Category: chlorides-buliding-blocks

Rojas Cabrera, Haydee published the artcileHomochiral L-prolinamido-sulfonamides and their use as organocatalysts in aldol reactions, Computed Properties of 21286-54-4, the publication is Tetrahedron: Asymmetry (2015), 26(4), 163-172, database is CAplus.

The synthesis of new homochiral L-prolinamido-sulfonamides 1-7 from enantiomerically pure (R,R)-11,12-diamino-9,10-dihydro-9,10-ethanoanthracene (R,R)-8 is reported. The L-prolinamido-sulfonamides 1-7 were tested as organocatalysts (10 mol %) in the aldol reaction of p-nitrobenzaldehyde and acetone in dichloromethane at room temperature in the presence of water (1 equiv) and acetic acid (20 mol %) giving good to high yields and enantioselectivities. Catalyst I (10 mol %) afforded the best results in the aldol reaction of acetone with p-substituted-benzaldehydes with electron withdrawing groups (i.e., nitro, cyano, bromo and chloro, up to 97% yield and 90% ee). The origin of the enantioselective induction was modeled using DFT methods. The estimated enantioselectivity for the model system is consistent with the exptl. data.

Tetrahedron: Asymmetry published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Computed Properties of 21286-54-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wils, E. R. J. published the artcileDetermination of mustard gas and related vesicants in rubber and paint by gas chromatography-mass spectrometry, Recommanded Product: 1,2-Bis(2-chloroethyl)disulfane, the publication is Journal of Chromatography (1992), 625(2), 382-6, database is CAplus.

The determination of mustard gas (2,2′-dichlorodiethyl sulfide) and some related vesicants in rubber and paint was investigated. The vesicants were isolated by extraction with CH₂Cl₂ or by dynamic headspace anal. at elevated temperatures The latter procedure had the advantage that high-boiling additives did not interfere during the anal. by capillary column gas chromatog.-mass spectrometry. The stability of the vesicants in the materials used proved to be good. No great losses were found after storage for weeks at room temperature

Journal of Chromatography published new progress about 1002-41-1. 1002-41-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1,2-Bis(2-chloroethyl)disulfane, and the molecular formula is C9H12O, Recommanded Product: 1,2-Bis(2-chloroethyl)disulfane.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sweis, Ramzi F. published the artcile2-(4-carbonylphenyl)benzoxazole inhibitors of CETP: scaffold design and advancement in HDLc-raising efficacy, HPLC of Formula: 18791-02-1, the publication is Bioorganic & Medicinal Chemistry Letters (2011), 21(6), 1890-1895, database is CAplus and MEDLINE.

The development of 2-phenylbenzoxazoles as inhibitors of cholesteryl ester transfer protein (CETP) is described. Initial efforts aimed at engineering replacements for the aniline substructures in the benchmark mol. I. Reversing the connectivity of the central aniline lead to a new class of 2-(4-carbonylphenyl)benzoxazoles. Structure-activity studies at the C-7 and terminal pyridine ring allowed for the optimization of potency and HDLc-raising efficacy in this new class of inhibitors. These efforts lead to the discovery of benzoxazole II, which raised HDLc by 24 mg/dL in the transgenic mouse PD model.

Bioorganic & Medicinal Chemistry Letters published new progress about 18791-02-1. 18791-02-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 2,3-Dibromopropionylchloride, and the molecular formula is C10H17N3O2, HPLC of Formula: 18791-02-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Lu, Nan published the artcileDrug repurposing: Discovery of troxipide analogs as potent antitumor agents, Application of 1-(Chloromethyl)-4-(trifluoromethyl)benzene, the publication is European Journal of Medicinal Chemistry (2020), 112471, database is CAplus and MEDLINE.

Drug repurposing plays a vital role in the discovery of undescribed bioactivities in clin. drugs. Based on drug repurposing strategy, we for the first time reported a novel series of troxipide analogs and then evaluated their antiproliferative activity against MCF-7, PC3, MGC-803, and PC9 cancer cell lines and WPMY-1, most of which showed obvious selectivity toward PC-3 over the other three cancer cell lines and WPMY-1. Compound 5q(I), especially, could effectively inhibit PC3 with an IC₅₀ value of 0.91μM, which exhibited around 53-fold selectivity toward WPMY-1. Data indicated that 5q effectively inhibited the colony formation, suppressed the cell migration, and induced G1/S phase arrest in PC3 cells. Also, compound 5q induced cell apoptosis by activating the two apoptotic signaling pathways in PC3 cells: death receptor-mediated extrinsic pathway and mitochondria-mediated intrinsic pathway. Compound 5q up-regulated the expression of both pro-apoptotic Bax and P53, while down-regulated anti-apoptotic Bcl-2 expression. Besides, compound 5q significantly increased the expression of cleaved caspase 3/9 and cleaved PARP. Therefore, the successful discovery of compound 5q may further validate the feasibility of this theory, which will encourage researchers to reveal undescribed bioactivities in traditional drugs.

European Journal of Medicinal Chemistry published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H6ClF3, Application of 1-(Chloromethyl)-4-(trifluoromethyl)benzene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wang, Weijin published the artcileNitromethane-enabled fluorination of styrenes and arenes, Product Details of C12H15ClO3, the publication is CCS Chemistry (2020), 2(6), 566-575, database is CAplus.

Herein, nitromethane (MeNO₂) as an efficient activator of Selectfluor and NFSI, as well as a stabilizer of carbocations was disclosed. Therefore, the fluoro-azidation, fluoroamination, fluoroesterification of styrenes, and C-H fluorination of (hetero)arenes were well realized just by the facilitation of MeNO₂. The mild reaction conditions and practicability made our current method a versatile protocol for accessing organofluorides.

CCS Chemistry published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C12H10FeO4, Product Details of C12H15ClO3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Lin, Yen-Jen published the artcileDithienylethene-containing cyclic and linear conjugated molecules: Synthesis, photochromism, and photoluminescence, COA of Formula: C15H14Cl2S2, the publication is Dyes and Pigments (2021), 109700, database is CAplus.

Cyclic and linear conjugated small mols. comprising dithienylethene (DTE) and thiophene groups were synthesized via Suzuki and McMurry couplings. The cyclic mol. was polymerized via ring-opening metathesis polymerization (ROMP) using a second-generation Grubbs catalyst to produce a DTE- and thienylene vinylene-containing conjugated polymer. DTE-containing small mols. exhibited (quasi-) reversible photochromism through alternating UV and visible light irradiation The small linear mols. showed faster photochromism than the cyclic mol. In contrast, the linear dimer and polymer did not undergo photochromism; however, they showed efficient photoluminescence, with quantum yields of 0.26 and 0.18, resp.

Dyes and Pigments published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C15H14Cl2S2, COA of Formula: C15H14Cl2S2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Noh, U. published the artcilePhototrophic degradation of (2-Cl)-phenol by Rhodopseudomonas palustris: a pathway combining anaerobic and aerobic reactions, Quality Control of 33697-81-3, the publication is Mededelingen – Faculteit Landbouwkundige en Toegepaste Biologische Wetenschappen (Universiteit Gent) (1998), 63(4b), 1867-1872, database is CAplus.

The advantage of anaerobic degradation processes of recalcitrant aromatic compounds are relatively low production of biomass and the possibility of dehalogenation of highly chlorinated compounds Phototrophic bacteria are known for their diverse metabolism, however, there is only little information about phototrophic degradation of phenol and chlorinated aromatic compounds Newly isolated and culture collection strains of Rhodopseudomonas palustris could transform 2-chlorophenol under phototrophic conditions in the presence of a second carbon source to 3-chloro-4-hydroxyphenylacetic acid, which were identified by HPLC, GC-MS and NMR anal. Dechlorination was demonstrated by stoichiometric release of Cl^– in the culture fluid. The occurrence of 4-hydroxyphenylacetic acid has never been observed in the degradation of phenol under methanogenic or nitrate reducing conditions, where phenol is first carboxylated to benzoate or p-hydroxybenzoate prior to reduction of the aromatic ring and complete mineralization. Further degradation of 4-hydroxyphenylacetic acid by R. palustris required oxygen, presumably for mono- and dioxygenases, which catalyze the ring cleaving reaction. In continuous cultures the amount of oxygen could be kept low enough to allow further degradation of 4-hydroxyphenylacetic acid and the expression of nitrogenase. Under these conditions phenolic compounds might be mineralized to mol. hydrogen and CO₂.

Mededelingen – Faculteit Landbouwkundige en Toegepaste Biologische Wetenschappen (Universiteit Gent) published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C8H7ClO3, Quality Control of 33697-81-3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Haney, Conor M. published the artcileDynamic covalent side-chain cross-links via intermolecular oxime or hydrazone formation from bifunctional peptides and simple organic linkers, SDS of cas: 42074-68-0, the publication is Journal of Peptide Science (2014), 20(2), 108-114, database is CAplus and MEDLINE.

Peptide cyclization via chemoselective reactions between side chains has proven a useful strategy to control folded structure. We report here a method for the synthesis of side-chain to side-chain cyclic peptides based on the intermol. reaction between a linear peptide functionalized with two aminooxy or hydrazide side chains and an organic dialdehyde linker. A family of oxime-based and hydrazone-based cyclic products is prepared in a modular and convergent fashion by combination of unprotected linear peptide precursors and various small mol. linkers in neutral aqueous buffer. The side-chain to side-chain linkages that result can alter peptide folding behavior. The dynamic covalent nature of the Schiff bases in the cyclic products can be utilized to create mixtures where product composition changes in response to exptl. conditions. Thus, a linear peptide precursor can select one organic linker from a mixture, and a cyclic product can dynamically exchange the small mol. component of the macrocycle. Copyright © 2014 European Peptide Society and John Wiley & Sons, Ltd.

Journal of Peptide Science published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C19H14Cl2, SDS of cas: 42074-68-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Hoyerova, Klara published the artcileAuxin molecular field maps define AUX1 selectivity: many auxin herbicides are not substrates, Application of 3-Chloro-4-hydroxyphenylacetic acid, the publication is New Phytologist (2018), 217(4), 1625-1639, database is CAplus and MEDLINE.

Summary : Developmental responses to auxin are regulated by facilitated uptake and efflux, but detailed mol. understanding of the carrier proteins is incomplete. We have used pharmacol. tools to explore the chem. space that defines substrate preferences for the auxin uptake carrier AUX1. Total and partial loss-of-function aux1 mutants were assessed against wild-type for dose-dependent resistance to a range of auxins and analogs. We then developed an auxin accumulation assay with associated math. modeling to enumerate accurate IC50 values for a small library of auxin analogs. The structure activity relationship data were analyzed using mol. field analyses to create a pharmacophoric atlas of AUX1 substrates. The uptake carrier exhibits a very high level of selectivity towards small substrates including the natural indole-3-acetic acid, and the synthetic auxin 2,4-dichlorophenoxyacetic acid. No AUX1 activity was observed for herbicides based on benzoic acid (dicamba), pyridinyloxyacetic acid (triclopyr) or the 6-arylpicolinates (halauxifen), and very low affinity was found for picolinic acid-based auxins (picloram) and quinolinecarboxylic acids (quinclorac). The atlas demonstrates why some widely used auxin herbicides are not, or are very poor substrates. We list mol. descriptors for AUX1 substrates and discuss our findings in terms of herbicide resistance management.

New Phytologist published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C8H7ClO3, Application of 3-Chloro-4-hydroxyphenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Oh, Keimei published the artcileSynthesis and structure-activity relationships of new pyrazole derivatives that induce triple response in Arabidopsis seedlings, Name: 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride, the publication is Journal of Pesticide Science (Tokyo, Japan) (2019), 44(4), 233-241, database is CAplus and MEDLINE.

Twenty-seven analogs of pyrazole derivatives I (R¹ = Me, Ph, allyl, tert-butyl; R² = 2-fluorophenyl, 3-chloro-4-fluorophenyl, 4-phenylazo, etc.) were synthesized and subjected to structure-activity relationship studies on inducing the triple response in Arabidopsis seedlings. The compound I (R¹ = allyl; R² = 3,4-dichlorophenyl) (II) has been found to exhibit potent activity on inducing the triple response in Arabidopsis seedlings. Compound II (10μM) induced an exaggerated apical hook in Arabidopsis seedlings. The curvature of the hook of the Arabidopsis seedlings was found to be 300 ± 23°, while ethephon (10μM), a prodrug of ethylene, and a non-chem. treated control were found to be 128 ± 19 and 58 ± 16°, resp. Compound II also exhibited potent activity on reducing stem elongation. The hypocotyl length of Arabidopsis seedlings treated with compound II (10μM) was found to be 0.25 ± 0.02 cm, while those of ethephon-treated (10μM) and treated controls were found to be 0.69 ± 0.06 and 1.15 ± 0.01 cm, resp. Compound II displayed potency inhibiting the root growth of Arabidopsis seedlings similar to that of ethephon.

Journal of Pesticide Science (Tokyo, Japan) published new progress about 32333-53-2. 32333-53-2 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Sulfonyl chlorides,Benzene, name is 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride, and the molecular formula is C7H3Cl2F3O2S, Name: 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics