Category: chlorides-buliding-blocks

On July 16, 2021, Cai, Wei; Zhou, Yiming; He, Yanlin; Chen, Kaihong; Yu, Cui; Huang, You published an article.COA of Formula: C11H19ClO2 The title of the article was Designing and Accurately Developing a [6 + 2] Dipolar Cycloaddition for the Synthesis of Benzodiazocines. And the article contained the following:

Herein, a concept for the design of 1,6-dipoles that bypasses the regioselectivity was described. Through the introduction of an amino group into Morita-Baylis-Hillman (MBH) carbonates, unprecedented [6 + 2] dipolar cycloadditions were accurately developed with Cs2CO3, efficiently delivering a series of benzodiazocines I (R1 = 9-Cl, 10-Me, 8-OMe, etc., R2 = Me, Et, i-Bu, etc.; R3 = OMe, OAllyl, Ph, etc.; R4 = 4-MeC6H4, 2,4-F2C6H3, 1-naphthyl, etc.) in mild conditions. Computational studies bring a deeper understanding of this reaction. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).COA of Formula: C11H19ClO2

The Article related to benzodiazocine preparation, morita baylis hillman carbonate isocyanate dipolar cycloaddition, Heterocyclic Compounds (More Than One Hetero Atom): Eight- and Higher-Membered Rings and other aspects.COA of Formula: C11H19ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On August 19, 2009, Baeyens-Cabrera, Jose Manuel; Buschmann, Helmut H.; Vela Hernandez, Jose Miguel; Zamanillo-Castanedo, Daniel; Nieto-Lopez, Francisco Rafael published a patent.Quality Control of 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride The title of the patent was Use of compounds binding to the sigma receptor for the treatment of neuropathic pain developing as a consequence of chemotherapy. And the patent contained the following:

The invention discloses the use of compounds binding to the sigma receptor for the treatment or prevention of neuropathic pain resulting from chemotherapy. The experimental process involved the reaction of 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride(cas: 4569-86-2).Quality Control of 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride

The Article related to chemotherapy neuropathic pain treatment sigma receptor ligand analgesic, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Quality Control of 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On August 27, 2009, Baeyens-Cabrera, Jose Manuel; Buschmann, Helmut H.; Vela-Hernandez, Jose-Miguel; Zamanillo-Castanedo, Daniel; Nieto-Lopez, Francisco Rafael published a patent.Product Details of 4569-86-2 The title of the patent was Use of compounds binding to the sigma receptor for the treatment of neuropathic pain developing as a consequence of chemotherapy. And the patent contained the following:

The present invention refers to the use of compounds binding to the sigma receptor for the treatment or prevention of neuropathic pain resulting from chemotherapy. The invention discloses the use of compounds binding to the sigma receptor for the treatment or prevention of neuropathic pain resulting from chemotherapy. The experimental process involved the reaction of 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride(cas: 4569-86-2).Product Details of 4569-86-2

The Article related to chemotherapy neuropathic pain treatment sigma receptor ligand analgesic, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Product Details of 4569-86-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On October 19, 2017, Kumoi, Hirofumi; Tanaka, Masato published a patent.Formula: C7H6ClF The title of the patent was Production method of phthalocyanine crystals and process for producing electrophotographic photoreceptor using the same. And the patent contained the following:

Title production method of phthalocyanine crystal includes mixing of phthalocyanine compound obtained by the acid pasting method with an organic compound and subjecting it to crystal transformation to obtain phthalocyanine crystal, which comprises a rotatable rotor and a jacket covering the rotor, at least the rotor has a flow path of a coolant or a heat medium therein and a gap between the rotor and the inner wall of the jacket has a portion forming an annular space, the rotor and the inner wall of the jacket both have a smooth surface and a crystal transformation is performed using a disperser having a structure in which a mixture of the phthalocyanine compound and the organic compound passes through the space filled with media particles. Thus, 0.3 parts of hydroxygallium phthalocyanine pigment powder (prepared by reacting chlorogallium phthalocyanine pigment with sulfuric acid), 9.7 parts of N,N-dimethylformamide were mixed in stainless steel container and then the mixed solution was subjected to dispersion treatment using glass beads as media particles and then the mixture was dispersed by using a dispersion machine to obtain hydroxygallium phthalocyanine crystals. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Formula: C7H6ClF

The Article related to phthalocyanine crystal organic compound electrophotog photoreceptor, Dyes, Organic Pigments, Fluorescent Brighteners, and Photographic Sensitizers: Phthalocyanines and other aspects.Formula: C7H6ClF

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On June 10, 2021, Yao, Hong; Uras, Giuseppe; Zhang, Pengfei; Xu, Shengtao; Yin, Ying; Liu, Jie; Qin, Shuai; Li, Xinuo; Allen, Stephanie; Bai, Renren; Gong, Qi; Zhang, Haiyan; Zhu, Zheying; Xu, Jinyi published an article.Formula: C7H6ClNO2 The title of the article was Discovery of Novel Tacrine-Pyrimidone Hybrids as Potent Dual AChE/GSK-3 Inhibitors for the Treatment of Alzheimer’s Disease. And the article contained the following:

Based on a multitarget strategy, a series of novel tacrine-pyrimidone hybrids were identified for the potential treatment of Alzheimer’s disease (AD). Biol. evaluation results demonstrated that these hybrids exhibited significant inhibitory activities toward acetylcholinesterase (AChE) and glycogen synthase kinase 3 (GSK-3). The optimal compound 27g (I) possessed excellent dual AChE/GSK-3 inhibition both in terms of potency and equilibrium (AChE: IC50 = 51.1 nM; GSK-3β: IC50 = 89.3 nM) and displayed significant amelioration on cognitive deficits in scopolamine-induced amnesia mice and efficient reduction against phosphorylation of tau protein on Ser-199 and Ser-396 sites in glyceraldehyde (GA)-stimulated differentiated SH-SY5Y cells. Furthermore, compound 27g exhibited eligible pharmacokinetic properties, good kinase selectivity, and moderate neuroprotection against GA-induced reduction in cell viability and neurite damage in SH-SY5Y-derived neurons. The multifunctional profiles of compound 27g suggest that it deserves further investigation as a promising lead for the prospective treatment of AD. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Formula: C7H6ClNO2

The Article related to tacrine pyrimidone hybrid ache gsk3 inhibitor alzheimer disease, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Formula: C7H6ClNO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On March 8, 2007, Buschmann, Helmut H. published a patent.Application of 4569-86-2 The title of the patent was Use of compounds binding to the sigma receptor for the treatment of diabetes-associated pain. And the patent contained the following:

The invention discloses the use of compounds active on the sigma receptor for the production of a medicament for the treatment of diabetes-associated pain. The experimental process involved the reaction of 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride(cas: 4569-86-2).Application of 4569-86-2

The Article related to diabetes pain analgesic sigma receptor binding compound, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Application of 4569-86-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On February 2, 2006, Baeyens Cabrera, Jose Manuel published a patent.Synthetic Route of 4569-86-2 The title of the patent was Use of compounds active on the sigma receptor for the treatment of mechanical allodynia. And the patent contained the following:

The invention discloses the use of compounds active on the sigma receptor for the treatment of mech. allodynia. The experimental process involved the reaction of 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride(cas: 4569-86-2).Synthetic Route of 4569-86-2

The Article related to mech allodynia treatment sigma receptor modulator, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Synthetic Route of 4569-86-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On May 23, 2007, Buschman, Helmut Heinrich published a patent.Electric Literature of 4569-86-2 The title of the patent was Use of compounds binding to the sigma receptor for the treatment of diabetes-associated pain. And the patent contained the following:

The invention discloses the use of compounds active on the sigma receptor for the production of a medicament for the treatment of diabetes-associated pain. The experimental process involved the reaction of 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride(cas: 4569-86-2).Electric Literature of 4569-86-2

The Article related to diabetes pain analgesic sigma receptor ligand, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Electric Literature of 4569-86-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On March 12, 2021, Wang, Kai; Jia, Fang; Song, Shihao; Zhao, Fang; Pan, Jie; Zhao, Yimei; Jiang, Jun; Ye, Wenjing published a patent.Reference of 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride The title of the patent was Preparation of methylene violet derivatives as fluorescent probes for sulfide ion detection. And the patent contained the following:

The title compounds with general formula I•Cl- [wherein R1 = -NHCOCH2-R3, -NH(CH2O)n-R3, –NH(CH2NH)n-R3, -NH(CH2)n-R3, -N=N-(p-phenyl)-R3 or R3, where R3 is 7-nitro-4-(1-piperazinyl-4-yl)-2,1,3-benzoxadiazole; R2 = NH2 or N(Et)2; n = independently 1-12] were prepared as fluorescent probes. For example, compound II•Cl- was prepared in a multi-step synthesis. The fluorescent probe can be used for sulfide ion detection or preparing photodynamic therapy probe. The invention has good water solubility, high detection sensitivity, simple synthesis, mild condition, and low cost. The experimental process involved the reaction of 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride(cas: 4569-86-2).Reference of 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride

The Article related to preparation methylene violet derivative fluorescent probes sulfide ion detection, Heterocyclic Compounds (More Than One Hetero Atom): Pyridazines, Cinnolines, and Phthalazines and other aspects.Reference of 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On June 15, 2011, Sukchol, Kulthida; Thongyai, Supakanok; Praserthdam, Piyasan published an article.HPLC of Formula: 14602-86-9 The title of the article was Preparation and characterization of novel polyimide with chiral side chain for twist nematic liquid crystal display. And the article contained the following:

The synthesis of novel polyimide (PI) films containing chirals in side chain was investigated for utilizing in twist nematic (TN) liquid crystal display (LCD). The polyimide with amine side groups (PI4 a.m.) was prepared by two steps copolymerization of 4,4′-hexafluoroisopropylidene diphthalic anhydride (6FDA), 4,4′-oxydianiline (ODA), and 3,3′-diaminobezidine (4AM) in N-methyl-2- pyrrolidinone (NMP). In the first step, the oligomer of 6FDA-ODA with mole ratio 4:3 was synthesized. In the second step, the oligomer was reacted with 4AM by gradually dropping the oligomer into 4AM solution with the mole ratio 4:5 to obtain amino groups containing polyimide P14AM. By reacting chiral compounds, mandelic acid, menthyl chloroformate, and menthyl glyoxylate hydrate using condensation reaction with amine groups along polyimide mols., the novel polyimides can be synthesized. Their chem. structures were confirmed by Fourier transform IR spectroscopy and NMR spectroscopy (1H-NMR). The coated glass slides pairs were coated with PI4AM and with each polyimide/chiral. The liquid crystals (LCs) were inserted between two coated glass slides at above the nematic temperature under the polarized light microscope to observe the alignment of LCs. The results showed the alignment of LCs in some certain direction under polyimide/chiral pair, regardless of the type of the chiral mol. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2011. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).HPLC of Formula: 14602-86-9

The Article related to polyimide chiral side chain alignment liquid crystal display, Radiation Chemistry, Photochemistry, and Photographic and Other Reprographic Processes: Other and other aspects.HPLC of Formula: 14602-86-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics