Category: chlorides-buliding-blocks

Lu, Xing published the artcileCatalytic Synthesis of Functional Silicon-Stereogenic Silanes through Candida antarctica Lipase B Catalyzed Remote Desymmetrization of Silicon-Centered Diols, Synthetic Route of 14799-93-0, the publication is European Journal of Organic Chemistry (2013), 2013(26), 5814-5819, database is CAplus.

Si-containing diols were synthesized and used in lipase-catalyzed remote desymmetrization. E.g., reaction of 3,3′-[methyl(phenyl)silanediyl]bis(3,1-phenylene)dimethanol with acetic anhydride in CHCl₃ in the presence of Candida antarctica lipase B gave 90% yield of 3-((3-(hydroxymethyl)phenyl)(methyl)(phenyl)silyl)benzyl acetate (78% ee). This synthetic method is valuable in the construction of optically active Si-stereogenic organosilicon compounds Good enantioselectivities of the remote desymmetrization was achieved with Candida antarctica lipase B (CAL-B) (up to 90:10 er).

European Journal of Organic Chemistry published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C9H20Cl2Si, Synthetic Route of 14799-93-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Lu, Xing published the artcileCatalytic Synthesis of Functional Silicon-Stereogenic Silanes through Candida antarctica Lipase B Catalyzed Remote Desymmetrization of Silicon-Centered Diols, Related Products of chlorides-buliding-blocks, the publication is European Journal of Organic Chemistry (2013), 2013(26), 5814-5819, database is CAplus.

Si-containing diols were synthesized and used in lipase-catalyzed remote desymmetrization. E.g., reaction of 3,3′-[methyl(phenyl)silanediyl]bis(3,1-phenylene)dimethanol with acetic anhydride in CHCl₃ in the presence of Candida antarctica lipase B gave 90% yield of 3-((3-(hydroxymethyl)phenyl)(methyl)(phenyl)silyl)benzyl acetate (78% ee). This synthetic method is valuable in the construction of optically active Si-stereogenic organosilicon compounds Good enantioselectivities of the remote desymmetrization was achieved with Candida antarctica lipase B (CAL-B) (up to 90:10 er).

European Journal of Organic Chemistry published new progress about 14799-94-1. 14799-94-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(hexyl)(methyl)silane, and the molecular formula is C7H16Cl2Si, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yang, Shizhong published the artcilePreliminary study on 6-coumarinsulfonyl chloride as luminescence labeling reagent, Application of Coumarin-6-sulfonyl chloride, the publication is Fenxi Ceshi Xuebao (1993), 12(3), 49-52, database is CAplus.

Excessive 6-coumarinsulfonyl chloride (C6SCL) is reacted with L-alanine in pH 9.11 buffer solution (H₃BO₃-NaOH) at 40°C for 40 min and the reaction mixture is extracted with Et acetate. When the extract is dropped on a polyamide membrane and developed with formic acid-water (1 + 1) solution, the alanine C6SCL derivative is separated The R_f value is 0.67, 0.47 and 0.50 for the derivative, C6SCL and C6SOH, resp. After spraying the spot of derivative with 1 mol L^-1 NaOH solution and pre-illuminating and drying under UV light for 10 min, fluorescence intensity of the spot has a good linear relationship with amount of alanine in the range of (4-60) × 10^-11 mol. In addition, more intensive room temperature phosphorescence (RTP) of the derivation is induced by using 1.0 mol/L Pb(OAc)₂ as the heavy atom perturber and filter paper as solid substrate. All results show that the C₆SCL can be expected to serve as not only a fluorescence labeling reagent, but also a RTP one for amino acid etc.

Fenxi Ceshi Xuebao published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C10H10O2, Application of Coumarin-6-sulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yang, Shizhong published the artcileA newly developed luminescent label – synthesis and properties of 6-coumarinsulfonyl chloride, Related Products of chlorides-buliding-blocks, the publication is Fenxi Huaxue (1992), 20(2), 202-4, database is CAplus.

The title compound (I) was prepared by reaction if coumarin with ClSO₃H. Effects of pH, lighting and surfactant on the fluorescence properties of its aqueous solution, and the reactiveness to amino acids etc. are studied. The results show that both basic condition and enough lighting are necessary conditions for obtaining stabilized and strong fluorescence from aqueous solution of I, and quaternary ammonium salt surfactant can enhance its fluorescence intensity. It also showed that this simple derivative of coumarin can be used as a luminescence labeling reagent for amino acid, amines etc. which has reactivity with SO₂Cl group.

Fenxi Huaxue published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C8H8BFO2, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhao, Yu. published the artcileSynthesis and molecular recognition study of 6-Cs-β-CD, HPLC of Formula: 10543-42-7, the publication is Guangpuxue Yu Guangpu Fenxi (1998), 18(4), 464-467, database is CAplus.

The reagents 6-coumarinsulfonyl-β-cyclodextrin (6-Cs-β-CD) with mol. recognition function were synthesized and identified. Both basic condition and enough illumination were necessary for obtaining stable and strong fluorescence. By using 6-Cs-β-CD as the host, cyclohexanol, cyclohexene, cyclohexane, or bromocyclohexane as the guest, the recognition properties were studied. The affinity of 6-Cs-β-CD and the guest is distinct with different hydrophobicity of the guest.

Guangpuxue Yu Guangpu Fenxi published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C28H41N2P, HPLC of Formula: 10543-42-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Li, Ziyong published the artcileSynthesis, photophysical properties and NIR photochromism of photoresponsive difluoroboron β-diketonate complex based on dithienylethene unit, SDS of cas: 219537-97-0, the publication is Dyes and Pigments (2019), 597-603, database is CAplus.

The development of stimuli-responsive difluoroboron β-diketonate materials has attracted more and more attention for their potential application in optoelectronics and functional bio-materials. In this study, we have designed and synthesized a novel photoresponsive dithienylethene-containing difluoroboron β-diketonate complex 1 by Knoevenagel condensation reaction. Its structure have been confirmed by ¹H NMR, ¹³C NMR and HRMS (ESI). And it exhibited solvent-dependent photophys. properties in solution before visible light irradiation Subsequently, photochromism of 1 was investigated in solution, and it was found that 1 revealed solvent-dependent and visible light-triggered NIR photochromic behaviors. Moreover, it also displayed excellent fluorescence switching behavior and photochromism in the film state upon visible light irradiation Accordingly, the dithienylethene 1 may be acted as a novel visible light-responsive fluorescence dyes in optoelectronic materials.

Dyes and Pigments published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C15H14Cl2S2, SDS of cas: 219537-97-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Cooperstein, S. J. published the artcileThe mechanism of Janus Green B staining of mitochondria. II. Reactions and properties of Janus Green B and its derivatives, HPLC of Formula: 4569-86-2, the publication is Experimental Cell Research, Supplement (1953), 69-82, database is CAplus.

The absorption spectra are reported of Janus Green B(I) and G(II) and their derivatives, diethylsafranine, leucosafranine, and dimethylsafranine. I was readily reduced by cysteine (III) and glutathione whereas II was not significantly reduced by III. At pH 7.48 I showed 2 reduction steps upon polarographic analysis, one at a potential of -0.001 v. and the other at -0.188 v. II had only one reduction step at -0.214 v.

Experimental Cell Research, Supplement published new progress about 4569-86-2. 4569-86-2 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride, and the molecular formula is C22H23ClN4, HPLC of Formula: 4569-86-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Arthuis, Martin published the artcilePd⁰-Catalyzed carbonylation of 1,1-dichloro-1-alkenes, a new selective access to Z-α-chloroacrylates, HPLC of Formula: 866-23-9, the publication is Chemical Communications (Cambridge, United Kingdom) (2010), 46(41), 7810-7812, database is CAplus and MEDLINE.

A novel and fully chemo- and stereoselective three component strategy leading to Z-α-chloroacrylates by a Pd⁰-catalyzed reaction of CO (1 atm) with 1,1-dichloro-1-alkenes and various alcs. is disclosed. This catalytic approach compares favorably with the Wittig type strategies as α-chloroacrylates of pure Z configuration are obtained in high yield.

Chemical Communications (Cambridge, United Kingdom) published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, HPLC of Formula: 866-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Lim, Chae Jo published the artcile4-Heteroaryl phthalazin-1(2H)-one derivatives as potent melanin concentrating hormone receptor 1 (MCH-R1) antagonists, Related Products of chlorides-buliding-blocks, the publication is Bulletin of the Korean Chemical Society (2012), 33(7), 2389-2392, database is CAplus.

The target compounds, 4-heteroaryl-2-{3-[4-(3-acetamidophenyl)piperidin-1-yl]propyl}phthalazin-1(2H)-ones, were prepared starting from 2-BrC₆H₄CO₂H in 4 steps starting via Li-halo exchange using excess BuLi, followed by acylation with appropriate heteroaroyl esters to give the corresponding 2-heteroaroylbenzoates. The key 4-heteroarylphthalazin-1(2H)-one intermediates were then generated by condensation with N₂H₄. Subsequent N-alkylation with Cl(CH₂)₃I using NaH base afforded 2-(3-chloropropyl)4-heteroarylphthalazin-1 (2H)-ones, which were transformed to the target compounds through coupling with N-[3-(4-piperidinyl)phenyl]acetamide in the presence of Na₂CO₃. The title compounds proved to be potent MCH-R1 antagonists. An extensive SAR study carried out with substances in this family containing C(4) pyridyl and 5-membered heteroaryl groups led to the identification of a 5-chlorothien-2-yl derivative as a highly potent MCH-R1 antagonist. This substance displayed good metabolic stability, no inhibition of CYP450 enzymes, and low hERG binding activity.

Bulletin of the Korean Chemical Society published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Fang, Chao published the artcileDiscovery of heterocyclic replacements for the coumarin core of anti-tubercular FadD32 inhibitors, Computed Properties of 854778-30-6, the publication is Bioorganic & Medicinal Chemistry Letters (2018), 28(22), 3529-3533, database is CAplus and MEDLINE.

Previous work established a coumarin scaffold as a starting point for inhibition of Mycobacterium tuberculosis (Mtb) FadD32 enzymic activity. After further profiling of the coumarin inhibitor 4 revealed chem. instability, the authors discovered that a quinoline ring circumvented this instability and had the advantage of offering addnl. substitution vectors to further optimize. Ensuing SAR studies gave rise to quinoline-2-carboxamides with potent antitubercular activity. Further optimization of ADME/PK properties culminated in I that exhibited compelling in vivo efficacy in a mouse model of Mtb infection.

Bioorganic & Medicinal Chemistry Letters published new progress about 854778-30-6. 854778-30-6 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic acid and ester, name is (2-Chloro-3-methoxyphenyl)boronic acid, and the molecular formula is C7H8BClO3, Computed Properties of 854778-30-6.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics