Chlorides-buliding-blocks

2770-11-8, Adding a certain compound to certain chemical reactions, such as: 2770-11-8, name is 2-(4-Chlorophenoxy)aniline, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2770-11-8.

General procedure: A mixture of NaOH solution (2 molL-1, 20mL), 1,4-dioxane (2 mL) and compound 4 (5 mmol) was dissolved and cooled to 0 C in an ice bath. While stirring the mixture, compound 14, 15 or 16 was added slowly. Afterwards, the mixture was stirred for another 5h at room temperature. The mixture was then extracted with ethyl acetate, and the solvent was removed in vacuum. The crude product was purified by column chromatography on silica gel to give compounds 17a-17i, 18a-18i or 19a-19i in yields of 30-73%. All the compounds were list in Table1 and the spectral parameters for 1H NMR, IR and MS were as follows.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(4-Chlorophenoxy)aniline, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Wen, Fang; Jin, Hong; Tao, Ke; Hou, Taiping; European Journal of Medicinal Chemistry; vol. 120; (2016); p. 244 – 251;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

2533-69-9, These common heterocyclic compound, 2533-69-9, name is Methyl 2,2,2-trichloroacetimidate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To the solution containing 4,5-diaminobenzo-15-crown-5 prepared in the last step, methyl 2,2,2-trichloroacetimidate (90 L, 0.70 mmol) was added. The mixture was stirred at rt shielded from light. After 9h, K2CO3 (6.0 g) was added to the mixture. The mixture was stirred for 11 h. The solvent was evaporated to give brown solid. Deionized water (70 mL) was added to the solid, and the mixture was stirred at rt for 5 h. The precipitate was filtered on Celite 545 mu, and washed with deionized water. The precipitate was eluted with a mixture of CHCl3/MeOH (1/1). The solution was concentrated under reduced pressure to give light brown solid, which was passed through a short alumina column chromatography by using a mixture of CHCl3/MeOH (10/1) as an eluent. The fractions were concentrated, and the residue was recrystalized from acetic acid to give 1 (104 mg, 21%) as pale yellow crystal. HRMS (FAB) m/z ([M + Na]+) 637.2486, calcd for C30H38N4O10Na 637.2486. 1H NMR (600 MHz, CDCl3): 7.05 (s, 4H, Ar), 3.96 (br, 8H, crown), 3.86 (br, 8H, crown), 3.75 (br, 16H, crown); 13C NMR (150 MHz, CDCl3): 148.19 (C), 142.92 (C), 133.03 (C), 99.26 (CH), 70.81 (CH2), 70.15 (CH2), 69.22 (CH2), 69.07 (CH2).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 2533-69-9.

Reference:
Article; Satake, Akiharu; Tanaka, Kazuo; Asakura, Hiroki; Okano, Masahiro; Hashimoto, Tsutsumu; Matsuura, You; Inaba, Yusuke; Oda, Tetsuhisa; Hirota, Shun; Koshino, Hiroyuki; Bulletin of the Chemical Society of Japan; vol. 87; 1; (2014); p. 88 – 97;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Adding some certain compound to certain chemical reactions, such as: 202197-26-0, name is 3-Chloro-4-((3-fluorobenzyl)oxy)aniline, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 202197-26-0. 202197-26-0

Example-1 Preparation of N1-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-N,N-dimethyl formamidine (8) Into a one liter four necked round bottomed flask, 500 mL of toluene, 50.0 g of 3-chloro-4-(3-fluoro-benzyloxy)-aniline, 50.0 g of dimethylformamide dimethyl acetal and 3.0 mL of acetic acid were charged under stirring. The reaction mixture was maintained at reflux temperature for about 2 hrs and the completion of the reaction was monitored by TLC. The solvent was completely distilled off under vacuum, the resulting syrupy liquid was cooled to room temperature. To this 200 mL of water was added and adjusted to basic pH by adding dilute sodium hydroxide solution. The product was extracted into ethylacetate and separated the organic layer. The organic layer was clarified by carbon treatment and filtered. The filtrate was completely distilled off under vacuum. The mass was cooled to room temperature and added 250 mL of hexane and stirred at 0 to 5 C. for about two hours to crystallize the product. The product was filtered and dried under vacuum at 30-35 C. to get 58.0 gram (95% by theory) of N1-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-N,N-dimethylformamidine as a white crystalline powder. Purity: 99.66% by HPLC Melting-range: 45-47 C. Mass: 307.5 [M+1] IR (KBr, cm-1): 2917, 2798, 2364, 1637, 1591, 1557, 1500, 1453, 1410, 1373, 1269, 1250, 1205, 1137, 1103, 1059, 1016, 926, 877, 859, 809, 772, 749, 704, 680, 637, 606, 519. 1H-NMR (400 MHz; DMSO-D6): delta 2.87 (s, 3H); delta 2.98 (s, 3H); delta 5.15 (s, 2H); delta 6.80-6.83 (dd, 1H); delta 6.99-7.00 (d, 1H); delta 7.04-7.06 (d, 1H); 7.14-7.18 (m, 1H); delta 7.26-7.30 (m, 2H); delta 7.42-7.47 (m, 1H); delta 7.72 (s, 1H) 13C-NMR (400 MHz; DMSO-D6): delta 33.90 (2C), 69.56, 114.0, 115.19, 120.21, 121.51, 121.90, 123.20, 130.45, 140.02, 146.71, 148.41, 153.76, 160.97, and 163.39.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 3-Chloro-4-((3-fluorobenzyl)oxy)aniline.

Reference:
Patent; Natco Pharma Limited; US2011/263852; (2011); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

6775-78-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6775-78-6, name is 6-Chloroimidazo[1,2-b]pyridazine, A new synthetic method of this compound is introduced below.

Step 1: 4-boronobenzoic acid (11.88 g, 71.61 mmol), K3P04 (27.60 g, 13.02 mmol) and Pd(PPh3)4 (3.75 g, 3.25 mmol) were added sequentially to a solution of 6-chloroimidazo[l,2- b]pyridazine (10 g, 65.10 mmol) in a mixture of l,4-dioxane/H20 (250:50 mL) at room temperature under argon atmosphere. The reaction mixture was refluxed for 6 h and was diluted with water (100 mL) and extracted with EtOAc (3×100 mL). The combined aqueous layer was acidified to pH 2 using citric acid. The precipitate was isolated by filtration and dried under reduced pressure to afford 4-(imidazo[ 1 ,2-b]pyridazin-6-yl)benzoic acid (4.5 g, 57%) as an off-white solid.1H NMR (400 MHz, DMSO-a?6) delta 13.01 (bs, 1H), 8.04 (s, 1H), 8.3-8.01 (m, 5H), 7.85 (d, J= 7.2 Hz, 2H); MS (ESI) m/z 240 [M+ H]+.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH; NACRO, Kassoum; DURAISWAMY, Athisayamani, Jeyaraj; CHENNAMANENI, Lohitha, Rao; WO2013/147711; (2013); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

A common heterocyclic compound, 626-43-7, name is 3,5-Dichloroaniline, molecular formula is C6H5Cl2N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 626-43-7.

General procedure: Substituted aniline 4a-4s (50 mmol) was dissolved in the 50 mL HCl (18%, aqueous) in the icebath. NaNO2 (50 mmol) dissolved in 50 mL water was added dropwise. The reaction mixture wasstirred for 1 h to obtain a clear solution. Then the solution of SnCl2 (0.1 mol) in 30 mL of concentratedHCl was added dropwise at 0 C. The mixture was stirred at room temperature for 2 h. Afterwards,the mixture was extracted with 50 mL EtOAc and the organic impurities were discarded. Then thesolution was basified with NaOH (40%, aqueous) until it reached pH 7.0. The reaction mass wasextracted with EtOAc three times. Finally, substituted phenylhydrzine 5a-5s was afforded after beingvapored under reduced pressure (in 55%-80% yield) [12].

The synthetic route of 3,5-Dichloroaniline has been constantly updated, and we look forward to future research findings.

Reference:
Article; Wang, Xing; Chen, Yong-Fei; Yan, Wei; Cao, Ling-Ling; Ye, Yong-Hao; Molecules; vol. 21; 11; (2016);,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

933190-51-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 933190-51-3 name is 8-Bromo-6-chloroimidazo[1,2-b]pyridazine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of 2,2-dimethylpyrrolidine (0.248 g, 2.5 mmol) in DMF (8 mL) was added NaH (0.060 g, 60% dispersion in mineral oil, 2.5 mmol) and stirred for 0.5 h. To this mixture was added 8-bromo-6-chloroimidazo[1,2-b]pyridazine (0.233 g, 1 mmol) under N2. The mixture was stirred at room temperature for 16 h. Then it was partitioned between 15 mL of saturated NH4Cl solution and 15 mL of ether. The organic layer was washed with water (10 mL¡Á3) and saturated NaCl solution (10 mL¡Á3), dried over NaSO4, concentrated in vacuo, and purified by chromatography (silica gel, 200-300 mesh, petroleum ether:ethyl acetate=3:1) to give 6-chloro-8-(2,2-dimethylpyrrolidin-1-yl)imidazo[1,2-b]pyridazine (0.140 g, 22%) as a light brown solid. LC-MS: [M+H]+, 251.1, tR=1.698 min.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 8-Bromo-6-chloroimidazo[1,2-b]pyridazine, and friends who are interested can also refer to it.

Reference:
Patent; Hoffmann-La Roche Inc.; Hermann, Johannes Cornelius; Kuglstatter, Andreas; Lucas, Matthew C.; Padilla, Fernando; Wanner, Jutta; Zhang, Xiaohu; US2013/109661; (2013); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

461-81-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 461-81-4, name is 1-Chloro-4-(trifluoromethoxy)benzene belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

A. 4-Chloro-2-nitro-1 -trifluoromethoxy-benzene and 1 -Chloro-2-nitro-4- trifluoronnethoxy-benzeneTo a mixture of i-chloro-4-trifluoromethoxy-benzene (9.24 g, 47 mol) in cone. H2SO4 (30 ml_) at 00C is added cone. HNO3 (10 ml_) dropwise over a 5 min period. After the mixture is stirred at 0 0C for 1 h, it was poured into ice. More H2O is added, and the resulting mixture is extracted with EtOAc. The organic extract is washed with H2O (3X) and brine, dried over MgSO4, filtered, and concentrated in vacuo to yield 10.87 g (95%) of the product as a mixture of 1 -chloro-2-nitro-4-trifluoromethoxy-benzene and 4-chloro-2-nitro-1-trifluoromethoxy-benzene (-50/50, based upon 19F NMR). 1H NMR (CDCI3): delta 8.05-7.95 and 7.85-7.70 (m, 1 H), 7.70-7.55 and 7.50-7.35 (m, 2H); 19 F NMR (CDCI3) delta -57.32 and -57.84 (s, 3F), -109.07 and -117.90 (t, J = 6.2Hz and d, J = 6.2 Hz, 1 F).

The synthetic route of 1-Chloro-4-(trifluoromethoxy)benzene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SANOFI-AVENTIS; CHOI-SLEDESKI, Yong-Mi; GARDNER, Charles, J.; LIANG, Guyan; POLI, Gregory, B.; SHUM, Patrick, Wai-Kwok; STOKLOSA, Gregory, T.; ZHAO, Zhicheng; WO2011/22449; (2011); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

41965-95-1, Adding a certain compound to certain chemical reactions, such as: 41965-95-1, name is 3-Chloro-4-methoxybenzylamine Hydrochloride, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 41965-95-1.

l-(10-((3-chloro-4-methoxybenzyl)amino)-3,4-dihydrobenzo[][l,6]naphthyridin- 2(lH)-yl)ethan-l-one, I [00241] A solution of 30 (1.15 mmol), 3-chloro-4-methoxybenzylamine hydrochloride (3.45 mmol), Nal (0.06 mmol), and triethylamine (3.45 mmol) in NMP (5.0 mL) was heated at 130 C for 6 h. The solvent was evaporated off and the residue was purified by Flash Chromatography (AcOEt: MeOH 8:2) to give I. MS ESI (m/z) 396 (M+H)+; 1H NMR (400 MHz, CDC13) delta 8.05- 8.02 (m, IH), 7.92 (d, IH, J=9.2 Hz), 7.67-7.63 (m, IH), 7.45-7.40 (m, IH), 7.35 (d, IH, J=2.4 Hz), 7.22 (dd, IH, Ji=2.0, J2=8.4 Hz), 6.92 (d, IH, J=8.4 Hz), 4.75 (s, 2H), 4.65 (d, 2H, J=5.2 Hz), 3.90 (s, 4H), 3.81 (t, 2H, J=6.0 Hz), 3.27 (t, 2H, J=6.4 Hz), 2.20 (s, 3H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Chloro-4-methoxybenzylamine Hydrochloride, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; LANDRY, Donald, W.; DENG, Shixian; FIORITO, Jole; ARANCIO, Ottavio; WASMUTH, Andrew; WO2015/9930; (2015); A2;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

57946-56-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 57946-56-2, name is 4-Chloro-2-fluoroaniline belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

EXAMPLE 5 Preparation of N-(4-chloro-2-fluorophenyl)-1-cyclohexene-1,2-dicarboximide A solution of 4-chloro-2-fluoroaniline (19.0 g, 130.6 mmol) and 3,4,5,6-tetrahydrophthalic anhydride (19.85 g, 130.6 mmol) in acetic acid is refluxed for 2 hours, treated with additional 4-chloro-2-fluoroaniline (3.0 g), refluxed for 90 minutes, stirred at room temperature overnight and poured into water. The resultant aqueous mixture is extracted with ethyl acetate. The organic extract is washed sequentially with water, saturated sodium hydrogen carbonate solution and brine, dried over anhydrous magnesium sulfate, and concentrated in vacuoto obtain a purple oil. Flash column chromatography of the oil using silica gel and 15 to 20% ethyl acetate in hexanes solutions gives the title product as an off-white solid (25.3 g, 69% yield, mp 81-82C) which is identified by 1H, 13C and 19F NMR spectral analyses.

The synthetic route of 4-Chloro-2-fluoroaniline has been constantly updated, and we look forward to future research findings.

Reference:
Patent; American Cyanamid Company; EP985670; (2000); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

A common compound: 626-43-7, name is 3,5-Dichloroaniline, belongs to chlorides-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 626-43-7

General procedure: To a solution of substituted aniline 22a-i (0.81 mmol) and triethylamine (0.89 mmol) in DCM (2 mL) at 0 C was added bromoacetyl bromide (0.81 mmol) dropwise over 15 min, and stirring was continued for an additional 1 h at 0 C. The mixture was dilutedwith DCM (10 mL), washed with HCl (2 10 mL), H2O (1 10 mL),sat. aqueous NaHCO3 (1 10 mL), brine (1 10 mL), dried (Na2SO4),and the solvent removed in vacuo to give bromoacetamides 21a-i.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 626-43-7, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Hung, Joy M.; Arabshahi, Homayon J.; Leung, Euphemia; Reynisson, Johannes; Barker, David; European Journal of Medicinal Chemistry; vol. 86; (2014); p. 420 – 437;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics