Category: chlorides-buliding-blocks

Kaboudin, B. published the artcileSurface-mediated solid phase reactions: microwave assisted Arbuzov rearrangement on the solid surface, HPLC of Formula: 866-23-9, the publication is Synthetic Communications (2001), 31(18), 2773-2776, database is CAplus.

Microwave assisted Arbuzov rearrangement under solvent-free condition is an efficient method for the preparation of dialkyl alkylphosphonates of alkyl halides. This method is an easy, rapid, and high-yielding reactions for the Arbuzov rearrangement. E.g., PhCH₂Cl reacts with P(OEt)₃ in the presence of Al₂O₃ under solvent-free conditions using microwave irradiation to give 85% yield of PhCH₂P(O)(OEt)₂.

Synthetic Communications published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, HPLC of Formula: 866-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Santos, Isabel C. M. S. published the artcileCatalytic performance of a boron peroxotungstate complex under homogeneous and heterogeneous conditions, Category: chlorides-buliding-blocks, the publication is Catalysis Today (2013), 87-94, database is CAplus.

The preparation and characterization (FTIR, FT-Raman, ¹¹B MAS NMR, diffuse reflectance, elemental anal.) of a novel boron peroxotungstate (BTBA)₄H[BW₄O₂₄] (BTBA = benzyltributylammonium) is reported, along with its use in the homogeneous oxidation of cis-cyclooctene, geraniol, linalool and (-)-carveol with H₂O₂ as oxidant and acetonitrile as solvent. High catalytic activity was registered for all the substrates studied under homogeneous conditions, namely 99% of conversion of geraniol after 2 h, 93% for linalool after 5 h, 74% for cis-cyclooctene after 6 h, and 100 % for (-)-carveol after 2 h of reaction. Some oxidation studies were carried out with the Venturello complex, [PW₄O₂₄]^3-, in the same conditions. Furthermore, the boron peroxotungstate (BW₄) was immobilized using two different strategies: (a) BW₄ anchored into a functionalized silica (aptesSiO₂) giving BW₄@aptesSiO₂ and (b) BW₄ encapsulated on a metal organic framework, commonly referred as MIL-101, giving BW₄@MIL-101. The catalytic activity of both heterogeneous materials was investigated for geraniol oxidation and the results were compared with those obtained with BW₄ under homogeneous conditions. The encapsulated boron peroxotungstate (BW₄@MIL-101) gave rise to the best results, reaching complete conversion of geraniol after 3 h of reaction and 78% selectivity for 2,3-epoxygeraniol. Addnl., this heterogeneous catalyst could be reused without appreciable loss of catalytic activity, affording similar 2,3-epoxygeraniol selectivity. The heterogeneous catalysts’ stability was also investigated after the oxidation reactions by different characterization techniques.

Catalysis Today published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C19H34ClN, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Baldwin, Ian published the artcileKinase array design, back to front: Biaryl amides, Quality Control of 6313-54-8, the publication is Bioorganic & Medicinal Chemistry Letters (2008), 18(19), 5285-5289, database is CAplus and MEDLINE.

New kinase inhibitors can be found by synthesis of targeted arrays of compounds designed using system-based knowledge as well as through screening focused or diverse compounds Most array strategies aim to add functionality to a fragment that binds in the purine subpocket of the ATP-site. Here, an alternative pharmacophore-guided array approach is described which set out to discover novel purine subpocket-binding groups. Results are shown for p38α and cFMS kinase, for which multiple distinct series with nanomolar potency were discovered. Some of the compounds showed potency in cell-based assays and good pharmacokinetic properties.

Bioorganic & Medicinal Chemistry Letters published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, Quality Control of 6313-54-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sinatra, Laura published the artcileHydroxamic Acids Immobilized on Resins (HAIRs): Synthesis of Dual-Targeting HDAC Inhibitors and HDAC Degraders (PROTACs), Application In Synthesis of 42074-68-0, the publication is Angewandte Chemie, International Edition (2020), 59(50), 22494-22499, database is CAplus and MEDLINE.

Inhibition of more than one cancer-related pathway by multi-target agents is an emerging approach in modern anticancer drug discovery. Here, based on the well-established synergy between histone deacetylase inhibitors (HDACi) and alkylating agents, we present the discovery of a series of alkylating HDACi using a pharmacophore-linking strategy. For the parallel synthesis of the target compounds, we developed an efficient solid-phase-supported protocol using hydroxamic acids immobilized on resins (HAIRs) as stable and versatile building blocks for the preparation of functionalized HDACi. The most promising compound, 3n (I), was significantly more active in apoptosis induction, activation of caspase 3/7, and formation of DNA damage (γ-H2AX) than the sum of the activities of either active principle alone. Furthermore, to demonstrate the utility of our preloaded resins, the HAIR approach was successfully extended to the synthesis of a proof-of-concept proteolysis-targeting chimera (PROTAC), which efficiently degrades histone deacetylases.

Angewandte Chemie, International Edition published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C7H3Cl2F3O2S, Application In Synthesis of 42074-68-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Santra, Sourav Kumar published the artcilePd^II/CuBr₂ catalysed keto α-C_sp3-H benzoxylation of N,N-dialkylamides directed by o-hydroxy groups, Recommanded Product: 5-Bromo-3-chloro-2-hydroxybenzaldehyde, the publication is Chemical Communications (Cambridge, United Kingdom) (2016), 52(24), 4501-4504, database is CAplus and MEDLINE.

A hydroxy group directed keto α-C_sp3-H benzoyloxylation of amides, including N,N-dialkylamides and cyclic amides, has been accomplished involving ortho-hydroxy substrates possessing either an aldehydic or a keto Me (-COCH₃) group with a Pd(II)/CuBr₂ catalytic combination. The carboxy group obtained via the in situ oxidation of -CHO or -COCH₃ groups of ortho-hydroxy substrates then undergoes a cross-dehydrogenative coupling (CDC) with amides to furnish an α-benzoyloxylation product with concurrent aromatic ring bromination.

Chemical Communications (Cambridge, United Kingdom) published new progress about 19652-33-6. 19652-33-6 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Bromide,Benzene,Phenol,Aldehyde, name is 5-Bromo-3-chloro-2-hydroxybenzaldehyde, and the molecular formula is C7H4BrClO2, Recommanded Product: 5-Bromo-3-chloro-2-hydroxybenzaldehyde.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Jagadeesh, Rajenahally V. published the artcileHighly selective transfer hydrogenation of functionalised nitroarenes using cobalt-based nanocatalysts, SDS of cas: 350-30-1, the publication is Green Chemistry (2015), 17(2), 898-902, database is CAplus.

Anilines are important feedstock for the synthesis of a variety of chems. such as dyes, pigments, pharmaceuticals and agrochems. The chemoselective catalytic reduction of nitro compounds represents the most important and prevalent process for the manufacture of functionalized anilines. Consequently, the development of selective catalysts for the reduction of nitro compounds in the presence of other reducible groups is a major challenge and is crucial. In this regard, herein we show that the cobalt oxide (Co₃O₄-NGr@C) based nano-materials, prepared by the pyrolysis of cobalt-phenanthroline complexes on carbon constitute highly selective catalysts for the transfer hydrogenation of nitroarenes to anilines using formic acid as a hydrogen source. Applying these catalysts, a series of structurally diverse and functionalized nitroarenes have been reduced to anilines with unprecedented chemo-selectivity tolerating halides, olefins, aldehyde, ketone, ester, amide and nitrile functionalities.

Green Chemistry published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C6H3ClFNO2, SDS of cas: 350-30-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sato, Takahiro published the artcileDiscovery of 3-(3-cyano-4-pyridyl)-5-(4-pyridyl)-1,2,4-triazole, FYX-051 – a xanthine oxidoreductase inhibitor for the treatment of hyperuricemia, Product Details of C6H4ClNO2, the publication is Bioorganic & Medicinal Chemistry Letters (2009), 19(21), 6225-6229, database is CAplus and MEDLINE.

A previous study identified 2-[2-(2-methoxy-ethoxy)-ethoxy]-5-[5-(2-methyl-4-pyridyl)-1H-[1,2,4]triazol-3-yl]-benzonitrile as a safe and potent xanthine oxidoreductase (XOR) inhibitor for the treatment of hyperuricemia. A series of 3,5-dipyridyl-1,2,4-triazole derivatives were synthesized and their in vivo activity in lowering the serum uric acid levels in rats was examined As a result, 3-(3-cyano-4-pyridyl)-5-(4-pyridyl)-1,2,4-triazole (FYX-051) to be one of the most potent XOR inhibitors; it exhibited an extremely potent in vivo activity, weak CYP3A4-inhibitory activity and a better pharmacokinetic profile than the previously identified compound FYX-051 is currently being evaluated in a phase 2 clin. trial.

Bioorganic & Medicinal Chemistry Letters published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, Product Details of C6H4ClNO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sato, Takahiro published the artcileDesign, synthesis, and pharmacological and pharmacokinetic evaluation of 3-phenyl-5-pyridyl-1,2,4-triazole derivatives as xanthine oxidoreductase inhibitors, Related Products of chlorides-buliding-blocks, the publication is Bioorganic & Medicinal Chemistry Letters (2009), 19(1), 184-187, database is CAplus and MEDLINE.

In an effort to find a potent xanthine oxidoreductase (XO) inhibitor, we discovered the best compound I. Here, we describe the following: (1) the design, synthesis, and structure-activity relationship of a series of 3-phenyl-5-pyridyl-1,2,4-triazole derivatives by in vitro studies of XO inhibitory activity in bovine milk and in vivo studies of serum uric acid (UA) reductive activity in rats, (2) a drug interaction study by a cytochrome P 450 3A4 (CYP3A4) assay, and (3) a pharmacokinetic (PK) study. Compound I exhibits potent XO inhibitory activity, serum UA-lowering activity in rats, weak CYP3A4 inhibitory activity, and moderate PK profile.

Bioorganic & Medicinal Chemistry Letters published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Churcher, Ian published the artcileA new series of potent benzodiazepine γ-secretase inhibitors, Application of 3-(2,6-Dichlorophenyl)propanoic acid, the publication is Bioorganic & Medicinal Chemistry Letters (2003), 13(2), 179-183, database is CAplus and MEDLINE.

A new series of benzodiazepine-containing γ-secretase inhibitors, e.g. I, with potential use in the treatment of Alzheimer’s disease is disclosed. Structure-activity relationships of the pendant hydrocinnamate side-chain which led to the preparation of highly potent inhibitors are described.

Bioorganic & Medicinal Chemistry Letters published new progress about 51656-68-9. 51656-68-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene, name is 3-(2,6-Dichlorophenyl)propanoic acid, and the molecular formula is C9H8Cl2O2, Application of 3-(2,6-Dichlorophenyl)propanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Patil, Vrushali published the artcileBiological evaluation of some synthesized benzothiazole derivatives and their characterization, Application In Synthesis of 3696-23-9, the publication is World Journal of Pharmaceutical Research (2015), 4(2), 842-850, database is CAplus.

Synthesis, characterization and biol. evaluation of [(1,3-benzothiazol-2-yl)-3,3-phenyl-1H-pyrazol-4-yl]methylidene thioureas I [R = H, 4-HO, 4-Cl, 4-C₂H₅O, 3,5-(MeO)₂] was reported. The compounds containing benzothiazole nucleus were treated with hydrazine hydrate to form hydrazone derivative followed by reaction with acetophenone and further cyclization via Vilsmeier-Haack reaction using DMF/POCl₃ and thus obtained intermediates were finally condensed with substituted thiourea. The structure of compounds I were confirmed by spectral anal. such as FT-IR, NMR, mass spectrophotometer and were further screened for various in-vitro biol. activities such as anti-oxidant, anti-inflammatory, anti-microbial activities. It was found that compounds I showed enhancing biol. activity.

World Journal of Pharmaceutical Research published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Application In Synthesis of 3696-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics