Category: chlorides-buliding-blocks

Profft, Elmar; Hoffmann, Hubert published the artcile< Thiophene. VIII. Sulfur derivatives of 2,3-dichloro-thiophene>, Synthetic Route of 31166-29-7, the main research area is .

The α-Cl atom of RCH2Cl (I) [R = 2,3-dichlorothien-5-yl] is very loosely held. Thus, 3.4 g. I reacted immediately in the cold with 1.7 g. KSCN in 30 ml. EtOH to give 68.8% RCH2SCN, m. 70° (petr. ether). I (51 g.) and 28 g. NH2CS2NH4 in 100 ml. EtOH gave RCH2SCSNH2 (II), yellowish crystals, m. 130° (petr. ether), almost quant. II warmed with 2N KOH gave 90.7% RCH2SH (III), b14.5136-8°. I (26.6 g.) warmed gently with KSH (from 9.4 g. KOH and H2S) in EtOH gave 56.6% crude III (which resinified on attempted distillation) and 41.4% (RCH2)2S (IV), m. 80-1°. III with Br in Et2O gave 80.5% (RCH2S)2 (V), m. 56°. III (2.5 g.) and 5 ml. H2O2 (Perhydrol) in 50 ml. HOAc at 50° gave 36.4% RCO2H, m. 196-7° (aqueous EtOH), probably via V. IV (2.8 g.) and 0.75 ml. Perhydrol in 25 ml. AcOH, after standing a few days, gave 99.2% (RCH2)2SO, m. 128° (EtOH). Similarly, 2.5 g. IV and 7 ml. Perhydrol gave 95.6% (RCH2)2SO2, m. 186° (EtOH). From I and Na mercaptides in absolute EtOH or from the Na salt of III and alkyl halides, the following RCH2SR’ (VI) were prepared in yields of 71-8% (R’ given): Et, b15 157°; Pr, b15 168°; Bu, b15 179°; Ph, m. 38° (EtOH); p-MeC6H4 (VII), m. 69° (EtOH). VI with a 4-fold excess of H2O2 in AcOH gave quant. the following RCH2SOR’ (R’ and m.p. given): Et, 92°; Pr, 106°; Bu, 82°; Ph, 137°. VII (1.2 g.) and 1 ml. Perhydrol in 10 ml. AcOH gave quant. p-MeC6H4SO2CH2R, m. 175-6° (EtOH). Portionwise addition of ClCH2COOK (from 4.8 g. acid) to an aqueous alc. solution of RCH2SK (from 10 g. III), keeping the temperature below 40°, and acidification, gave 77.5% RCH2SCH2COOH, m. 95° (petr. ether). No pure product could be isolated from the reaction of III with HNO3. I did not react with K3SO3 at room temperature; at a higher temperature (RCH2)2O was formed.

Journal fuer Praktische Chemie (Leipzig) published new progress about 31166-29-7. 31166-29-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C5H2Cl2O2S, Synthetic Route of 31166-29-7.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Dayagi, Shlomo; Degani, Jair; Friedlander, Ruth; Patai, Saul published the artcile< Tritylation and detritylation of active methylene compounds. IV. Formation and reactions of some hexasubstituted ethanes>, Quality Control of 90940-40-2, the main research area is .

Attempts were made by various methods to prepare hexasubstituted ethanes Ph3CCXYZ, where X and Y are strongly electron-attracting groups and Z is alkyl or aryl. Use of different active methine compounds gave the desired products in only a few cases. Heterolysis of these compounds was much more difficult than when Z = H.

Journal of the Chemical Society published new progress about Methylene group. 90940-40-2 belongs to class chlorides-buliding-blocks, and the molecular formula is C10H9ClO2, Quality Control of 90940-40-2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

El’tsov, A. V.; Sokolova, N. B.; Grigor’ev, A. D.; Dmitrieva, N. M.; Shtol’vin, A. S. published the artcile< Synthesis of Quinizarin and Its Derivatives under Conditions of Microwave Activation>, Application In Synthesis of 118-45-6, the main research area is microwave quinizarin preparation; anthracenedione dihydroxy microwave quinizarin preparation; isoindoledione chlorophenol microwave quinizarin preparation; cyclocondensation phthalic anhydride chlorophenol microwave quinizarin preparation.

In a microwave field, phthalic anhydride reacts with p-chlorophenol to give 1,4-dihydroxyanthraquinone (quinizarin) within 10 min. The reaction with 4-chlorophthalic anhydride occurs similarly. Phthalic and chlorophthalic acids can be used instead of anhydrides. 3-Nitrophthalic acid and 3,4,5,6-tetrabromophthalic anhydride do not react with p-chlorophenol under these conditions.

Russian Journal of General Chemistry (Translation of Zhurnal Obshchei Khimii) published new progress about Cyclocondensation reaction. 118-45-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H3ClO3, Application In Synthesis of 118-45-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Han, Yingzhi; Sun, Yadong; Abdukader, Ablimit; Liu, Bifu; Wang, Duozhi published the artcile< PhI-Catalyzed Intramolecular Oxidative Coupling Toward Synthesis of 2-Amino-1,3,4-Thiadizoles>, Recommanded Product: 5-(3-Chlorophenyl)-1,3,4-thiadiazol-2-amine, the main research area is aminothiadiazole preparation; aldehyde thiosemicarbazide iodobenzene catalyst oxidative coupling reaction.

A highly efficient method for the synthesis of thiadiazole derivatives via intramol. oxidative coupling of thiosemicarbazide, using the in situ generated hypervalent iodine(III) reagents was developed. The protocol can be carried out smoothly and provides a variety of thiadiazole derivatives in moderate to excellent yields.

Catalysis Letters published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 70057-67-9 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClN3S, Recommanded Product: 5-(3-Chlorophenyl)-1,3,4-thiadiazol-2-amine.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kilic, Deniz; Karaca Balta, Demet; Saloglu, Didem; Temel, Gokhan published the artcile< Synthesis and characterization of POSS hybrid organogels using Menschutkin quaternization chemistry>, Reference of 1592-20-7, the main research area is POSS hybrid organogel Menschutkin quaternization chem.

The present research describes a series of organic-inorganic hybrid gels based on polystyrene and polyhedral oligomeric silsesquioxanes (POSSs) prepared using free radical copolymerization and Menschutkin chem. techniques. In the first step, poly(styrene-co-chloromethylstyrene) is readily achieved by thermally initiated radical copolymerization and the subsequently obtained copolymer reacts with diethanolamine functional POSS nanoparticles which are employed as the crosslinker. The resulting hybrid network possesses ionic moieties and inorganic POSS nanoparticles. The POSS-containing hybrid gels exhibit excellent organic solvent absorption and show good mech. behavior. Gel containing 0.8 × 10-3 mmol of POSS(DEA)8 (DEA, diethanolamine) reached the highest swelling ratio; hence, the corresponding gel can absorb organic solvent up to 20× its weight The rate constant, coefficients and diffusional behavior of hybrid organogels in organic solvent were examined as well. The organic solvent intake of the hybrid gel follows a non-Fickian type diffusion. © 2018 Society of Chem. Industry.

Polymer International published new progress about Crosslinking agents. 1592-20-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H9Cl, Reference of 1592-20-7.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Carney, Daniel W.; Lukesh, John C. III; Brody, Daniel M.; Brutsch, Manuela M.; Boger, Dale L. published the artcile< Ultrapotent vinblastines in which added molecular complexity further disrupts the target tubulin dimer-dimer interface>, Application of C4H3NO3, the main research area is ultrapotent vinblastine derivative preparation tubulin binding cancer; chemical synthesis; drug design; protein–protein interaction; tubulin; vinblastine.

Approaches to improving the biol. properties of natural products typically strive to modify their structures to identify the essential pharmacophore, or make functional group changes to improve biol. target affinity or functional activity, change phys. properties, enhance stability, or introduce conformational constraints. Aside from accessible semisynthetic modifications of existing functional groups, rarely does one consider using chem. synthesis to add mol. complexity to the natural product. In part, this may be attributed to the added challenge intrinsic in the synthesis of an even more complex compound Herein, we report synthetically derived, structurally more complex vinblastines inaccessible from the natural product itself that are a stunning 100-fold more active (IC50 values, 50-75 pM vs. 7 nM; HCT116), and that are now accessible because of advances in the total synthesis of the natural product. The newly discovered ultrapotent vinblastines, which may look highly unusual upon first inspection, bind tubulin with much higher affinity and likely further disrupt the tubulin head-to-tail α/β dimer-dimer interaction by virtue of the strategic placement of an added conformationally well-defined, rigid, and extended C20′ urea along the adjacent continuing protein-protein interface. In this case, the added mol. complexity was used to markedly enhance target binding and functional biol. activity (100-fold), and likely represents a general approach to improving the properties of other natural products targeting a protein-protein interaction.

Proceedings of the National Academy of Sciences of the United States of America published new progress about Colorectal carcinoma. 672948-03-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H3NO3, Application of C4H3NO3.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Lee, Woorim; Marcotullio, Sandro; Yeom, Hoonsik; Son, Heejong; Kim, Tae-Hun; Lee, Yunho published the artcile< Reaction kinetics and degradation efficiency of halogenated methylparabens during ozonation and UV/H2O2 treatment of drinking water and wastewater effluent>, Recommanded Product: Methyl 3-chloro-4-hydroxybenzoate, the main research area is halogenated methylparaben degradation ozonation oxidative wastewater treatment; Hydroxyl radical; Micropollutant; Ozone; Paraben; UV/H(2)O(2).

This study investigated the reaction kinetics and degradation efficiency of methylparaben and its halogenated products (Cl-, Br-, Cl,Cl-, Br,Cl-, and Br,Br-methylparabens) during ozonation and UV254/H2O2 treatment. Second-order rate constants for reactions of the parabens with ozone and .OH were kO3 = 107 – 108 M-1 s-1 and [Formula Omitted] = (2.3 – 4.3)x 109 M-1 s-1 at pH 7. Species-specific kO3 values of the protonated and deprotonated parabens were closely related to phenol ring substituent effects via quant. structure-activity relationships with other substituted phenols. The UV photolysis rate of the parabens [kUV = (2.4 – 7.2)x 10-4 cm2 mJ-1] depended on the halogenation state of the paraben and solution pH, from which species-specific quantum yields were also determined In simulated treatments of drinking water and wastewater effluent, the parabens were efficiently eliminated during ozonation, requiring a specific ozone dose of > 0.26 gO3/gDOC for > 97% degradation During UV/H2O2 treatment with 10 mg L-1 H2O2, the degradation levels were > 90% at a UV fluence of 2000 mJ cm-2, except for Cl,Cl-methylparaben. Kinetic models based on the obtained reaction kinetic parameters could successfully predict the degradation levels of the parabens. Overall, ozonation and UV/H2O2 were effective in controlling parabens and their halogenated products during advanced water treatment.

Journal of Hazardous Materials published new progress about Absorptivity. 3964-57-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, Recommanded Product: Methyl 3-chloro-4-hydroxybenzoate.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Birgul, Kaan; Uba, Abdullah Ibrahim; Cuhadar, Ozan; Sevinc, Sevgi Kocyigit; Tiryaki, Selen; Tiber, Pinar Mega; Orun, Oya; Telci, Dilek; Yilmaz, Ozgur; Yelekci, Kemal; Guniz Kucukguzel, S. published the artcile< Synthesis and molecular modeling of MetAP2 of thiosemicarbazides, 1,2,4-triazoles, thioethers derived from (S)-Naproxen as possible breast cancer agents>, Category: chlorides-buliding-blocks, the main research area is naproxen thiosemicarbazide triazole thioether preparation mol modeling antitumor human.

New thiosemicarbazides, 1,2,4-triazoles and thioethers I (R1 = Ph, 4-FC6H4, Bn, etc.; R2 = Bn, 3-FC6H4CH2, 4-MeOC6H4CH2, etc.) from derived (S)-Naproxen were synthesized in this study. The mol. binding of the compounds on MetAP-2 was performed. Anticancer effects of the synthesized compounds were studied by using MTT assay method on MCF-7 (includes estrogen and progesterone receptors) and MDA-MB-231 (lacks estrogen and progesterone receptors) adenocarcinoma cell lines at 0, 10, 25, 50, 75 and 100μM concentrations for 24 h. The IC50 values of novel (S)-Naproxen derivatives were determined between from 5 to 100μM on MCF-7 breast cancer cell line and MDA-MB-231 cell lines. The apoptotic activity of selected compounds I (R1 = 4-ClC6H4; R2 = 3-FC6H4CH2) and I (R1 = Ph; R2 = 4-MeC6H4CH2) were first analyzed by Annexin V staining using Tali Image-Based Cytometer. Mitochondrial membrane potential changes determined in fluorescence plate reader following JC-1 stain for compounds I (R1 = 4-ClC6H4; R2 = 3-FC6H4CH2) and I (R1 = Ph; R2 = 4-MeC6H4CH2) in MCF-7 and MDA-MB-231 cells. The effect of these compounds on the cell viability 4T1 mouse mammary tumor cell line was tested at 1 to 5 times of calculated IC50 value (IC50x1, IC50x2, IC50x3, IC50x4, and IC50x5). Next in order to determine the toxicity of the combination of compound I (R1 = Bn; R2 = 3-FC6H4CH2) and Docetaxel, WST-1 cell viability and proliferation assay was performed with 4T1.

Journal of Molecular Structure published new progress about Antitumor agents. 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, Category: chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zeng, Lingping; Liao, Yunchuan; Wang, Jianchuan; Wei, Zidong published the artcile< Construction of highly efficient ion channel within anion exchange membrane based on interpenetrating polymer network for H2/Air (CO2-free) alkaline fuel cell>, Quality Control of 1592-20-7, the main research area is alk fuel cell interpenetrating polymer network anion exchange membrane.

Interpenetrating polymer network anion exchange membrane (IPN AEM) consists of cross-linked quaternized poly (vinylbenzyl chloride) and cross-linked poly (vinyl alc.) is synthesized in this work. Electron microscope clearly reveals the IPN structure, and with this structural design, a highly efficient ion channel within IPN AEMs is constructed. This specially designed structure leads to high hydroxide (OH-) conductivity (e.g., 141.7 mS cm-1 at 80°C) at a moderate ion exchange capacity (IEC) of 1.61 mmol g-1, and a remarkable peak power d. of 0.64 W cm-2 with non-noble metal oxygen reduction reaction (ORR) catalyst in H2/Air (CO2-free) anion exchange membrane fuel cells (AEMFCs) test.

Journal of Power Sources published new progress about Alkaline fuel cells. 1592-20-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H9Cl, Quality Control of 1592-20-7.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kawatsu, Takahiro; Aoyagi, Keiya; Nakajima, Yumiko; Choi, Jun-Chul; Sato, Kazuhiko; Matsumoto, Kazuhiro published the artcile< Catalytic Decarboxylation of Silyl Alkynoates to Alkynylsilanes>, Application In Synthesis of 3240-10-6, the main research area is copper catalyzed decarboxylation silyl alkynoate.

Herein, the authors describe a decarboxylative approach to the preparation of alkynylsilanes. Treatment of a silyl alkynoate in DMF at 80° in the presence of catalytic amounts of CuCl and PCy3 produced the corresponding alkynylsilane in excellent yield. The Cu-catalyzed decarboxylation proceeded smoothly with low catalyst loadings (0.5 mol % of CuCl and 1.0 mol % of PCy3) under mild reaction conditions and is easily scalable to gram quantities.

Organometallics published new progress about Alkynes Role: RCT (Reactant), RACT (Reactant or Reagent) (silyl alkynoates). 3240-10-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H5ClO2, Application In Synthesis of 3240-10-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics