Category: chlorides-buliding-blocks

Alkyl 2-Aryl-2-thioxoethanoates and -thioates: Preparation, Dimerization, and EPR Spectra of the Corresponding Radical Anions was written by Voss, Jurgen;Sawluk, Andrzej;Lange, Gisela;Adiwidjaja, Gunadi. And the article was included in Phosphorus, Sulfur and Silicon and the Related Elements in 2009.SDS of cas: 7476-66-6 This article mentions the following:

The title compounds were prepared by reaction of the corresponding α-halocarboxylic or α-halothiolocarboxylic esters with tetraethylammonium thiosulfate and subsequent treatment of the resulting Bunte salts with sodium hydroxide in a two-phase system. Under elimination of sulfite, the deep-blue colored thiones were generated. These labile compounds could not always be isolated from the solutions in a pure state. Instead, frequently the [2+2]-dimers (dialkyl 2,4-diaryl-1,3-dithietane-2,4-carboxylates) or other follow-up products were obtained. Nevertheless, the EPR spectra of the monomer radical anions could be recorded even if solutions of the dimers were reduced by internal electrolysis. Addnl. EPR spectra were observed in several cases, which the authors assign to the radical anions of dialkyl 2,3-diaryl-2-butene-1,4-dioate radical anions originating from electron induced sulfur extrusion of the corresponding 1,3-dithietanes. Radical trianions were observed when a 1,4-benzene-bis-α -thioxo ester or -thioxo-thiol ester was electroreduced at a more neg. electrode potential. In the experiment, the researchers used many compounds, for example, Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6SDS of cas: 7476-66-6).

Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.SDS of cas: 7476-66-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and urease inhibitory activities of benzophenone semicarbazones/thiosemicarbazones was written by Arshia, Arshia;Khan, Ajmal;Khan, Khalid Mohammed;Saad, Syed Muhammad;Siddiqui, Nida Iqbal;Javaid, Sumaira;Perveen, Shahnaz;Choudhary, M. Iqbal. And the article was included in Medicinal Chemistry Research in 2016.Name: 2,4-Dichlorophenylisothiocyanate This article mentions the following:

Twenty-five benzophenone semicarbazones and thiosemicarbazones were synthesized starting from benzophenones via hydrazones treated with different aryl isocyanates and isothiocyantes under reflux. All synthetic derivatives were evaluated for their urease inhibitory potential. A good-to-moderate inhibition trend against urease was observed with IC₅₀ values in the range of 8.7-119.5 μM, when compared with the standard thiourea (IC₅₀ = 21.2 ± 1.3 μM). One compound showed better inhibition than the standard having an IC₅₀ value of 8.7 ± 0.6 μM. Nine compounds with IC₅₀ values within the range of 26.1-43.6 μM, demonstrated good-to-moderate activities while one compound (IC₅₀ = 119.5 ± 1.6 μM) displayed very weak activity. The enzyme kinetic studies on the 2 most active compounds were performed to deduce their modes of inhibition and K_i values. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Name: 2,4-Dichlorophenylisothiocyanate).

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Name: 2,4-Dichlorophenylisothiocyanate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Occurrence and partitioning of bisphenol analogues, triclocarban, and triclosan in seawater and sediment from East China Sea was written by Xie, Jiahui;Zhao, Nan;Zhang, Yingying;Hu, Hongmei;Zhao, Meirong;Jin, Hangbiao. And the article was included in Chemosphere in 2022.Formula: C13H9Cl3N2O This article mentions the following:

Bisphenol analogs (BPs), triclocarban (TCC), and triclosan (TCS) are well-known environmental endocrine disrupters. Many studies have characterized their occurrence in the freshwater environment. However, their environmental behaviors in the coastal marine environment remain poorly understood. Here, matched seawater and sediment samples were collected from East China Sea, and analyzed for 13 BPs (including halogenated derivatives of bisphenol A), TCC, and TCS. Bisphenol A (BPA; mean 23 ng/L) was the predominant BP in seawaters, followed by tetrabromobisphenol A (TBBPA; 2.3 ng/L) and bisphenol S (BPS; 2.2 ng/L). Seawater concentrations of TCS (<LOD-8.7 ng/L) were much higher (p < 0.01) than that of TCC (<LOD-0.33 ng/L). In sediments BPA was still the major BP (mean 13 ng/g dw, dry weight), followed by bisphenol F (1.6 ng/g dw) and BPS (0.69 ng/g dw). All sediment samples contained measurable TCC (0.12-6.6 ng/g dw), while TCS was occasionally detected. For the first time, this study reports the environmental occurrence of bisphenol M and 4,4′-sulfonylbis (2-aminophenol) (a first discovered BPS analog) in seawaters and sediments. Spatially, inshore seawater and sediment samples contained higher (p < 0.01) BPA and BPS concentrations, compared with offshore samples. The mean log-transformed sediment-seawater partitioning coefficients (log K_oc) ranged from 2.3 (TBBPA) to 4.0 (TCC). The log Koc values of BPA, BPS, and BPAF were lower than those previously reported in the freshwater environment. Overall, this study provides first data on the spatial distribution patterns and partitioning behaviors of BPs, TCC, and TCS in marine environment. In the experiment, the researchers used many compounds, for example, 1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea (cas: 101-20-2Formula: C13H9Cl3N2O).

1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea (cas: 101-20-2) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Formula: C13H9Cl3N2O

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Mechanism of radical chlorination of hydrocarbons with N-halosulfonamides. Effect of structural factors on the reaction selectivity was written by Dneprovskii, A. S.;Eliseenkov, E. V.;Osmonov, T. A.. And the article was included in Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii) in 1998.Recommanded Product: 14070-51-0 This article mentions the following:

Radical chlorination of alkanes and their derivatives with N-halosulfonamides was studied by the method of competing reactions under conditions where H is abstracted only by sulfonylaminyl radical. The selectivity of reactions with N-halosulfonamides is intermediate between radical chlorination and bromination with mol. halogens. Radicals with captodative properties exhibit the highest selectivity. In the experiment, the researchers used many compounds, for example, 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0Recommanded Product: 14070-51-0).

2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Recommanded Product: 14070-51-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Cu-Catalyzed intermolecular [3 + 3] annulation involving oxidative activation of an unreactive C(sp³)-H bond: access to pyrimidine derivatives from amidines and ketones was written by Guo, Wei;Liu, Dongqing;Liao, Jianhua;Ji, Fanghua;Wu, Wanqing;Jiang, Huanfeng. And the article was included in Organic Chemistry Frontiers in 2017.HPLC of Formula: 18637-02-0 This article mentions the following:

A facile and efficient approach for the synthesis of various pyrimidine derivatives, e.g., I from amidines RC(NH₂)=NH (R = Me, Ph, 4-pyridyl, cyclopropyl, etc.) and ketones, e.g., 4-CH₃OC₆H₄C(O)CH₂CH₃ via a Cu-catalyzed intermol. oxidative coupling process using TEMPO/O₂ as a co-oxidant has been developed. This novel protocol features unreactive C(sp³)-H bond amination, a wide range of substrates, good functional group tolerance and mild reaction conditions. In the experiment, the researchers used many compounds, for example, 2-Chloro-benzamidine hydrochloride (cas: 18637-02-0HPLC of Formula: 18637-02-0).

2-Chloro-benzamidine hydrochloride (cas: 18637-02-0) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.HPLC of Formula: 18637-02-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis, structure-activity relationships and molecular docking studies of phenyldiazenyl sulfonamides as aromatase inhibitors was written by Giampietro, Letizia;Gallorini, Marialucia;Gambacorta, Nicola;Ammazzalorso, Alessandra;De Filippis, Barbara;Della Valle, Alice;Fantacuzzi, Marialuigia;Maccallini, Cristina;Mollica, Adriano;Cataldi, Amelia;Nicolotti, Orazio;Amoroso, Rosa. And the article was included in European Journal of Medicinal Chemistry in 2021.Reference of 63624-28-2 This article mentions the following:

In this respect, a series of phenyldiazenyl sulfonamides (E)-RS(O)₂NHC₆H₄N=NC₆H₅ (R = Me, Ph, 5-chlorothiophen-2-yl, etc.) and (E)-I was designed, synthesized and tested. Compounds (E)-RS(O)₂NHC₆H₄N=NC₆H₅ (R = 4-cyanophenyl, 2,4-dimethoxyphenyl (II)), and (E)-I (R = 2,4-dimethoxyphenyl) showed an aromatase inhibition in the micromolar range and were evaluated in vitro on the human breast cancer cell line MCF7 by MTT assay, cytotoxicity assay (LDH release), cell cycle anal. and apoptosis, revealing a dose-dependent inhibition profile. In particular, (II) displayed the best reduction in terms of metabolic activity and an anti-proliferative effect on MCF7 cells, being blocked in the G1/S phase checkpoint. Moreover, computational studies were carried out to better understand at a mol. level of detail the rationale behind the effective binding to the active site of aromatase of the more active inhibitor (II). The obtained results allow to consider this compound as an interesting lead for the development of a new class of non-steroidal aromatase inhibitors. In the experiment, the researchers used many compounds, for example, 2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2Reference of 63624-28-2).

2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Reference of 63624-28-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synergistic degradation of Methylene Blue by novel Fe-Co bimetallic catalyst supported on waste silica in photo-Fenton-like system was written by Quiton, Khyle Glainmer N.;Lu, Ming-Chun;Huang, Yao-Hui. And the article was included in Sustainable Environment Research in 2022.Product Details of 61-73-4 This article mentions the following:

In this present study, a novel method to fabricate bimetallic Fe-Co catalyst supported on waste silica was investigated for the photo-Fenton-like (PFL) degradation of Methylene Blue (MB) dye. The uniqueness of this work is on the preparation of the catalyst via fluidized-bed crystallization (FBC) process. Under the optimum conditions of initial pH of 3.0, 3.0 mM of H2O2, and 1.0 g L-1 of FBC-derived Fe-Co/SiO2 catalyst (fFCS), the maximum response for the decoloration and mineralization efficiencies of 20 mg L-1 of MB in 60 min were 100 and 65%, resp. Compared to the impregnated Fe-Co/SiO2 catalyst, the fFCS catalyst exhibited comparable decoloration and mineralization efficiencies, and relatively lower metal leaching for both iron and cobalt. Superoxide radical was unveiled to be the dominant reactive oxygen species in the PFL system over the fFCS catalyst. The catalysts were characterized by Fourier Transform IR spectroscopy, Energy Dispersive X-ray spectroscopy and SEM. The results show the successful incorporation of iron and cobalt on the surface of the SiO2 support material. In the experiment, the researchers used many compounds, for example, 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride (cas: 61-73-4Product Details of 61-73-4).

3,7-Bis(dimethylamino)phenothiazin-5-ium chloride (cas: 61-73-4) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Product Details of 61-73-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

A General Synthesis of N-Hydroxyindoles was written by Wong, Audrey;Kuethe, Jeffrey T.;Davies, Ian W.. And the article was included in Journal of Organic Chemistry in 2003.Recommanded Product: 16588-16-2 This article mentions the following:

A general method for the formation of N-hydroxyindoles is demonstrated through a Pb-promoted intramol. reductive cyclization of o-nitrobenzyl ketones and aldehydes under transfer hydrogenation conditions. The N-hydroxyindoles are isolated in high purity and excellent yield (>90%) in an operationally simple procedure. This new method is exemplified by a two-step synthesis of the naturally occurring 1-methoxyindole-3-carboxaldehyde, which is pivotal in many alkaloid total syntheses. In the experiment, the researchers used many compounds, for example, Ethyl 4-chloro-3-nitrobenzoate (cas: 16588-16-2Recommanded Product: 16588-16-2).

Ethyl 4-chloro-3-nitrobenzoate (cas: 16588-16-2) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Recommanded Product: 16588-16-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Structure-activity relationship of aloperine derivatives as new anti-liver fibrogenic agents was written by Wang, Kun;Guo, Zhihao;Bao, Yunyang;Pang, Yudong;Li, Yinghong;He, Hongwei;Song, Danqing. And the article was included in Molecules in 2020.Recommanded Product: 3-(Trifluoromethyl)benzene-1-sulfonyl chloride This article mentions the following:

Novel 12N-substituted aloperine derivatives I [R = Et, 3,4,5-trimethylphenyl, oxan-4-yl, etc.; R¹ = H, Me, naphthalen-2-yl; RR¹ = -(CH₂)₄-] and 12N-N’-phenoxazinylcarbamoylmethyl aloperine, II [R² = naphthalen-1-yl, 3-(trifluoromethyl)phenyl, Ph, 4-bromo-3-(trifluoromethyl)phenyl], III [R² = Bu, 3-(trifluoromethoxy)phenyl, 3-bromophenyl, etc.]were synthesized and investigated for their inhibitory effects on collagen α1 (I) (COL1A1) promotor in human hepatic stellate LX-2 cells, taking aloperine (1) as the hit. A structure-activity relationship (SAR) study disclosed that the introduction of suitable substituents on the 12N atom might enhance the activity. Compound 12N-N’-phenoxazinylcarbamoylmethyl aloperine exhibited a good promise on down-regulating COL1A1 expression with the IC₅₀ value of 16.5μM. Its inhibitory activity against COL1A1 was further confirmed on both mRNA and protein levels. Meanwhile, it effectively inhibited the expression of other fibrogenic proteins, such as transforming growth factor β1 (TGF-α1) and smooth muscle actin (α-SMA). It also exhibited good in vivo safety profile with the oral LD₅₀ value of 400 mg kg^-1 in mice. The results initiated the anti-liver fibrogenic study of aloperine derivatives, and the key compound 12N-N’-phenoxazinylcarbamoylmethyl aloperine was selected as a novel lead for further investigation against liver fibrogenesis. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Recommanded Product: 3-(Trifluoromethyl)benzene-1-sulfonyl chloride).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Recommanded Product: 3-(Trifluoromethyl)benzene-1-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Effect of fluorine substitution of α- and β-hydrogen atoms in ethyl phenylacetate and phenylpropionate on their stereoselective hydrolysis by cultured cancer cells was written by Yamazaki, Yoshimitsu;Yusa, Shiro;Kageyama, Yu-ichi;Tsue, Hirohito;Hirao, Ken-ichi;Okuno, Hiroaki. And the article was included in Journal of Fluorine Chemistry in 1996.Recommanded Product: 7476-66-6 This article mentions the following:

(±)-Et 2-fluoro-2-phenylacetate was stereoselectively hydrolyzed by cultured cells of several rat cancer cell lines to give the carboxylic acid rich in the R enantiomer. The stereoselectivity increased for (±)-Et 2-fluoro-2-phenylpropionate (I) with all present cell lines and for (±)-Et 2-phenyl-3,3,3-trifluoropropionate with rat hepatoma McA-RH7777 cell line. The stereoselectivity was different for the different cell lines, as McA-RH7777 cells preferred (R)-I in contrast with the preference towards (S)-I by other cells such as ras oncogene-transformed rat liver Anr4 cells. These stereoselectivities were different from those for non-fluorinated (±)-Et 2-phenylpropionate. Thus fluorine atoms are recognized by ester hydrolases of cancer cells, and fluorine substitution on the acyl group will be useful for making ester-type anticancer prodrugs more specific to cancer cells. In the experiment, the researchers used many compounds, for example, Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6Recommanded Product: 7476-66-6).

Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Recommanded Product: 7476-66-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics