Category: chlorides-buliding-blocks

Brasca, Maria Gabriella published the artcilePyrrole-3-carboxamides as potent and selective JAK2 inhibitors, Safety of (5-Chloro-2-(trifluoromethyl)phenyl)boronic acid, the publication is Bioorganic & Medicinal Chemistry (2014), 22(17), 4998-5012, database is CAplus and MEDLINE.

We report herein the discovery, structure guided design, synthesis and biol. evaluation of a novel class of JAK2 inhibitors. Optimization of the series led to the identification of the potent and orally bioavailable JAK2 inhibitor (I; NMS-P953). I displayed significant tumor growth inhibition in SET-2 xenograft tumor model, with a mechanism of action confirmed in vivo by typical modulation of known biomarkers, and with a favorable pharmacokinetic and safety profile.

Bioorganic & Medicinal Chemistry published new progress about 1195945-67-5. 1195945-67-5 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Boronic acid and ester,Benzene,Boronic Acids,Boronic Acids,Boronic acid and ester, name is (5-Chloro-2-(trifluoromethyl)phenyl)boronic acid, and the molecular formula is C7H5BClF3O2, Safety of (5-Chloro-2-(trifluoromethyl)phenyl)boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Freidlina, R. Kh. published the artcileThermal telomerization of olefins with silicon hydrides, HPLC of Formula: 14799-94-1, the publication is Khim. i Prakt. Primenenie Kremneorgan. Soedin., Tr. Konf., Leningrad (1961), 1958(6), 72-82, database is CAplus.

Compounds containing Si-H bonds undergo addition reactions with olefins in a steel autoclave at temperatures of 260-300° and at 100-560 atm. with no other catalyst or initiator. Products are of the type Si(olefin)_nH (I), where n = 1-6. The autoclave itself does not appear to act as an initiator by reacting with Cl in chlorosilanes to give metal chlorides, since a similar reaction takes place when no Cl is present in the Si compound The reaction appears to proceed by a free radical route. The influence of temperature and olefin concentration on the product mixture was investigated. With increasing C₂H₄ concentration, where n = 1, the yield of I decreases; where n = 2 or 3, remains the same; where n >3, increases. Increasing temperature in range 285°-400°, with constant (2:1) excess of olefin in mixture, increased the yield of I where n = 1 at expense of n >3; where n = 2 or 3, the yield varied little. For comparison, the reaction was carried out in the presence of certain metallic chlorides. H₂PtCl₆ catalyzes addition reaction at room temperature, but chlorides of Zr, Ti, and Sn, require temperatures ≃200° and give less satisfactory conversion. This reaction appears to proceed via polar intermediates.

Khim. i Prakt. Primenenie Kremneorgan. Soedin., Tr. Konf., Leningrad published new progress about 14799-94-1. 14799-94-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(hexyl)(methyl)silane, and the molecular formula is C7H16Cl2Si, HPLC of Formula: 14799-94-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wagare, Devendra S. published the artcileHighly efficient microwave-assisted one-pot synthesis of 4-aryl-2-aminothiazoles in aqueous medium, Recommanded Product: 1-(4-Chlorophenyl)thiourea, the publication is Environmental Chemistry Letters (2017), 15(3), 475-479, database is CAplus.

A one-pot protocol for the synthesis of 4-aryl-2-aminothiazoles from the reaction of aromatic ketones, NBS (N-bromosuccinimide) and thioureas under microwave irradiation at 80-85° in PEG (polyethylene glycol)-400 and water as a green reaction medium was developed. The products were obtained in 84-89% yields in 28-32 min. The method had several advantages such as use of green solvent, easy work-up, excellent yield and avoiding use of lachrymatory α-haloketones.

Environmental Chemistry Letters published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C8H7N3, Recommanded Product: 1-(4-Chlorophenyl)thiourea.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhou, Xin published the artcileElectrochemical reduction of fluoroalkyl sulfones for radical fluoroalkylation of alkenes, Formula: C9H5Cl2F3, the publication is Chemical Communications (Cambridge, United Kingdom) (2021), 57(70), 8750-8753, database is CAplus and MEDLINE.

Radical fluoroalkylation of alkenes has been developed by electrochem. reduction of fluoroalkyl sulfones. A series of electron-deficient alkenes readily underwent hydrofluoroalkylation in good to excellent yields. This chem. represents the first example of electrochem. generation of fluoroalkyl radicals from sulfones, which are used for practical radical fluoroalkylation of organic compounds

Chemical Communications (Cambridge, United Kingdom) published new progress about 864725-22-4. 864725-22-4 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Alkenyl,Benzene, name is 1,3-Dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene, and the molecular formula is C8H13NO3, Formula: C9H5Cl2F3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ma, Junjie published the artcileSemicarbazone derivatives bearing phenyl moiety: synthesis, anticancer activity, cell cycle, apoptosis-inducing and metabolic stability study, Safety of 3-Chlorobenzylchloride, the publication is Chemical & Pharmaceutical Bulletin (2019), 67(4), 351-360, database is CAplus and MEDLINE.

A series of semicarbazone derivatives bearing Ph moiety I [R = Me, Et; R¹ = H, benzyloxidanyl, 2-(2H-1,3-benzodioxol-5-ylmethyl)-(1,3-thiazol-4-yl)-methyloxy, [(4-chlorophenyl)methyl]oxidanyl, etc.; R² = t-Bu, H, prop-2-en-1-yl; R³ = H, t-Bu] was synthesized and evaluated for the vitro anticancer activities in four human cancer cell lines (human colon cancer (HT29), human neuroblastoma (SK-N-SH), human breast cancer (MDA-MB-231), and human gastric cancer (MKN45)). Biol. evaluation led to the identification of I [(I) R = Me, R¹ H, R² = R³ = t-Bu; (II) R = Et, R¹ H, R² = R³ = t-Bu], which showed excellent anticancer activities against tested cancer cell lines with IC₅₀ values ranging from 0.32 to 1.57 μM, resp., while exhibiting weak cytotoxicity on the normal cells (human umbilical vein endothelial cell (HUVEC)). Flow cytometric assay for cell cycle and apoptosis revealed that (I) and (II) caused an arrest in the Sub-G1 cell cycle and inhibited proliferation of cancer cells by inducing apoptosis in a dose-dependent manner. Further enzymic assay suggested that (I) and (II) could significantly activated procaspase-3 to caspase-3. Metabolic stability study indicated that (I) and (II) showed moderate stability in vitro in human and rat liver microsomes. In view of promising pharmacol. activities of (I) and (II), which had emerged as the valuable lead for further development in the treatment for cancer.

Chemical & Pharmaceutical Bulletin published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, Safety of 3-Chlorobenzylchloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ma, Junjie published the artcileSemicarbazone derivatives bearing phenyl moiety: synthesis, anticancer activity, cell cycle, apoptosis-inducing and metabolic stability study, SDS of cas: 939-99-1, the publication is Chemical & Pharmaceutical Bulletin (2019), 67(4), 351-360, database is CAplus and MEDLINE.

A series of semicarbazone derivatives bearing Ph moiety I [R = Me, Et; R¹ = H, benzyloxidanyl, 2-(2H-1,3-benzodioxol-5-ylmethyl)-(1,3-thiazol-4-yl)-methyloxy, [(4-chlorophenyl)methyl]oxidanyl, etc.; R² = t-Bu, H, prop-2-en-1-yl; R³ = H, t-Bu] was synthesized and evaluated for the vitro anticancer activities in four human cancer cell lines (human colon cancer (HT29), human neuroblastoma (SK-N-SH), human breast cancer (MDA-MB-231), and human gastric cancer (MKN45)). Biol. evaluation led to the identification of I [(I) R = Me, R¹ H, R² = R³ = t-Bu; (II) R = Et, R¹ H, R² = R³ = t-Bu], which showed excellent anticancer activities against tested cancer cell lines with IC₅₀ values ranging from 0.32 to 1.57 μM, resp., while exhibiting weak cytotoxicity on the normal cells (human umbilical vein endothelial cell (HUVEC)). Flow cytometric assay for cell cycle and apoptosis revealed that (I) and (II) caused an arrest in the Sub-G1 cell cycle and inhibited proliferation of cancer cells by inducing apoptosis in a dose-dependent manner. Further enzymic assay suggested that (I) and (II) could significantly activated procaspase-3 to caspase-3. Metabolic stability study indicated that (I) and (II) showed moderate stability in vitro in human and rat liver microsomes. In view of promising pharmacol. activities of (I) and (II), which had emerged as the valuable lead for further development in the treatment for cancer.

Chemical & Pharmaceutical Bulletin published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H6ClF3, SDS of cas: 939-99-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Masuda, Takeshi published the artcileSugar-induced stereoselectivity in the Fe³⁺-complexation of boronic acid-appended trihydroxamate-type artificial siderophores, Synthetic Route of 332154-58-2, the publication is Supramolecular Chemistry (2000), 11(4), 301-314, database is CAplus.

Two linear- and two tripodal-trihydroxamate siderophore mimics, suspending phenylboronic acid as the sugar-binding site, have been newly prepared These siderophore mimics strongly bind Fe³⁺ ions to give rise to the ligand-Fe³⁺ 1:1 complexes over a wide range of pH 2 to 11. CD spectra of these complexes in the presence of a sugar, D-fructose, exhibit moderately strong bisignate Cotton effects of first neg. and second pos. signs in aqueous alk. media. The sign and extent of the observed CD signals depend largely on the solution pH and the concentration and absolute configuration of the bound sugars, implying that the phenylboronate-sugar covalent interactions are capable of inducing a chirality around the metal center.

Supramolecular Chemistry published new progress about 332154-58-2. 332154-58-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,acyl chloride,Boronic Acids,Boronic Acids,Boronic acid and ester,, name is (3-(Chlorocarbonyl)phenyl)boronic acid, and the molecular formula is C7H6BClO3, Synthetic Route of 332154-58-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Pedreira, Julia G. B. published the artcileBioisosteric Replacement of Arylamide-Linked Spine Residues with N-Acylhydrazones and Selenophenes as a Design Strategy to Novel Dibenzosuberone Derivatives as Type I 1/2 p38α MAP Kinase Inhibitors, Application In Synthesis of 620-20-2, the publication is Journal of Medicinal Chemistry (2020), 63(13), 7347-7354, database is CAplus and MEDLINE.

The recent disclosure of type I 1/2 inhibitors for p38α MAPK demonstrated how the stabilization of the R-spine can be used as a strategy to greatly increase the target residence time (TRT) of inhibitors. Herein, for the first time, we describe N-acylhydrazone and selenophene residues as spine motifs, yielding metabolically stable inhibitors with high potency on enzymic, NanoBRET, and whole blood assays, improved metabolic stability, and prolonged TRT.

Journal of Medicinal Chemistry published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, Application In Synthesis of 620-20-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sharath, N. published the artcileSynthesis, DNA Binding, and Photonuclease Activity of New Tetraaza Macrocyclic Constrained Isoxazole Rings as Subunit in Metal Complexes, Category: chlorides-buliding-blocks, the publication is Nucleosides, Nucleotides & Nucleic Acids (2012), 31(11), 813-829, database is CAplus and MEDLINE.

The DNA-binding and photonuclease activity of newly synthesized tetra-azamacrocyclic ligand L (C₃₂H₃₂N₈O₄) and its complexes of type [MLCl₂] and [ML]Cl₂ (where M = Co(II), Fe(II) and Cu(II)); L = N,N’-[3-(4-{5-[(2-amino-ethylamino)-methyl]-isoxazol-3yl}-phenyl)-isoxazol-5-yl methyl-ethane-1,2-diamine] are specified. An octahedral geometry has been proposed for Fe(II) and Co(II) complexes, while the Cu(II) complex has a square planar environment. The absorption spectral results indicate that the complexes bind with the base pairs of DNA, with an intrinsic binding constant K_b of, and complexes found to be 3.2 × 10⁴ M^-1, 5.3 × 10⁴ M^-1, and 4.2 × 10⁴ M^-1, resp., in 5 mM Tris-HCl/50 mM NaCl buffer at pH 7.2. The large enhancement in the relative viscosity of DNA on binding to the complexes supports the proposed DNA binding modes. The viscosity and thermal denaturation studies sustain the effective intercalation with DNA. The DNA photocleavage studies demonstrated that compounds exhibit significant photonuclease activity by a concentration dependent on singlet oxygen mediated mechanism.

Nucleosides, Nucleotides & Nucleic Acids published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C4H10BBrO2, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kikuchi, Mikio published the artcilePredicting changes in aquatic toxicity of chemicals resulting from solvent or dispersant use as vehicle, Application of 3-Chloro-4-fluoronitrobenzene, the publication is Chemosphere (2016), 34-39, database is CAplus and MEDLINE.

The influence of two vehicles (N,N-dimethylformamide [DMF] as solvent and polyoxyethylene hydrogenated castor oil [HCO-40] as a dispersant) on the acute toxicity of eight hydrophobic chems. with a non-specific mode of action to Daphnia magna was investigated according to the OECD Guidelines for the Testing of Chems., Number 202. An increased 48-h EC₅₀ value for D. magna or reduced toxicity resulting from the addition of HCO-40 to the test medium was observed for five of the eight chems. examined Each of eight chems. was dissolved in water at a concentration of either 10 mg/L or 1.0 mg/L, with or without DMF or HCO-40. Silicone film as a model of a biol. membrane was then immersed in each solution, and the concentration of each chem. in the water was monitored until equilibrium was reached for each test substance, after which the adsorbed amount of each chem. was determined The amounts of p-pentylphenol and four other substances with log P_ow (1-octanol/water partition coefficient) values greater than 3.4 adsorbed onto the silicone film decreased with increasing concentrations of HCO-40. However, 3-chloro-4-fluoronitrobenzene and two other substances with log P_ow values less than 2.6 demonstrated no changes in adsorption with either increasing HCO-40 concentration or the addition of DMF. The reduced adsorption in the presence of a vehicle on the silicone film correlated closely with changes in toxicity. These results indicate that the methodol. developed in this study enables the prediction of changes in toxicity resulting from the addition of vehicles to a test system.

Chemosphere published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C6H3ClFNO2, Application of 3-Chloro-4-fluoronitrobenzene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics