Chlorides-buliding-blocks

Synthetic Route of 110407-59-5, A common heterocyclic compound, 110407-59-5, name is 2-Chloro-4-fluorobromobenzene, molecular formula is C6H3BrClF, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of l-bromo-2-chloro-4-fluorobenzene (2.5 g, 12.0 mmol) in toluene (10 mL) at -70 C was added n-BuLi (1.6 M in hexane) (7.5 mL, 12.0 mmol) dropwise over 5 min by syringe along the wall of the flask. After adding, the reaction was stirred at this temperature for 30 min. Then the resulting solution was added into a solution of (S)- tert-butyl l,6-dioxohexahydropyrrolo[l,2-a]pyrazine-2(lH) -carboxylate (2.8 g, 10.9 mmol) in toulene (10 mL). After stirred at -70 C for 5 min, the reaction mixture was quenched with saturated NH4CI and extracted with EtOAc (2 x 20 mL). The organic layer was washed with brine, dried over Na2S04, filtered and concentrated in vacuo. The residue was purified by silica gel chromatography to give the title compound (850.0 mg, yield : 20%); m/z (ES+): 385 [M + H] + .

The synthetic route of 110407-59-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; LEO PHARMA A/S; BLADH, Haakon; FELDING, Jakob; ZHOU, Ding; CAI, Zhen-wei; SØRENSEN, Morten Dahl; WO2015/24878; (2015); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 62593-17-3, name is 2,4-Dichloro-6-(trifluoromethyl)aniline belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C7H4Cl2F3N

Example 62 (General Procedure (D)) 3-Bromo-5-Tert-Butyl-N-(2,4-Dichloro-6-Trifluoromethyl-Phenyl)-6-Hydroxy-2-Methylbenzamide. The title compound was prepared from 3-tert-butyl-5-bromo-6-methylsalicylic acid and 2,4-dichloro-6-trifluoromethylanilin. 1H-NMR: (CDCl3, 400 MHz): delta ppm 1.40 (s, 9 H) 2.69 (s, 3 H) 7.15 (s, 1 H) 7.56 (s, 1 H) 7.68 (s, 1 H) 7.76 (s, 1 H) 9.50 (s, 1 H).); HPLC-MS (Method A): m/z=498, 500, 502 (M+1); Rt=5.9 min.

The synthetic route of 62593-17-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Hansen, Birgit Sehested; Hansen, Thomas Kruse; Tullin, Soren; Colding-Jorgensen, Morten; US2004/138301; (2004); A1;,
Chloride – Wikipedia,
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Electric Literature of 10061-02-6, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 10061-02-6 as follows.

11h were made from corresponding terminal alkyne and vinyl chloride S139 via route shown in Scheme 7. To a solution of S13 (600mg, 3.04 mmol ) in CH3CN was added K2CO3 (4.2g, 30.4 mmol) and continue stirred half of a hour, then added S9 (1g, 9.13 mmol) at room temperature, after the solution was heated at 40 C for 7h. The reaction was filter, and concentrated in vacuo. Purification via flash chromatography on silica gel(PE/EA = 20/1) provided S14( 490 mg,60% yield).Pd(PPh3)4 (97 mg, 0.084 mmol) andcopper iodide (32 mg, 0.169 mmol) were added to a seal-tube.Absorb the air andfill with nitrogen.S14 (460 mg, 1.69mmol) , prop-2-yn-1-ylbenzene ( 224 mg, 2.03 mmol ), tert-butylamine (185 mg,2.54 mmol) and 8 mL toluene was added.The mixture was heated to 70 C and stirred for 6 h. The reaction was thencooled and diluted with Et2O (10 mL) and saturated aqueous NH4Cl(5 mL). The organics were extracted with Et2O (2 *10 mL), dried overNa2SO4, filtered, and concentrated in vacuo. Purification via flash chromatography on silica gel (PE/EA = 10/1) provided 11h (317mg, 65% yield).

According to the analysis of related databases, 10061-02-6, the application of this compound in the production field has become more and more popular.

Reference:
Article; Xu, Hua-Dong; Wu, Hao; Jiang, Chun; Chen, Peng; Shen, Mei-Hua; Tetrahedron Letters; vol. 57; 26; (2016); p. 2915 – 2918;,
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Related Products of 1005-56-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1005-56-7, name is O-Phenyl carbonochloridothioate belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

(Scheme 5) 438.5 mg (1.0 mmol) of a rhodamine compound (for example, a synthetic product of 1,6-dihydroxy naphthalene and 4-diethylamino keto acid),690.4 mg (4.0 mmol) phenyl thiochloroformate and (350 muL)N,N-diisopropylethylamine(DIPEA) dissolved in 15 mL of dichloromethane,Then stir at room temperature for 15h,After vortexing to obtain a crude product,Finally using dichloromethane:Column chromatographic separation of the methanol system (30:1, v/v)506 mg of pure product was obtained with a yield of 88%.

The synthetic route of O-Phenyl carbonochloridothioate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; University of Jinan; Zhang Meng; Wu Liu; Zhao Ziyang; Yuan Ruifang; Fang Zhaotong; Wang Ruikang; Liu Caiyun; Zhu Baocun; (11 pag.)CN107903237; (2018); A;,
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These common heterocyclic compound, 4090-55-5, name is 2-Chloro-5,5-dimethyl-1,3,2-dioxaphosphorinane 2-oxide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C5H10ClO3P

Comparative Synthesis Example 1 (Synthesis of Comparative Phosphorus Compound 1); A mixture was obtained in the same manner as in Synthesis example 1 except that 114.4 g of toluene were used in place of 114.4 g of chlorobenzene, 89.3 g (0.95 mole) of phenol were used in place of 161.5 g (0.95 mole) of 2-phenylphenol (ortho-phenylphenol) and chlorobenzene was not used to add to the reaction mixture.(After-treatment) The obtained mixture was neutralized at 85 C by adding hydrochloric acid solution which corresponds to an excess amount of triethylamine and the mixture was allowed to stand to separate an oil phase. Next, the obtained oil phase was washed with approximately 85 C water and then any liquid was removed by a centrifugal filter. The obtained solid was dried by a vacuum desiccator at 100 C, to give 210.0 g of a white solid. The purity of the obtained solid was found to be 99.2 area % by GPC. Also, if all of the solids were assumed to be an object compound, the crude yield was 86.8 %.

The synthetic route of 2-Chloro-5,5-dimethyl-1,3,2-dioxaphosphorinane 2-oxide has been constantly updated, and we look forward to future research findings.

Reference:
Patent; DAIHACHI CHEMICAL INDUSTRY CO., LTD.; EP1925622; (2008); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 771583-81-4, name is 4-Chloro-2-(trifluoromethyl)benzylamine, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 771583-81-4

5-((4- (ethylsulfonyl) benzyl) carbamoyl) -2-isopropoxybenzoic acid (300.0 mg, 0.7 mmol), HATU (422.0 mg, 1.1 mmol) and DIPEA (477.2 mg , 3.7 mmol) was dissolved in tetrahydrofuran (10 mL), and after stirring at room temperature for 0.5 hours, 4-chloro-2- (trifluoromethyl) benzylamine (232.6 mg, 1.1 mmol) was added, and the reaction was performed at room temperature for 4 hours. Then, add an appropriate amount of water and extract 3 times with ethyl acetate. The organic phases were combined and washed with a saturated sodium chloride solution, dried over anhydrous sodium sulfate, filtered, and the filtrate was concentrated. The concentrate was purified by preparative high performance liquid chromatography to obtain the title compound (300.0 mg, yield: 65%).

According to the analysis of related databases, 771583-81-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Sichuan Kelun Botai Bio-pharmaceutical Co., Ltd.; Liu Chunchi; Liu Jinming; Ren Yun; Cai Jiaqiang; Wang Lichun; Wang Jingyi; (42 pag.)CN110724075; (2020); A;,
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Synthetic Route of 29671-92-9, A common heterocyclic compound, 29671-92-9, name is Carbamimidic chloride hydrochloride, molecular formula is CH4Cl2N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 3; The previous aminobenzonitrile (40.0 mg; 0.15 mmol) and chloroformamidine hydrochloride (18.0 mg; 0.16 mmol) were heated at 140 C in diglyme for 3 hours. The reaction mixture was diluted with water, stirred for 2 hours, filtered, washed with water and dried. Purification by silica gel chromatography (5- 10% methanol in dichloromethane) to yield 14 milligrams of 5-(4- chlorophenoxymethyl) quinazoline-2,4-diamine.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; DECODE CHEMISTRY, INC.; SINGH, Jasbir; GURNEY, Mark E.; WO2005/123724; (2005); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 2533-69-9, name is Methyl 2,2,2-trichloroacetimidate, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2533-69-9, HPLC of Formula: C3H4Cl3NO

A mixture of 1.98 g of 4-trifluoromethylbenzene-1, 2-diamine and 15 ml of acetic acid was added to a mixture of1.98 g of methyl-2,2,2-trichloroacetimidate and 15 ml of acetic acid under ice cooling, followed by stirring for 3 hours at room temperature. The reaction mixture was concentrated under reduced pressure, ethyl acetate was added to the residues, and the resultant was washed with an aqueous saturated sodium hydrogen carbonate solution and saturated saline. The organic layer was dried over magnesium sulfate and then concentrated under reduced pressure, thereby obtaining 3.39 g of 2-trichioromethyl-5-trifluoromethylbenzimidazole. 1H-NMR (DMSO-D5) oe: 8.18-8.00 (m, 1H), 7.94-7.80 (m, 1H), 7.72-7.65 (m, 1H)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2,2,2-trichloroacetimidate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; Mukumoto, Fujio; Tamaki, Hiroaki; Kusaka, Shintaro; Iwakoshi, Mitsuhiko; US2015/289512; (2015); A1;,
Chloride – Wikipedia,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 870-24-6, name is 2-Chloroethanamine hydrochloride, A new synthetic method of this compound is introduced below., Product Details of 870-24-6

4-Methoxythiophenol (50 g, 0.357 mol), 2-chloroethylamine monohydrochloride (39.8 g, 0.343 mol.), K2CO3(78.8 g, 0.57 mol) and diisopropyl ethylamine (32 mL, 0.178 mol) were mixed in 200 mL of THF. The mixture was degassed for 5 min. under reduced pressure and refluxed under argon overnight. The solvent was removed and water (300 mL) was added to the flask. The mixture was extracted with dichloromethane (3*200 mL). The organics were collected, dichloromethane was removed and 50 mL conc. HCl was added, followed by 200 mL of water. The solution was extracted with 1:1 EtOAc/hexane (3*200 mL). The aqueous layer was adjusted to pH 10 with 2 M NaOH, and was extracted with dichloromethane (3*200 mL). The combined organic solution was dried over anhydrous sodium sulfate. Removal of solvent provided 61 g of the target compound as a colorless liquid, with a yield of 97%. 1H-NMR (300 MHz, CDCl3): 7.35 (d, J=8.7 Hz, 2H), 6.81 (d, J=8.7 Hz, 2H), 3.77 (s, 3H), 2.88-2.80 (m, 4H), 1.44 (s, 2H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Deng, Shixian; Belvedere, Sandro; Yan, Jiaming; Landry, Donald; US2009/227788; (2009); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Some common heterocyclic compound, 694-80-4, name is 1-Bromo-2-chlorobenzene, molecular formula is C6H4BrCl, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 694-80-4

General procedure: In a Schlenk flask under N2 atmosphere, 2a (5 mg, 0.011 mmol), PdCl2 (2 mg, 0.011 mmol), Cs2CO3 (358 mg, 1,1 mmol) and DMF(1.5 mL) were added. The reaction mixture was heated at 90 C for 30 min. Then, an aryl halide (1.0 mmol) and an olefin (1.2 mmol)were added and the mixture was further stirred at 125 C under air atmosphere conditions. The reaction progress was monitored by Thin Layer Chromatography (EtOAc/hexane, 1:9). After completion of the reaction, the mixture was cooled to room temperature, and water (8 mL) was added and was extracted with EtOAc (3 10 mL).The organic solvent was dried over Na2SO4 and was evaporated under vacuum to give the crude product which was further purified by column chromatography using EtOAc/hexane, 1:9.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 694-80-4, its application will become more common.

Reference:
Article; Takallou, Ahmad; Habibi, Azizollah; Halimehjani, Azim Ziyaei; Balalaie, Saeed; Journal of Organometallic Chemistry; vol. 888; (2019); p. 24 – 28;,
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