Category: chlorides-buliding-blocks

Steinbach, J. published the artcileReaction of the two-component system trialkyl phosphite/carbon tetrachloride with nucleophiles containing hydrogen. 2. Reaction with ammonia and amines, Name: Diethyltrichloromethylphosphonate, the publication is Zeitschrift fuer Anorganische und Allgemeine Chemie (1985), 180-6, database is CAplus.

RNH₂ (R = H, Pr, Bu, PhCH₂, Ph) reacted 1:1 with (R¹O)₃P (R¹ = Et, Bu) and CCl₄ to give (R¹O)₂P(O)NHR. If excess RNH₂ was used, R¹OP(O)(NHR)₂ and OP(NHR)₃ also formed. The reaction of (R¹O)₃P/CCl₄ in the presence of secondary and tertiary amines gave (R¹O)₂P(O)CCl₃, which reacted with the amine to give [Cl₃CP(O)(O^–)(OR¹)][⁺NRR²R³R⁴].

Zeitschrift fuer Anorganische und Allgemeine Chemie published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C14H10O4S2, Name: Diethyltrichloromethylphosphonate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Albrecht, Steffen published the artcileDirect synthesis of dialkyl N,N-diorganophosphoramidates from trialkyl phosphites, Application In Synthesis of 866-23-9, the publication is Phosphorus, Sulfur and Silicon and the Related Elements (1991), 62(1-4), 189-92, database is CAplus.

Amidation of (RO)₃P (R = Et, Bu) with secondary amines R¹R²NH (R¹ = R² = Bu, Et; R¹ = Ph, R² = Me, Et) in the presence of amine hydrochloride catalysts and CCl₄ in MeCN as solvent gave title compounds, (RO)₂P(O)(NR¹R²). The mechanism is discussed.

Phosphorus, Sulfur and Silicon and the Related Elements published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Application In Synthesis of 866-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Boutevin, B. published the artcileSynthesis of phosphonic compounds with chlorofluorinated chains. Part I, Formula: C5H10Cl3O3P, the publication is Phosphorus and Sulfur and the Related Elements (1981), 11(3), 373-81, database is CAplus.

The redox catalysis and free-radical telomerizations of di- and trichloromethylphosphonyl dichlorides and their esters with chlorotrifluoroethylene (I) [79-38-9] were studied. Also investigated was phosphonation of telomers of I and CCl₄ using Kinnear-Perren and Michaelis-Arbuzov methods. Phosphonic compounds containing chlorofluorinated blocks are obtained with these two methods. By-products are described and explained using known mechanisms.

Phosphorus and Sulfur and the Related Elements published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Formula: C5H10Cl3O3P.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kosmalski, Tomasz published the artcileThe Oxime Ethers with Heterocyclic, Alicyclic and Aromatic Moiety as Potential Anti-Cancer Agents, HPLC of Formula: 939-99-1, the publication is Molecules (2022), 27(4), 1374, database is CAplus and MEDLINE.

Chemotherapy is one of the most commonly used methods of cancer disease treatment. Due to the acquisition of drug resistance and the possibility of cancer recurrence, there is an urgent need to search for new mols. that would be more effective in destroying cancer cells. In this study, 1-(benzofuran-2-yl)ethan-1-one oxime and 26 oxime ethers containing heterocyclic, alicyclic or aromatic moiety were screened for their cytotoxicity against HeLa cancer cell line. The most promising derivatives with potential antitumor activity were 2-(cyclohexylideneaminoxy)acetic acid (18) and (E)-acetophenone O-2-morpholinoethyl oxime (22), which reduced the viability of HeLa cells below 20% of control at concentrations of 100-250 μg/mL. Some oxime ethers, namely thiazole and benzothiophene derivatives (24-27), also reduced HeLa cell viability at similar concentrations but with lower efficiency. Further cytotoxicity evaluation confirmed the specific toxicity of (E)-acetophenone O-2-morpholinoethyl oxime (22) against A-549, Caco-2, and HeLa cancer cells, with an EC₅₀ around 7 μg/mL (30 μM). The most potent and specific compound was (E)-1-(benzothiophene-2-yl)ethanone O-4-methoxybenzyl oxime (27), which was selective for Caco-2 (with EC₅₀ 116 μg/mL) and HeLa (with EC₅₀ 28 μg/mL) cells. Considering the bioavailability parameters, the tested derivatives meet the criteria for good absorption and permeation. The presented results allow us to conclude that oxime ethers deserve more scientific attention and further research on their chemotherapeutic activity.

Molecules published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H6ClF3, HPLC of Formula: 939-99-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Haszeldine, Robert N. published the artcilePerfluoroalkyl derivatives of sulfur. Part XIX. Reaction of fluoroolefins with fluoride ion in the presence of dimethyl disulfide, and related reactions, Category: chlorides-buliding-blocks, the publication is Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) (1976), 1178-82, database is CAplus.

F2C:CF2 reacted with CsF in the presence of MeS2Me to give 15% CF3CFRSMe (I; R = F), 77% MeSCF2CFRSMe (II; R = F), and 2% CF3CF2H, whereas F2C:CFCl gave 15% I (R = Cl), 56% II (R = Cl) and 13% of a mixture (III) of cis- and trans-MeSCF:CFR (R = Cl. Under similar conditions CF3CF:CF2 gave 38% I (R = CF3) and 12-21% III (R = CF3) together with olefin telomers. F2C:CF2 with CsF in the presence of Me2S gave only CF3CF2H. F2C:CFCl and CF3CF:CF2 reacted with NaSMe in Et2O at -196° to give 77 and 90% III, resp.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about 1002-41-1. 1002-41-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1,2-Bis(2-chloroethyl)disulfane, and the molecular formula is C4H8Cl2S2, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sumida, Yuto published the artcileBoron-Selective Biaryl Coupling Approach to Versatile Dibenzoxaborins and Application to Concise Synthesis of Defucogilvocarcin M, Formula: C7H8BClO2, the publication is Organic Letters (2014), 16(23), 6240-6243, database is CAplus and MEDLINE.

An efficient synthetic method for versatile dibenzoxaborins based on boron-selective Suzuki-Miyaura cross-coupling between o-borylphenols and aryl halides or triflates bearing a 1,8-diaminonaphthalene-protected o-boryl group is reported [e.g., I + II (dan = 1,8-diaminonaphthalene) â†?III (quant) using Pd(OAc)₂, CyJohnPhos as ligand and K₃PO₄ as base]. A short synthesis of defucogilvocarcin M (IV) was achieved using the proposed method in combination with several other boron-mediated transformations.

Organic Letters published new progress about 145349-62-8. 145349-62-8 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids, name is 2-Chloro-4-methylphenylboronic acid, and the molecular formula is C18H24N6O6S4, Formula: C7H8BClO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sykes, Thomas C. published the artcileSubstrate Wettability Influences Internal Jet Formation and Mixing during Droplet Coalescence, Application In Synthesis of 14799-93-0, the publication is Langmuir (2020), 36(32), 9596-9607, database is CAplus and MEDLINE.

The internal dynamics during the axisym. coalescence of an initially static free droplet and a sessile droplet of the same fluid are studied using both laboratory experiments and numerical simulations. A high-speed camera captured internal flows from the side, visualized by adding a dye to the free droplet. The numerical simulations employ the volume of fluid method, with the Kistler dynamic contact angle model to capture substrate wettability, quant. validated against the image-processed experiments It is shown that an internal jet can be formed when capillary waves reflected from the contact line create a small tip with high curvature on top of the coalesced droplet that propels fluid toward the substrate. Jet formation is found to depend on the substrate wettability, which influences capillary wave reflection; the importance of the advancing contact angle subordinated to that of the receding contact angle. It is systematically shown via regime maps that jet formation is enhanced by increasing the receding contact angle and by decreasing the droplet viscosity. Jets are seen at volume ratios very different from those accepted for free droplets, showing that a substrate with appropriate wettability can improve the efficiency of fluid mixing.

Langmuir published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is 0, Application In Synthesis of 14799-93-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Karthiraj, T. published the artcileTask-specific deep eutectic solvent based extraction coupled cascade chromatography quantification of α-glucosidase inhibitory peptide from Ocimum tenuriflorum seeds, HPLC of Formula: 23616-79-7, the publication is Microchemical Journal (2020), 104883, database is CAplus.

A sustainable method for purification and quantification of α-glucosidase inhibitory peptides from Ocimum tenuriflorum is described in the present investigation. Nine tailor-made DESs under diverse categories were synthesized and their thermophys. properties were determined Selective extraction of these therapeutic peptides using sustainable DESs is carried out. Three DESs having better phase ratios were selected and their partition coefficient was assessed with a tripeptide as a marker. Ultrasound-assisted liquid-phase microextraction (UA-LPME) based purification of bioactive peptides is performed. Further, response surface methodol. based optimization for effective isolation of α-amylase inhibitory peptide from mango seed hydrolyzate for DES formed with carnitine and maltose was determined as 96%. Preparative purification (43μg/g) of bioactive peptides was carried out with size exclusion chromatog. The preconcd. fractions were exposed to anion exchange chromatog. and ultrapure peptides (88%) with high inhibitory activity were obtained. α-amylase inhibition kinetics was established for the resultant ultrapure bioactive peptides to evaluate and quantify its inhibitory property.

Microchemical Journal published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C19H34ClN, HPLC of Formula: 23616-79-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kinnear, A. M. published the artcileComposition of mustard gas made by the Levinstein process, HPLC of Formula: 1002-41-1, the publication is Journal of the Society of Chemical Industry, London, Transactions and Communications (1948), 107-10, database is CAplus.

cf. Fuson, et al., C.A. 41, 689g. A sample of Levinstein mustard gas was found to contain 61.4% S(CH₂CH₂Cl)₂ (I), m. 14.45°; 4.3% S₂(CH₂CH₂Cl)₂ (II), colorless liquid, m. 0.2°, b_0.3 90-2°; 17.4% S₃(CH₂CH₂Cl)₂ (III), m. 27°, b_0.3 110-12°; 10.7% S (free and combined with III); 6.2% tars and exptl. losses. I, II, and III were synthesized as follows: HOCH₂CH₂Cl and Na₂S₄ gave S(C₂H₄OH)₂, S₂(C₂H₄OH)₂, and S₃(C₂H₄OH)₂. These products and HCl gave I, II, and III, resp. On boiling with NaI in MeOH, II gave S₂(CH₂CH₂I)₂, m. 42°. II and PhONa in alc. gave S₂(CH₂CH₂OPh)₂, m. 96°. The labile polysulfide (IV) (S combined with III), upon boiling in Me₂CO formed S and III. IV was synthesized by heating 1 g. mol. III with 3 g. atoms rhombic S at 110° for several hrs. Since I or II do not form polysulfides on heating with S, it is thought that IV has a structure of the type (ClCH₂CH₂S)₂S→S→Sâ†?or(ClCH₂CH₂S)₂Sâ†?sub>S→Sâ†?/sub>→S→Sâ†?

Journal of the Society of Chemical Industry, London, Transactions and Communications published new progress about 1002-41-1. 1002-41-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1,2-Bis(2-chloroethyl)disulfane, and the molecular formula is C4H8Cl2S2, HPLC of Formula: 1002-41-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Pitts-McCoy, Anthony M. published the artcileGas-phase ion/ion chemistry as a probe for the presence of carboxylate groups in polypeptide cations, Product Details of C7H16ClNO2, the publication is Journal of the American Society for Mass Spectrometry (2019), 30(2), 329-338, database is CAplus and MEDLINE.

The reactivity of 1-hydroxybenzoyl triazole (HOBt) esters with the carboxylate functionality present in peptides is demonstrated in the gas phase with a doubly deprotonated dianion. The reaction forms an anhydride linkage at the carboxylate site. Upon ion trap collisional-induced dissociation (CID) of the modified peptide, the resulting spectrum shows a nominal loss of the mass of the reagent and a water mol. Analogous phenomenol. was also noted for model peptide cations that likely contain zwitterionic/salt-bridged motifs in reactions with a neg. charged HOBt ester. Control experiments indicate that a carboxylate group is the likely reactive site, rather than other possible nucleophilic sites present in the peptide. These observations suggest that HOBt ester chem. may be used as a chem. probe for the presence and location of carboxylate groups in net pos. charged polypeptide ions. As an illustration, deprotonated sulfobenzoyl HOBt was reacted with the [M+7H]⁷⁺ ion of ubiquitin. The ion was shown to react with the reagent and CID of the covalent reaction product yielded an abundant [M+6H-H₂O]⁶⁺ ion. Comparison of the CID product ion spectrum of this ion with that of the water loss product generated from CID of the unmodified [M+6H]⁶⁺ ion revealed the glutamic acid at residue 64 as a reactive site, suggesting that it is present in the deprotonated form.

Journal of the American Society for Mass Spectrometry published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Product Details of C7H16ClNO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics