Category: chlorides-buliding-blocks

Synthesis of 2-(pyrrolidin-1-yl)pyrimidines by reactions of N-(4,4-diethoxybutyl)pyrimidin-2-amine with (hetero)aromatic C-nucleophiles was written by Smolobochkin, Andrey V.;Rizbayeva, Tanzilya S.;Gazizov, Almir S.;Voronina, Julia K.;Chugunova, Elena A.;Akylbekov, Nurgali I.;Appazov, Nurbol O.;Burilov, Alexander R.;Pudovik, Michael A.. And the article was included in Chemistry of Heterocyclic Compounds in 2019.Application of 95-88-5 The following contents are mentioned in the article:

A method was developed for the synthesis of 2-(pyrrolidin-1-yl)pyrimidines I•CF₃CO₂H [R = 2,4-di-OH-5-ClC₆H₂, 2-hydroxy-1-naphthyl, 6-hydroxy-1,3-benzodioxol-5-yl, etc.] and 2-[(4,4-diarylbutyl)amino]pyrimidine by reactions of (hetero)aromatic C-nucleophiles with N-(4,4-diethoxybutyl)pyrimidin-2-amine in the presence of trifluoroacetic acid. The structures of the obtained products were confirmed by methods of IR spectroscopy, ¹H and ¹³C NMR spectroscopy and X-ray structural anal. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Application of 95-88-5).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Application of 95-88-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Structure-Based Optimization of 10-DEBC Derivatives as Potent and Selective Pim-1 Kinase Inhibitors was written by Li, Gudong;Zhang, Wei;Xie, Yuting;Li, Yang;Cao, Rao;Zheng, Guojun;Huang, Niu;Zhou, Yu. And the article was included in Journal of Chemical Information and Modeling in 2020.Product Details of 6294-17-3 The following contents are mentioned in the article:

Pim-1 kinase has been widely regarded as an attractive target for anticancer drugs. Here, we reported our continued efforts in structure-based optimization of compound 10-DEBC, a previously identified micromolar Pim-1 inhibitor. Guided by the Site Identification by Ligand Competitive Saturation (SILCS) method, we quickly obtained a series of 10-DEBC derivatives with significantly improved activity and selectivity. In particular, compound 26 exhibited an IC₅₀ value of 0.9 nM, as well as 220- and 8-fold selectivity over Pim-2 and Pim-3 kinases, resp. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Product Details of 6294-17-3).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Product Details of 6294-17-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and anticancer activity of open-resorcinarene conjugates was written by Daniel Pedro-Hernandez, Luis;Hernandez-Montalban, Carlos;Martinez-Klimova, Elena;Ramirez-Apan, Teresa;Martinez-Garcia, Marcos. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2020.Category: chlorides-buliding-blocks The following contents are mentioned in the article:

The first example of conjugation of open-resorcinarenes with chlorambucil, ibuprofen, naproxen and indomethacin are presented. The cytotoxic properties of the obtained conjugates were tested against the cancer cell lines U-251, PC-3, K-562, HCT-15, MCF-7 and SKLU-1. It was found that the conjugate with chlorambucil, naproxen or indomethacin (having 8 moieties) was toxic towards cancer cell lines U-251 and K-562, with no activity against non-cancerous COS-7 cells. The conjugates with naproxen and indomethacin showed high selectivity towards U-251 tumor cells. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Category: chlorides-buliding-blocks).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Highly Selective Construction of Medium-Sized Lactams by Palladium-Catalyzed Intramolecular Hydroaminocarbonylation of Aminoalkynes was written by Hu, Yue;Huang, Hanmin. And the article was included in Organic Letters in 2017.HPLC of Formula: 1186603-47-3 The following contents are mentioned in the article:

In the presence of Pd(cod)Cl₂ and Ph₂P(CH₂)_nPPh₂ (n = 4, 6) in anisole at 80°, alkynylamines such as I underwent chemoselective and regioselective carbonylative hydroamination reactions to yield seven- and eight-membered lactams such as dihydrobenzazepinone II in 41-99% yields. The structures of II, of three other dihydrobenzazepinones, of a dihydronaphthazepinone, of a dihydroazepinone, and of a dihydrobenzazocinone were determined by X-ray crystallog. This study involved multiple reactions and reactants, such as 5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3HPLC of Formula: 1186603-47-3).

5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.HPLC of Formula: 1186603-47-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of bis(phenylamino)-1,3,5-triazine derivatives was written by Kapadia, Kishor;Solankee, Pankit;Prajapati, Yogesh;Patel, Hiral;Solankee, Sejal;Solankee, Anjani. And the article was included in Organic Chemistry: An Indian Journal in 2007.Synthetic Route of C9H6Cl2N4 The following contents are mentioned in the article:

A method for the synthesis of the title compounds is reported here. The title compounds thus prepared included 1-[4-[[2,4-bis(phenylamino)-1,3,5-triazin-2-yl]amino]phenyl]-1-propen-1-one derivatives and N,N’-bis(phenylamino)-N”-[4-(2-amino-3-pyrimidinyl)phenyl]-1,3,5-triazine-2,4,6-triamine and N,N’-bis(phenylamino)-N”-[4-(2,3-dihydro-1,5-benzothiazepin-4-yl)phenyl]-1,3,5-triazine-2,4,6-triamine derivatives The constitutions of newly synthesized compounds have been established on the basis of their elemental anal., IR and ¹H NMR spectral data. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Synthetic Route of C9H6Cl2N4).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Synthetic Route of C9H6Cl2N4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Transition Metal Free Stannylation of Alkyl Halides: The Rapid Synthesis of Alkyltrimethylstannanes was written by Li, Songyi;Lian, Chang;Yue, Guanglu;Zhang, Jianning;Qiu, Di;Mo, Fanyang. And the article was included in Journal of Organic Chemistry in 2022.Electric Literature of C6H12BrCl The following contents are mentioned in the article:

A transition metal free stannylation reaction of alkyl bromides and iodides with hexamethyldistannane was developed. This protocol is operationally convenient and features a rapid reaction and good functional group tolerance. A wide range of functionalized primary and secondary alkyl and benzyl tri-Me stannanes were prepared in moderate to excellent yields. The success of the gram-scale procedure and tandem Stille coupling reaction has allowed this protocol to demonstrate potential for application in organic synthesis. Both exptl. and theor. studies reveal the mechanistic details of this stannylation reaction. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Electric Literature of C6H12BrCl).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Electric Literature of C6H12BrCl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of selenated tetracyclic indoloazulenes via iodine and diorganyl diselenides was written by Win, Khin Myat Noe;Sonawane, Amol D.;Koketsu, Mamoru. And the article was included in Organic & Biomolecular Chemistry in 2021.Reference of 1186603-47-3 The following contents are mentioned in the article:

An efficient protocol for the synthesis of selenated tetracyclic indoloazulenes I (R = H, Me, F; R¹ = Me, n-Pr, n-Bu, Ph; R² = H, OMe; R³ = H, OMe, Cl) was reported. The reaction of diorganyl diselenides R¹SeSeR¹ with mol. iodine in dichloromethane leads to the in situ formation of organo selenenyl iodide. The synthesis of selenylated tetracyclic indoloazulenes I through intramol. cascade cyclization has been achieved via organo selenenyl iodide and bisindole at room temperature under metal-free conditions in good yields. This study involved multiple reactions and reactants, such as 5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3Reference of 1186603-47-3).

5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Reference of 1186603-47-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Heat Capacity of α,ω-Bromochloroalkanes and α,ω-Dibromoalkanes: Their Dependence on the Hydrocarbon Chain Length and Temperature (285.15 to 355.15) K was written by Goralski, Pawel;Tkaczyk, Mariola. And the article was included in Journal of Chemical & Engineering Data in 2012.SDS of cas: 6294-17-3 The following contents are mentioned in the article:

The heat capacities at constant pressure of some α,ω-bromochloroalkanes (from C2 to C6) and α,ω-dibromoalkanes (from C2 to C12, without C7 and C10) were measured within the temperature range of (285.15 to 355.15) K. The measurements were performed by means of a Micro DSC III (Setaram) differential scanning calorimeter. The dependence of molar heat capacity on temperature and hydrocarbon chain length was described by the group additivity method. The densities of α,ω-bromochloroalkanes within the temperature range (288.15 to 318.15) K and their volumetric expansion coefficients at 298.15 K were also determined This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3SDS of cas: 6294-17-3).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.SDS of cas: 6294-17-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Electrochemical B-H Nitrogenation: Access to Amino Acid and BODIPY-Labeled nido-Carboranes was written by Yang, Long;Bongsuiru Jei, Becky;Scheremetjew, Alexej;Kuniyil, Rositha;Ackermann, Lutz. And the article was included in Angewandte Chemie, International Edition in 2021.Electric Literature of C4H12ClN The following contents are mentioned in the article:

Electrocatalyzed oxidative B-H nitrogenations of nido-carborane (nido-7,8-C₂B₉H₁₂^–) with N-heterocycles have been established, enabling the preparation of various N-substituted nido-carboranes without chem. oxidants or metal catalyst under ambient conditions. The electrolysis manifold occurred with high levels of efficiency as well as chemo- and position- selectivity, employing sustainable electricity as the sole oxidant. The strategy set the stage for a user-friendly access to novel amino acid and fluorogenic boron-dipyrrin (BODIPY)-labeled nido-carborane hybrids. This study involved multiple reactions and reactants, such as Tetramethylammonium chloride (cas: 75-57-0Electric Literature of C4H12ClN).

Tetramethylammonium chloride (cas: 75-57-0) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Electric Literature of C4H12ClN

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis, characterization and evaluation of 1,3,5-triazine aminobenzoic acid derivatives for their antimicrobial activity was written by Al-Zaydi, Khadijah M.;Khalil, Hosam H.;El-Faham, Ayman;Khattab, Sherine N.. And the article was included in Chemistry Central Journal in 2017.COA of Formula: C9H6Cl2N4 The following contents are mentioned in the article:

1,3,5-Triazines, particularly aminochlorotriazinylbenzoates and diaminotriazinylbenzoates such as I (R = PhNH, PhCH₂NH, Et₂N, 4-morpholinyl, 1-piperidinyl; R¹ = Cl, PhNH, PhCH₂NH, Et₂N, 4-morpholinyl, 1-piperidinyl; R² = H, Me) were prepared and tested for their antibacterial activities against Escherichia coli and Staphylococcus aureus and for their antifungal activities against Candida albicans. The toxicities of I (R = PhCH₂NH, 1-piperidinyl; R¹ = Cl; R² = H) were determined This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4COA of Formula: C9H6Cl2N4).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).COA of Formula: C9H6Cl2N4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics