Chlorides-buliding-blocks

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1435-48-9 as follows. Product Details of 1435-48-9

Into a four necked RB flask of 1-lit capacity equipped with over head stirrer, a glass condenser and addition funnel, DCFB (250 g, 1.51 mol) and A1C13 (322 g, 2.41 mol) were added. The suspension was stirred at room temperature. Acetyl chloride (125 g, 1.60 mol) was added drop wise within two hours by maintaining the temperature 30-350C. After complete addition of acetyl chloride the mixture was quickly heated to 110-1200C for 5-6 hrs. The reaction kinetics was monitored by taking samples every two hrs. After the reaction was stopped the crude reaction mixture was cooled to ambient temperature. Then the reaction mixture was quenched using 1 kg ice and 500 ml water maintaining the temperature below 5O0C. The aqueous layer thus obtained was extracted with 200 ml of DCM thrice and combined all the extracts for evaporation. After the evaporation of DCM, 298.8g of brown product was obtained with the following composition.% Conversion of DCFB by GC = 76 % (24% DCFB as solvent)% DCFA = 68.64 %% Selectivity by GC = 91.5 %% Isomer = 4-5 %% DCFB = 24 %% H. B. = 4.1 %

According to the analysis of related databases, 1435-48-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ADITYA BIRLA SCIENCE & TECHNOLOGY CO. LTD.; MANDAL, Sisir; PATIL, Narendra; SULEMAN, Inamdur; MORE, Vinod; PURI, Prashant; WO2010/58421; (2010); A2;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Some common heterocyclic compound, 17318-08-0, name is 5-Bromo-1,3-dichloro-2-fluorobenzene, molecular formula is C6H2BrCl2F, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. category: chlorides-buliding-blocks

To an oven dried 8 mL vial with teflon cap purged with N2 was added Zinc dust (298 mg, 4.56 mmol), DMF(1.5 mL), and iodine (57.8 mg, 0.228 mmol). To this mixture was added (R)-methyl 2-((tert-butoxycarbonyl)amino)-3-iodopropanoate (500 mg, 1.519 mmol), immediately followed by iodine (57.8 mg, 0.228 mmol).Pd2(dba)3 (69.6 mg, 0.076 mmol), 2-dicyclohexylphosphino-2?,6?-dimethoxybiphenyl (62.4 mg, 0.152mmol), 5-bromo-1,3-dichloro-2-fluorobenzene (556 mg, 2.279 mmol) and the reaction mixture was allowedto stir at rt for 16 h. The crude mixture was diluted in 30 mL of EtOAc and DMF was removed using fouraqueous washes. The organic phase was dried over anhydrous sodium sulfate. The solution was filtered andconcentrated and the crude product was purified by silica gel chromatography using 100% hexanes to 30%EtOAc/Hexanes. The desired product was obtained as a pale yellow oil, (S)-methyl 2-((tertbutoxycarbonyl)amino)-3-(3,5-dichloro-4-fluorophenyl)propanoate, 0.102 g which was taken into next stepdirectly.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 17318-08-0, its application will become more common.

Reference:
Patent; Bristol-Myers Squibb Company; Miller, Michael Matthew; Mapelli, Claudio; Allen, Martin Patrick; Bowsher, Michael S.; Boy, Kenneth M.; Gillis, Eric P.; Langley, David R.; Mull, Eric; Poirier, Maude A.; Sanghvi, Nishith; Sun, Li-Qiang; Tenney, Daniel J.; Yeung, Kap-Sun; Zhu, Juliang; Reid, Patrick C.; Scola, Paul Michael; (892 pag.)US9308236; (2016); B2;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1996-30-1, name is 3-Bromo-4-fluorochlorobenzene, A new synthetic method of this compound is introduced below., HPLC of Formula: C6H3BrClF

A solution of 250 mg (0.686 mmol) (R)-tert-butyl 4-benzyl-2-((S)-2-hydroxy-3- methoxypropyl)piperazine-l -carboxylate and 0.1 ml 2-bromo-4-chloro-l-fluorobenzene (1.2 eq.) in DMSO (5 ml) under nitrogen atmosphere was stirred at room temperature for 2 h. The reaction mixture was poured onto brine and extracted twice with EtOAc. Combined extracts were washed with water three times and with saturated sodium chloride solution, dried over MgS04 and evaporated to dryness. The residue was purified by flash chromatography on silica with dichloromethane/methanol. (R)-tert- butyl 4-benzyl-2-((S)-2-(2-bromo-4-chlorophenoxy)-3-methoxypropyl)piperazine- 1 – carboxylate was obtained as oil (192 mg, 51 %).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; ABBVIE DEUTSCHLAND GMBH & CO. KG; BACKFISCH, Gisela; BAKKER, Margaretha Henrica Maria; BLAICH, Guenter; BRAJE, Wilfried; DRESCHER, Karla; ERHARD, Thomas; HAUPT, Andreas; HOFT, Carolin; LAKICS, Viktor; MACK, Helmut; OELLIEN, Frank; PETER, Raimund; RELO, Ana Lucia; (141 pag.)WO2017/89458; (2017); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 821-10-3, name is 1,4-Dichlorobut-2-yne belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. COA of Formula: C4H4Cl2

General procedure: A solution of 1,4-dichloro-2-butyne (1.23 g, 10 mmol) and the respective N-alkylazole (20 mmol) in MeCN (15 mL) was stirred at 80 C for 24 h. The precipitate wascollected by filtration, washed with MeCN, and dried under reduced pressure.

The synthetic route of 821-10-3 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Haslinger, Simone; Laus, Gerhard; Oberparleiter, Stefan; Wurst, Klaus; Kahlenberg, Volker; Nerdinger, Sven; Schreiner, Erwin; Schottenberger, Herwig; Heterocycles; vol. 95; 2; (2017); p. 1148 – 1158;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthetic Route of 13078-79-0, The chemical industry reduces the impact on the environment during synthesis 13078-79-0, name is 2-(3-Chlorophenyl)ethanamine, I believe this compound will play a more active role in future production and life.

At 0C, methyl chloroformate (4.6 g, 48 mmol) was added dropwise to a solution of 2-(3-chloro-phenyl)-ethylamine (5.0 g, 32 mmol) and Et3N (6.4 g, 64 mmol) in DCM (100 mL). After the addition, the mixture was stirred at room temperature for 0.5 hours. The organic layer was washed with water (3 x 30 mL), iN HC1 (20 mL) and brine (30 mL), dried over anhy. Na2SO4, filtered and concentrated in vacuo. After vacuum drying, the titlecompound was obtained (6.49 g, 95%) as a white solid. MS: 214.1 (M+Hj.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(3-Chlorophenyl)ethanamine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; AEBI, Johannes; AMREIN, Kurt; CHEN, Wenming; HORNSPERGER, Benoit; KUHN, Bernd; LIU, Yongfu; MAERKI, Hans P.; MARTIN, Rainer E.; MAYWEG, Alexander V.; TAN, Xuefei; WANG, Lisha; ZHOU, Mingwei; WO2014/191340; (2014); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 202197-26-0, name is 3-Chloro-4-((3-fluorobenzyl)oxy)aniline, This compound has unique chemical properties. The synthetic route is as follows., name: 3-Chloro-4-((3-fluorobenzyl)oxy)aniline

Step 2) N-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)-6-nitroquinazolin-4-amine A mixture of 4-chloro-6-nitroquinazoline (7.50 g, 35.8 mmol) and 3-chloro-4-((3-fluorobenzyl)oxy)aniline (9.00 g, 35.8 mmol) in isopropanol (150 mL) was heated to 80 C and stirred for 3.0 hours. The resulting mixture was then cooled to 20 C, and a yellow solid precipitated out. The mixture was filtered. The filter cake was washed with isopropanol (20 mL) and dried under vacuum to give the title compound as a yellow solid (8.50 g, 59.8%). The compound was characterized by the following spectroscopic data: MS (ESI, pos.ion) m/z : 425.8 [M+l]+; and NMR (400 MHz, CDC13) delta: 11.30 (brs, 1H), 9.54-9.48 (m, 1H), 8.45-8.41 (m, 1H), 8.31-8.25 (m, 1H), 7.98-7.89 (m, 1H), 7.50-7.47 (m, 1H), 7.35-7.26 (m, 1H), 7.05-6.96 (m, 1H), 6.90-6.80 (m, 2H), 7.74-7.60 (m, 2H), 4.84 (s, 2H).

According to the analysis of related databases, 202197-26-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Yingjun; LIU, Bing; LIU, Jinlei; ZHANG, Jiancun; ZHENG, Changchun; WO2014/177038; (2014); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 918538-05-3, name is 2,4-Dichloropyrrolo[2,1-f][1,2,4]triazine, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 2,4-Dichloropyrrolo[2,1-f][1,2,4]triazine

Weigh the intermediate 1-e (50 mg, 0.27 mmol)1-methyl-1H-pyrazole-4-boronic acid pinacol ester (55 mg, 0.27 mmol)2N aqueous Na2CO3 solution (0.27 ml, 0.54 mmol)Bis (triphenylphosphine) palladium (II) chloride (19 mg, 0.027 mmol)Dioxane (5 ml) was added to the flask and heated to 70 C for 16 h.After stopping the reaction,To the reaction solution was added 100 ml of water,Stir,Ethyl acetate (20 ml * 4)Drying the ester layer with anhydrous sodium sulfate,Concentrated, separated by column chromatography (petroleum ether: ethyl acetate = 5: 1),A yellow solid (55 mg, 88%) was obtained.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 918538-05-3.

Reference:
Patent; Jiangsu Xiansheng Pharmaceutical Co., Ltd.; Xin Minxing; Wen Jun; Tu Chongxing; Liu Zhaoyu; Shen Han; Wang Mengyu; Zhao Xinge; (36 pag.)CN104003990; (2017); B;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reference of 433-94-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 433-94-3 name is 2-Chloro-6-(trifluoromethyl)aniline, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Step A: 4-bromo-2-chloro-6-(trifluoromethyl)aniline N-bromo succinimide (910 mg, 5.1 mmol) was added to a solution of 2-chloro-6-(trifluoromethyl)aniline (1.0 g, 5.1 mmol) and acetic acid (3 mL) in acetonitrile (10 mL) at room temperature. The mixture was heated at reflux, with stirring, for 18 h. The reaction mixture was then filtered through Celite and concentrated to give the title compound, which was used in the next step without further purification.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Chloro-6-(trifluoromethyl)aniline, and friends who are interested can also refer to it.

Reference:
Patent; Valeant Pharmaceuticals North America; US2008/139610; (2008); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reference of 1871-57-4,Some common heterocyclic compound, 1871-57-4, name is 3-Chloro-2-chloromethyl-1-propene, molecular formula is C4H6Cl2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

1.0kg 3-chloro-2-chloromethylprop-1-ene,37.6g pinacol and 28.6g dibenzo-18-crown-6 were dissolved in 4.2kg tribromomethane,At a temperature controlled at 18-25 degrees, dropwise add 3.2kg of sodium hydroxide and 460g of potassium bromide to dissolve in 3.2kg of aqueous solution.Reaction for 50 hours; after the reaction is complete, add water and toluene, filter through celite pad,Wash the filter cake, combine the filtrates, separate the liquid, collect the organic phase, and concentrate to a small volume,Add n-heptane to crystallize at 0 degree, filter,Drying gave 1.185kg 1,1-dibromo-2,2-bis(chloromethyl)cyclopropane, light yellow solid, yield 50%, HPLC purity 98.7%.

The synthetic route of 1871-57-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Aisite (Chengdu) Bio-pharmaceutical Co., Ltd.; Wang Yin; Ha Leikeruishennan·kelatuer·nalaximuhan·kunqitapadamu; La Gehaiwende·laao·moshala; Zhao Zhenyu; Xu Hui; Guo Peng; (9 pag.)CN110759840; (2020); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reference of 771583-81-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 771583-81-4, name is 4-Chloro-2-(trifluoromethyl)benzylamine belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Example 28: 1-(4-chloro-2-(trifluoromethyl)benzyl)-3-(2,3-dihydro-2-oxobenzo[d]oxazol-4-yl)urea scheme 1) Preparation of 1-(4-chloro-2-(trifluoromethyl)benzyl)-3-(2,3-dihydro-2-oxobenzo[d]oxazol-4-yl)urea Commercially available 4-chloro-2-trifluoromethylbenzylamine (1 g, 4.77 mmol) was dissolved in 20ml of AcOEt and at 0C triphosgene (1.41 g, 4.77 mmol) was added to the solution. The mixture was warmed at 80C for 4 hours then evaporated and the residue was dissolved in 5 ml of DMF. The solution of the isocyanate was added dropwise to a solution in DMF (5 ml) of compound 1b (475 mg, 3.2 mmol) and the mixture was warmed at 80C for 8 hours. (TLC AcOEt 4 / petroleum ether 6). The solvent was evaporated and the crude was dissolved in AcOEt (30 ml) and washed with water (1 X 20 ml) and brine. The organic phase was dried over sodium sulfate and concentrated under vacuum. The purification of the crude residue by chromatographic column gave 120 mg of a white solid. Yield = 9.7% 1HNMR (DMSO, 200 MHz) delta 4.45 (2H, d, J = 5.6 Hz), 6.99 (4H, m), 7.65 (1H, d), 7.73 (1H, d), 7.85 (1H, bs), 8.62 (1H, bs), 11.04 (1H, bs); [M+1] 386.6 (C16H11ClF3N3O3 requires 385.73).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Chloro-2-(trifluoromethyl)benzylamine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Pharmeste S.r.l.; EP2377850; (2011); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics