/L) at 80 C. Then sodium azide (3 eq., Sigma Aldrich) is added and the mixture is kept under reflux and magnetic stirring for the night. The mixture is cooled to room temperature then to 0 C. using an ice bath. Potassium hydroxide (same amount as 2-chloroethylamine hydrochlorate, Prolabo) is added and after total dissolution, the product is extracted using diethyl ether. Organic phase is dried over magnesium sulfate (Acros Organics), filtered and finally evaporated to obtain 2-aminoethylazide (20 mol.% yield).

The synthetic route of 2-Chloroethanamine hydrochloride has been constantly updated, and we look forward to future research findings.

Reference:
Patent; UNIVERSITE DE BORDEAUX; Centre national de la recherche scientifique; INSTITUT DES CORPS GRAS ETUDES ET RECHERCHES TECHNIQUES-ITERG; INSTITUT POLYTECHNIQUE DE BORDEAUX; Institut Technologique FCBA; CRAMAIL, Henri; GRELIER, Jean-Pierre Albert Stephane; PICHAVANT, Frederique; DA SILVA PEREZ, Denilson; ALFOS, Carine; CHEMIN, Suzanne Maud; (16 pag.)US2018/2453; (2018); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics