Category: chlorides-buliding-blocks

Golzadeh, Robab published the artcileGreen synthesis of methadone in eutectic solvent, Name: 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, the publication is Main Group Chemistry (2021), 20(4), 463-474, database is CAplus.

Synthesis of di-Ph acetonitrile with 1-dimethylamino-2-chloropropane by a eutectic’s solvent was described. In addition, methadone I was synthesized from the reaction of 2,2-diphenyl-4-dimethylaminovaleronitrile with Et magnesium bromide in the presence of solvent eutectic, which was in optimal and environmentally compatible conditions and by principles of green chem.

Main Group Chemistry published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C5H13Cl2N, Name: 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Cross, R. Matthew published the artcileOptimization of 1,2,3,4-Tetrahydroacridin-9(10H)-ones as Antimalarials Utilizing Structure-Activity and Structure-Property Relationships, Synthetic Route of 209919-30-2, the publication is Journal of Medicinal Chemistry (2011), 54(13), 4399-4426, database is CAplus and MEDLINE.

Antimalarial activity of 1,2,3,4-tetrahydroacridin-9(10H)-ones (THAs) has been known since the 1940s and has garnered more attention with the development of the acridinedione floxacrine in the 1970s and analogs thereof such as WR 243251 in the 1990s. These compounds failed just prior to clin. development because of suboptimal activity, poor solubility, and rapid induction of parasite resistance. Moreover, detailed structure-activity relationship (SAR) studies of the THA core scaffold were lacking and SPR studies were nonexistent. To improve upon initial findings, several series of 1,2,3,4-tetrahydroacridin-9(10H)-ones were synthesized and tested in a systematic fashion, examining each compound for antimalarial activity, solubility, and permeability. Furthermore, a select set of compounds was chosen for microsomal stability testing to identify physicochem. liabilities of the THA scaffold. Several potent compounds (EC₅₀ < 100 nM) were identified to be active against the clin. relevant isolates W2 and TM90-C2B while possessing good physicochem. properties and little to no cross-resistance.

Journal of Medicinal Chemistry published new progress about 209919-30-2. 209919-30-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids,Boronic acid and ester, name is 4-Chloro-2-methylphenylboronic acid, and the molecular formula is C7H8BClO2, Synthetic Route of 209919-30-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Bigolin, Alisson published the artcileA novel sulfonamide derivative as a strong and selective apototic agent against hematological malignancies, Safety of ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, the publication is Chemical Papers (2020), 74(9), 2965-2976, database is CAplus.

Abstract: Currently available chemotherapeutic drugs against hematol. malignancies have several adverse effects and are associated with high mortality rates. Thus, in this study we evaluated the cytotoxic effect of 26 new sulfonamide derivatives on acute leukemia and multiple myeloma cells in order to try to discover a new selective and safe compound that might be used as a prototype for new chemotherapeutic agents. The most cytotoxic compound, DFS16, reduced the cell viability of K562, Jurkat and MM.1S cells in a concentration- and time- dependent manner and it was significantly less cytotoxic to non-tumor cells. On acute leukemia cells, sulfonamide DFS16 activated intrinsic and extrinsic apoptosis with Bax/Bcl-2 inversion, increased FasR expression and m loss. In K562, DFS16 induced apoptosis by caspase-3 activation, while in Jurkat, it induced AIF release and caspase-3 independent apoptosis. In multiple myeloma, DFS16 induced cell cycle arrest at the G2/M phase and apoptosis with m loss. Altogether, the results suggest that the new sulfonamide derivative DFS16 induces apoptotic-like cell death in acute leukemia and multiple myeloma cells. DFS16 is a promising new mol. that could be used as a prototype for the development of chemotherapeutics against hematol. malignancies.

Chemical Papers published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Safety of ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sureshkumar, Devarajulu published the artcileRegio- and Stereoselective Synthesis of Aziridino Epoxides from Cyclic Dienes, Synthetic Route of 7080-50-4, the publication is Journal of Organic Chemistry (2006), 71(4), 1653-1657, database is CAplus and MEDLINE.

Two different routes for the regio- and stereoselective synthesis of aziridino epoxides from cyclic dienes have been explored. The first strategy involves regiospecific aziridination of cyclic diene derivatives and subsequent epoxidation with m-CPBA to yield cis-aziridino epoxides as major products. The second strategy utilizes regiospecific epoxidation of cyclic diene derivatives followed by Sharpless aziridination to provide exclusively trans-aziridino epoxides. Synthesis of both enantiomers of cis-aziridino epoxides from (R)-(-)- and (S)-(+)-carvones are also reported.

Journal of Organic Chemistry published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C8H6ClNO, Synthetic Route of 7080-50-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Shultz, Michael D. published the artcileStructure-efficiency relationship of [1,2,4]triazol-3-ylamines as novel nicotinamide isosteres that inhibit tankyrases, Application of 3-(2,6-Dichlorophenyl)propanoic acid, the publication is Journal of Medicinal Chemistry (2013), 56(17), 7049-7059, database is CAplus and MEDLINE.

Tankyrases 1 and 2 are members of the poly(ADP-ribose) polymerase (PARP) family of enzymes that modulate Wnt pathway signaling. While amide- and lactam-based nicotinamide mimetics that inhibit tankyrase activity, such as XAV939, are well-known, the discovery and evaluation of a novel nicotinamide isostere that demonstrates selectivity over other PARP family members is reprted. The utilization of lipophilic efficiency-based structure-efficiency relationships (SER) to rapidly drive the evaluation of this series is demonstrated. These efforts led to a series of selective, cell-active compounds with solubility, physicochem., and in vitro properties suitable for further optimization.

Journal of Medicinal Chemistry published new progress about 51656-68-9. 51656-68-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene, name is 3-(2,6-Dichlorophenyl)propanoic acid, and the molecular formula is C15H19BO2, Application of 3-(2,6-Dichlorophenyl)propanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Vennerstrom, Jonathan L. published the artcileAntimalarial dyes revisited: xanthenes, azines, oxazines, and thiazines, SDS of cas: 4569-86-2, the publication is Antimicrobial Agents and Chemotherapy (1995), 39(12), 2671-7, database is CAplus and MEDLINE.

In 1891, P. Guttmann and P. Ehrlich (1891) were the first to report the antimalarial properties of a synthetic, rather than a natural, material when they described the clin. cure of two patients after oral administration of a thiazine dye, methylene blue. Since that time, sporadic reports of the antimalarial properties of several xanthene and azine dyes related to methylene blue have been noted. We report here the results from a reexamination of the antimalarial properties of methylene blue, Janus green B, and three rhodamine dyes and disclose new antimalarial data for 16 com. available structural analogs of these dyes. The 50% inhibitory concentrations for the chloroquine-susceptible D6 clone and SN isolate and the chloroquine-resistant W2 clone of Plasmodium falciparum were determined by the recently described parasite lactate dehydrogenase enzyme assay. No cross-resistance to chloroquine was observed for any of the dyes. For the 21 dyes tested, no correlation was observed between antimalarial activity and cytotoxicity against KB cells. No correlation between log P (where P is the octanol/water partition coefficient) or relative catalyst efficiency for glucose oxidation and antimalarial activity or cytotoxicity was observed for the dyes as a whole or for the thiazine dyes. Thiazine dyes were the most uniformly potent structural class tested, and among the dyes in this class, methylene blue was notable for both its high antimalarial potency and selectivity.

Antimicrobial Agents and Chemotherapy published new progress about 4569-86-2. 4569-86-2 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride, and the molecular formula is C44H28ClFeN4, SDS of cas: 4569-86-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Udovitskaya, V. V. published the artcileSynthesis and antimicrobiol activity of ammonium derivatives of cyclohexane, Quality Control of 38146-42-8, the publication is Khimiko-Farmatsevticheskii Zhurnal (1970), 4(1), 17-20, database is CAplus.

Haloacetates (Ia) of substituted cyclohexanols, XCH2CO2R, were prepared by the method of Conrad (1877) as follows (R, X, b.p./mm, % yield, n20D, and d20 reported): 4-MeC6H10, Cl, 92-4°/5, 50.7, 1.4576, 1.0937; 4-MeC6H10, Br, 136-8°/30, 49.0, 1.4772, 1.3051; 3,3,5-Me3C6H8, Cl, 154-6°/50, 85.0, 1.4575, 1.0419; 3,3,5-Me3C6H8, Br, 156-8°/30, 71.4, 1.4717, 1.2152; menthyl, Cl, 132-4°/8, 41.0, 1.4625, 1.0420. Ia with tertiary amines in EtOH or Me2CO gave quaternary ammonium salts [ZNCH2CO2R]+X- (I). The following I derived from dl-menthol were reported (ZN, X, m.p., and % yield given): Me3N, Cl, 226°, 97; Et3N, Cl, 179°, 94; Et2NCH2CH2OH, Br, 144-6°, 94; Et2NCH2CH2O2CC6H4NH2-p, Cl, 89°, 83; C5H5N, Br, 173-4°, 86; 4-methylpyridine, Br, 196-7°, 81; quinolin e, Br, 197°, 78; 4-aminoquinaldine, Br, 169°, 73; N-methylmorpholine, Br, 161-2°, 74. An analogous reaction with tertiary diamines gave the following [RO2CCH2Me2N+(CH2)nN+Me2CH2CO2R]-2X- (R, n, X, m.p., and % yield given): 4-MeC6H10, 2, Br, 176-7°, 85; 3,3,5-Me3C6H6, 2, Br, 184-5 °, 93; 4-MeC6H10, 6, Br, 165-6°, 93; 4-MeC6H10, 6, Cl, 102-4°, 72; 3,3,5-Me3C6H8, 6, Br, 134-5°, 83; 3,3,5-Me3C6H8, 6, Cl, 110-12°, 66; C6H11, 10, Cl, 96-8°, 86; 4-MeC6H10, 10, Br, 82-5°, 85; 3,3,5-Me3C6H8, 10, Br, 92-4°, 82; 3,3,5-Me3C6H8, 10, Cl, 85-7°, 92; l-menthyl, 10, Br, 142°, 67; l-menthyl, 10, Cl, 167-8°, 92; dl-menthyl, 10, Cl, 116-18°, 56. All the quaternary salts prepared were tested in vitro against Staphylococcus aureus and Escherichia coli.

Khimiko-Farmatsevticheskii Zhurnal published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C10H12O5, Quality Control of 38146-42-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Titenko, K. S. published the artcileUse of a new antimicrobial preparation, decamethoxin for treatment of purulent-inflammatory diseases of anterior chamber of the eye, HPLC of Formula: 38146-42-8, the publication is Oftal’mologicheskii Zhurnal (1977), 32(3), 217-21, database is CAplus and MEDLINE.

Decamethoxin [38146-42-8] in 0.02% NaCl solutions applied topically to the eyes of rats exerted bactericidal activity against purulent infections of the cornea and conjunctiva caused by common bacteria. When applied clin., decamethoxin was safe and effective in combination antibiotic therapy against ulcerative infections of the cornea and conjunctival membrane.

Oftal’mologicheskii Zhurnal published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C11H9NO3, HPLC of Formula: 38146-42-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Garvey, Edward P. published the artcileNucleotide and Nucleoside Analogs as Inhibitors of Cytosolic 5′-Nucleotidase I from Heart, Recommanded Product: Diethyltrichloromethylphosphonate, the publication is Biochemistry (1998), 37(25), 9043-9051, database is CAplus and MEDLINE.

Substrate and product specificity studies were used to develop inhibitors of the cytosolic 5′-nucleotidase I (c-N-I) from myocardium. As measured by V_max/K_m, c-N-I preferred pyrimidine 2′-deoxyribonucleotides as substrates with thymidine monophosphate (TMP) being the most efficient. In product inhibition studies, thymidine inhibited noncompetitively and inorganic phosphate inhibited competitively, consistent with an ordered release of nucleoside prior to phosphate. Mirroring nucleotide substrate specificities, pyrimidine nucleosides were more potent product inhibitors than purine nucleosides. Thus, pyrimidine nucleotide and nucleoside analogs were developed as inhibitors. Phosphonate analogs of TMP were synthesized by a novel method. The most potent was the 5′-phosphonate of 3′-deoxythymidine (ddT) (apparent K_i value of 63 nM). In addition, pyrimidine nucleoside analogs were inhibitors with 5-ethynyl-2′,3′-dideoxyuridine being the most potent (apparent K_i value of 3.7 μM). The most potent nucleotide and nucleoside inhibitor were both greater than 1000-fold more potent inhibiting c-N-I than the cytosolic 5′-nucleotidase II. The nucleoside analog was also greater than 1000-fold more potent against c-N-I than the membrane ecto-5′-nucleotidase (e-N). Because the phosphonate analogs measurably inhibited e-N (apparent K_i values of 6-12 μM), the selectivity of the phosphonates for c-N-I vs. e-N was less (40-200-fold). Because of the high selectivity for c-N-I vs. both of the other 5′-nucleotidases, the nucleoside inhibitors of c-N-I may be useful biochem. tools in discerning the role that c-N-I plays in generating adenosine within myocardium.

Biochemistry published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Recommanded Product: Diethyltrichloromethylphosphonate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sanin, P. I. published the artcileAntiwear additives of phosphonate type, Application of Diethyltrichloromethylphosphonate, the publication is Neftekhimiya (1974), 14(2), 317-22, database is CAplus.

The effectiveness of esters of phosphonic acids depended on their structure and on the friction regime. The esters containing no Cl had no effect at high and low loads. Those containing CCl3 groups were effective at both high and low loads or only at high and only at low ones. The difference was assumed to be due to different chem. and adsorption activity of the compounds and chem. modification of the friction surface. The effectiveness depended on the concentration of additive (1.5-6 mmole/100 g oil).

Neftekhimiya published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Application of Diethyltrichloromethylphosphonate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics