chlorides-buliding-blocks Archives - Page 51 of 1743

Alizadeh, Abdolali et al. published their research in Tetrahedron in 2016 | CAS: 6590-96-1

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Formula: C7H3Cl2NS

One-pot regio- and chemo-selective synthesis of thiaazatricyclododecane was written by Alizadeh, Abdolali;Bagherinejad, Akram;Bayat, Fahimeh;Zhu, Long-Guan. And the article was included in Tetrahedron in 2016.Formula: C7H3Cl2NS This article mentions the following:

A highly regio- and chemo-selective heteroannulation protocol for the synthesis of unreported polysubstituted thiaazatricyclododecanes I (R¹ = H, Br, Cl, OCH₃; R² = H, Cl; R³ = H, Br; R⁴ = H, Cl, F) has been developed by a sequential four-component reaction of isoquinoline, 2-bromoacetophenones R¹C₆H₄C(O)CH₂Br, aryl isothiocyanates 2-R²-3-R³-4-R⁴-C6H2NCS, and Me 4-chloro-3-oxobutanoate under mild conditions in CH₃CN. The method features formation of various C-N, C-S, and C-C bonds, low-cost and readily available substrates, as well as simple one-pot operation, which makes this process highly profitable. This synthesis serves as a nice addition to chem. in which purification via chromatog. and recrystallization can be avoided, and the pure products were obtained simply by washing the crude products with hexane-Et acetate (10:1). In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Formula: C7H3Cl2NS).

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Porta, Riccardo et al. published their research in Advanced Synthesis & Catalysis in 2017 | CAS: 12083-92-0

Dichlorodi(cyclopenta-1,3-dien-1-yl)platinate(II) (cas: 12083-92-0) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Reference of 12083-92-0

Solid Supported Chiral N-Picolylimidazolidinones: Recyclable Catalysts for the Enantioselective, Metal- and Hydrogen-Free Reduction of Imines in Batch and in Flow Mode was written by Porta, Riccardo;Benaglia, Maurizio;Annunziata, Rita;Puglisi, Alessandra;Celentano, Giuseppe. And the article was included in Advanced Synthesis & Catalysis in 2017.Reference of 12083-92-0 This article mentions the following:

A new class of solid supported chiral imidazolidinone organocatalysts for the catalytic reduction of imines with trichlorosilane was developed. Polystyrene proved to be a more effective support than SiO₂ in terms of both chem. and stereochem. efficiency. Even with a loading ≥1 mol% the best performing supported catalyst showed a remarkable activity and stereocontrol ability, promoting the reduction with stereoselectivities reaching 98% ee and in most cases ranging between 90-95% ee The general scope of the methodol. and the good recyclability of the immobilized catalyst were demonstrated. The polystyrene-anchored chiral catalyst was also used to prepare packed bed reactors for the continuous flow synthesis of chiral amines, that were obtained in excellent yields and enantioselectivities. By exploiting the chiral organocatalytic reactor, the in-flow stereoselective synthesis of a common, immediate precursor of rivastigmine, of the calciomimetic (R)-NPS 568 and of Acrylamide (S)-A, currently under study for the treatment of neuropathic pain, was successfully accomplished. In the experiment, the researchers used many compounds, for example, Dichlorodi(cyclopenta-1,3-dien-1-yl)platinate(II) (cas: 12083-92-0Reference of 12083-92-0).

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Wu, Xiongyu et al. published their research in Journal of Medicinal Chemistry in 2006 | CAS: 1138-56-3

4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Recommanded Product: 4-Butoxybenzene-1-sulfonyl chloride

Selective Angiotensin II AT₂ Receptor Agonists: Arylbenzylimidazole Structure-Activity Relationships was written by Wu, Xiongyu;Wan, Yiqian;Mahalingam, A. K.;Murugaiah, A. M. S.;Plouffe, Bianca;Botros, Milad;Karlen, Anders;Hallberg, Mathias;Gallo-Payet, Nicole;Alterman, Mathias. And the article was included in Journal of Medicinal Chemistry in 2006.Recommanded Product: 4-Butoxybenzene-1-sulfonyl chloride This article mentions the following:

Structural alterations in the 2- and 5-positions of the first drug-like selective angiotensin II AT₂ receptor agonist I have been performed. The imidazole ring system was proven to be a strong determinant for the AT₂ selectivity, and with few exceptions all variations gave good AT₂ receptor affinities and with retained high AT₂/AT₁ selectivities. On the contrary to the findings with AT₁ receptor agonists, the impact of structural modifications in the 5-position of the AT₂ selective compounds were less pronounced regarding activation of the AT₂ receptor. The butyloxyphenyl (56) and the propylthienyl (50) derivatives were found to exert a high agonistic effect as deduced from their capacity to induce neurite elongation in neuronal cells, as does angiotensin II. In the experiment, the researchers used many compounds, for example, 4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3Recommanded Product: 4-Butoxybenzene-1-sulfonyl chloride).

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Rehse, Henning et al. published their research in Makromolekulare Chemie in 1989 | CAS: 18437-66-6

tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Related Products of 18437-66-6

Polymer amino-protecting groups based on tert-butoxycarbonyl- and benzoylcarbonyl function-containing polymethacrylamides was written by Rehse, Henning;Ritter, Helmut. And the article was included in Makromolekulare Chemie in 1989.Related Products of 18437-66-6 This article mentions the following:

The synthesis of tert-butoxycarbonyl- and benzyloxycarbonyl-modified monomers was performed by the addition of p-ClC₆H₄NCO or PhCH₂NCO to the free OH groups of N-(2-hydroxy-2-methylpropyl)methacrylamide, N-(2-hydroxy-2-methylpropyl)-6-methylacrylamidohexanamide and N-β-hydroxyphenethylmethacrylamide. The monomers were homopolymerized and copolymerized with Me methacrylate. The kinetics of acidic-induced amine cleavage from the amino-protecting groups was followed by NMR spectroscopy, and the polymers were suitable amino-protecting groups. Ca²⁺ ions enhanced the rate of amine cleavage considerably. Neighboring group effects and the influence of comonomers and spacer groups on the reactivity of the urethane groups were also discussed. In the experiment, the researchers used many compounds, for example, tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6Related Products of 18437-66-6).

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kumar, G. Pavan et al. published their research in Journal of Chemistry in 2013 | CAS: 18437-66-6

tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Reference of 18437-66-6

Iodine-mediated neutral and selective N-Boc deprotection was written by Kumar, G. Pavan;Rambabu, D.;Rao, M. V. Basaveswara;Pal, Manojit. And the article was included in Journal of Chemistry in 2013.Reference of 18437-66-6 This article mentions the following:

A simple, efficient, and alternative method was developed for the N-Boc deprotection of structurally diverse protected amines. Selective removal of N-Boc groups was achieved with excellent yields under solvent-free conditions or in a solvent using I₂ as a catalyst. The methodol. involving the use of iodine for N-Boc deprotection of protected amines represents an effective and useful alternative to previously reported methods. In the experiment, the researchers used many compounds, for example, tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6Reference of 18437-66-6).

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Di Matteo, Mauro et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2016 | CAS: 63624-28-2

2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Electric Literature of C8H9ClO4S

Synthesis and biological characterization of 3-(imidazol-1-ylmethyl)piperidine sulfonamides as aromatase inhibitors was written by Di Matteo, Mauro;Ammazzalorso, Alessandra;Andreoli, Federico;Caffa, Irene;De Filippis, Barbara;Fantacuzzi, Marialuigia;Giampietro, Letizia;Maccallini, Cristina;Nencioni, Alessio;Parenti, Marco;Soncini, Debora;Del Rio, Alberto;Amoroso, Rosa. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2016.Electric Literature of C8H9ClO4S This article mentions the following:

The most frequently used treatment for hormone receptor pos. breast cancer in post-menopausal women are aromatase inhibitors. In order to develop new aromatase inhibitors, we designed and synthesized new imidazolylmethylpiperidine sulfonamides using the structure of the previously identified aromatase inhibitor SYN 20028567 as starting lead. By this approach, three new aromatase inhibitors with IC₅₀ values that are similar to that of letrozole and SYN 20028567 were identified. In the experiment, the researchers used many compounds, for example, 2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2Electric Literature of C8H9ClO4S).

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Manju, N. et al. published their research in Indian Journal of Heterocyclic Chemistry in 2018 | CAS: 16588-16-2

Ethyl 4-chloro-3-nitrobenzoate (cas: 16588-16-2) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Formula: C9H8ClNO4

Microwave-assisted synthesis of Benzimidazole derivatives through nitro reductive cyclization and their biological study was written by Manju, N.;Kalluraya, Balakrishna;Asma;Kumar, Madan S.. And the article was included in Indian Journal of Heterocyclic Chemistry in 2018.Formula: C9H8ClNO4 This article mentions the following:

A simple, effective and eco-friendly method was developed for the synthesis of 1,2-disubstituted benzimidazole derivatives I [R = Me, n-Pr, n-Bu; Ar = 4-HC≡CCH₂OC₆H₄, pyren-1-yl, 5-Cl-3-Me-1-phenyl-pyrazol-4-yl, etc.] via one-pot nitro reductive cyclization of Et 4-(alkylamino)-3-nitro-benzoates with aryl aldehydes using sodium dithionite reagent under microwave irradiation The newly synthesized compounds I were characterized by LC-MS, Fourier transform IR, ¹H-NMR, ¹³C-NMR, CHN anal. and also by X-ray diffraction method. The antioxidant activity studies indicated that compounds I [R = n-Pr, Ar = 5-oxido-3-(p-tolyl)oxadiazol-3-ium-4-yl; R = n-Bu, Ar = 5-oxido-3-(p-tolyl)oxadiazol-3-ium-4-yl; R = n-Bu, Ar = 2-chloro-3-quinolyl] having IC₅₀ values of 1.95, 1.27 and 4.08 were very potent against nitric oxide free radicals. Compound I [R = n-Bu, Ar = 2-chloro-3-quinolyl] exhibited comparable 2,2-diphenyl-1-picrylhydrazyl radical inhibition (76.57) with that of standard employed. The antimicrobial activity results indicated that compounds I [R = n-Bu, Ar = 5-oxido-3-(p-tolyl)oxadiazol-3-ium-4-yl; R = n-Pr, Ar = 4-HC≡CCH₂OC₆H₄; R = n-Bu, Ar = 5-Cl-3-Me-1-phenyl-pyrazol-4-yl] were moderately active against bacterial strains and rest of the compounds were moderately active against fungal strains. In the experiment, the researchers used many compounds, for example, Ethyl 4-chloro-3-nitrobenzoate (cas: 16588-16-2Formula: C9H8ClNO4).

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Quernheim, Martin et al. published their research in Angewandte Chemie, International Edition in 2015 | CAS: 206559-40-2

5-Bromo-2-chloro-m-xylene (cas: 206559-40-2) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Category: chlorides-buliding-blocks

The Precise Synthesis of Phenylene-Extended Cyclic Hexa-peri-hexabenzocoronenes from Polyarylated [n]Cycloparaphenylenes by the Scholl Reaction was written by Quernheim, Martin;Golling, Florian E.;Zhang, Wen;Wagner, Manfred;Raeder, Hans-Joachim;Nishiuchi, Tomohiko;Muellen, Klaus. And the article was included in Angewandte Chemie, International Edition in 2015.Category: chlorides-buliding-blocks This article mentions the following:

The longitudinal extension of cycloparaphenylenes (CPP) towards ultrashort carbon nanotubes (CNTs) is essential for the solution based bottom-up synthesis of CNTs. Herein, the longitudinal extension of the CPP skeleton by the introduction of hexaphenylbenzene units towards polyarylated [n]CPPs is described. Further, the applicability of the Scholl reaction to selectively form graphenic sidewalls is demonstrated. The ring size and substitution patterns of the polyarylated [n]CPPs were varied to overcome strain-induced side reactions during the oxidative cyclodehydrogenation and cyclic para-hexa-peri-hexabenzocoronene trimers ([3]CHBCs) were selectively obtained. This concept is envisioned as an access to ultrashort carbon nanotubes subject to the condition that further benzene rings with the right connectivity will be inserted. In the experiment, the researchers used many compounds, for example, 5-Bromo-2-chloro-m-xylene (cas: 206559-40-2Category: chlorides-buliding-blocks).

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Bhaskar, C. et al. published their research in Journal of Molecular Structure in 2022 | CAS: 620-19-9

1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Related Products of 620-19-9

Synthesis, XRD, Hirshfeld surface analysis, DFT studies, cytotoxicity and anticancer activity of di(m-chlorobenzyl) (dichloro) (4, 7-diphenyl-1,10-phenanthroline) tin (IV) complex was written by Bhaskar, C.;Elangovan, N.;Sowrirajan, S.;Chandrasekar, S.;Ali, Ola A. Abu;Mahmoud, Samy F.;Thomas, Renjith. And the article was included in Journal of Molecular Structure in 2022.Related Products of 620-19-9 This article mentions the following:

The complex di(m-chlorobenzyl) (dichloro) (4, 7-diphenyl-1,10-phenanthroline) tin (IV) complex (B2) was synthesized and characterized by FT-IR, FT-Raman, ¹H NMR, ¹³C NMR, ¹¹⁹Sn NMR, and XRD. The above-synthesized complex compared with the theor. method using Gaussian software at DFT/B3LYP/Lanl2DZ. Wavefunctiona based properties like ELF and LOL helped to identify the electron distributions. X-ray study confirmed that compound crystallizes in monoclinic space group with P2₁/c,. The crystal structure of the B2 shows a regular octahedral geometry. Hydrogen bond formation is observed through chlorine anion via C-H-Cl. The complex showed excellent cytotoxicity and anticancer activity against Vero and Hela cell line when compared to the standard drug cisplatin. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9Related Products of 620-19-9).

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Das, Debapratim et al. published their research in Advanced Synthesis & Catalysis in 2018 | CAS: 777-44-6

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Formula: C7H4ClF3O2S

Iridium(III)-Catalyzed Regiocontrolled Direct Amidation of Isoquinolones and Pyridones was written by Das, Debapratim;Samanta, Rajarshi. And the article was included in Advanced Synthesis & Catalysis in 2018.Formula: C7H4ClF3O2S This article mentions the following:

Iridium(III)-catalyzed highly regiocontrolled C3/C8 amidation of isoquinolones and C6 amidation of 2-pyridones has been successfully accomplished with various azides. The optimized method is operationally simple with a broad substrate scope. The protocol has been found to be scalable. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Formula: C7H4ClF3O2S).

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics