Category: chlorides-buliding-blocks

Kong, Haiyan; Meng, Xianshe; Hou, Rui; Yang, Xiaoxiao; Han, Jihong; Xie, Zhouling; Duan, Yajun; Liao, Chenzhong published the artcile< Novel 1-(prop-2-yn-1-ylamino)-2,3-dihydro-1H-indene-4-thiol derivatives as potent selective human monoamine oxidase B inhibitors: Design, SAR development, and biological evaluation>, Formula: C8H8BrCl, the main research area is propynylamino dihydro indene thiol preparation hMAO B inhibitor; antiParkinson agent structure activity relationship; Fragment-based drug design; HMAO-B; Isoform selectivity; Structure activity relationship.

Successes have been achieved in developing human monoamine oxidase B (hMAO-B) inhibitors as anti-Parkinson’s disease (PD) drugs. However, low efficiency and unwanted side effects of the marketed hMAO-B inhibitors hamper their medical applications, therefore, novel potent selective hMAO-B inhibitors are still of great interest. Herein we report 1-(prop-2-yn-1-ylamino)-2,3-dihydro-1H-indene-4-thiol derivatives as hMAO-B inhibitors, which were designed by employing a fragment-based drug design strategy to link rasagiline to hydrophobic fragments. Among the synthesized 31 compounds, I and II demonstrated very encouraging hMAO-B inhibitory activities and selectivity over hMAO-A, better than rasagiline and safinamide. In vitro studies indicated that K8 and K24 are nontoxic to nervous tissue cells and they have considerable effects against ROS formation and potential neuroprotective activity. Further mice behavioral tests demonstrated these two compounds have good therapeutic effects on MPTP-induced PD model mice. All these experiment results suggest that compounds K8 and K24 can be promising candidates for further research for treatment of PD.

Bioorganic & Medicinal Chemistry Letters published new progress about Antiparkinsonian agents. 16799-05-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H8BrCl, Formula: C8H8BrCl.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Jacobs, Jon; Grum-Tokars, Valerie; Zhou, Ya; Turlington, Mark; Saldanha, S. Adrian; Chase, Peter; Eggler, Aimee; Dawson, Eric S.; Baez-Santos, Yahira M.; Tomar, Sakshi; Mielech, Anna M.; Baker, Susan C.; Lindsley, Craig W.; Hodder, Peter; Mesecar, Andrew; Stauffer, Shaun R. published the artcile< Discovery, Synthesis, And Structure-Based Optimization of a Series of N-(tert-Butyl)-2-(N-arylamido)-2-(pyridin-3-yl) Acetamides (ML188) as Potent Noncovalent Small Molecule Inhibitors of the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) 3CL Protease>, Electric Literature of 672948-03-7, the main research area is butylarylamidopyridinyl acetamide preparation; inhibitor severe acute respiratory syndrome coronavirus 3CL protease; SARS CoV inhibitor antiviral preparation.

A high-throughput screen of the NIH mol. libraries sample collection and subsequent optimization of a lead dipeptide-like series of severe acute respiratory syndrome (SARS) main protease (3CLpro) inhibitors led to the identification of probe compound ML188 (I), [(R)-N-(4-(tert-butyl)phenyl)-N-(2-(tert-butylamino)-2-oxo-1-(pyridin-3-yl)ethyl)furan-2-carboxamide, Pubchem CID: 46897844]. Unlike the majority of reported coronavirus 3CLpro inhibitors that act via covalent modification of the enzyme, I is a noncovalent SARS-CoV 3CLpro inhibitor with moderate MW and good enzyme and antiviral inhibitory activity. A multicomponent Ugi reaction was utilized to rapidly explore structure-activity relationships within S1′, S1, and S2 enzyme binding pockets. The X-ray structure of SARS-CoV 3CLpro bound with I was instrumental in guiding subsequent rounds of chem. optimization. I provides an excellent starting point for the further design and refinement of 3CLpro inhibitors that act by a noncovalent mechanism of action.

Journal of Medicinal Chemistry published new progress about Antiviral agents. 672948-03-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H3NO3, Electric Literature of 672948-03-7.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Raju, D. Suryanarayana; Sasidhar, R. L. C.; Vidyadhara, S. published the artcile< Synthesis and characterization of some novel 5-chloro benzimidazole-2-one derivatives with specific docking studies against PPAR-γ>, HPLC of Formula: 611-19-8, the main research area is piperidinyl benzimidazolone preparation mol docking; peroxisome proliferator activated receptor gamma; benzyl halide acyl chloride alkylation acylation.

A series of 5-chloro-1-(piperidin-4-yl)-1H-benzo[d]imidazole-2(3H)-one derivatives I (Ar = Ph, 4-ClC6H4, 4-BrC6H4, etc.) and II have been synthesized. The compounds were docked against peroxisome proliferator activated receptor-γ (PPAR-γ) by using MCULE software. It was found that the synthesized mols. were active against PPAR-γ by their comparative docking scores with that of standard marketed drugs i.e. Rosiglitazone and Pioglitazone. In particular compounds II (Ar = 2-MeC6H4) and I (Ar = 2-MeC6H4, 4-MeC6H4) showed more binding capacity. The synthesized mols. were identified to have good binding capacity with PPAR- γ according to their docking data.

International Journal of Life Science and Pharma Research published new progress about Aralkyl chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, HPLC of Formula: 611-19-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Xie, Dengbing; Zhang, Songlin published the artcile< Selective Reduction of Quinolinones Promoted by a SmI2/H2O/MeOH System>, Recommanded Product: (E)-Cinnamoyl chloride, the main research area is dihydroquinolinone preparation; quinolinone selective reduction.

The selective reduction of quinolin-2(1H)-ones promoted by a SmI2/H2O/MeOH system is reported for the first time. The reaction is effectively carried out to afford 3,4-dihydroquinoline-2(1H)-ones under mild conditions in a one-pot fashion with good to excellent yields.

Journal of Organic Chemistry published new progress about Chemoselectivity. 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Recommanded Product: (E)-Cinnamoyl chloride.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Li, Rongrong; Yao, Ganbing; Xu, Hui; Zhao, Hongkun published the artcile< Solid-Liquid Equilibrium and Phase Diagram for the Ternary 4-Chlorophthalic Anhydride + 3-Chlorophthalic Anhydride + Ethyl Acetate System>, Application of C8H3ClO3, the main research area is phase diagram ternary system chlorophthalic anhydride isomer ethyl acetate; solubility ternary system chlorophthalic anhydride isomer ethyl acetate.

The mutual solubility for ternary system of 4-chlorophthalic anhydride + 3-chlorophthalic anhydride + Et acetate was measured exptl. at different temperatures Four isothermal phase diagrams of the system were constructed based on the measured solubility At each temperature, there existed two pure solid phases, pure 4-chlorophthalic anhydride and pure 3-chlorophthalic anhydride, which were identified by the Schreinemakers’ wet residue method. When temperature decreases, the crystallization regions of 4-chlorophthalic anhydride and 3-chlorophthalic anhydride increase. At a certain temperature, the crystallization region of 4-chlorophthalic anhydride is smaller than that of 3-chlorophthalic anhydride.

Journal of Chemical & Engineering Data published new progress about Phase diagram. 118-45-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H3ClO3, Application of C8H3ClO3.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chakraborty, Subhasish K.; Chakraborty, Savitri; Bhattacharyya, Anjan; Chowdhury, Ashim published the artcile< Photolysis of oxyfluorfen in aqueous methanol>, Synthetic Route of 35852-58-5, the main research area is UV sunlight oxyfluorfen methanol photolysis.

Photolysis of oxyfluorfen, an herbicide of the nitrodiphenyl ether class, was studied in aqueous methanol under UV and sunlight. UV irradiation was carried out in a borosilicate glass photoreactor (containing 250 ppm oxyfluorfen in 50% aqueous methanol) equipped with a quartz filter and 125 W mercury lamp (maximum output 254 nm) at 25 ± 1°C. Sunlight irradiation was conducted at 28 ± 1°C in borosilicate Erlenmeyer flasks containing 250 ppm oxyfluorfen in 50% aqueous methanol. The samples from both the irradiated conditions were withdrawn at a definite time interval and extracted to measure oxyfluorfen content by gas chromatog.-flame ionization detector for rate study. The half-life values were 20 h and 2.7 days under UV and sunlight exposure, resp. Photolysis of oxyfluorfen yielded 13 photoproducts of which three were characterized by IR spectrophotometer and 1H NMR and 13C NMR spectroscopy. The rest of the photoproducts were identified by gas chromatog.-mass spectrometry (GC-MS) and thin layer chromatog. (TLC). An ionization potential 70 eV was used for electron impact-mass spectrometry (EI-MS) and methane was used as reagent gas for chem. ionization-mass spectrometry (CI-MS). Two of the photoproducts were also synthesized for comparison. The main phototransformation pathways of oxyfluorfen involved nitro reduction, dechlorination, and hydrolysis as well as nucleophiles displacement reaction.

Journal of Environmental Science and Health, Part B: Pesticides, Food Contaminants, and Agricultural Wastes published new progress about Chemical ionization mass spectrometry. 35852-58-5 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H4ClF3O, Synthetic Route of 35852-58-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Wang, Xiu; Wang, Zhenhua; Ishida, Takumi; Nishihara, Yasushi published the artcile< Methoxylation of Acyl Fluorides with Tris(2,4,6-trimethoxyphenyl)phosphine via C-OMe Bond Cleavage under Metal-Free Conditions>, Computed Properties of 17082-09-6, the main research area is methyl ester preparation; methoxylation acyl fluoride methoxyphenylphosphine.

Aryl fluorides (prepared from the corresponding aryl chlorides) underwent methoxylation reactions with tris(2,4,6-trimethoxyphenyl)phosphine (TMPP) (in the absence of added metal catalysts or reagents) in toluene to yield Me esters.

Journal of Organic Chemistry published new progress about Acid chlorides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Computed Properties of 17082-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Ishimaru, Hiromasa; Tsuda, Yasumasa; Kage, Hidenori; Kawano, Tomoaki; Takayama, Shinji; Morimoto, Yoshihito; Goto, Kazumi; Watanabe, Kazuhiro published the artcile< Pressure compatibility test of closed system drug transfer devices for 71 anticancer drugs>, Category: chlorides-buliding-blocks, the main research area is drug transfer device pressure compatibility anticancer agent.

Occupational exposure to anticancer drugs may increase the risk of cancer and the risk of miscarriage and stillbirth, and cause other adverse events such as hypersensitivity reactions, skin/mucous reactions, and digestive symptoms. Several studies have investigated the use of closed-system drug-transfer devices (CSTDs) to reduce the environmental pollution by hazardous drugs. However, few reports have verified whether CSTDs contain the hazardous drugs within the vials. The BD PhaSeal System is a CSTD that is frequently used in Japan. However, the fit of each anti-cancer drug vial has not been investigated. We investigated the fit of 71 major anti-cancer drug vials and protectors released and frequently used in Japan by means of a pressure compatibility test that we developed. The pressure compatibility test involved attaching a three-way stopcock to a Luer lock syringe and attaching an injector in line with the syringe. The pressure tubing was connected to the other side of the three-way stopcock and connected to the pressure inlet of the pressure gauge. The pressure in the anti-cancer drug vial was raised to 100 kPa and connected/disconnected repeatedly. If the pressure fluctuation during the 10th connection was within 6%, it was defined as “”no change””, and the compatibility of the protector and the vial was evaluated. The median pressure reduction rates at the 10th connection ranged from -1.98% to -4.95%. All drugs surveyed had an error rate within 6%. The BDPhaSeal Protector was shown to be compatible with the 71 anti-cancer drugs we surveyed.

Yakugaku Zasshi published new progress about Antitumor agents. 6055-19-2 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H17Cl2N2O3P, Category: chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics