Category: chlorides-buliding-blocks

Huynh, Uyen published the artcileFormation, Alkylation, and Hydrolysis of Chiral Nonracemic N-Amino Cyclic Carbamate Hydrazones: An Approach to the Enantioselective α-Alkylation of Ketones, Application of ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, the publication is Journal of Organic Chemistry (2018), 83(21), 12951-12964, database is CAplus and MEDLINE.

The α-alkylation of ketones is a fundamental synthetic transformation. The development of asym. variants of this reaction is important given that numerous natural products, drugs, and related compounds exist as α-functionalized ketones or derivatives thereof. Authors previously reported preliminary studies on the development of a new enantioselective ketone α-alkylation procedure using N-amino cyclic carbamate (ACC) auxiliaries. In comparison to other auxiliary-based methods, ACC alkylation offers a number of advantages and is both highly enantioselective and high yielding. Herein, authors provide a full account of their studies on the enantioselective ACC ketone α-alkylation method.

Journal of Organic Chemistry published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Application of ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhebentyaev, A. I. published the artcileInteraction between biologically active quaternary ammonium salts and eosine dyes, Application of N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, the publication is Zhurnal Analiticheskoi Khimii (1987), 42(3), 518-24, database is CAplus.

In order to determine optimal conditions for spectrophotometric determination of biol. active quaternary ammonium compounds (QAC), complex formation of QAC with eosine  [17372-87-1] was studied. The monocharged dye anions, having an ionized group, were the most reactive. The chem. nature of QAC is discussed. QAC solutions obeyed the basic light absorption law. The method is applied to determination of QAC in dosage forms from a citrate buffer solution by measuring the absorbance of the eosine complex at 540 nm.

Zhurnal Analiticheskoi Khimii published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C26H45N5O7Si2, Application of N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Pitre, Spencer P. published the artcileLibrary of Cationic Organic Dyes for Visible-Light-Driven Photoredox Transformations, Application In Synthesis of 4569-86-2, the publication is ACS Omega (2016), 1(1), 66-76, database is CAplus and MEDLINE.

Organic dyes can be excellent catalysts for photoredox chem., offering low price, low toxicity, and an exceptional range of available materials. Their use has been limited because in comparison to their transition-metal catalysts the spectroscopic, kinetic, and electrochem. information available is far more limited. To remediate this situation, we have determined the necessary data for 14 readily available dyes with excellent potential as photoredox catalysts. We have also demonstrated the utility of these dyes through visible-light-mediated reductive dehalogenation and Aza-Henry reactions. We envision that this collection of data will lead to an increase in the use of cationic dyes in photoredox processes because users will find the necessary information readily available.

ACS Omega published new progress about 4569-86-2. 4569-86-2 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride, and the molecular formula is C22H23ClN4, Application In Synthesis of 4569-86-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Cui, J. Jean published the artcileDiscovery of a Novel Class of Exquisitely Selective Mesenchymal-Epithelial Transition Factor (c-MET) Protein Kinase Inhibitors and Identification of the Clinical Candidate 2-(4-(1-(Quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)-1H-pyrazol-1-yl)ethanol (PF-04217903) for the Treatment of Cancer, COA of Formula: C8H7ClO3, the publication is Journal of Medicinal Chemistry (2012), 55(18), 8091-8109, database is CAplus and MEDLINE.

The c-MET receptor tyrosine kinase is an attractive oncol. target because of its critical role in human oncogenesis and tumor progression. An oxindole hydrazide hit 6 (VI) was identified during a c-MET HTS campaign and subsequently demonstrated to have an unusual degree of selectivity against a broad array of other kinases. The cocrystal structure of the related oxindole hydrazide c-MET inhibitor 10 (X) with a nonphosphorylated c-MET kinase domain revealed a unique binding mode associated with the exquisite selectivity profile. The chem. labile oxindole hydrazide scaffold was replaced with a chem. and metabolically stable triazolopyrazine scaffold using structure based drug design. Medicinal chem. lead optimization produced 2-(4-(1-(quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)-1H-pyrazol-1-yl)ethanol (2, II, PF-04217903), an extremely potent and exquisitely selective c-MET inhibitor. 2 Demonstrated effective tumor growth inhibition in c-MET dependent tumor models with good oral PK properties and an acceptable safety profile in preclin. studies. 2 Progressed to clin. evaluation in a Phase I oncol. setting.

Journal of Medicinal Chemistry published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C8H7ClO3, COA of Formula: C8H7ClO3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Jansen, Johan F. G. A. published the artcileThe Dendritic Box: Shape-Selective Liberation of Encapsulated Guests, Name: 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride, the publication is Journal of the American Chemical Society (1995), 117(15), 4417-18, database is CAplus.

Several guests have been encapsulated in a dendritic box. The maximum number of guests is determined by the shape and size of cavities and guests. Shape-selective liberation of guests with different sizes is achieved by the hydrolysis of the shell in a two-step process. First the shell is perforated by the hydrolysis of the protecting N-t-BOC groups of the L-Phe end group, furnishing the liberation of small guests (p-nitrophenol, p-nitro-benzoic acid or an EPR probe) upon dialysis. The larger guests–bengal rose, rhodamine, new coccine and methylene violet 3RAX–still being imprisoned in the box with a perforated shell, are liberated by subsequent hydrolysis of the amide groups. By changing the amino acid and the protected groups used, it is possible to tune the shape-selectivity in the liberation of guests of different size.

Journal of the American Chemical Society published new progress about 4569-86-2. 4569-86-2 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride, and the molecular formula is C22H23ClN4, Name: 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sanad, Sherif M. H. published the artcileTandem synthesis, cytotoxicity, and in silico study of new 1,3,4-oxadiazoles as potential thymidylate synthase inhibitors, Recommanded Product: Sodium chloro(tosyl)amide trihydrate, the publication is Archiv der Pharmazie (Weinheim, Germany), database is CAplus and MEDLINE.

A new series of pyrrole-linked mono- and bis(1,3,4-oxadiazole) hybrids I [R = H, Me, Cl, etc.] and II [R¹ = -PhO(CH₂)₂OPh-, -PhO(CH₂)₃OPh-, -PhO(CH₂)₄OPh-, etc.], attached to various arene units, was prepared using a two-step tandem protocol. Therefore, a benzohydrazide derivative was condensed with the appropriate aldehydes RCHO in ethanol at 80°C for 60-150 min to give the corresponding N-(benzoylhydrazones). Without isolation, the previous intermediates underwent intramol. oxidative cyclization in DMSO at 180°C for 90-200 min in the presence of chloramine trihydrate to afford the target hybrids I. The cytotoxicity of all hybrids was examined in vitro against the MCF-7, HEPG2 and Caco2 cell lines. Arene-linked hybrids I [R = NO2, 4-acetoxy], were the most potent ones, with IC₅₀ values ranging from 5.47 to 8.80 and 12.75 to 21.22 μM, resp., when tested on the above cell lines. At the tested concentrations of 5 and 7.5 μM, hybrid I [R = 4-nitro] inhibited thymidylate synthase (TS) with the best inhibition percentages of 72.3 and 91.3, whereas hybrid I [R = 4-acetoxy] displayed comparable inhibitory activity to the reference pemetrexed. Hybrid I [R = 4-acetoxy] had inhibition percentages of 62.7 and 82.6, whereas pemetrexed had inhibition percentages of 59.2 and 80.2, resp. The capability of hybrids I [R = 4-nitro, 4-acetoxy] as potential TS inhibitors was supported by mol. docking studies, while SwissADME predicts their efficacy as drug-like scaffolds.

Archiv der Pharmazie (Weinheim, Germany) published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C7H13ClNNaO5S, Recommanded Product: Sodium chloro(tosyl)amide trihydrate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Cuyegkeng, Maria Assunta published the artcileChromatographic separation of enantiomers and barriers to enantiomerization of axially chiral aromatic carboxamides, Synthetic Route of 36335-47-4, the publication is Chemische Berichte (1987), 120(5), 803-9, database is CAplus.

The enantiomers (M) and (P) of a series of similar aromatic carboxamides were for the first time examined anal. and enriched preparatively by liquid chromatog. on triacetylcellulose. Enantiomeric purities (7-99%), sp. rotations, and barriers to rotation about the C(sp²)-C(sp²) bond (87-120 kJ/mol) were determined These energies were discussed in terms of the size of ortho substituents and of the buttressing effects by meta substituents.

Chemische Berichte published new progress about 36335-47-4. 36335-47-4 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Ether, name is 3-Chloro-2,6-dimethoxybenzoic acid, and the molecular formula is C9H9ClO4, Synthetic Route of 36335-47-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Che, Chao published the artcileSynthesis and bioactivity of 2-amino-5[(2-chloropyrid)-4-yl]-1,3,4-thiadiazole derivatives, Product Details of C6H4ClNO2, the publication is Yingyong Huaxue (2002), 19(8), 795-797, database is CAplus.

By combining 2-chloropyridine, 1,3,4-thiadiazole and acylamide, three toxophoric moieties, seven title compounds I (R = Me, Ph, Et, i-Pr, Bn, n-Bu, α-Furanyl) were synthesized in seven steps. The preliminary biol. activity tests showed that the title compounds had certain plant growth regulating effect as well as fungicidal activity.

Yingyong Huaxue published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, Product Details of C6H4ClNO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Li, Xiantang published the artcileNickel/Photo-Cocatalyzed Acyl C-H Benzylation of Aldehydes with Benzyl Chlorides, Synthetic Route of 620-20-2, the publication is European Journal of Organic Chemistry (2022), 2022(17), e202200214, database is CAplus.

Authors have developed a nickel/TBADT cocatalyzed acyl C-H benzylation of both aliphatic and aromatic aldehydes with primary and secondary benzyl chlorides under mild reaction conditions. The protocol provides a convenient and efficient method to synthesize a variety of ketones.

European Journal of Organic Chemistry published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, Synthetic Route of 620-20-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Miranda, Alexandre S. published the artcileDihomooxacalix[4]arene-based fluorescent receptors for anion and organic ion pair recognition, Quality Control of 6249-56-5, the publication is Molecules (2020), 25(20), 4708, database is CAplus and MEDLINE.

Fluorescent dihomooxacalix[4]arene-based receptors 5a-5c, bearing two naphthyl(thio)ureido groups at the lower rim via a Bu spacer, were synthesized and obtained in the cone conformation in solution The X-ray crystal structures of 1,3-(5a) and 3,4-dinaphthylurea (5b) derivatives are reported. Their binding properties towards several anions of different geometries were assessed by 1H-NMR, UV-Vis absorption and fluorescence titrations Structural and energetic insights of the naphthylurea 5a and 5b complexes were also obtained using quantum mech. calculations The data showed that all receptors follow the same trend, the association constants increase with the anion basicity, and the strongest complexes were obtained with F^–, followed by the oxoanions AcO^– and BzO^–. Proximal urea 5b is a better anion receptor compared to distal urea 5a, and both are more efficient than thiourea 5c. Compounds 5a and 5b were also investigated as heteroditopic receptors for biol. relevant alkylammonium salts, such as the neurotransmitter γ-aminobutyric acid (GABA·HCl) and the betaine deoxycarnitine·HCl. Chiral recognition towards the guest sec-butylamine·HCl was also tested, and a 5:2 selectivity for (R)-sec-BuNH₃⁺·Cl^– towards (P) or (M) enantiomers of the inherently chiral receptor 5a was shown. Based on DFT calculations, the complex [(S)-sec-BuNH₃⁺·Cl^–/(M)-5a] was indicated as the more stable.

Molecules published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Quality Control of 6249-56-5.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics