Category: chlorides-buliding-blocks

Kim, Mi-hyun published the artcileStructure based design and syntheses of amino-1H-pyrazole amide derivatives as selective Raf kinase inhibitors in melanoma cells, Recommanded Product: 2-Chloroisonicotinic acid, the publication is Bioorganic & Medicinal Chemistry (2011), 19(6), 1915-1923, database is CAplus and MEDLINE.

The synthesis of a novel series of N-(5-amino-1-(4-methoxybenzyl)-1H-pyrazol-4-yl) amide derivatives 6a-o, 7a-s and their antiproliferative activities against A375P melanoma cell line were described. Most compounds showed competitive antiproliferative activities to sorafenib, the reference standard Among them, N-(5-amino-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-5-(3-(4-chloro-3-(trifluoromethyl)phenyl) ureido)-2-methylbenzamide 7c exhibited potent activities (GI₅₀ = 0.27 μM). Especially, 7c was found to be a potent and selective B-Raf V600E and C-Raf inhibitor (IC₅₀ = 0.26 μM, IC₅₀ = 0.11 μM, resp.), showing a possibility as melanoma therapeutics.

Bioorganic & Medicinal Chemistry published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, Recommanded Product: 2-Chloroisonicotinic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Cho, Yongsung published the artcileThe SAR analysis of TRPV1 agonists with the α-methylated B-region, Name: 3-Chloro-4-hydroxyphenylacetic acid, the publication is Bioorganic & Medicinal Chemistry Letters (2012), 22(16), 5227-5231, database is CAplus and MEDLINE.

A series of TRPV1 agonists with amide, reverse amide, and thiourea groups in the B-region and their corresponding α-methylated analogs were investigated. Whereas the α-methylation of the amide B-region enhanced the binding affinities and potencies as agonists, that of the reverse amide and thiourea led to a reduction in receptor affinity. The anal. indicated that proper hydrogen bonding as well as steric effects in the B-region are critical for receptor binding.

Bioorganic & Medicinal Chemistry Letters published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C8H7ClO3, Name: 3-Chloro-4-hydroxyphenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Lee, Jung Kul published the artcileModification of chitosan to improve its hypocholesterolemic capacity, SDS of cas: 4584-49-0, the publication is Bioscience, Biotechnology, and Biochemistry (1999), 63(5), 833-839, database is CAplus and MEDLINE.

Cholestyramine is the most widely used bile acid sequestrant in the treatment of hypercholesterolemia. However, cholestyramine has unpleasant side effects as a consequence of its hydrophobic backbone. Therefore, high-capacity bile acid sequestering biopolymers with cationic chitosan derivatives were developed, because electrostatic interactions are important for binding with bile acid anions. Dialkylaminoalkylation and reductive amination of chitosan were done to add dialkylaminoalkyl and an addnl. free amino group at a hydroxyl site in the chitosan backbone resp. and the aminoderivatized chitosan derivatives were quaternized with Me iodide to produce a cationic polyelectrolyte. The in vitro bile acid binding capacity of the chitosan derivatives in aqueous NaCl was measured by reversed-phase HPLC. The binding capacities of sodium glycocholate (a major bile acid) to chitosan, DEAE-chitosan, quaternized DEAE-chitosan, and cholestyramine were 1.42, 3.12, 4.06, and 2.78 mmol/g resin, resp. With quaternized DEAE-chitosan, the bile acid binding capacity increased ∼50% over that of cholestyramine. The bile acid binding capacity of dialkylaminoalkyl chitosan derivatives increased with the number of carbons in the alkyl groups, indicating that hydrophobic interaction is a secondary factor for the sequestration of bile acids.

Bioscience, Biotechnology, and Biochemistry published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C5H13Cl2N, SDS of cas: 4584-49-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kim, Kwang Soo published the artcileDyeing properties of reactive disperse dye having bromoacrylamide group, Application In Synthesis of 18791-02-1, the publication is Journal of the Korean Fiber Society (2001), 38(12), 683-692, database is CAplus.

A reactive disperse azo dye having an α-bromoacrylamido group was synthesized and its dyeing and fastness properties were compared with those of a a disperse dye. The amount of absorbed reactive disperse dye was less on polyester fabric than the disperse dye, and was much higher on nylon fabric. When polyester and nylon fiber were simultaneously dyed, the nylon absorbed more reactive disperse dye than polyester. The use of a carrier or a variation of dyebath pH was not able to provide the same color depth on both fibers. A nylon/polyester union fabric could be dyed with the reactive disperse dye and the color fastness was good to excellent.

Journal of the Korean Fiber Society published new progress about 18791-02-1. 18791-02-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 2,3-Dibromopropionylchloride, and the molecular formula is C3H3Br2ClO, Application In Synthesis of 18791-02-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kang, Dong Wook published the artcileHalogenation of 4-hydroxy/amino-3-methoxyphenyl acetamide TRPV1 agonists showed enhanced antagonism to capsaicin, HPLC of Formula: 33697-81-3, the publication is Bioorganic & Medicinal Chemistry (2010), 18(22), 8092-8105, database is CAplus and MEDLINE.

As an extension of our anal. of the effect of halogenation on thiourea TRPV1 agonists, we have now modified selected 4-hydroxy(or 4-amino)-3-methoxyphenyl acetamide TRPV1 agonists by 5- or 6-halogenation on the aromatic A-region and evaluated them for potency for TRPV1 binding and regulation and for their pattern of agonism/antagonism (efficacy). Halogenation shifted the functional activity at TRPV1 toward antagonism with a greater extent of antagonism as the size of the halogen increased (I > Br > Cl), as previously observed for the thiourea series. The extent of antagonism was greater for halogenation at the 5-position than at the 6-position, in contrast to SAR for the thiourea series. In this series, compounds 55 (I) and 75 showed the most potent antagonism, with K _i (ant) = 2.77 and 2.19 nM, resp., on rTRPV1 expressed in Chinese hamster ovary cells. The compounds were thus ca. 40-60-fold more potent than 6′-iodononivamide.

Bioorganic & Medicinal Chemistry published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C8H7ClO3, HPLC of Formula: 33697-81-3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Mandour, A. H. published the artcileSynthesis of N-(Coumarinsulfonyl)thiohydantoin and -hydantoin derivatives, Product Details of C9H5ClO4S, the publication is Afinidad (2000), 57(489), 344-348, database is CAplus.

Acylation of glycine with 6-coumarinylsulfonyl chloride or (6-nitro-3-coumarinyl)sulfonyl chloride gave N-[(coumarinyl)sulfonyl]glycine derivatives Treatment of the latter compounds with ammonium thiocyanate and acetic anhydride afforded N-[(coumarinyl)sulfonyl]-3-thiohydantoins. The key intermediates thus prepared were 1-[(2-oxo-2H-1-benzopyran-6-yl)sulfonyl]-2-thioxo-4-imidazolidinone and 1-[(6-nitro-2-oxo-2H-1-benzopyran-3-yl)sulfonyl]-2-thioxo-4-imidazolidinone. Hydrolysis of these intermediates using aqueous chloroacetic acid gave N-[(coumarinyl)sulfonyl]hydantoins. Thus, the above (thioxo)imidazolidinones were transformed into the resp. diones, 1-[(2-oxo-2H-1-benzopyran-6-yl)sulfonyl]-2,4-imidazolidinedione and 1-[(6-nitro-2-oxo-2H-1-benzopyran-3-yl)sulfonyl]-2,4-imidazolidinedione. Condensation of N-[(coumarinyl)sulfonyl]-3-thiohydantoins and N-[(coumarinyl)sulfonyl]-3-hydantoins with (arylidene)malononitrile in piperidine gave the corresponding pyrano[2,3-d]imidazolidines. Also, the condensation of the above intermediates with aromatic aldehyde led to the formation of 5(arylidene)thiohydantoins and 5-(arylidene)hydantoins. The condensation of the latter compounds with malononitrile was also carried out.

Afinidad published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C9H5ClO4S, Product Details of C9H5ClO4S.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Jankowiak, Aleksandra published the artcile4-Substituted 1-Acyloxypyridine-2(1 H)-thiones: Experimental and Computational Studies of the Substituent Effect on Electronic Absorption Spectra, SDS of cas: 6313-54-8, the publication is Journal of Organic Chemistry (2009), 74(19), 7441-7448, database is CAplus and MEDLINE.

A series of eight 4-substituted 1-(adamantane-1-carbonyloxy)-4-X-pyridine-2(1H)-thiones (1, X = H, OC₇H₁₅, Me, CF₃, SC₃H₇, CN, COOMe, and Cl) was prepared and characterized by UV-vis spectroscopy in MeCN and cyclohexane. The observed lowest energy transition, designated as π_CS → π*_ring, exhibits a substantial substituent effect and λ_max ranges from 333 (X = OC₇H₁₅) to 415 nm (X = CN). Exptl. λ_max values for all esters except for 1b (X = OC₇H₁₅) correlate with the σ_p^– parameter (ρ = 0.41 ± 0.03, r² = 0.95). In contrast, the energy of the absorption band at about 295 nm, designated as π_CS → π*_CS, is practically substituent independent. Both absorption bands exhibit a modest neg. solvatochromic effect. The exptl. absorption energies correlate better with excitation energies calculated for N-acetyloxy analogs 2 with the ZINDO//DFT than with the TD-DFT//DFT method. Calculations for a series of 12 N-acetates 2 predict the most blue-shifted π → π* transition for the alkoxy substituent and most red-shifted for the NO₂ group relative to the parent 2a (X = H).

Journal of Organic Chemistry published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, SDS of cas: 6313-54-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Okawara, Tadashi published the artcileFacile synthesis of four-, five-, six-, and seven-membered heterocyclic compounds by the reaction of hydrazines and thiosemicarbazides with α- and β-halogenoacyl halides in a two-phase system, Application of 2,3-Dibromopropionylchloride, the publication is Journal of Chemical Research, Synopses (1987), 254-5, database is CAplus.

Phase-transfer cyclization of RNHNHR (I, R = Ph, Me) with R¹CHXCOCl (II, R¹ = H, X = Cl; R¹ = Me, Et, Ph, X = Br) in the presence of PhCH₂N⁺Et₃ Cl^– gave diazetidinones III (R² = R) in 20-45% yields. Cyclization of thiosemicarbazides R³NHCSNHNH₂ (R³ = Bu, cyclohexyl, PhCH₂, Ph) with ClCH₂COCl gave diazetidinones III [R = R¹ = H, R² = C(:NR³)SCOCH₂Cl] in 52-84% yields. Similar cyclization of R⁴NHCSNMeNHMe (R⁴ = Ph, cyclohexyl, 1-naphthyl) with II gave thiadiazinone derivatives IV in 52-81% yields. Cyclization of I (R = Ph) with XCH₂CR⁵R⁶COCl (V, R⁵ = H, Me, R⁶ = X = Br; R⁵ = R⁶ = Me, X = Cl) gave diphenylpyrazolinones VI. Phase-transfer cyclization of R⁷NHCSNR⁸NH₂ (R⁷ = cyclohexyl, R⁸ = H, Me) with V (R⁵ = R⁶ = Me, X = Cl) gave 1,3,4-thiadiazepines, e.g. VII, along with azetidinone derivatives

Journal of Chemical Research, Synopses published new progress about 18791-02-1. 18791-02-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 2,3-Dibromopropionylchloride, and the molecular formula is C3H3Br2ClO, Application of 2,3-Dibromopropionylchloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Tamao, Kohei published the artcileCoupling of (amino)alkylchlorosilanes with lithium: new access to symmetrical di- and tetrafunctional alkyldisilanes, Product Details of C7H16Cl2Si, the publication is Organometallics (1993), 12(2), 580-2, database is CAplus.

Homocoupling reactions of amino- and diaminoalkylchlorosilanes with Li metal proceed readily in THF at room temperature to form the corresponding sym. diamino- and tetraaminoalkyldisilanes, resp., in high yields, which are transformed into chloroalkyldisilanes by the action of acyl chloride or dry HCl and into ethoxyalkyldisilanes by ethanolysis under mild conditions. The following are the compounds prepared in this study: XR¹R²SiSiR¹R²X where R¹ = R² = Me, X = Et₂N and Cl; R¹ = R² = iso-Pr, X = Et₂N and Cl; R¹ = Me,R² = n-hexyl, X = Et₂N, Cl and EtO, and X₂MeSiSiMeX₂ where X = Et₂N and EtO.

Organometallics published new progress about 14799-94-1. 14799-94-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(hexyl)(methyl)silane, and the molecular formula is C38H74Cl2N2O4, Product Details of C7H16Cl2Si.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Suzuki, Nobutaka published the artcilePhotochemical type I and II elimination reactions of dialkyl (trichloromethyl)phosphonates, Computed Properties of 866-23-9, the publication is Bulletin of the Chemical Society of Japan (1980), 53(5), 1421-4, database is CAplus.

Irradiation of CCl₃P(O)(OR)₂ (I; R = Et, Pr, CH₂CHMe₂) in MeCN gave the corresponding monoesters and olefins via photochem. type-II elimination. In addition, products via type-I elimination were obtained from I (R = Me, CH₂CHMe₂).

Bulletin of the Chemical Society of Japan published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H6BNO2, Computed Properties of 866-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics