Category: chlorides-buliding-blocks

Improvement of mechanical properties and heat distortion temperature of polylactic acid by highly aromatic hyperbranched polyamide was written by Sun, Jianjian;Huang, Yansong;Jin, Yujuan;Tian, Huafeng;Men, Shuang. And the article was included in Journal of Applied Polymer Science in 2022.HPLC of Formula: 4422-95-1 This article mentions the following:

The highly aromatic hyperbranched polyamide (HBPA) was synthesized and used as a modifier in order to enhance the phys. performance of polylactic acid (PLA). The results showed that compared to the neat PLA, the tensile strength of the PLA/HBPA blends increased by 41.8%; fracture energy increased by 42.8% when the content of HBPA was 1.0 phr. The addition of HBPA can significantly improve the thermal deformation temperature of PLA. The polarized optical microscope images suggested that HBPA can act as a nucleating agent for PLA during the isothermal crystallization This research indicated HBPA exhibits excellent reinforcing effect for PLA, due to the formation of hydrogen bonds and/or chem. crosslinking between HBPA and PLA. In the experiment, the researchers used many compounds, for example, Trimesoylchloride (cas: 4422-95-1HPLC of Formula: 4422-95-1).

Trimesoylchloride (cas: 4422-95-1) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.HPLC of Formula: 4422-95-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Enol-keto tautomerism of 伪-ketophosphonates was written by Tam, Coretta C.;Mattocks, Karen L.;Tishler, Max. And the article was included in Proceedings of the National Academy of Sciences of the United States of America in 1981.HPLC of Formula: 6834-42-0 This article mentions the following:

R¹CHR²COP(O)(OEt)₂ (I; R¹ = H, R² = Me, CMe₃, Ph, o-, m-, p-MeOC₆H₄, 3,4-(MeO)₂C₆H₃, p-O₂NC₆H₄; R¹ = R² = Me) were prepared in 60-90% yield by reaction of R¹CHR²COCl with P(OEt)₃; the keto-enol tautomerism of I was studied by proton and P NMR and IR and the FeCl₃ test. Aliphatic I existed largely in the keto tautomeric forms, with only a small amount of enol forms present; however, aromatic I enolized extensively. Reaction of I (R¹ = H, R² = p-MeOC₆H₄) with CH₂N₂ gave a mixture of O-methylation and carbene insertion products; similar reaction of I (R¹ = R² = Me) gave only carbene insertion products. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0HPLC of Formula: 6834-42-0).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.HPLC of Formula: 6834-42-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Structure-Activity Relationship Studies To Identify Affinity Probes in Bis-aryl Sulfonamides That Prolong Immune Stimuli was written by Chan, Michael;Lao, Fitzgerald S.;Chu, Paul J.;Shpigelman, Jonathan;Yao, Shiyin;Nan, Jason;Sato-Kaneko, Fumi;Li, Vicky;Hayashi, Tomoko;Corr, Maripat;Carson, Dennis A.;Cottam, Howard B.;Shukla, Nikunj M.. And the article was included in Journal of Medicinal Chemistry in 2019.Category: chlorides-buliding-blocks This article mentions the following:

Agents that safely induce, enhance, or sustain multiple innate immune signaling pathways could be developed as potent vaccine adjuvants or coadjuvants. Using high-throughput screens with cell-based nuclear factor 魏B (NF-魏B) and interferon stimulating response element (ISRE) reporter assays, we identified a bis-aryl sulfonamide bearing compound 1 that demonstrated sustained NF-魏B and ISRE activation after a primary stimulus with lipopolysaccharide or interferon-伪, resp. Here, we present systematic structure-activity relationship (SAR) studies on the two Ph rings and amide nitrogen of the sulfonamide group of compound 1 focused toward identification of affinity probes. The murine vaccination studies showed that compounds 1 and 33 when used as coadjuvants with monophosphoryl lipid A (MPLA) showed significant enhancement in antigen ovalbumin-specific Ig responses compared to MPLA alone. SAR studies pointed to the sites on the scaffold that can tolerate the introduction of aryl azide, biotin, and fluorescent rhodamine substituents to obtain several affinity and photoaffinity probes which will be utilized in concert for future target identification and mechanism of action studies. In the experiment, the researchers used many compounds, for example, 4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3Category: chlorides-buliding-blocks).

4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Exploring ibuprofen derivatives as 伪-glucosidase and lipoxygenase inhibitors: Cytotoxicity and in silico studies was written by Daud, Saima;Abid, Obaid-ur-Rahman;Sardar, Asma;Abdullah, Shawana;Shahid, Wardah;Ashraf, Muhammad;Ejaz, Syeda Abida;Saeed, Amna;Shah, Basit Ali;Niaz, Basit. And the article was included in Archiv der Pharmazie (Weinheim, Germany) in 2022.Synthetic Route of C7H3Cl2NS This article mentions the following:

This study reports the synthesis of a series of ibuprofen derivatives, including thiosemicarbazides 4a-f, 1,3,4-oxadiazoles 5a-f, 1,3,4-thiadiazoles 6a-f, 1,2,4-triazoles 7a-f, and their S-alkylated derivatives 8a-d. All of the newly synthesized derivatives were analyzed using 1H NMR, 13C NMR spectroscopy, and high-resolution mass spectra (electron ionization) spectrometry. These synthetic mols. were examined for their in vitro baking yeast 伪-glucosidase and soybean 15-lipoxygenase (15-LOX) inhibition and cell viability studies. The results revealed that the compounds N-(3,4-dichlorophenyl)-5-[1-(4-isobutylphenyl)ethyl]-1,3,4-oxadiazol-2-amine 5f (IC50 3.05 卤 1.23 渭M) and N-(3-fluorophenyl)-5-[1-(4-isobutylphenyl)ethyl]-1,3,4-oxadiazol-2-amine 5b (IC50 3.12 卤 1.21 渭M) were the most potent with respect to the 伪-glucosidase enzyme while in case of 15-LOX, the compound 4-(2,4-dichlorophenyl)-1-[2-(4-isobutylphenyl)propanoyl]thiosemicarbazide 4e showed potent inhibition with an IC50 value of 55.41 卤 0.41 渭M. All these compounds were found least toxic by displaying a blood mononuclear cell viability value of 69.2%-97.8% by the MTT assay compared to the standards when assayed at 0.25 mM concentration Mol. docking analyses were conducted to evaluate the inhibition profiles of these derivatives against the said enzymes and the data supported the in vitro profiles. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Synthetic Route of C7H3Cl2NS).

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Synthetic Route of C7H3Cl2NS

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Design, synthesis and biological activities of novel 5-isopropyl-2-methylphenolhydrazide-based sulfonamide derivatives was written by Bagul, Suresh D.;Rajput, Jamatsing D.;Tadavi, Samina K.;Bendre, Ratnamala S.. And the article was included in Research on Chemical Intermediates in 2017.HPLC of Formula: 777-44-6 This article mentions the following:

Abstract: Sulfonamides have enormous importance in biol. sciences. In the present investigation, the fundamental energetic group, hydrazide-based sulfonamide, has been incorporated into a naturally occurring phenolic monoterpenoid, carvacrol (5-isopropyl-2-methylphenol) moiety, with the aim of combining the active groups to generate more potent antimicrobial and anti-oxidant agents. Series of hydrazide-based sulfonamide derivatives (IV a-g) have been synthesized and characterized by modern sophisticated techniques such as ¹H NMR, ¹³C NMR and LC-MS. The newly synthesized derivatives were screened for their antimicrobial activities against three fungal (Aspergillus niger, A. flavus and A. fumigatus) and three bacterial (Escherichia coli, Staphylococcus aureus and Bacillus subtilis) species, of which compounds IVc and IVd were found to have good antifungal activity and compounds IVd and IVg exhibited decent antibacterial activities. Antioxidant activity was performed by DPPH radical scavenging assay. Compound IVd has been found to be more active in comparison to standard ascorbic acid and compounds IVa, IVb, and IVc demonstrated excellent antioxidant activity. Graphical Abstract: [Figure not available: see fulltext.]. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6HPLC of Formula: 777-44-6).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.HPLC of Formula: 777-44-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Efficient Syntheses of Benzothiazepines as Antagonists for the Mitochondrial Sodium-Calcium Exchanger: Potential Therapeutics for Type II Diabetes was written by Pei, Yazhong;Lilly, Michael J.;Owen, David J.;D’Souza, Lawrence J.;Tang, Xiao-Qing;Yu, Jinghua;Nazarbaghi, Ramina;Hunter, Andrew;Anderson, Christen M.;Glasco, Susan;Ede, Nicholas J.;James, Ian W.;Maitra, Uday;Chandrasekaran, S.;Moos, Walter H.;Ghosh, Soumitra S.. And the article was included in Journal of Organic Chemistry in 2003.Computed Properties of C11H14ClNO2 This article mentions the following:

Type II diabetes mellitus is a chronic metabolic disorder that can lead to serious cardiovascular, renal, neurol., and retinal complications. While several drugs are currently prescribed to treat type II diabetes, their efficacy is limited by mechanism-related side effects (weight gain, hypoglycemia, gastrointestinal distress), inadequate efficacy for use as monotherapy, and the development of tolerance to the agents. Consequently, combination therapies are frequently employed to effectively regulate blood glucose levels. We have focused on the mitochondrial sodium-calcium exchanger (mNCE) as a novel target for diabetes drug discovery. We have proposed that inhibition of the mNCE can be used to regulate calcium flux across the mitochondrial membrane, thereby enhancing mitochondrial oxidative metabolism, which in turn enhances glucose-stimulated insulin secretion (GSIS) in the pancreatic 尾-cell. In this paper, we report the facile synthesis of benzothiazepines, e.g., I, and derivatives by S-alkylation using 2-aminobenzhydrols. The syntheses of other bicyclic analogs based on benzothiazepine, benzothiazecine, benzodiazecine, and benzodiazepine templates are also described. These compounds have been evaluated for their inhibition of mNCE activity, and the results from the structure-activity relationship (SAR) studies are discussed. In the experiment, the researchers used many compounds, for example, tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6Computed Properties of C11H14ClNO2).

tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Computed Properties of C11H14ClNO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Constructing chemical stable 4-carboxyl-quinoline linked covalent organic frameworks via Doebner reaction for nanofiltration was written by Yang, Yongliang;Yu, Ling;Chu, Tiancheng;Niu, Hongyun;Wang, Jun;Cai, Yaqi. And the article was included in Nature Communications in 2022.Quality Control of 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride This article mentions the following:

Covalent linkages are the key component of covalent organic frameworks (COFs). The development of stable and functional linkages is essential to expand the COFs family and broaden their application prospects. In this work, we report the synthesis of crystalline and chem. stable 4-carboxyl-quinoline linked COFs (QL-COFs) via Doebner reactions in both one-pot (OP) and post-synthetic modification (PSM) methods. Both methods can be universally applied to most of the reported imine COFs family via bottom-up construction or linkage conversion. Owing to the contractive pore size, more hydrophilic structure and better chem. stability than the conventional imine COFs endowed by 4-carboxyl-quinoline linkage, QL-COFs are supposed to possess a wider application range. We further demonstrate the nanofiltration membrane (NFM) based on QL-COF exhibited a desirable separation capacity with high rejection for small dye mols. (> 90%), high water permeance (850 L m^-2 h^-1 MPa^-1) and tolerance of extreme conditions (1 M HCl/NaOH), which were benefitted from the enhanced properties of QL-COFs. Addnl., efficient ion sieving properties were also achieved by QL-COF membrane. We anticipate that this work opens up a way for the construction of robust and functional COFs materials for practical applications. In the experiment, the researchers used many compounds, for example, 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride (cas: 61-73-4Quality Control of 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride).

3,7-Bis(dimethylamino)phenothiazin-5-ium chloride (cas: 61-73-4) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Quality Control of 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Influence of mass ratio and calcination temperature on physical and photoelectrochemical properties of ZnFe-layered double oxide/cobalt oxide heterojunction semiconductor for dye degradation applications was written by Zhang, Yufei;Zheng, Junjie;Nan, Jiejie;Gai, Chengjie;Shao, Qian;Murugadoss, Vignesh;Maganti, Srihari;Naik, Nithesh;Algadi, Hassan;Huang, Mina;Xu, Ben Bin;Guo, Zhanhu. And the article was included in Particuology in 2023.Recommanded Product: 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride This article mentions the following:

A visible light-active photoelectrocatalyst, ZnFe-layered double oxide (LDO)/cobalt(II,III) oxide (Co₃O₄) composites were obtained by calcining the Co loaded ZnFe-layered double hydroxide (LDH) prepared by a hydrothermal and microwave hydrothermal method. The morphol. studies revealed that the ZnFe-LDO/Co₃O₄ composites exhibited a flower-like structure comprising Co₃O₄ nanowires and ZnFe-LDO nanosheets. Further, when the mass ratio of Co(NO₃)₂.6H₂O/LDH was 1:1.8 and the calcination temperature was 550掳C, the ZnFe-LDO/Co₃O₄ composite exhibited 93.3% degradation efficiency for methylene blue (MB) at the applied voltage of 1.0 V under visible light after 3 h. Furthermore, the Mott-Schottky model experiments showed that the formation of a p-n heterojunction between ZnFe-LDO and Co₃O₄ could effectively inhibit the recombination of electrons and holes in the photoelectrocatalytic process. Meanwhile, free radical scavenging experiments showed that the active radicals of .OH played an important role in the degradation of MB. Therefore, the photoelectrocatalytic effect of ZnFe-LDO/Co₃O₄ provides a simple and effective strategy for the removal of organic pollutants. In the experiment, the researchers used many compounds, for example, 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride (cas: 61-73-4Recommanded Product: 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride).

3,7-Bis(dimethylamino)phenothiazin-5-ium chloride (cas: 61-73-4) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Recommanded Product: 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Structure-Activity Relationship Studies on Diversified Salicylamide Derivatives as Potent Inhibitors of Human Adenovirus Infection was written by Xu, Jimin;Berastegui-Cabrera, Judith;Chen, Haiying;Pachon, Jeronimo;Zhou, Jia;Sanchez-Cespedes, Javier. And the article was included in Journal of Medicinal Chemistry in 2020.Application In Synthesis of 5-Chloro-2-methoxybenzoic acid This article mentions the following:

The effective treatment of adenovirus (HAdV) infections in immunocompromised patients still poses great challenges. Herein, we reported our continued efforts to optimize a series of salicylamide derivatives as potent inhibitors of HAdV infection. Of these, nine compounds (11, 13, 14, 17, 20, 58, 60, 62, and 70) showed significantly improved anti-HAdV activities with nanomolar to submicromolar IC₅₀ values and high selectivity indexes (SI > 100), indicating better safety windows, compared to those of the lead compound niclosamide. Our mechanistic assays suggest that compounds 13, 62, and 70 exert their activities in the HAdV entry pathway, while compounds 14 and 60 likely target the HAdV DNA replication, and 11, 17, 20, and 58 inhibit later steps after DNA replication. Given the broad anti-viral activity profile of niclosamide, these derivatives may also offer therapeutic potential for other viral infections. In the experiment, the researchers used many compounds, for example, 5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2Application In Synthesis of 5-Chloro-2-methoxybenzoic acid).

5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Application In Synthesis of 5-Chloro-2-methoxybenzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Bioengineering of CuO porous (nano)particles: role of surface amination in biological, antibacterial, and photocatalytic activity was written by Bagherzadeh, Mojtaba;Safarkhani, Moein;Ghadiri, Amir Mohammad;Kiani, Mahsa;Fatahi, Yousef;Taghavimandi, Fahimeh;Daneshgar, Hossein;Abbariki, Nikzad;Makvandi, Pooyan;Varma, Rajender S.;Rabiee, Navid. And the article was included in Scientific Reports in 2022.Formula: C16H18ClN3S This article mentions the following:

Nanotechnol. is one of the most impressive sciences in the twenty-first century. Not surprisingly, nanoparticles/nanomaterials have been widely deployed given their multifunctional attributes and ease of preparation via environmentally friendly, cost-effective, and simple methods. Although there are assorted optimized preparative methods for synthesizing the nanoparticles, the main challenge is to find a comprehensive method that has multifaceted properties. The goal of this study has been to synthesize aminated (nano)particles via the Rosmarinus officinalis leaf extract-mediated copper oxide; this modification leads to the preparation of (nano)particles with promising biol. and photocatalytic applications. The synthesized NPs have been fully characterized, and biol. activity was evaluated in antibacterial assessment against Bacillus cereus as a model Gram-pos. and Pseudomonas aeruginosa as a model Gram-neg. bacterium. The bio-synthesized copper oxide (nano)particles were screened by MTT assay by applying the HEK-293 cell line. The aminated (nano)particles have shown lower cytotoxicity (鈭?21%), higher (鈭?50%) antibacterial activity, and a considerable increase in 味 potential value (鈭?+ 13.4 mV). The prepared (nano)particles also revealed considerable photocatalytic activity compared to other studies wherein the dye degradation process attained 97.4% promising efficiency in only 80 min and just 7% degradation after 80 min under dark conditions. The biosynthesized copper oxide (CuO) (nano)particle’s biomedical investigation underscores an eco-friendly synthesis of (nano)particles, their noticeable stability in the green reaction media, and impressive biol. activity. In the experiment, the researchers used many compounds, for example, 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride (cas: 61-73-4Formula: C16H18ClN3S).

3,7-Bis(dimethylamino)phenothiazin-5-ium chloride (cas: 61-73-4) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Formula: C16H18ClN3S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics