Category: chlorides-buliding-blocks

Tan, Wen-Juan published the artcileA photochromic diarylethene dyad based on perylene diimide, Recommanded Product: 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, the publication is Dyes and Pigments (2011), 89(3), 260-265, database is CAplus.

A new photochromic diarylethene dyad based on perylene diimide (PDI-DTE) was synthesized. The photochromic reaction of PDI-DTE induced the significant change of the absorption spectra and fluorescence intensity. The color of PDI-DTE in THF solution was not changed obviously upon UV irradiation, while the fluorescence intensity is increased unexpectedly with the photochromic cyclization of the diarylethene units. With not visible change of color accompanied to the enhanced fluorescence, PDI-DTE can be potentially applied to anti-counterfeiting technol.

Dyes and Pigments published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C8H8BNO2, Recommanded Product: 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Song, Song published the artcileDMSO-catalysed late-stage chlorination of (hetero)arenes, Recommanded Product: 3-Chloro-2,6-dimethoxybenzoic acid, the publication is Nature Catalysis (2020), 3(2), 107-115, database is CAplus.

A highly efficient aromatic chlorination of arenes such as 1-methyl-indazole, imidazo[1,2-a]pyrazine, phenylthiophene, anthracene, etc. that is catalyzed by DMSO with N-chlorosuccinimide as the chloro source is reported. The mild conditions, easy-availability and stability of the catalyst and reagents, as well as good functional-group tolerance, showed the approach to be a versatile protocol for the late-stage aromatic chlorination of complex natural products, e.g., papaverine, drugs, e.g., diclofenac and peptides, e.g., I. The multi-gram experiment and low-cost of N-chlorosuccinimide and DMSO show great potential for drug discovery and development in industrial applications.

Nature Catalysis published new progress about 36335-47-4. 36335-47-4 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Ether, name is 3-Chloro-2,6-dimethoxybenzoic acid, and the molecular formula is C19H14O2, Recommanded Product: 3-Chloro-2,6-dimethoxybenzoic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Li, Ziyong published the artcileMulti-modulated photochromic behavior of a D-A type dithienylethene, Computed Properties of 219537-97-0, the publication is Dyes and Pigments (2019), 712-720, database is CAplus.

The development of multiresponsive photochromic materials is of increasing interest for their potential application in the complicated chem. and biol. environment. Here, a novel D-A type dithienylethene derivative NDM, in which dimethylamino group acted as both electron donor (D) and recognition moiety for H⁺, and the dicyanovinyl group functioned as electron acceptor (A) and responsed to cyanide anion, has been designed and synthesized. Its structure was confirmed by ¹H NMR, ¹³C NMR and HRMS (ESI). As expected, dithienylethene NDM exhibited distinctive multi-modulated photochromic properties by solvent, acid and cyanide anion stimulation. Moreover, NDM can be acted as a potential fluorescent turn-on pH-sensor and colorimetric sensor for CN^– in biol. field.

Dyes and Pigments published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C15H14Cl2S2, Computed Properties of 219537-97-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wang, Ke published the artcileSynthesis and in vitro cytotoxic activities of sorafenib derivatives, Quality Control of 33697-81-3, the publication is Chinese Chemical Letters (2014), 25(5), 702-704, database is CAplus.

A series of novel sorafenib derivatives were designed and synthesized. The cytotoxic activities of these compounds were tested in three tumor cell lines. Most of the compounds showed potent antiproliferative activity against the tested cell lines with IC₅₀ = 0-20 μmol/L. Some compounds demonstrated competitive antiproliferative activities to sorafenib against all three cancer cell lines. Among them, one of the compounds demonstrated significant inhibitory activity against A549, ACHN, and MDA-MB-231 cell lines with IC₅₀ values of 1.29, 1.99, 3.11 μmol/L, resp.

Chinese Chemical Letters published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C21H24O8, Quality Control of 33697-81-3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Fan, Jing published the artcileLight-Directing Omnidirectional Circularly Polarized Reflection from Liquid-Crystal Droplets, Safety of 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, the publication is Angewandte Chemie, International Edition (2015), 54(7), 2160-2164, database is CAplus and MEDLINE.

Constructing and tuning self-organized 3-dimensional (3D) superstructures with tailored functionality is crucial in the nanofabrication of smart mol. devices. A self-organized, phototunable 3D photonic superstructure was fabricated from monodisperse droplets of 1-dimensional cholesteric liquid crystal (CLC) containing a photosensitive chiral mol. switch with high helical twisting power. The droplets are obtained by a glass capillary microfluidic technique by dispersing into PVA solution that facilitates planar anchoring of the liquid-crystal mols. at the droplet surface, as confirmed by the observation of normal incidence selective circular polarized reflection in all directions from the core of individual droplet. Photoirradiation of the droplets furnishes dynamic reflection colors without thermal relaxation, whose wavelength can be tuned reversibly by variation of the irradiation time. The results provided clear evidence on the phototunable reflection in all directions.

Angewandte Chemie, International Edition published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C15H14Cl2S2, Safety of 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zheng, Zhi-gang published the artcileThree-dimensional control of the helical axis of a chiral nematic liquid crystal by light, Name: 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, the publication is Nature (London, United Kingdom) (2016), 531(7594), 352-356, database is CAplus and MEDLINE.

Chiral nematic liquid crystals – otherwise referred to as cholesteric liquid crystals (CLCs) – are self-organized helical superstructures that find practical application in, for example, thermog., reflective displays, tuneable color filters and mirrorless lasing. Dynamic, remote and three-dimensional control over the helical axis of CLCs is desirable, but challenging. For example, the orientation of the helical axis relative to the substrate can be changed from perpendicular to parallel by applying an alternating-current elec. field, by changing the anchoring conditions of the substrate, or by altering the topog. of the substrate’s surface; sep., in-plane rotation of the helical axis parallel to the substrate can be driven by a direct-current field. Here we report three-dimensional manipulation of the helical axis of a CLC, together with inversion of its handedness, achieved solely with a light stimulus. We use this technique to carry out light-activated, wide-area, reversible two-dimensional beam steering-previously accomplished using complex integrated systems and optical phased arrays. During the three-dimensional manipulation by light, the helical axis undergoes, in sequence, a reversible transition from perpendicular to parallel, followed by in-plane rotation on the substrate surface. Such reversible manipulation depends on exptl. parameters such as cell thickness, surface anchoring condition, and pitch length. Because there is no thermal relaxation, the system can be driven either forwards or backwards from any light-activated intermediate state. We also describe reversible photocontrol between a two-dimensional diffraction state, a one-dimensional diffraction state and a diffraction ‘off’ state in a bilayer cell.

Nature (London, United Kingdom) published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C39H35N5O8, Name: 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Liu, Jing-Bo published the artcileAnthranilic diamides derivatives as potential ryanodine receptor modulators: Synthesis, biological evaluation and structure activity relationship, HPLC of Formula: 1869-22-3, the publication is Bioorganic & Medicinal Chemistry (2018), 26(12), 3541-3550, database is CAplus and MEDLINE.

A series of novel anthranilic diamides derivatives (7a-s) containing halogen, trifluoromethyl group and cyano group were designed, synthesized, and characterized by m.p., ¹H NMR, ¹³C NMR and elemental analyses. The bioactivity revealed that most of them showed moderate to excellent activities against oriental armyworm (Mythimna separata) and diamondback moth (Plutella xylostella). Above all, the larvicidal activity of I against oriental armyworm was 100% and 40% at 0.25 and 0.1 mg L^-1, comparable to that of the standard chlorantraniliprole (100%, 0.25 mg L^-1 and 20%, 0.1 mg L^-1). What is more, 7o against diamondback moth displayed 90% insecticidal activity at 0.01 mg L^-1, superior to chlorantraniliprole (45%, 0.01 mg L^-1). The experiments I on the American cockroach (Periplaneta Americana) heart beating rates (Dorsal vessel) and contractile force were compared with chlorantraniliprole. In addition, I could affect the calcium homeostasis in the central neurons of the third larvae of oriental armyworm, which revealed that the ryanodine receptor is the potential target of I. The d. functional theory (DFT) calculation results revealed the amide bridge, the benzene ring of anthraniloyl moiety and pyrazole ring might play an important role in the insecticidal activity through hydrophobic interactions and π-π conjugations.

Bioorganic & Medicinal Chemistry published new progress about 1869-22-3. 1869-22-3 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Hydrazine,Amine,Benzene, name is 1-(2-Chloro-5-(trifluoromethyl)phenyl)hydrazine, and the molecular formula is C7H6ClF3N2, HPLC of Formula: 1869-22-3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Liu, Jing-Bo published the artcileSynthesis, insecticidal evaluation and 3D-QSAR study of novel anthranilic diamide derivatives as potential ryanodine receptor modulators, Formula: C6H3ClFNO2, the publication is Pest Management Science (2019), 75(4), 1034-1044, database is CAplus and MEDLINE.

BACKGROUND : Anthranilic diamide insecticides control lepidopteran pests through selectively binding and activating insect ryanodine receptors. In order to search for potential insecticides targeting the ryanodine receptors, a series of anthranilic diamide analogs including trifluoromethyl, nitro, or chloro groups were designed and synthesized by the principle of bioisosterism and structural optimization. RESULTS : Insecticidal data indicated that some compounds displayed good activity against oriental armyworm (Mythimna separata) and diamondback moth (Plutella xylostella). In particular, the larvicidal activity of 6p against P. xylostella was 95% at 0.01 mg L^-1, equivalent to chlorantraniliprole (85%, 0.01 mg L^-1). The comparative mol. similarity index anal. model obtained indicated that hydrogen bond acceptor and electron-withdrawing groups in the R’₃ group are favorable for insecticidal activity against M. separata, which is consistent with the structure-activity relationships. Moreover, the calcium imaging experiment indicated, like chlorantraniliprole, that 6h and 6p are interacting with the ryanodine receptor. CONCLUSION : Introducing trifluoromethyl, nitro, or chloro groups to a specific position in the N-phenylpyrazole could improve or maintain the activity against M. separata and P. xylostella. 6h and 6p could be used as potential lead compounds for ryanodine receptor modulators.Μ.

Pest Management Science published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C6H3ClFNO2, Formula: C6H3ClFNO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Li, Xiao-Gen published the artcileHydrogenation of Esters by Manganese Catalysts, Related Products of chlorides-buliding-blocks, the publication is Advanced Synthesis & Catalysis (2022), 364(4), 744-749, database is CAplus.

The hydrogenation of esters catalyzed by a manganese complex of phosphine-aminopyridine ligand was developed. Using this protocol, a variety of (hetero)aromatic and aliphatic carboxylates including biomass-derived esters and lactones were hydrogenated to primary alcs. R¹CH₂OH [R¹ = Me, Ph, 2-furyl, etc.] with 63-98% yields. The manganese catalyst was found to be active for the hydrogenation of Me benzoate, providing benzyl alc. with turnover numbers (TON) as high as 45,000. Investigation of catalyst intermediates indicated that the amido manganese complex was the active catalyst species for the reaction.

Advanced Synthesis & Catalysis published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C12H15ClO3, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Li, Wen-xiao published the artcileA study on preparing 3-chloro-4-fluoroaniline by hydrogenation, Formula: C6H3ClFNO2, the publication is Ranliao Yu Ranse (2014), 51(6), 35-39, database is CAplus.

The compound 3-chloro-4-fluoro aniline synthesized from 3-chloro-4-fluoride nitrobenzene with catalyst Pt-Cu-S/C by low-pressure hydrogenation was studied. The performances of the catalyst for hydrogenation of 3-chloro-4-fluoro nitrobenzene were investigated, and probed into the main factors influencing the hydrogenation. Experiments showed that the catalyst has high catalytic activity and selectivity. In conditions of mass fraction of Pt in the catalyst 1%, mass fraction of Cu in the catalyst 0.1%, the mass fraction of S in the catalyst 0.03%, catalyst amount 0.5% (in weight of nitro compound), the amount of solvent 2 mL ethanol/1 g nitro compounds, the reaction temperature 80°C, pressure 1.5 MPa, yield of 3-chloro-4-fluoro aniline was 98%, purity more than 99.5%.

Ranliao Yu Ranse published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C6H3ClFNO2, Formula: C6H3ClFNO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics