Category: chlorides-buliding-blocks

Bunnett, J. F.; Bachman, D. M.; Snipper, L. P.; Maloney, J. H. published the artcile< Chlorination of 2-thiophenecarboxylic acid>, COA of Formula: C5H2Cl2O2S, the main research area is .

2-Thiophenecarboxylic acid (I) 3 g. (0.023 mole), NaOCl 0.042 mole, and excess NaOH in 400 cc. total volume were treated at pH 11.0 and 48° with 25 cc. 6 N HCl for 6 min. The temperature rose to 53°, the pH dropped to 1.3, and a white precipitate formed. After addition of 5 cc. 6 N HCl and 107 g. NaCl, the mixture was cooled and filtered to give 1.75 g. (46%) 5-chloro-2-thiophenecarboxylic acid (II), m. 134-7°, and, after recrystallization and sublimation, m. 149-50°, did not depress the m. p. of II prepared by KMnO4 oxidation of 5-chloro-2-acetylthiophene. Similarly 1.9 g. I (0.015 mole) and 0.037 mole NaOCl gave 0.4 g. (14%) 4,5-dichloro-2-thiophenecarboxylic acid, m. 194-4.5° (from H2O) (cf. m.p. 196-7° of Steinkopf and Kohler in C.A. 32, 3391.1). Oily by-products from several runs were combined to give a considerable fraction of 2,5-dichlorothiophene (III), b. 160-5°, nD16 1.5624; 3,4-dinitro derivative m. 85-5.5°. The by-product oil from a mixture of I and 3 moles NaOCl was a mixture of chlorinated thiophenes, with III the principal constituent.

Journal of the American Chemical Society published new progress about Chlorination. 31166-29-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C5H2Cl2O2S, COA of Formula: C5H2Cl2O2S.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Sawodny, Wolfgang; Niedenzu, Kurt; Hynes, John B.; Dawson, John W. published the artcile< Vibrational spectra of trihalo-s-triazines C3F3-nClnN3>, Application In Synthesis of 1435-43-4, the main research area is TRIAZINES VIBRATIONAL SPECTRA; HALOTRIAZINES VIBRATIONAL SPECTRA; TRIHALOTRIAZINES VIBRATIONAL SPECTRA.

The ir and Raman spectra of 2-fluoro-4,6-dichloro-s-triazine and 2,4-difluoro-6-chloro-s-triazine were recorded and an assignment of the normal vibrations in the series C3Cl3-nFnN3 is proposed. The ir spectra of the series C3Br3-nFnN3 are evaluated in somewhat less detail. 24 references.

Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy published new progress about 1435-43-4. 1435-43-4 belongs to class chlorides-buliding-blocks, and the molecular formula is C6H3ClF2, Application In Synthesis of 1435-43-4.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Budiman, Yudha P.; Lorenzen, Sabine; Liu, Zhiqiang; Radius, Udo; Marder, Todd B. published the artcile< Base-Free Pd-Catalyzed C-Cl Borylation of Fluorinated Aryl Chlorides>, Quality Control of 1435-43-4, the main research area is palladium catalyzed carbon chloride bond activation borylation fluoroaryl chloride; fluoroaryl borane preparation; boronate ester; borylation; cross-coupling; fluoroarene; palladium-catalyzed.

Catalytic C-X borylation of aryl halides containing two ortho-fluorines is challenging, as most previous methods require stoichiometric amounts of base and the polyfluorinated aryl boronates suffer from protodeboronation, which is accelerated by ortho-F substituents. Herein, the authors report that a combination of Pd(dba)2 (dba = dibenzylideneacetone) with SPhos (2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl) as a ligand is efficient to catalyze the C-Cl borylation of aryl chlorides containing two ortho-F substituents. This method, conducted under base-free conditions, is compatible with the resulting di-ortho-fluorinated aryl boronate products which are sensitive to base.

Chemistry – A European Journal published new progress about Aryl chlorides Role: RCT (Reactant), RACT (Reactant or Reagent) (fluorinated). 1435-43-4 belongs to class chlorides-buliding-blocks, and the molecular formula is C6H3ClF2, Quality Control of 1435-43-4.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Du, Guangyan; Rao, Suman; Gurbani, Deepak; Henning, Nathaniel J.; Jiang, Jie; Che, Jianwei; Yang, Annan; Ficarro, Scott B.; Marto, Jarrod A.; Aguirre, Andrew J.; Sorger, Peter K.; Westover, Kenneth D.; Zhang, Tinghu; Gray, Nathanael S. published the artcile< Structure-Based Design of a Potent and Selective Covalent Inhibitor for SRC Kinase That Targets a P-Loop Cysteine>, Application of C7H8ClN, the main research area is drug target design SRC kinase inhibitor antitumor.

SRC is a major regulator of many signaling pathways and contributes to cancer development. However, development of a selective SRC inhibitor has been challenging, and FDA-approved SRC inhibitors, dasatinib and bosutinib, are multi-targeted kinase inhibitors. Here, we describe our efforts to develop a selective SRC covalent inhibitor by targeting cysteine 277 on the P-loop of SRC. Using a promiscuous covalent kinase inhibitor (CKI) SM1-71 as a starting point, we developed covalent inhibitor 15a, which discriminates SRC from other covalent targets of SM1-71 including TAK1 and FGFR1. As an irreversible covalent inhibitor, compound 15a exhibited sustained inhibition of SRC signaling both in vitro and in vivo. Moreover, 15a exhibited potent antiproliferative effects in nonsmall cell lung cancer cell lines harboring SRC activation, thus providing evidence that this approach may be promising for further drug development efforts.

Journal of Medicinal Chemistry published new progress about Antiproliferative agents. 29027-20-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H8ClN, Application of C7H8ClN.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Hafner, Andreas; Meisenbach, Mark; Sedelmeier, Joerg published the artcile< Flow Chemistry on Multigram Scale: Continuous Synthesis of Boronic Acids within 1 s>, Recommanded Product: 4-Chloro-2-methoxybenzaldehyde, the main research area is multigram scale boronic acid chem synthesis.

The benefits and limitations of a simple continuous flow setup for handling and performing of organolithium chem. on the multigram scale is described. The developed metalation platform embodies a valuable complement to existing methodologies, as it combines the benefits of Flash Chem. (chem. synthesis on a time scale of <1 s) with remarkable throughput (g/min) while mitigating the risk of blockages. Organic Letters published new progress about Boronic acids Role: SPN (Synthetic Preparation), PREP (Preparation). 53581-86-5 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO2, Recommanded Product: 4-Chloro-2-methoxybenzaldehyde.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Genzer, Jerome D.; Huttrer, Charles P.; Van Wessem, G. C. published the artcile< Phenoxy- and benzyloxyalkyl thiocyanates>, HPLC of Formula: 16799-05-6, the main research area is .

A series of phenoxy- and benzyloxyalkyl thiocyanates was prepared for pharmacol. evaluation as fungicides against pathogenic fungi associated with dermatophytosis. Procedure 1: o-iso-PrC6H4OH (136 g.), then 250 g. Br(CH2)3Br, were added to 23 g. Na in 450 cc. absolute EtOH at a moderate rate, and the mixture refluxed 5 hrs., cooled, filtered, and fractionated. Procedure 2: p-MeC6H4O(CH2)4Cl was prepared from p-cresol, Cl(CH2)4Cl, and aqueous NaOH (Marvel and Tannenbaum, C.A. 23, 2162). Procedure 3: 139 g. p-O2NC6H4OH in 250 cc. absolute EtOH and 250 g. Br(CH2)3Br were added to 23 g. Na in 300 cc. absolute EtOH and the mixture refluxed 5 hrs. Procedure 4: 2 g. of the ester was heated with a slight excess of alc. KOH about 5 min. at 50°, the mixture poured into a large excess of cold water, and the solution acidified with 1:1 HCl. Procedure 5: 10 cc. xylene, then 20 g. o-ClC6H4CH2Cl in 9 cc. xylene were added (dropwise) to 1.6 g. Na in 18.6 g. (CH2OH)2, and the mixture refluxed 15 min., filtered, and fractionated. Procedure 6: 4.8 g. SOCl2 in 3.4 cc. CHCl3 was added to 7 g. o-ClC6H4CH2OCH2CH2OH in 4.5 g. cold Me2NPh (temperature kept at 20-30°), the mixture refluxed 30 min., cooled, poured into 50 cc. dilute HCl, the upper layer extracted twice with CHCl3, and the combined extracts fractionated. Procedure 7: 36 g. p-O2NC6H4OCH2CH2CH2Br and 15 g. KSCN in 80 cc. absolute EtOH were refluxed 6 hrs.; 7a: pure or crude bromide could be used; 7b: after the mixture was refluxed 9 hrs., 10 g. KI was added and the mixture refluxed 7 hrs. Procedure 8: 150 cc. alc., 52.7 g. Cl compound, 29.9 g. KSCN, and 1 g. powd. Cu were refluxed 24 hrs. Table I; Phenoxyalkyl halides, RC6H4(CH2)nX; R, n, X, B.p./mm., nD20, M.p., Yield (%), Procedure; , 4, Cl, 150°/0.2, 1.5215, , 21, 1; , 5, Cl, 116°/1.3, 1.5144, , 16, 1; o-Br, 2, Br, 116°/0.2, , , 63, 2; p-Br, 2, Br, , , 57°, 44, 2; o-Cl, 2, Br, 136°/5, 1.569, , 40, 2; m-Cl, 2, Br, 85°/0.1, 1.5680, , 23, 2; p-Cl, 2, Br, 108°/1, , 68°, 26, 2; o-Me, 2, Br, 100°/0.6, 1.5479, , 52, 2; m-Me, 2, Br, 80°/1.1, 1.5472, , 54, 2; p-Me, 2, Br, 110°/1, , 49°, 33, 2; p-Br, 3, Br, 150°/0.7, 1.5792, 50°, 53, 2; o-Cl, 3, Br, 120°/0.5, 1.5590, , 44, 2; m-Cl, 3, Br, 108°/1, 1.5580, , 31, 2; p-Cl, 3, Br, , , 37°, poor, 2; m-Me, 3, Br, 120°/2, 1.5422, , 10, 2; p-Br, 4, Cl, 128°/0.03, 1.5548, , 38, 2; o-Cl, 4, Cl, 130°/2, 1.5350, , 59, 2; m-Cl, 4, Cl, 114°/0.4, 1.5345, , 48, 2; o-Me, 4, Cl, 114°/1.5, 1.5189, , 26, 1; m-Me, 4, Cl, 93°/0.1, 1.5199, , 45, 1; p-Me, 4, Cl, 97°/0.2, 1.5180, , 20, 3; p-NO2, 3, Br, 155°/0.1, , , 35, 3; p-OMe, 2, Br, 95-104°/0.3, , , 14, 1; o-Me2CH, 2, Br, 80°/0.4, 1.5329, , 19, 2; o-Me2CH, 3, Br, 84°/0.1, , , 35, 1; 3,4-Me2C:, 2, Br, 90°/0.3, , , 21, 2; o-MeO2C 3, Br, 150-5°/1.4, , , 37, 1; p-MeO2C; 3, Br, 164°/1.5, , , 29, 1; o-MeO2C, 3, Cl, 140°/1.2, , , 37, 1; p-MeO2C, 3, Cl, 163°/3.2, , , 40, 1; o-HO2C, 3, Br, , , 71°, 100(from ester), 4; p-HO2C, 3, Br, , , 161°, 100, 4; o-HO2C, 3, Cl, , , 75°, 100, 4; p-HO2C, 3, Cl, , , 156-7°, 100, 4; Benzyloxyalkanols, RC6H4CH2OCH2O(CH2)nOH; , 2, 95°/0.25, 1.5209, 81, 5; , 3, 114°/0.9, 1.5184, 60, 5; , 5, 140°/0.4, 1.5099, 35, 5; o-Cl, 2, 84°/0.3, 1.5348, 84, 5; o-Cl, 3, 94°/0.5, 1.5245, 28, 5; o-Cl, 5, 139°/0.5, 1.5202, 54, 5; Benzyloxyalkyl chlorides, RC6H4CH2O(CH2)nCl; , 2, 75°/0.2, 1.5181, 77, 6a; , 3, 88°/0.5, 1.5113, 65, 6; , 4, 75°/0.7, 1.5109, 13, b; , 5, 86°/0.1, 1.5079, 75, 6; o-Cl, 2, 72°/0.1, 1.5339, 77, 6;o-Cl, 3, 120°/0.1, 1.5268, 48, 6; o-Cl, 5, 144°/1.6, 1.5193, 7, 6; Thenyloxy analog, b0.1 69-70°. Prepared from PhCH2OH, Na, and Cl(CH2)4Cl by refluxing 30 min., and distilling; Phenoxyalkyl thiocyanates, RC6H4O(CH2)nSCN; , 2, 152°/0.4, 1.5599, 81, 7; , 3, 125°/0.4, 1.5518, 83, 7; , 4, 155°/0.1, 1.5480, 38-9°, 37, 7b; p-Br, 2, , , 62-3°, 51, 7; o-Cl, 2, 180°/3.0, , 37-9°, 83, 7; m-Cl, 2, 126°/0.1, , , 33, 7; p-Cl, 2, 137°/0.1, 1.5710, 17, 7; o-Me, 2, 132°/0.3, , 60, 7; m-Me, 2, 158°/4.0, 1.5534, 63, 7; p-Me, 2, 130°/0.5, 1.5530, 66, 7; p-Br, 3, , , 48-9°, 53, 7,7a; o-Cl, 3, 165°/1.3, 1.5644, , 52, 7; m-Cl, 3, 164°/1.2, 1.5624, , 96, 7; p-Cl, 3, 50°/0.5, , , 40, 7; m-Me, 3, 138°/0.6, 1.5471, 42, 7; p-Br, 4, 180°/0.5, 1.5410, 66, 7b; m-Cl, 4, 186°/1.9, 1.5543, 55, 7b; o-Me, 4, 138°/0.1, 1.5533, 15, 7b; p-Me, 4, 193°/5.0, 1.5410, 27, 7b; o-HO2C, 3, , , 69-70°, 35, 7; p-HO2C, 3, , , 159°, 35, 7; p-O2N, 3, , , 53-4°, 44, 7; p-MeO, 2, 141°/0.4, , , 43, 7; o-Me2CH, 2, 123°/0.3, 1.5402, , 47, 7,7a; 3,4-Me2C:, 2, 130°/0.3, , , 51, 7; o-Me2CH, 3, 140°/0.1, 1.5363, , 60, 7,7a; o-Br, 2, 162°/1.7, , 1.5920, 51, 7; o-Cl, 4, 164°/0.5, 1.5544, , 40, 8; Benzyloxyalkyl thiocyanates, RC6H4CH2O(CH2)nSCN; , 3, 124°/0.1, 1.5348, 13, 8; , 5, 161°/0.6, 1.5292, 47, 8; o-Cl, 2, 160°/1.5, 1.5528, 16, 8; o-Cl, 3, 152°/0.8, 1.5506, 18, 8;

Journal of the American Chemical Society published new progress about Tinea pedis. 16799-05-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H8BrCl, HPLC of Formula: 16799-05-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Logsdon, Amanda L.; Herring, Betty J.; Lockard, Jarrett E.; Miller, Brittany M.; Kim, Hanna; Hood, Ronald D.; Bailey, Melissa M. published the artcile< Exposure to Green Tea Extract Alters the Incidence of Specific Cyclophosphamide-Induced Malformations>, Category: chlorides-buliding-blocks, the main research area is green tea extract cyclophosphamide monohydrate teratogenicity fetus natural pharmaceutical.

BACKGROUND: Green tea extract (GTE) has been shown to have antioxidative properties due to its high content of polyphenols and catechin gallates. Previous studies indicated that catechin gallates scavenge free radicals and attenuate the effects of reactive oxygen species. Cyclophosphamide (CP) produces reactive oxidative species, which can have adverse effects on development, causing limb, digit, and cranial abnormalities. The current study was performed to determine if exposure to GTE can decrease teratogenic effects induced by CP in CD-1 mice. METHODS: From gestation days (GD) 6-13, mated CD-1 mice were dosed with 400 or 800 mg/kg/d GTE; 100, 200, 400, or 800 mg/kg/d GTE + CP; CP alone, or the vehicle. GTE was given by gavage. CP (20 mg/kg) was given by i.p. injection on GD 10. Dams were sacrificed on GD 17, and their litters were examined for adverse effects. RESULTS: The highest GTE dose did not effectively attenuate, and in some cases exacerbated the neg. effect of CP. GTE alone was also associated with an increased incidence of microblepharia. Conversely, moderate GTE doses (200 and/or 400 mg/kg/d) attenuated the effect of CP on fetal weight and (GTE 200 mg/kg/d) decreased the incidences of certain defects resulting from CP exposure. CONCLUSIONS: Exposure of a developing mammal to moderate doses of GTE can modulate the effects of exposure to CP during development, possibly by affecting biotransformation, while a higher GTE dose tended to exacerbate the developmental toxicity of CP. GTE alone appeared to cause an adverse effect on eyelid development.

Birth Defects Research, Part B: Developmental and Reproductive Toxicology published new progress about Arm. 6055-19-2 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H17Cl2N2O3P, Category: chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chen, Chien Han; Jheng, Jia Kai; Juang, Tzong Yuan; Abu-Omar, Mahdi M.; Hsuan Lin, Ching published the artcile< Structure-property relationship of vinyl-terminated oligo(2,6-dimethyl-1,4-phenylene ether)s (OPEs): Seeking an OPE with better properties>, Recommanded Product: 1-(Chloromethyl)-4-vinylbenzene, the main research area is vinyl terminated oligodimethylphenylene ether.

Vinylbenzyl ether-terminated oligo(2,6-dimethyl-1,4-phenylene ether) (1) has been commercialized by Mitsubishi Gas Chem. in the name of OPE-2St. OPE (1) is used in high-frequency printed circuit board due to its low-dielec. characteristic after curing. However, for thermoset of (1), there is room for property improvement in thermal mech. property, dielec. property, oxygen permeation resistance, and so on. In this work, we report the preparation of three new oligo(2,6-dimethyl-1,4-phenylene ether)s: the vinyl benzoate-terminated OPE (2), the 3,5-bis(vinylbenzyl ether)benzyl ether-terminated OPE (3), and the 3,5-bis(vinylbenzyl ether)benzoate-terminated OPE (4), and compare their fundamental materials properties with the vinylbenzyl ether-terminated OPE (1). We discussed the effect of the number of vinyl groups (two or four) and the linker (benzyl ether or benzoate) on the properties of the four OPE thermosets. Through property evaluation and data analyses, we found that the thermoset of (4) show the highest Tg, modulus, oxygen permeation resistance, dimensional stability, and the lowest water absorption, and dielec. constant We also found that the toughness of thermoset of (4) can be significantly enhanced by the copolymerization with epoxy resin (HP7200) through the exchange reactions of benzoate and epoxy groups. In short, through properties comparison of four thermosets of (1-4), we demonstrate that (4) is a promising material for high-frequency printed circuit board.

European Polymer Journal published new progress about Contact angle. 1592-20-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H9Cl, Recommanded Product: 1-(Chloromethyl)-4-vinylbenzene.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Seo, Kyutae; Kang, Hyo published the artcile< Vertical Orientation of Liquid Crystal on Polystyrene Substituted with n-Alkylbenzoate-p-oxymethyl Pendant Group as a Liquid Crystal Precursor>, Formula: C9H9Cl, the main research area is polystyrene oxymethyl pendant liquid crystal polymer film physicochem property; anisotropic material; liquid crystal; n-alkyl-p-hydroxybenzoate; orientation layer; polystyrene.

We synthesized a series of polystyrene derivatives modified with precursors of liquid crystal (LC) mols. via polymer modification reactions. Thereafter, the orientation of the LC mols. on the polymer films, which possess part of the corresponding LC mol. structure, was investigated systematically. The precursors and the corresponding derivatives used in this study include ethyl-p-hydroxybenzoate (homopolymer P2BO and copolymer P2BO#, where # indicates the molar fraction of ethylbenzoate-p-oxymethyl in the side chain (# = 20, 40, 60, and 80)), n-butyl-p-hydroxybenzoate (P4BO), n-hexyl-p-hydroxybenzoate (P6BO), and n-octyl-p-hydroxybenzoate (P8BO). A stable and uniform vertical orientation of LC mols. was observed in LC cells fabricated with P2BO#, with 40 mol% or more ethylbenzoate-p-oxymethyl side groups. In addition, the LC mols. were oriented vertically in LC cells fabricated with homopolymers of P2BO, P4BO, P6BO, and P8BO. The water contact angle on the polymer films can be associated with the vertical orientation of the LC mols. in the LC cells fabricated with the polymer films. For example, vertical LC orientation was observed when the water contact angle of the polymer films was greater than ∼86°. Good orientation stability was observed at 150°C and with 20 J/cm2 of UV irradiation for LC cells fabricated with the P2BO film.

Polymers (Basel, Switzerland) published new progress about Contact angle. 1592-20-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H9Cl, Formula: C9H9Cl.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics