Category: chlorides-buliding-blocks

Sitnikov, Nikolay S. published the artcileDesign and Synthesis of New Protease-Triggered CO-Releasing Peptide-Metal-Complex Conjugates, Safety of 2-Chlorotrityl chloride, the publication is European Journal of Organic Chemistry (2019), 2019(40), 6830-6837, database is CAplus.

Aiming at the development of novel protease-triggered CO-releasing mols. (PT-CORMs) the authors designed oxycyclohexadiene-Fe(CO)₃ complexes, which are connected through a self-immolative linker with a plasmin-specifying peptide unit. The challenging synthesis of these compounds was elaborated employing a combination of solid-phase peptide synthesis and solution chem. synthesis. Late-stage attachment of the organometallic unit and Pd-catalyzed cleavage of an alloc-protected lysine side chain afforded the target compounds in good yields and high purity.

European Journal of Organic Chemistry published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C25H23NO4, Safety of 2-Chlorotrityl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Abd-El-Hafez, O. M. published the artcileSynthesis of some new coumarin derivatives with evaluation of their antimicrobial activity, Recommanded Product: Coumarin-6-sulfonyl chloride, the publication is Egyptian Journal of Pharmaceutical Sciences (1994), 35(1-6), 113-26, database is CAplus.

6-Aminocoumarin (I) was condensed with some aromatic aldehydes to give the Schiff’s bases II (R = N:CHR², R¹ = H, R² = C₆H₄OMe-4, C₆H₄Cl-2, C₆H₄Cl-4, C₆H₄NO₂-4, C₆H₄NMe₂, 2-thienyl, X = O). I was also reacted with some halo-compounds to give coumarin-6-amino derivatives II (R = NHR³, R¹ = H, R³ = COCH₂Cl, CH₂CHO, COPh, X = O). 6-Nitrocoumarin-3-sulfonyl chloride II (R = NO₂, R¹ = SO₂R⁴, R⁴ = Cl, X = O) and thiocoumarin-6-sulfonyl chloride II (R = SO₂R⁴, R⁴ = Cl, R¹ = H, X = S) were reacted with some amines to give 6-nitrocoumarin-3-sulfonamide derivatives II (R = NO₂, R¹ = SO₂R⁴, R⁴ = NHNH₂, NMe₂, pyrrolidino, 2-pyridinyl, morpholino, etc., X = O) and thiocoumarin-6-sulfonamide derivatives II (R = SO₂R⁴, R¹ = H, R⁴ = piperidino, pyrrolidino, morpholino), resp. On the other hand, thiocoumarin II (R = R¹ = H, X = S) was reacted with primary amines to give benzopyran-2-imino derivatives II (X = NR⁵, R⁵ = NH₂, Me, NHPh, CH₂Ph, 2-pyridinyl, Ph). The antimicrobial activity of the prepared compounds was also investigated.

Egyptian Journal of Pharmaceutical Sciences published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C9H5ClO4S, Recommanded Product: Coumarin-6-sulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Shalaby, A. M. published the artcileSynthesis of some coumarin-6-sulfono-N-amino acids and evaluation of their antimicrobial activity, Recommanded Product: Coumarin-6-sulfonyl chloride, the publication is Bulletin of the National Research Centre (Egypt) (1994), 19(2), 97-106, database is CAplus.

The reaction of 6-coumarinsulfonyl chloride with amino acid esters gave N-[(coumarinyl)sulfonyl]glycine derivatives that were converted to the corresponding N-[(coumarinyl)sulfonyl]glycine hydrazides I (R = alkyl, benzyl, etc.). The antimicrobial activity of N-[(coumarinyl)sulfonyl]glycine hydrazide s and preparation of N-[(coumarinyl)sulfonyl]dipeptides was reported.

Bulletin of the National Research Centre (Egypt) published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C16H12O, Recommanded Product: Coumarin-6-sulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Badolato, Mariateresa published the artcileTriazolopyrimidinium salts: discovery of a new class of agents for cancer therapy, Recommanded Product: 3-Chlorobenzylchloride, the publication is Future Medicinal Chemistry (2020), 12(5), 387-402, database is CAplus and MEDLINE.

Aim: The [1,2,4]triazolo[1,5-a]pyrimidine core is highly privileged in medicinal chem. due to its versatile pharmacol. activity profile. Recently, the search for novel anticancer agents has focused on [1,2,4]triazolo[1,5-a]pyrimidine derivatives Results: Our hit functionalization has led to the discovery of new [1,2,4]triazolo[1,5-a]pyrimidinium salts with potential anticancer activity. Among a small library of mols., compound 9 significantly inhibits cancer cell growth in a panel of in vitro models. Mol. docking studies and preliminary binding assay have displayed that 9 could directly bind the Src homol. 2 (SH2) domain of STAT3 protein. Conclusion: Compound 9 is a novel promising lead compound that motivates addnl. evaluation of [1,2,4]triazolo[1,5-a]pyrimidinium salts as novel potential chemotherapeutics.

Future Medicinal Chemistry published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, Recommanded Product: 3-Chlorobenzylchloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ferla, Salvatore published the artcileRational modifications, synthesis and biological evaluation of new potential antivirals for RSV designed to target the M2-1 protein, HPLC of Formula: 939-99-1, the publication is Bioorganic & Medicinal Chemistry (2020), 28(8), 115401, database is CAplus and MEDLINE.

Respiratory syncytial virus (RSV) is the main cause of lower respiratory tract diseases in infants and young children, with potentially serious and fatal consequences associated with severe infections. Despite extensive research efforts invested in the identification of therapeutic measures, no vaccine is currently available, while treatment options are limited to ribavirin and palivizumab, which both present significant limitations. While clin. and pre-clin. candidates mainly target the viral fusion protein, the nucleocapsid protein or the viral polymerase, our focus has been the identification of new antiviral compounds targeting the viral M2-1 protein, thanks to the presence of a zinc-ejecting group in their chem. structure. Starting from an anti-RSV hit we had previously identified with an in silico structure-based approach, we have designed, synthesized and evaluated a new series of dithiocarbamate analogs, with which we have explored the antiviral activity of this scaffold. The findings presented in this work may provide the basis for the identification of a new antiviral lead to treat RSV infections.

Bioorganic & Medicinal Chemistry published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H6ClF3, HPLC of Formula: 939-99-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Raoufmoghaddam, Saeed published the artcileImportance of the Reducing Agent in Direct Reductive Heck Reactions, Synthetic Route of 21286-54-4, the publication is ChemCatChem (2018), 10(1), 266-272, database is CAplus.

The role of the reductant in the palladium N-heterocyclic carbene (NHC) catalyzed reductive Heck reaction and its effect on the mechanism of the reaction is reported. For the first time in this type of transformation, the palladium-NHC-catalyzed reductive Heck reaction was shown to proceed in the presence of LiOMe and iPrOH even at 10 °C to give the products very efficiently in excellent yields and with exceptional chemoselectivities. This study shows that the reaction proceeds through two distinct mechanisms that depend on the nature of the reducing agent. In the presence of a protic solvent or acidic medium the reaction undergoes protonation to yield the reduced product, whereas in the absence of proton source, it proceeds through the insertion of the reductant followed by reductive elimination. The kinetic data reveal that the oxidative addition is the rate-determining step in the reaction. The reaction profiles show first-order kinetics in aryl iodide and Pd and zero-order kinetics in LiOMe, benzylideneacetone, and the excess amount of NHC ligand. In addition, the reaction progress kinetic anal. shows that neither catalyst decomposition nor product inhibition occurs during the reaction. DFT calculations of the key steps confirm that the oxidative addition step is the rate-determining step in the reaction. Deuterium-labeling experiments indicate that the product is formed by the protonation of the Pd-C_alkyl bond of the intermediate formed after enone insertion into the Pd-C_Ar bond. Application of chiral NHC ligands in the asym. reductive Heck reaction only results in poor enantioselectivities (enantiomeric excess up to 20 %) and is also substrate specific. DFT calculations suggest that the migration of the aryl group to the alkene of the substrate is the enantioselectivity-determining step of the reaction. It is further shown that if the steric bulk at the enone is small (a Me group), the two transition state barriers from [Pd^II(L²)(ArI)(enone)] species C_re and C_si, which have the re and si face of the enone substrate coordinated to Pd, are very similar, in line with the exptl. results. With a slightly larger group (an iso-Pr substituent) a significant difference in energy barriers is calculated (2.6 kcal mol^-1), and in the experiment this product is formed with a modest enantiomeric excess (up to 20 %).

ChemCatChem published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Synthetic Route of 21286-54-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Gou, Fei-Hu published the artcileNickel-catalyzed cross-coupling of amino-acid-derived alkylzinc reagents with alkyl bromides/chlorides: Access to diverse unnatural amino acids, Product Details of C7H4ClF3, the publication is Organic Letters (2022), 24(1), 240-244, database is CAplus and MEDLINE.

Unnatural α-amino acids are important synthetic targets in the field of peptide science. Herein we report an efficient, versatile, and straightforward strategy for the synthesis of homophenylalanine derivatives via the nickel-catalyzed Csp³-Csp³ cross-coupling of (fluoro)benzyl bromides/chlorides with natural α-amino-acid-derived alkylzinc reagents. The current protocol features the advantages of a low-cost nickel catalyst system, synthetic convenience, and the tolerance of rich functionality and stereochem.

Organic Letters published new progress about 243139-71-1. 243139-71-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 2,4,5-Trifluorobenzyl chloride, and the molecular formula is C7H4ClF3, Product Details of C7H4ClF3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wu, Jie published the artcileSynthesis and biological evaluation of ursolic acid derivatives containing an aminoguanidine moiety, Application of 3-Chlorobenzylchloride, the publication is Medicinal Chemistry Research (2019), 28(7), 959-973, database is CAplus.

Three series of ursolic acid derivatives containing an aminoguanidine moiety were designed, synthesized, and evaluated for anti-bacterial and anti-inflammatory activity. Some compounds displayed potent anti-bacterial activity against Gram-pos. bacterial strains (including multidrug-resistant clin. isolates) and Gram-neg. bacterial strains, with min. inhibitory concentration (MIC) values in the range of 2-64 μg/mL. Compounds 3a, 5a, and 7l showed significant inhibitory activity against the Gram-pos. bacterial strain Staphylococcus aureus RN 4220, the Gram-neg. bacterial strain Escherichia coli 1924, and four multidrug-resistant Gram-pos. bacterial strains, with MIC values of 2 and 4 μg/mL. In anti-inflammatory tests, most of the compounds exhibited potent activity, in particular compound 3a displayed the most potent activity with 81.61% inhibition after i.p. administration, which was more potent than ursolic acid and the reference drugs (ibuprofen and indomethacin). The cytotoxic activity of compound 3a was assessed in HeLa, Hep3B, and A549 cells.

Medicinal Chemistry Research published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C21H26BF4NO, Application of 3-Chlorobenzylchloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wang, Shuai published the artcileDiscovery of new [1,2,4] Triazolo[1,5-a]Pyrimidine derivatives that Kill gastric cancer cells via the mitochondria pathway, Safety of 1-(Chloromethyl)-4-(trifluoromethyl)benzene, the publication is European Journal of Medicinal Chemistry (2020), 112630, database is CAplus and MEDLINE.

A novel series of [1,2,4]triazolo[1,5-a]pyrimidine-based compoundsI [R¹ = benzyl, 4-fluorobenzyl, 4-chlorobenzyl, etc.; R² = Me, Et, Ph; R³ = H, Me] and II [R⁴ = Ph, (4-(3-(6-bromo-2-pyridyl)prop-2-enoyl)phenyl), (4-(3-(5-bromo-2-pyridyl)prop-2-enoyl)phenyl), etc.] were synthesized and tested their anti-proliferation efficacy against gastric cancer cell line MGC-803. Among them, compounds II [R⁴ = (4-(3-(6-bromo-2-pyridyl)prop-2-enoyl)phenyl), (4-(3-(5-bromo-2-pyridyl)prop-2-enoyl)phenyl)] inhibited gastric cancer cells at micromolar level. Compound II [R⁴ = (4-(3-(6-bromo-2-pyridyl)prop-2-enoyl)phenyl)] caused G2/M arrest and induced mitochondria-dependent apoptosis in MGC-803 and SGC-7901. However, inhibiting apoptosis pathway cannot prevent the inhibitory activity of compound II [R⁴ = (4-(3-(6-bromo-2-pyridyl)prop-2-enoyl)phenyl)] against gastric cancer cell. To our surprising, ROS level was increased by compound II [R⁴ = (4-(3-(6-bromo-2-pyridyl)prop-2-enoyl)phenyl)] and elevation of ROS could be rescued by NAC. In accordance with that, NAC absolutely prevented the anti-proliferation efficacy of compound 4o. We further found that autophagy inhibitor CQ rather than 3-MA partially reversed inhibitory activity of compound II [R⁴ = (4-(3-(6-bromo-2-pyridyl)prop-2-enoyl)phenyl)] in MGC-803 cells. Taken together, compound II [R⁴ = (4-(3-(6-bromo-2-pyridyl)prop-2-enoyl)phenyl)] exhibited its anti-proliferative activity via increasing ROS level and inducing autophagy, thus leading to apoptosis of gastric cancer cells. Therefore, compound II [R⁴ = (4-(3-(6-bromo-2-pyridyl)prop-2-enoyl)phenyl)] may support further development of lead compounds for gastric cancer therapy via mitochondria pathway.

European Journal of Medicinal Chemistry published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C6H12F3NO5S, Safety of 1-(Chloromethyl)-4-(trifluoromethyl)benzene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Chen, Guanghui published the artcileSynthesis of Functional Olefin Copolymers with Controllable Topologies Using a Chain-Walking Catalyst, Name: trimethyloxosulphonium chloride, the publication is Journal of the American Chemical Society (2003), 125(22), 6697-6704, database is CAplus and MEDLINE.

The branching topol. of ethylene polar copolymers was for the first time successfully controlled by copolymerization of ethylene with polar olefins using a palladium-bisimine chain-walking catalyst, in which ethylene pressure and comonomer concentration were used to control the competition between isomerization (chain-walking) and monomer insertion processes. Although the overall branching d. changes slightly, the topol. of the copolymers becomes more dendritic as the ethylene pressure and comonomer feed concentration are decreasing. This provides a straightforward one-pot synthesis to access a full range of functional copolymers having controllable branching topologies. To demonstrate the utility of this methodol., dendritic functional copolymers having hydroxyl, epoxide, and carbohydrate groups were prepared in a one-pot polymerization as potential functional materials.

Journal of the American Chemical Society published new progress about 5034-06-0. 5034-06-0 belongs to chlorides-buliding-blocks, auxiliary class Salt,Aliphatic hydrocarbon chain, name is trimethyloxosulphonium chloride, and the molecular formula is C3H9ClOS, Name: trimethyloxosulphonium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics