Category: chlorides-buliding-blocks

Ren, Feng published the artcileDiscovery of novel 1,2,4-thiadiazole derivatives as potent, orally active agonists of sphingosine 1-phosphate receptor subtype 1 (S1P₁), Application of 2-(3-Chloro-4-isopropoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, the publication is Journal of Medicinal Chemistry (2012), 55(9), 4286-4296, database is CAplus and MEDLINE.

A novel series of 1,2,4-thiadiazole compounds was discovered as selective S1P₁ agonists. The extensive structure-activity relationship studies for these analogs were reported. Among them, I was identified to show high in vitro potency with reasonable free unbound fraction in plasma (F_u > 0.5%), good brain penetration (BBR > 0.5), and desirable pharmacokinetic properties in mouse and rat. Oral administration of 1 mg/kg I resulted in significant peripheral lymphocytes reduction at 4 h after dose and rapid lymphocytes recovery at 24 h. Compound I showed a transient lymphopenia profile in the repeated dose study in mouse. In addition, I also demonstrated efficacy comparable to that of FTY720 (II) in the mouse EAE model of MS.

Journal of Medicinal Chemistry published new progress about 1260023-79-7. 1260023-79-7 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Ether,Boronate Esters,Boronic Acids,Boronic acid and ester,, name is 2-(3-Chloro-4-isopropoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C15H22BClO3, Application of 2-(3-Chloro-4-isopropoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Barry, A. J. published the artcileReaction of olefins and chlorohydrosilanes, Product Details of C9H20Cl2Si, the publication is Journal of the American Chemical Society (1947), 2916, database is CAplus.

Organic Si compounds have been prepared by heating an unsaturated organic compound and R_xSiCl_y under pressure at temperatures from 160° (slow reaction) to 400° (rapid reaction). Thus 406 g. HSiCl₃ and 756 g. octadecene, heated to 300° during 2.5 hrs., give 94% octadecyltrichlorosilane, b_2-3 185-99°. PrMeSiCl₂, b₇₄₇ 123-4°, results in 72% yield on heating 345 g. MeSiHCl₂ and 128 g. C₃H₆ 12 hrs. at 300°. The following new compounds were thus prepared: sec-butyltrichlorosilane, b₇₃₆ 145-6°; (2-methylpentyl)trichlorosilane, b₅₀ 98°; 3-(2,2,4-trimethylpentyl)trichlorosilane (from diisobutylene), b₂₀ 94-6°; hexadecyltrichlorosilane, b_7.5 194-6°; butenyltrichlorosilane, b₄₀ 64°; trichlorosilyl(trichlorosilylethyl)cyclohexane, b₆ 161°; hexenyltrichlorosilane, b₅₀ 103-40°; bis(trichlorosilyl)hexane, b₁₀ 148-53°; propyltribromosilane, b₇₅₆ 183°; ethylmethyldichlorosilane, b₇₄₄ 100°; butylmethyldichlorosilane, b₇₄₄ 147.5-8°; hexylmethyldichlorosilane, b₇₄₃ 192°; methyloctyldichlorosilane, b₂₀ 100-16°; methyloctadecyldichlorosilane, b₆ 200-10°; cyclohexylmethyldichlorosilane, b₇₄₅ 204°; phenylpropyldichlorosilane, b_44-7 140-4°; diethylpropylchlorosilane, b₇₄₂ 164-6°; methylphenylpropylchlorosilane, b₃₀ 124-6°; diphenylpropylchlorosilane, b₁₀ 174-6°.

Journal of the American Chemical Society published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C9H20Cl2Si, Product Details of C9H20Cl2Si.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Barry, A. J. published the artcileReaction of olefins and chlorohydrosilanes, Recommanded Product: Dichloro(hexyl)(methyl)silane, the publication is Journal of the American Chemical Society (1947), 2916, database is CAplus.

Organic Si compounds have been prepared by heating an unsaturated organic compound and R_xSiCl_y under pressure at temperatures from 160° (slow reaction) to 400° (rapid reaction). Thus 406 g. HSiCl₃ and 756 g. octadecene, heated to 300° during 2.5 hrs., give 94% octadecyltrichlorosilane, b_2-3 185-99°. PrMeSiCl₂, b₇₄₇ 123-4°, results in 72% yield on heating 345 g. MeSiHCl₂ and 128 g. C₃H₆ 12 hrs. at 300°. The following new compounds were thus prepared: sec-butyltrichlorosilane, b₇₃₆ 145-6°; (2-methylpentyl)trichlorosilane, b₅₀ 98°; 3-(2,2,4-trimethylpentyl)trichlorosilane (from diisobutylene), b₂₀ 94-6°; hexadecyltrichlorosilane, b_7.5 194-6°; butenyltrichlorosilane, b₄₀ 64°; trichlorosilyl(trichlorosilylethyl)cyclohexane, b₆ 161°; hexenyltrichlorosilane, b₅₀ 103-40°; bis(trichlorosilyl)hexane, b₁₀ 148-53°; propyltribromosilane, b₇₅₆ 183°; ethylmethyldichlorosilane, b₇₄₄ 100°; butylmethyldichlorosilane, b₇₄₄ 147.5-8°; hexylmethyldichlorosilane, b₇₄₃ 192°; methyloctyldichlorosilane, b₂₀ 100-16°; methyloctadecyldichlorosilane, b₆ 200-10°; cyclohexylmethyldichlorosilane, b₇₄₅ 204°; phenylpropyldichlorosilane, b_44-7 140-4°; diethylpropylchlorosilane, b₇₄₂ 164-6°; methylphenylpropylchlorosilane, b₃₀ 124-6°; diphenylpropylchlorosilane, b₁₀ 174-6°.

Journal of the American Chemical Society published new progress about 14799-94-1. 14799-94-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(hexyl)(methyl)silane, and the molecular formula is C7H16Cl2Si, Recommanded Product: Dichloro(hexyl)(methyl)silane.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Padhya, A. C. published the artcileAntimicrobial properties of azomethines of salicylaldehyde derivatives, Name: 5-Bromo-3-chloro-2-hydroxybenzaldehyde, the publication is Indian Journal of Microbiology (1974), 14(2), 91-3, database is CAplus.

Many azomethine derivatives of 5-chloro-, 5-bromo-, 3-bromo-5-chloro-, and 5-bromo-3-chlorosalicylaldehyde were prepared and tested for their antibacterial and antifungal activities. The azomethine derivatives of 5-chlorosalicylaldehyde showed no antibacterial activity, but were active against all tested fungi except Nocardia asteroides. The azomethine derivatives of 5-bromosalicylaldehyde had no antibacterial activity, and species variable antifungal activity. The azomethine derivatives of 5-bromo-3-chloro- and 3-chloro-5-bromosalicylaldehyde were poor antifungal agents, compared with the 5-chloro or 5-bromosalicylaldehyde derivatives, probably due to the blocking of the phenolic group by substituents on both sides. However, they were better antibacterial agents than the 5-monosubstituted salicylaldehyde derivatives, most being active against S. aureus at 6.25-12.5 μg/ml.

Indian Journal of Microbiology published new progress about 19652-33-6. 19652-33-6 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Bromide,Benzene,Phenol,Aldehyde, name is 5-Bromo-3-chloro-2-hydroxybenzaldehyde, and the molecular formula is C7H4BrClO2, Name: 5-Bromo-3-chloro-2-hydroxybenzaldehyde.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Thakur, Alok S. published the artcileSynthesis and Anticonvulsant Effect of Novel Thiazolidinedione Containing Benzene-sulfonylurea and Sulfonylthiourea Derivatives, HPLC of Formula: 3696-23-9, the publication is Central Nervous System Agents in Medicinal Chemistry (2016), 16(2), 152-157, database is CAplus and MEDLINE.

A newer series of 1-(4-substitutedphenyl)-3-(4-((2,4-dioxothiazolidin-5-lidene)methyl)phenyl sulfonyl)urea/thiourea (4a-l) were synthesized for their anticonvulsant activity. The activity is attributed to its potential to restrain astrocytic Na+, 2HCl, and K+ co-transport similar to torasemide which has sulfonylurea in its structure. Torasemide having the similar action as the furosemide that obstructs kainic acid-induced elec. discharges observed from cortex and it has neuroprotective agents, for instance antagonizing the N-methyl-D-aspartate (NMDA) and non-NMDA receptors for evaluating antiepileptic activity. The structures of new derivatives were established by elemental anal. and spectroscopic techniques viz. FTIR, 1H NMR and LC-MS. The all twelve derivatives were assessed for anticonvulsant activity at three different doses at 30, 100 and 300 mg/kg body weight into maximal electroshock (MES) and s.c. pentylenetetrazole (sports) models. Compounds 4c and 4e were formed to be most active among all the derivatives for both the models of anticonvulsant activity. Beside these compounds 4g, 4i and 4k also possessed the prominent anticonvulsant activity devoid of any neurotoxicity. The sulfonylurea and sulfonylthiourea both were proved to be effective anticonvulsant pharmacophore. Other structure activity relationships were established by considering the aspect of substitution in the lead.

Central Nervous System Agents in Medicinal Chemistry published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C24H12, HPLC of Formula: 3696-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Thakur, M. R. published the artcileSynthesis, characterization and investigation of novel benzoyl protected glycosyl 1-formamidino-3-aryl formamidino thiocarbamides for antimicrobial activity, Application In Synthesis of 3696-23-9, the publication is Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry (2016), 55B(10), 1248-1253, database is CAplus.

In the present investigation, a series of novel benzoyl protected glycosyl 1-formamidino-3-aryl formamidino thiocarbamides have been synthesized by interaction of various benzoyl protected glycosyl bromides and 1-aryl-formamidino-3-formamidino thiocarbamides. The required benzoyl protected glycosyl bromides have been synthesized by benzoylation followed by bromination and 1-aryl-formamidino-3-formamidino thiocarbamides have been synthesized by interaction of aryl thiocarbamides and cyanoguanidine. All the newly synthesized compounds have been characterized by usual chem. transformations, elemental anal., IR, 1H NMR and mass spectral studies. These compounds have been investigated for their potential against several human pathogenic bacteria and fungi for their antibacterial and antifungal activity against Escherichia coli, Staphylococcus aureus, Salmonella typhi and Penicilium notatum, Aspergillus niger resp. Some of the synthesized compounds show very promising activity.

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C12H23N3S, Application In Synthesis of 3696-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ansari, Mohammed M. published the artcileSynthesis antimicrobial and anticancer evaluation of 1-aryl-5-(o-methoxyphenyl)-2-s-benzyl isothiobiurets, SDS of cas: 3696-23-9, the publication is International Journal of Medicinal Chemistry (2014), 352626/1-352626/6, database is CAplus and MEDLINE.

A series of S-benzyl aryl thiourea were condensed with o-methoxy phenylisocyanate to yield resp. isothiobiuret derivatives I [R = H, 4-CH₃, 4-Cl, 2-CH₃, 2-Cl, 3-Cl]. The newly synthesized compounds I were evaluated for their antibacterial, antifungal and anticancer activity.

International Journal of Medicinal Chemistry published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, SDS of cas: 3696-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ghayalkar, Renu B. published the artcileSynthesis and antimicrobial activity of N-glucosylated derivatives of thiadiazolidines, Related Products of chlorides-buliding-blocks, the publication is Indian Journal of Heterocyclic Chemistry (2014), 23(3), 257-260, database is CAplus.

A series of new 1-(3-arylimino-4-aryl-5-imino-1,2,4-thiadiazolidines)-3-tetra-O-benzoyl-β-D-glucosyl carbamides, e.g. I, were synthesized by the interaction of tetra-O-benzoyl-β-D-glucosyl isocyanate with 3-arylimino-4-aryl-5-imino-1,2,4-thiadiazolidines. The identities of these newly synthesized N-glucosylated thiadiazolidine carbamides have been established on the basis of usual chem. transformations and IR, ¹H NMR and Mass spectral studies. These compounds were screened for their antibacterial activity and antifungal activity against some selected pathogenic organisms to get potent bioactive mol.

Indian Journal of Heterocyclic Chemistry published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Karhe, Usha W. published the artcileSynthesis of some biologically important per-O-benzoyl maltosyl isothiocarbamides and isodithiobiurets as antibacterial and antifungal agents, Computed Properties of 3696-23-9, the publication is Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry (2014), 53B(2), 212-217, database is CAplus.

Several S-hepta-O-benzoyl maltosyl-1-arylisothiocarbamides have been synthesized through several steps viz. benzoylation, bromination and interaction of hepta-O-benzoyl maltosyl bromide with aryl thiocarbamides. S-Hepta-O-benzoyl maltosyl-1-aryl-5-phenyl-2,4-isodithiobiurets have been synthesized by the interaction of S-hepta-O-benzoyl maltosyl-1-arylisothiocarbamides with Ph isothiocyanate. All new compounds have been characterized by spectral anal. such as IR, ¹H NMR and mass spectra as well as elemental anal. and in-vitro antimicrobial activity of maltosyl isothiocarbamides and related isodithiobiurets has been evaluated against several human pathogens. Out of 12 compounds prepared and screened, four compounds have shown significant activity against different human pathogens.

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Computed Properties of 3696-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zade, Varsha S. published the artcileSynthesis and characterization of per-acetylated S-maltosyl 2-isothiobiurets and 2,4-isodithiobiurets and their in vitro antimicrobial activity, Synthetic Route of 3696-23-9, the publication is Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry (2015), 54B(6), 815-820, database is CAplus.

A series of S-hepta-O-acetyl-maltosyl-1-aryl-5-p-tolyl-2-isothio-biurets, S-hepta-O-acetyl-maltosyl-1-aryl-5-p-chloro-phenyl-2-isothio-biurets and S-hepta-O-acetyl maltosyl-1-aryl-5-p-tolyl-2,4-isodithio-biurets have been synthesized by the interaction of various S-hepta-O-acetyl maltosyl-1-aryl isothiocarbamides with p-tolyl isocyanate, p-chloro-Ph isocyanate and p-tolyl isothiocyanate resp. The required maltosyl arylisothiocarbamides are synthesized by the displacement of anomeric bromide of acetobromomaltose with aryl thiocarbamides. The identities of these newly synthesized thiomaltosides have been established on the basis of chem. transformations and IR, mass, 1H and 13C NMR spectral studies. These compounds have been screened for their antibacterial and antifungal activities against E. coli, S. aureus, Ps. aeruginosa, S. typhi, R. oligosporus and A. niger. These compounds show most promising activity towards these micro-organisms.

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H4BrClO2, Synthetic Route of 3696-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics