Chlorides-buliding-blocks

Synthetic Route of 19752-55-7,Some common heterocyclic compound, 19752-55-7, name is 1-Bromo-3,5-dichlorobenzene, molecular formula is C6H3BrCl2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In a nitrogen environment, it was dissolved in I-31(32 g, 59.8 mmol) and 250 mL THF, here the 1-bromo-3,5-dichlorobenzene(16.2 g, 71.7 mmol) and tetrakis (triphenylphosphine) put the palladium (0.69 g, 0.60 mmol) was stirred. Into a potassium carbonate (20.7 g, 150 mmol) in saturated water was heated to reflux at 80 ¡ã C for 13 hours. After the reactionwas completed, the reaction solution into water and extracted with DCM then water was removed with anhydrous MgSO4,filter and was concentrated under reduced pressure. Thus the resulting residue was separated and purified by flash columnchromatography to obtain the compound I-32(25.9 g, 78percent).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Bromo-3,5-dichlorobenzene, its application will become more common.

Reference:
Patent; Cheil Industries Co., Ltd; Lee, Han Ir; Yu, Uhn Sun; Kang, Dong Min; Kang, Uii Soo; Yang, Yong Tak; Oh, Jae Jin; Yu, Dong Gyu; Lee, Sang Sin; Jang, Yuna; Jung, Su Young; Han, Su Jin; Hong, Jin Suk; (59 pag.)KR2015/6758; (2015); A;,
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Some common heterocyclic compound, 1871-57-4, name is 3-Chloro-2-chloromethyl-1-propene, molecular formula is C4H6Cl2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 1871-57-4

To a cold (-78 C, acetone/solid CO2) and magnetically stirred solution of diisopropylamine (0.8 mL, 5.7 mmol) in anhydrous THF (15 mL) under an argon atmosphere, a solution of n-BuLi in hexanes (2.3 mL, 2.5 M, 5.7 mmol) was added dropwise.When n-BuLi addition was finished, the solution was allowed to warm to 0 C for 1 h, it was cooled again to -78 C, and a solution of 11 (690 mg, 2.38 mmol) in anhydrous THF (8 mL) was added dropwise. Then, the solution was stirred a -78 C for 15 min and allowed to warm to 0 C for 1 h. The solution was again cooled to -78 C and 3-chloro-2-(chloromethyl)-1-propene (0.36mL 96% content, 373 mg, 3.0 mmol) was added dropwise. The reaction mixture was allowed towarm to room temperature and it was stirred for 3 days at this temperature. The mixture was made acidic with aqueous 1N HCl (10 mL) and was extracted with Et2O (3¡Á50 mL). The combined organic extracts were dried (anhydrous Na2SO4) and concentrated in vacuo to give abrown waxy residue (960 mg) that was subjected to column chromatography (silica gel 35-70mum, 30 g, hexane/EtOAc mixtures) to give on elution with hexane/EtOAc 9:1, product 12 (515mg, 63% yield) as a yellow solid. Rf 0.51 (silica gel, 8 cm, hexane/EtOAc 8:2); mp 190-192 C (from EtOAc/hexane); IR (ATR, numax, cm-1): 1770w and 1693s (C=O st); 1H NMR (400 MHz,CDCl3) delta 1.65 (br s, H2O), 2.11 [dt, 2JHH 16.4 Hz, 4JHH 2.4 Hz, 2H, 16(18)-Hn], 2.47 (s, 3H, NCH3),2.64 [br d, 2JHH 16.4 Hz, 2H, 16(18)-Hx], 4.51 [s, 2H, 4(9)-H], 4.61-4.62 (br s, 2H,C17=CH2), 7.06-7.10 [m, 2H, 6(7)-H], 7.17-7.20 [m, 2H, 12(13)-H], 7.21-7.25 [m, 2H, 5(8)-H], 7.34-7.38 [m, 2H, 11(14)-H]; 13C NMR (100.6 MHz, CDCl3) delta 24.5 (CH3, N-CH3), 39.3[CH2, C16(18)], 49.5 [CH, C4(9)], 62.0 [C, C3a(9a)], 108.8 (CH2, C17=CH2), 124.9 [CH,C5(8)], 126.6 [CH, C11(14)], 126.81 [CH, C12(13)], 126.85 [CH, C6(7)], 139.6 [C, C4a(8a)],139.9 [C, C10(15)], 146.6 (C, C17), 180.1 [C, C1(3)]; HRMS (ESI-TOF): calcd. for[C23H19NO2+H]+: 342.1489. Found: 342.1485; Anal. calcd. for C23H19NO2¡¤0.25H2O: C, 79.86;H, 5.68; N, 4.05%. Found: C, 79.47; H, 5.62; N, 3.88%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1871-57-4, its application will become more common.

Reference:
Article; Camps, Pelayo; Gomez, Tania; Otermin, Ane; ARKIVOC; vol. 2014; 2; (2014); p. 103 – 119;,
Chloride – Wikipedia,
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Related Products of 4584-46-7, The chemical industry reduces the impact on the environment during synthesis 4584-46-7, name is 2-Chloro-N,N-dimethylethanamine hydrochloride, I believe this compound will play a more active role in future production and life.

Solution of 2-(dimethylamino)ethyl chloride in heptane. To 2-(dimethylamino)ethyl chloride hydrochloride (10 g, 100 mmol) was added water (12 mL) and heptane (10 g). The mixture was stirred, and the pH of the aqueous phase was cautiously adjusted to pH 10 using a concentrated solution of sodium hydroxide, and the mixture was stirred for 45 min. The organic phase was separated, and the aqueous phase was extracted with further heptane (2.5 g). The combined organic phases were washed with water (5 mL) and then dried over anhydrous potassium carbonate for 15 min before filtering. This solution was used directly in the following step. Analysis by MR indicated that the concentration of 2- (dimethylamino)ethyl chloride was approximately 25 % w/w in heptane.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Chloro-N,N-dimethylethanamine hydrochloride, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; H. LUNDBECK A/S; B?GES?, Klaus, Peter; JUHL, Karsten; ZHONG, Huailing; L?LAND, Claus, Juul; WO2013/110313; (2013); A1;,
Chloride – Wikipedia,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 932-32-1, name is 2-Chloro-N-methylaniline belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. name: 2-Chloro-N-methylaniline

Weigh BTC (58mg, 0.2mmol) in a 25mL two-neck bottle.Add 5 mL of anhydrous dichloromethane, magnetically stir, add equivalents of N-methyl-o-chloroaniline, triethylamine (0.25 mmol) and 5 mL of dichloromethane in a 25 mL constant pressure dropping funnel.Under the ice bath,Slowly add dropwise, remove the ice salt bath after the end of the addition, and stir at room temperature for 4 h.HZA (40 mg, 0.1 mmol) was added to a 10 ml vial, and traces of DMAP, 5 mL of dichloromethane were added, and magnetically stirred at room temperature until completely dissolved. The solution was slowly added dropwise to the above reaction solution under ice salt bath, and the ice salt bath was removed by dropwise addition, and stirred at room temperature. After the reaction is completed, 3 to 6 times the volume of the reaction liquid is added to the above reaction liquid, and distilled water is added.The organic layer was extracted with EtOAc (EtOAc) (EtOAc m.The crude product was then eluted with a petroleum ether:ethyl acetate volume ratio of 20:1 in a mixed solvent, and a thin layer was detected to collect an eluent having a strong ultraviolet at 254 nm and a polarity less than HZA.The combined eluate and the product obtained by evaporating the solvent under reduced pressure are dried to obtain HZAM-12.The yield was 88%.

The synthetic route of 932-32-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Zhejiang University of Technology; Zhan Zhajun; Shan Weiguang; Chen Yan; Shu Renhuan; Wang Jianwei; Ma Liefeng; (31 pag.)CN109956952; (2019); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application of 93-50-5, These common heterocyclic compound, 93-50-5, name is 4-Chloro-2-methoxyaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of 8-chloro-4-oxo-chromene-2-carboxylic acid (Int-1, lg, 4.45 mmol) in DCM (20 mL) was added 4-chloro-2-methoxyaniline (842 mg, 5.34 mmol), DIPEA (1.15 g, 8.9 mmol) and HATU (3.3 g, 8.9 mmol) at room temperature and the resulting mixture was then stirred at room temperature for 18 hours. After the reaction was completed, the mixture was diluted with water (30 mL) and extracted with EtOAc (50 mL) three times. The combined organic layer was washed with brine, dried over anhydrous Na2S04 and concentrated in vacuo. The residue was purified by silica gel flash chromatography (elution with PE/EtOAc=lO:l~l:3) to give 8-chloro-N-(4-chloro-2-methoxyphenyl)-4-oxo-chromene-2-carboxamide (1.3 g, 80.3 %) as a yellow solid. MS obsd. (ESI+) [(M+H)+]: 364.1.

The synthetic route of 93-50-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; FENG, Song; LIANG, Chungen; LIU, Yongfu; TAN, Xuefei; WU, Jun; WANG, Jianping; (134 pag.)WO2020/79106; (2020); A1;,
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Chlorides – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 62356-27-8, name is 1-Bromo-3-chloro-2-methylbenzene, This compound has unique chemical properties. The synthetic route is as follows., name: 1-Bromo-3-chloro-2-methylbenzene

Embodiment 48 (S,E)-2-(2,6-Dimethoxy-4-(2-(4′-methoxy-2-methylbiphenyl-3-yl)vinyl)benz ylamino)-3 -hydroxypropionic acid 48 Synthetic route Synthesis of compound 48-c 2-Bromo-6-chlorotoluene (8.0g, 38.93mmol) and vinylboronic acid pinacol ester (7.3g, 46.72mmol) were dissolved in toluene (100mL), followed by addition of bis(tri-tert-butylphosphine)palladium (1.4g, 2.73mmol) and triethylamine (35.52g, 311.44mmol). After the reaction system was purged three times with nitrogen, the reaction solution was heated to 80C and stirred for 16 hours. Then the reaction solution was cooled to room temperature, diluted with ethyl acetate (100mL), washed successively with water (100mL x 3) and saturated brine (100mL). The organic phase was dried over anhydrous sodium sulfate. The residue was purified by silica gel column chromatography (petroleum ether) to give compound 48-c (7.19g, yield 65.8%). 1H NMR (400 MHz, CDCl3) delta: 7.66-7.61 (d, J = 23.0Hz, 1H), 7.42-7.41 (d, J = 9.5Hz, 1H), 7.32-7.30 (d, J = 9.5Hz, 1H), 7.13-7.09 (t, 1H), 6.06-6.02 (d, J = 22.5Hz, 1H), 2.45 (s, 3H), 1.32 (s, 12H) ppm.

According to the analysis of related databases, 62356-27-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Guangzhou Maxinovel Pharmaceuticals Co., Ltd.; WANG, Yuguang; XU, Zusheng; WU, Tianzhi; HE, Min; ZHANG, Nong; (113 pag.)EP3483142; (2019); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 54932-72-8, name is 4-Bromo-1-chloro-2-methylbenzene, A new synthetic method of this compound is introduced below., Safety of 4-Bromo-1-chloro-2-methylbenzene

To a stirring solution of 4-bromo-1-chloro-2-methyl-benzene 5 (4.92mL, 37.1mmol) in THF (75mL) cooled to -78C was added n-butyllithium (14.9mL, 37.1mmol) dropwise. The solution was stirred at -78C for 30min and then was added to a stirring solution of phthalic anhydride 6 (5.00g, 33.8mmol) in THF (90mL) at -78C. The reaction was stirred at -78C for 2h before being quenched with 1N HCl (100mL). The solution was allowed to warm to rt, the layers were separated and the aqueous layer was extracted with EtOAc (3¡Á100mL). The combined organic layers were passed through a phase separator and concentrated. The crude material was purified using Teledyne ISCO Combi-Flash system (solid loading, 40G column, 40-80% EtOAc, 20min run) to give 2-(4-chloro-3-methyl-benzoyl)benzoic acid 7 (4.67g, 50.4% yield) as a white solid. 1H NMR (400MHz, CDCl3) delta (ppm): 8.10 (d, J=7.8Hz, 1H), 7.68 (dt, J=7.6, 1.2Hz, 1H), 7.64-7.62 (m, 1H), 7.59 (dt, J=7.9, 1.2Hz, 1H), 7.44 (dd, J=8.2, 2.2Hz, 1H), 7

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; McGowan, Kevin M.; Nance, Kellie D.; Cho, Hykeyung P.; Bridges, Thomas M.; Jeffrey Conn; Jones, Carrie K.; Lindsley, Craig W.; Bioorganic and Medicinal Chemistry Letters; vol. 27; 6; (2017); p. 1356 – 1359;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Electric Literature of 6940-78-9, The chemical industry reduces the impact on the environment during synthesis 6940-78-9, name is 1-Bromo-4-chlorobutane, I believe this compound will play a more active role in future production and life.

Example 47:7 – hydroxy – 250 ml 111H-quin -2 – ketone (8.06g, unitunitunitant ), potassium carbonate (0.05 muM, unitunitunitant 0.075 muM), N, N’ – 50 ml dimethylacetamide), N, N?-dimethylformamido 40 C), and 7.95g bromo 10 min-chlorobutane (10.29g 1 – 0.06 muM, unitunitunits -4 -) were added to the unitunito-type reaction flask. Unitunitaceous . 50 C was stirred under the unitunitaceous 5 hours conditions. After completion of the reaction, water is quenched, solid precipitated, filtered, washed, and the solid obtained is recrystallized, obtaining 7 – (4 – polychloroprene) – 111H-quinoline -2 – ketone 11.8g, 93.7% and gave a Kunit, and a 98.5% purity Kunitz . Example 47 of data characterization: 7 – (4 – Chlorphenoxy) – 111H-quinolin -2 -one prepared.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-4-chlorobutane, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Zhejiang University of Technology; Weng Yiyi; Yang Ting; (25 pag.)CN109970705; (2019); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Some common heterocyclic compound, 2106-02-7, name is 2-Chloro-4-fluoroaniline, molecular formula is C6H5ClFN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 2106-02-7

General procedure: The synthesis of azides were carried out according to the publish procedure [59]. Briefly, aniline (1eq) was dissolved in6N HCl solution (10mL/mmol of aniline) at room temperature and cooled up to 0C, followed by addition of aqueous NaNO2 (1eq) solution under stirring. After 10min of stirring at same temperature, sodium azide (1.2eq) was added to the reaction mixture. This mixture was further stirred at room temperature for 2-3h. The reaction was worked up by extraction with chloroform. The organic layer was washed with brine solution and dried over Na2SO4. After evaporation of the solvent, the crude product (3a-r) was pure enough for further reactions. All the synthesized azides were stored at-20C.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2106-02-7, its application will become more common.

Reference:
Article; Kant, Rama; Singh, Vishal; Nath, Gopal; Awasthi, Satish Kumar; Agarwal, Alka; European Journal of Medicinal Chemistry; vol. 124; (2016); p. 218 – 228;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthetic Route of 20850-43-5, These common heterocyclic compound, 20850-43-5, name is 5-(Chloromethyl)benzo[d][1,3]dioxole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Preparation of compound Ig: 2-(Benzo[l,3]dioxol-5-ylmethyl-methyI-amino)-ethanol. 2-(Methylamino)ethanol (22.0 g, 290 mmol) was added to a stirred solution of 3,4- methylenedioxybenzyl chloride (25.0 g, 147 mmol) in DCM (45 mL) at -780C under nitrogen. The solution was stirred for 15 minutes at -78 0C then warmed to room temperature and stirred for 16h. 1.2 M NaOH (100 mL) was added and the phases were separated. The organic layer was washed water (2 x 150 mL) and concentrated under vacuum to give 25.3 g (83%) of 2-(benzo[l,3]dioxol-5-ylmethyl- methyl-amino)-ethanol as a clear oil.

Statistics shows that 5-(Chloromethyl)benzo[d][1,3]dioxole is playing an increasingly important role. we look forward to future research findings about 20850-43-5.

Reference:
Patent; KALYPSYS, INC.; WO2007/62410; (2007); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics