Category: chlorides-buliding-blocks

Xiong, Jin; Liu, Yunyun published the artcile< Transition-Metal-free C5, C7-Dihalogenation and the Switchable C5 Halogenation of 8-Hydroxyquinolines>, Recommanded Product: 1-Chloropyrrolidine-2,5-dione, the main research area is dihalogenated hydroxyquinoline preparation; hydroxyquinoline acyl chloride halosuccinimide dihalogenation; halogenated hydroxyquinoline preparation; quinolinyl benzoate halosuccinimide halogenation.

The first example of the C5, C7-dihalogenation of 8-hydroxyquinolines based on an in situ O-acyl 8-hydroxyquinoline formation was realized under catalyst-free condition in toluene to synthesize 5,7-dihalogenated-8-hydroxyquinolines I [Ar = Ph, 4-FC6H4, 3-ClC6H4, etc.; R = H, 2-Me; X = Cl, Br, I]. Modifying the reaction conditions by directly utilizing O-acylated 8-hydroxyquinolines in the presence of AlCl3 enabled the electrophilic halogenation in the C5 position, led to the tunable synthesis of C5 halogenated products. The O-acyl group could be easily removed from the product to provide halogenated quinolines containing free hydroxyl group by simple hydrolysis.

ChemistrySelect published new progress about Esters Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, Recommanded Product: 1-Chloropyrrolidine-2,5-dione.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Pawar, Hari R.; Kamble, Narendra R.; Kamble, Vinod T. published the artcile< Chemoselective, room temperature and solvent-free synthesis of thio-esters using effective synergistic catalytic system>, Computed Properties of 17082-09-6, the main research area is thioester preparation chemoselective green chem; acyl chloride thiol acylation silver perchlorate niobium chloride solventless.

A simple and highly efficient room temperature catalytic protocol was developed towards the synthesis of thioesters R1C(O)SR2 (R1 = Me, Ph, 2-phenylethenyl, etc.; R2 = Ph, 4-methylphenyl, Et, propyl) from acyl chlorides R1C(O)Cl and thiols R2SH under solvent-free conditions. Ambient reaction conditions, short reaction time, and excellent product yields are notable features of this methodol.

Rasayan Journal of Chemistry published new progress about Acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Computed Properties of 17082-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Shegavi, Mahadev L.; Agarwal, Abhishek; Bose, Shubhankar Kumar published the artcile< Efficient synthesis of alkylboronic esters via magnetically recoverable copper nanoparticle-catalyzed borylation of alkyl chlorides and bromides>, Synthetic Route of 19995-38-1, the main research area is green chem alkyl boronic ester preparation; borylation copper nanoparticle catalyst alkyl chloride bromide green chem.

We report a magnetically separable Cu nanocatalyst (Fe-DOPA-Cu) for the borylation of alkyl halides with alkoxy diboron reagents, providing alkylboronic esters in high yields, with broad functional group tolerance under mild reaction conditions. The procedure is also applicable to the borylation of benzyl chlorides and bromides. Radical clock experiments support a radical-mediated process. Easy recycling of the catalyst resulted in no significant loss of activity up to ten runs.

Green Chemistry published new progress about Adsorption. 19995-38-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C6H7ClS, Synthetic Route of 19995-38-1.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Bazzi, Sakna; Schulz, Emmanuelle; Mellah, Mohamed published the artcile< Electrogenerated Sm(II)-Catalyzed CO2 Activation for Carboxylation of Benzyl Halides>, Computed Properties of 611-19-8, the main research area is phenylacetic acid preparation; benzyl halide carbon dioxide reductive electrochem carboxylation samarium catalyst.

Sm(II)-catalyzed carboxylation of benzyl halides is reported through the electrochem. reduction of CO2. The transformation proceeds under mild reaction conditions to afford the corresponding phenylacetic acids in good to excellent yields. This user-friendly and operationally simple protocol represents an alternative to traditional strategies, which usually proceeds through the C(sp3)-halide activation pathway.

Organic Letters published new progress about Aromatic carboxylic acids Role: SPN (Synthetic Preparation), PREP (Preparation). 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, Computed Properties of 611-19-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Formenti, Dario; Topf, Christoph; Junge, Kathrin; Ragaini, Fabio; Beller, Matthias published the artcile< Fe2O3/NGr@C- and Co-Co3O4/NGr@C-catalysed hydrogenation of nitroarenes under mild conditions>, Application of C7H8ClN, the main research area is aniline preparation green chem chemoselective; nitroarene hydrogenation reaction doped graphene iron cobalt nanocatalyst.

An improved hydrogenation of nitroarenes such as nitrobenzene, 2-nitrobiphenyl, 2,4,6-tri-t-butylnitrobenzene, etc. using nano-structured iron- and cobalt-based catalysts has been presented. Modifications of the heterogeneous catalysts by N-doped graphene-flakes are crucial for the success of selective reductions The use of polar solvents and basic additives has a significant pos. influence on the rate of reduction of nitroarenes. This allows performing non-noble metal-catalyzed hydrogenations under very mild reaction conditions (e.g. 70 °C and 20 bar). On the basis of the obtained catalytic results a heterolytic mechanism for the hydrogenation process is postulated, too.

Catalysis Science & Technology published new progress about Aromatic amines Role: SPN (Synthetic Preparation), PREP (Preparation). 29027-20-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H8ClN, Application of C7H8ClN.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Dub, Pavel A.; Matsunami, Asuka; Kuwata, Shigeki; Kayaki, Yoshihito published the artcile< Cleavage of N-H Bond of Ammonia via Metal-Ligand Cooperation Enables Rational Design of a Conceptually New Noyori-Ikariya Catalyst>, SDS of cas: 67421-02-7, the main research area is ammonia bond cleavage metal ligand cooperation; ionic ruthenium iridium metallacycle Noyori Ikariya precatalyst asym catalysis.

The asym. transfer hydrogenation (ATH) of ketones/imines with Noyori-Ikariya catalyst represents an important reaction in both academia and fine chem. industry. The method allows for the preparation of chiral secondary alcs./amines with very good to excellent optical purities. Remarkably, the same chiral Noyori-Ikariya complex is also a precatalyst for a wide range of other chemo- and stereoselective reductive and oxidative transformations. Among them are enantioselective sulfonamidation of acrylates (intramol. aza-Michael reaction) and carboxylation of indoles with CO2. Development of these catalytic reactions has been inspired by the realized cleavage of the N-H bond of sulfonamides and indoles by the 16e- amido derivative of the 18e- precatalyst via metal-ligand cooperation (MLC). This paper summarizes our efforts to investigate N-H bond cleavage of gaseous ammonia in solution via MLC and reports the serendipitous discovery of a new class of chiral tridentate κ3[N,N’,N”] Ru and Ir metallacycles, derivatives of the famous M-FsDPEN catalysts (M = Ru, Ir). The protonation of these metallacycles by strong acids containing weakly coordinating (chiral) anions generates ionic complexes, which were identified as conceptually novel Noyori-Ikariya precatalysts. For example, the ATH of aromatic ketones with some of these complexes proceeds with up to 99% ee.

Journal of the American Chemical Society published new progress about Aralkyl alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 67421-02-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C24H36Cl4Ru2, SDS of cas: 67421-02-7.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Nam, Nguyen-Hai; Huong, Tran Lan; Dung, Do Thi Mai; Dung, Phan Thi Phuong; Oanh, Dao Thi Kim; Park, Sang Ho; Kim, Kyungrok; Han, Byung Woo; Yun, Jieun; Kang, Jong Soon; Kim, Youngsoo; Han, Sang-Bae published the artcile< Synthesis, bioevaluation and docking study of 5-substituted phenyl-1,3,4-thiadiazole-based hydroxamic acids as histone deacetylase inhibitors and antitumor agents>, Application of C8H6ClN3S, the main research area is thiadiazole hydroxamic acid preparation histone deacetylase inhibitor antitumor; 5-phenyl-1,3,4-thiadiazole; cytotoxicity; heterocycle; histone deacetylase (HDAC) inhibitors.

Since the first histone deacetylase (HDAC) inhibitor (Zolinza, widely known as suberoylanilide hydroxamic acid; SAHA) was approved by the Food and Drug Administration for the treatment of T-cell lymphoma in 2006, the search for newer HDAC inhibitors has attracted a great deal of interest of medicinal chemists worldwide. As a continuity of the ongoing research in this area, the authors designed and synthesized a series of thiadiazole-based hydroxamic acids I [R = H, 2-Cl, 4-Me, etc.] as analogs of SAHA and evaluated their biol. activities. A number of compounds in this series, e.g. I [R = H], I [R = 2-Cl], I [R = 4-MeO], were found to possess potent anticancer cytotoxicity and HDAC inhibition effects. These compounds were generally two- to five-fold more potent in terms of cytotoxicity compared to SAHA against five cancer cell lines tested. Docking studies revealed that these hydroxamic acid displayed higher affinities than SAHA toward HDAC8.

Journal of Enzyme Inhibition and Medicinal Chemistry published new progress about Antitumor agents. 70057-67-9 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClN3S, Application of C8H6ClN3S.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Borges-Gonzalez, Jorge; Garcia-Monzon, Irma; Martin, Tomas published the artcile< Conformational Control of Tetrahydropyran-based Hybrid Dipeptide Catalysts Improves Activity and Stereoselectivity>, Category: chlorides-buliding-blocks, the main research area is aldehyde nitrostyrene dipeptide catalyst enantioselective diastereoselective Michael addition; nitro phenyl alkanal preparation.

It was demonstrated as to how carbohydrates can be used as conformational control units of organocatalysts to tune their catalytic properties was introduced. New hybrid dipeptide-like organocatalysts based on ζ-sugar aminoacids and proline were prepared and tested for the asym. Michael addition of aldehydes to β-nitrostyrenes. Taking full advantage of the modular nature of the carbohydrate motif, both reactivity and stereoselectivity were significantly improved. By simple structural changes, such as the elimination of the methoxy group in the C4 position of the tetrahydropyran ring, we obtained two complementary catalysts that allow accessed to both enantiomers of the γ-nitroaldehydes with excellent yields, diastereoselectivity and enantiomeric excesses between 97 and 99%, using a catalytic load even below 1 mol%.

Advanced Synthesis & Catalysis published new progress about Aldehydes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 5153-70-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClNO2, Category: chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Shingdilwar, Shashikant; Dolui, Subrata; Kumar, Devendra; Banerjee, Sanjib published the artcile< Facile access to template-shape-replicated nitrogen-rich mesoporous carbon nanospheres for highly efficient CO2 capture and contaminant removal>, COA of Formula: C9H9Cl, the main research area is nitrogen carbon dioxide capture nanosphere atom transfer radical polymerization.

Rising atm. CO2 levels and water pollution have necessitated new research towards the development of novel CO2 capture materials and innovative methods for wastewater treatment. Herein, we demonstrate a facile fabrication strategy to prepare novel template-shape-replicated nitrogen-rich mesoporous carbon nanospheres (NMCN) with high surface area, pore volume and ordered pore geometry via a combination of in situ co-condensation, surface-confined atom transfer radical polymerization (SC-ATRP) and post-polymerization modification. NMCN exhibited efficient CO2 capture performance and contaminant removal capability from wastewater. This work may open a new direction for the design of novel porous nanomaterials for CO2 capture and other emerging applications.

Materials Advances published new progress about Adsorption (isotherm). 1592-20-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H9Cl, COA of Formula: C9H9Cl.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Rouissi, Kamel; Hamrita, Bechr; Kouidi, Soumaya; Messai, Yosra; Jaouadi, Bassem; Hamden, Khaled; Medimegh, Imen; Ouerhani, Slah; Cherif, Mohamed; Elgaaied, Amel Benammar published the artcile< In vivo prevention of bladder urotoxicity: purified hydroxytyrosol ameliorates urotoxic effects of cyclophosphamide and buthionine sulfoximine in mice>, Formula: C7H17Cl2N2O3P, the main research area is hydroxytyrosol bladder urotoxicity antioxidant cyclophosphamide monohydrate BSO.

Urotoxicity is a troublesome complication associated with cyclophosphamide (CP) and L-buthionine-SR-sulfoximine (BSO) treatment in chemotherapy. With this concern in mind, the present study investigated the potential effects of a hydroxytyrosol extract from olive mill waste (OMW) on urotoxicity induced by acute CP and BSO doses using a Swiss albino mouse model. Toxicity modulation was evaluated by measuring lipid peroxidation (LPO) and antioxidants in urinary bladder. The findings revealed that the hydroxytyrosol extract exerted a protective effect not only on LPO but also on enzymic antioxidants. When compared to the controls, the CP-treated animals underwent significant decreases in the glutathione S-transferase (GST), glutathione reductase (GR), glutathione peroxidase (GP), and catalase (CAT) activities. The level of glutathione (GSH) was also reduced with increased doses of LPO in the CP-treated animals. L-Buthionine-SR-sulfoximine treatment exerted an additive toxic effect on the CP-treated animals. Interestingly, pretreatment with the hydroxytyrosol extract restored the activities of all enzymes back to normal levels and exhibited an overall protective effect on the CP- and BSO-induced toxicities in urinary bladder. The restoration of GSH through the treatment with the hydroxytyrosol extract can play an important role in reversing CP-induced apoptosis and free radical-mediated LPO.

International Journal of Toxicology published new progress about Antioxidants. 6055-19-2 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H17Cl2N2O3P, Formula: C7H17Cl2N2O3P.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics