Category: chlorides-buliding-blocks

Kallepalli, Venkata A. published the artcileHarnessing C-H Borylation/Deborylation for Selective Deuteration, Synthesis of Boronate Esters, and Late Stage Functionalization, Name: 2-(3-Chloro-5-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, the publication is Journal of Organic Chemistry (2015), 80(16), 8341-8353, database is CAplus and MEDLINE.

In the presence of iridium catalysts such as [Ir(cod)OMe]₂, aryl and heteroaryl mono- and di(pinacolboronates) underwent regioselective deborylation; reaction of aryl- and heteroaryl mono(pinacolboronates) using D₂O yielded regioselectively deuterated arenes, while deborylation of di(pinacolboronates) yielded mono(pinacolboronates) with different and complementary regioselectivity from a direct monoborylation. Di(pinacolboronates) were prepared using iridium-catalyzed borylation; diborylation and chemoselective deborylation reactions were performed in one pot in some instances. The iridium-catalyzed borylations were compared to palladium-catalyzed deborylations of diborylated indoles described by Movassaghi; for a 3-methylindole-derived diboronate and for three thiophenediboronates, the iridium-catalyzed conditions were more effective. Nonracemic clopidogrel was regioselectively deuterated and monoborylated using iridium-catalyzed mono- and diborylation and deborylation reactions.

Journal of Organic Chemistry published new progress about 929626-16-4. 929626-16-4 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronate Esters, name is 2-(3-Chloro-5-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C13H18BClO3, Name: 2-(3-Chloro-5-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Craig, Donald published the artcileTransannular, decarboxylative Claisen rearrangement reactions for the synthesis of sulfur-substituted vinylcyclopropanes, Application In Synthesis of 7080-50-4, the publication is Chemical Communications (Cambridge, United Kingdom) (2010), 46(27), 4991-4993, database is CAplus and MEDLINE.

Unsaturated ε-lactones, e.g., I, bearing an α-arylsulfonyl or α-arylsulfoximinyl substituent undergo stereoselective transannular, decarboxylative Claisen rearrangement to give substituted vinylcyclopropanes, e.g., II.

Chemical Communications (Cambridge, United Kingdom) published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C7H13ClNNaO5S, Application In Synthesis of 7080-50-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ligor, Tomasz published the artcileSorbents for trapping organic pollutants from air, Recommanded Product: Dichloro(methyl)(octyl)silane, the publication is International Journal of Occupational Safety and Ergonomics (1998), 4(2), 153-167, database is CAplus and MEDLINE.

A series of siliceous adsorbents with chem. bonded phases (CBP) of different polarity were tested as sorbents for trapping air pollutants (petroleum ether) using controlled setup. Moreover, special attention was paid to the potential role of metal impurities as strong adsorption sites. Sorbents were characterized by various physico-chem. methods, such as porosimetry, inductively coupled plasma (ICP) anal., elemental anal., derivatog., and gas chromatog. Trapping tubes were utilized for sorption of toxic pollutants from indoor air: VOCs air anal. adsorbents surface characterization gas chromatog.

International Journal of Occupational Safety and Ergonomics published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C9H20Cl2Si, Recommanded Product: Dichloro(methyl)(octyl)silane.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Toja, E. published the artcileAmnesia-reversal activity of a series of 5-alkoxy-1-arylsulfonyl-2-pyrrolidinones, Application In Synthesis of 32333-53-2, the publication is European Journal of Medicinal Chemistry (1991), 26(4), 403-13, database is CAplus.

A series of 5-alkoxy-1-arylsulfonyl-2-pyrrolidinones were prepared by condensation of arylsulfonyl chlorides with 5-alkoxy-2-pyrrolidinones. Most compounds reversed electroconvulsive shock-induced amnesia in mice, showing the typical inverted U-shaped dose-response curve. The results for 58 compounds indicate that the potency is maximum when there is a 5-ethoxy group and progressively declines as the ether alkyl chain is either elongated or shortened. Substitution on the Ph ring or its replacement with heterocyclic rings or its hydrogenation decreases the activity. The most promising compounds, with anti-amnesic properties superior in many respects (greater potency, greater efficacy and broader active dose-range) to those of piracetam and antiracetam were further evaluated for reversing scopolamine-induced amnesia and for their antihypoxic activity. 5-Ethoxy-1-phenylsulfonyl-2-pyrrolidinone and 5-(1-methylethoxy)-1-[3-(trifluoromethyl)phenylsulfonyl]-2-pyrrolidinone were selected for further evaluation because of their potent anti-amnesic and/or antihypoxic activity.

European Journal of Medicinal Chemistry published new progress about 32333-53-2. 32333-53-2 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Sulfonyl chlorides,Benzene, name is 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride, and the molecular formula is C9H7NO2, Application In Synthesis of 32333-53-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sabatini, Stefano published the artcileRe-evolution of the 2-Phenylquinolines: Ligand-Based Design, Synthesis, and Biological Evaluation of a Potent New Class of Staphylococcus aureus NorA Efflux Pump Inhibitors to Combat Antimicrobial Resistance, Synthetic Route of 4584-49-0, the publication is Journal of Medicinal Chemistry (2013), 56(12), 4975-4989, database is CAplus and MEDLINE.

Overexpression of efflux pumps is an important mechanism by which bacteria evade the effects of antimicrobial agents that are substrates. NorA is a Staphylococcus aureus efflux pump that confers reduced susceptibility to many structurally unrelated agents, including fluoroquinolones, biocides, and dyes, resulting in a multidrug resistant (MDR) phenotype. In this work, a series of 2-phenylquinoline derivatives was designed by means of ligand-based pharmacophore modeling in an attempt to identify improved S. aureus NorA efflux pump inhibitors (EPIs). Most of the 2-phenylquinoline derivatives displayed potent EPI activity against the norA overexpressing strain SA-1199B. The antibacterial activity of ciprofloxacin, when used in combination with some of the synthesized compounds, was completely restored in SA-1199B and SA-K2378, a strain overexpressing norA from a multicopy plasmid. Compounds I and II also showed potent synergistic activity with the ethidium bromide dye in a strain overexpressing the MepA MDR efflux pump.

Journal of Medicinal Chemistry published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C5H13Cl2N, Synthetic Route of 4584-49-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Droge, Steven T. J. published the artcileIon-Exchange Affinity of Organic Cations to Natural Organic Matter: Influence of Amine Type and Nonionic Interactions at Two Different pHs, Name: N-Benzyl-N,N-dibutylbutan-1-aminium chloride, the publication is Environmental Science & Technology (2013), 47(2), 798-806, database is CAplus and MEDLINE.

Sorption to standard soil organic matter (SOM) was studied for a wide variety of organic cations using a flow through method with fully aqueous medium as eluent. SOM sorption for weak bases (pK_a 4.5-7) was stronger at pH 4.5 than at pH 7, indicating that the ion-exchange affinity of the cationic species to SOM was higher than the bulk partition coefficient of corresponding neutral species to SOM. At pH 4.5-7, the effect of pH on the sorption coefficients for strong bases with pK_a >7 was small, within 0.3 log units. For cations with the mol. formula C_xH_yN, sorption was accurately predicted by a model accounting for size (increase with alkyl chain length) and type of charged group (1° amine >4° ammonium of equal size). In addition to the C_xH_yN-model, several empirical correction factors were derived from the data for organic cations with polar functional groups. Models based on K_OW or pK_a fail to explain differences in sorption affinity of the ionic species. Our data on ion-exchange affinities for 80 organic cations show many examples where specific chem. moieties, for example, CH₂-units, aromatic rings or hydroxyl groups, contribute differently to the sorption coefficient as compared to bulk partitioning data of neutral compounds Other sorption models that were evaluated to explain variation between compounds suffered from outliers of >1 log unit and did not reduce relative log mean standard errors <0.5. A wider range of sorption coefficients and more sorption data in general are required to improve modeling efforts further.

Environmental Science & Technology published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C19H34ClN, Name: N-Benzyl-N,N-dibutylbutan-1-aminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Droge, Steven T. J. published the artcileSorption of Organic Cations to Phyllosilicate Clay Minerals: CEC-Normalization, Salt Dependency, and the Role of Electrostatic and Hydrophobic Effects, HPLC of Formula: 23616-79-7, the publication is Environmental Science & Technology (2013), 47(24), 14224-14232, database is CAplus and MEDLINE.

Sorption to the phyllosilicate clay minerals Illite, kaolinite, and bentonite has been studied for a wide variety of organic cations using a flow-through method with fully aqueous medium as the eluent. Linear isotherms were observed at concentrations below 10% of the cation-exchange capacity (CEC) for Illite and kaolinite and below 1 mmol/kg (<1% CEC) for bentonite. Sorption to clays was strongly influenced by the electrolyte composition of the eluent but with a consistent trend for a diverse set of compounds on all clays, thus allowing for empirical correction factors. When sorption affinities for a given compound to a given clay are normalized to the CEC of the clay, the differences in sorption affinities between clays are reduced to less than 0.5 log units for most compounds Although CEC-normalized sorption of quaternary ammonium compounds to clay was up to 10-fold higher than CEC-normalized sorption to soil organic matter, CEC-normalized sorption for most compounds was comparable between clays and soil organic matter. The clay fraction is thus a potentially relevant sorption phase for organic cations in many soils. The sorption data for organic cations to clay showed several regular trends with mol. structure but also showed quite a few systematic effects that we cannot explain. A model on the basis of the mol. size and charge d. at the ionized nitrogen is used here as a tool to obtain benchmark values that elucidate the effect of specific polar moieties on the sorption affinity.

Environmental Science & Technology published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C19H34ClN, HPLC of Formula: 23616-79-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Fu, Ying published the artcileCopper-Catalyzed Monoorganylation of Trialkyl Borates with Functionalized Organozinc Pivalates, HPLC of Formula: 209919-30-2, the publication is ChemCatChem (2018), 10(19), 4253-4257, database is CAplus.

Organozinc pivalates, a recently developed air- and moisture-stable organozinc species, were found for the 1st time as excellent organometallic species in the monoorganylation of trialkyl borates whereby boronic acids were prepared in high yields. The significant advantage of organozinc pivalates over another previously employed organometallic reagents, e. g., organolithium reagents, Grignard reagents and organozinc halides, is that the generation of multiorganylation byproducts such as borinic acids and trialkylboranes were completely suppressed. Addnl., the in situ generated boronates could be directly arranged into Suzuki-Miyaura type cross-coupling reactions to produce biaryls in high yields.

ChemCatChem published new progress about 209919-30-2. 209919-30-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids,Boronic acid and ester, name is 4-Chloro-2-methylphenylboronic acid, and the molecular formula is C7H8BClO2, HPLC of Formula: 209919-30-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Braunstein, Pierre published the artcileCarbonyl clusters with a capping methylidyne phosphonate ligand. Crystal structure of [Co₃(CO)₉{η¹-μ₃-[CP(O)(OEt)₂]}], Application In Synthesis of 866-23-9, the publication is Journal of Organometallic Chemistry (1997), 541(1-2), 417-422, database is CAplus.

The bridging methylidyne clusters [Co₃(CO)₉{η¹-μ₃-[CP(O)(OR)₂]}] (1, R = Et; 3, R = SiMe₃) with α-phosphoryl substituents were synthesized by reaction of Cl₃CP(O)(OR)₂ with Co₂(CO)₈, followed by protonation. Cluster 3 was also obtained by the reaction of 1 with Me₃SiBr. The structure of 1 was determined by x-ray crystallog. The donor properties of the P:O function toward Lewis acids such as [Cp₂MCl]⁺ (M = Ti, Zr) were used to assemble early-late metal systems.

Journal of Organometallic Chemistry published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Application In Synthesis of 866-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Aksnes, Gunnar published the artcileIntermolecular hydrogen bond association between phenol and organophosphorus compounds, Synthetic Route of 866-23-9, the publication is Acta Chemica Scandinavica (1960), 1485-94, database is CAplus.

The intermol. H-bond association constants between phenol and 18 organophosphorus compounds were determined at 20° and 50°. The ΔF, ΔH, and ΔS values of the equilibrium reactions vary linearly with the H-bond shift in such a way that an increase in enthalpy is counteracted by a decrease in entropy. The strong influence of the substituents in organophosphorus compounds on the H-bond association constants is discussed in terms of the electronic properties of the P atom and the substituents. The connection between H-bond formation and the proton-transfer reaction is commented on.

Acta Chemica Scandinavica published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Synthetic Route of 866-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics